Xiang-qiang (Rosie) Chu

Transcription

1 Xiang-qiang (Rosie) Chu Department of Physics and Astronomy Wayne State University Tel: Detroit, MI EMPLOYMENTS 2017 Present Associate Professor, Department of Physics and Astronomy, Wayne State University Assistant Professor, Department of Physics and Astronomy, Wayne State University Postdoctoral Research Associate, Biology and Soft Matter Division, Oak Ridge National Laboratory (ORNL) EDUCATION Ph.D., Nuclear Science and Engineering, Massachusetts Institute of Technology (MIT) M. S., B. S., Nuclear Physics, Peking University, Beijing, China RESEARCH INTERESTS Neutron and X-ray Scattering; Protein dynamics; Membrane protein structures; Protein-water interactions; Dynamics of liquids on biological and nano-scale material surfaces PROFESSIONAL SOCIETY MEMBERSHIPS American Physical Society (APS), Biophysical Society (BPS), Neutron Scattering Society of America (NSSA), American Chemical Society (ACS), American Crystallographic Association (ACA) SELECTED GRANTS AND AWARDS NSF Division of Molecular and Cellular Biosciences (MCB), Investigation of Protein Dynamics on Multiple Timescales by Neutron Scattering and Molecular Dynamics Simulations, $428,271, 07/01/ /30/2019 (PI); 1000 Young Talents Plan 2017; Successful Research Proposals as Principal Investigator, (Overall instrument time estimated worth over $2,500,000): 59 days of beam-time at Spallation Neutron Source, Oak Ridge National Lab (ORNL); 48 days of beam-time at NIST Center for Neutron Research; 19 days of beam-time at Advance Photon Source, Argonne National Lab (ANL); 6 days of beam-time at Brookhaven National Lab (BNL); 11 days of beam-time at Institut Laue Langevin (ILL), France. Richard J. Barber Summer Research Program Grants, Wayne State University (2013, 2014) Research Cluster Grant for a High-performance computer cluster from Silicon Mechanics, $190,000 value, 2014 (co-pi); Biophysical Society CPOW Travel Award, 2015; ORAU Travel Grants, 2013; Manson Benedict Fellowship, MIT, 2010 Xiang-qiang (Rosie) Chu 1/5

2 TEACHING AND ADVISING 2016 Fall, PHY 5750, Biological Physics; Winter: PHY6780, Research Methods in Biomedial Physics; 2015 Fall, 2014 Fall, 2013 Fall: PHY2130, General Physics; 2012 Fall PHY2130, General Physics Quiz Sections; Guest Lecturing: PSL7215 (NanoBioScience), PHY 6450, PHY6991. Postdoctoral Advisee: Dr. Debsindhu Bhowmik, Wayne State University, Feb Feb Graduate students: Gurpreet Dhindsa (Ph.D. in 2015), Utsab Shrestha (Rumble Fellowship, ; Ph.D. in 2017), Kavindya Senanayake, Kurt William Van Delinder (M.S. in 2014), Mohamad Bazzi (Bioengineering); Undergraduate students: Rifat Sattar, Nicholas Faucher, Andrew Rusek, Resiola Neli (Chemistry), Everett Hall (Chemistry), Eric Darnell, Joshua Jacob Kovoor SCHOLARLY AND PROFESSIONAL ACTIVITIES Referee for Nature Communications, the Journal of Physical Chemistry Letters, Biopolymers, Chemical Physics; PLOS One; Computational and Structural Biotechnology Journal, Frontiers of Physics Editorial Board Member: Scientific Reports, Nature Publishing Group Organizing committee and session chair, ACNS Local Organizing Committee member of Conference for undergraduate women in Physics (CUWiP) 2017 Co-organizer and chair for an invited session at the APS March Meeting 2014 Reviewer, NSF DMCB, Biophysics program, 2017 Reviewer, the DOE SCGSR program, May 2015 SELECTED PRESENTATIONS AND INVITED TALKS 1. Invited Talk at Chinese Physical Society (CPS) Fall meeting, Chengdu, China Sep Invited Talk at American Conference on Neutron Scattering (ACNS), Long Beach, CA, July Invited Talk at ihuman Institute, ShanghaiTech University, Shanghai, China, May Invited Talk at College of Chemistry and Molecular Engineering, Peking University, Beijing, China, May Invited Talk at School of Physics, Wuhan University, Wuhan, China, May Invited Talk at China Institute of Atomic Energy, Beijing, China, May Invited Talk at Institute of Physics, Chinese Academy of Sciences, Beijing, China, May Invited Talk at School of Physics, Nanjing University, China, Apr Invited Talk at Frontiers in Structural Biology of Membrane Protein & Pittsburgh Diffraction Conference, Huntsville, AL, Mar Invited Talk at Institute for Bioscience and Biotechnology Research, Rockville, MD, Feb Invited Talk at Institute of Marine and Environmental Technology, Baltimore, MD, Jan Invited Talk at College of Engineering and Applied Sciences, Nanjing University, China, Dec Invited Talk at School of Physics, Huazhong University of Science and Technology, Dec Invited Talk at School of Medicine, Wayne State University, Detroit, MI, Dec Xiang-qiang (Rosie) Chu 2/5

3 15. Invited Talk at the SNS/HFIR User Meeting, Oak Ridge National Laboratory, TN, Oct. 26, Invited Talk at International Workshop on the Structure and Dynamics of Supercooled Water and Other Glassy Materials, Palermo, Italy, Oct. 13, Invited Talk at Department of Physics, Shanghai Jiaotong University, Shanghai, China, June, Invited Talk at the APS (American Physical Society) March Meeting, Denver, CO, Mar. 6, Contributed talk at the APS March Meeting, Denver, CO, Mar. 5, Talk at Biophysical Society (BPS) 58th Annual Meeting, San Francisco, CA, Feb. 17, Invited talk at Department of Physics and Material Science, Hong Kong City University, Hong Kong, China, June 16, Invited talk at Department of Physics, Tsinghua University, Beijing, China, June 19, Invited talk at the International Center for Quantum Materials (ICQM), Peking University, Beijing, China, June 18, Invited talk at the Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, China, June 30, Invited talk at Medical School, Yangzhou University, Yangzhou, China, July 2, Invited talk at Department of Physics, Binghamton University, Binghamton, NY, Oct 21, Invited talk at Department of Physics, Oakland University, Rochester, MI, Sep 26, Invited talk at Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, Aug 14, Plenary talk at the 8th Annual Midwest Conference on Protein Folding, Assembly and Molecular Motions, University of Notre Dame, Notre Dame IN, May 4, Contributed talk at the APS March Meeting, Baltimore, MD, Mar , Invited talk at Department of Chemistry, Wayne State University, Detroit, MI, Jan 25, Plenary talk at the 6th Annual WSU Undergraduate Physics Research Conference, Wayne State University, Nov. 16, Talk at the ACA (American Crystallographic Association) Meeting 2012, Boston, MA, Jul. 31, Talk at American Conference on Neutron Scattering (ACNS) 2012, Washington, DC, Jun. 27, Talk at the 243 rd ACS (American Chemical Society) National Meeting, San Diego CA, Mar. 26, Talk at the APS (American Physical Society) March Meeting 2012, Boston, MA, Feb. 29, Invited talk at Physics Dept. Colloquium, Wayne State University, Detroit, MI, Feb. 16, Invited talk at Department of Physics, Boston University, Boston, MA, May 27, Invited talk at Department of Engineering Physics, Tsinghua University, Beijing, China, Apr Invited talk at Department of Mechanical Engineering, Boston University, Boston, MA, Oct SELECTED PUBLICATIONS (*Corresponding Author) (Total publications = 30, total citations = 693, h-index = 13) 1. U. R Shrestha, D. Bhowmik, K. W. Van Delinder, E. Mamontov, H. M. O'Neill, Q. Zhang, A. Alatas, and X.-Q. Chu*, Collective Excitations in Protein as a Measure of Balance Between Its Softness and Rigidity, J. Phys. Chem. B, 121, (2017). 2. Utsab R Shrestha, Suchithranga MDC Perera, Debsindhu Bhowmik, Udeep Chawla, Eugene Mamontov, Michael F Brown, X.-Q. Chu*, Quasi-elastic neutron scattering reveals ligand-induced protein dynamics of a G-protein-coupled receptor, J. Phys. Chem. Lett. 7, (2016). 3. G.K. Dhindsa, D. Bhowmik, M. Goswami, H.M. O'Neill, E. Mamontov, B.G. Sumpter, L. Hong, P. Xiang-qiang (Rosie) Chu 3/5

4 Ganesh, and X.-Q. Chu *, Enhanced Dynamics of Hydrated trna on Nanodiamond Surfaces: A Combined Neutron Scattering and MD Simulation Study, J. Phys. Chem. B, 120, (2016). 4. U. R. Shrestha, D. Bhowmik, J. R. D. Copley, M.S. Tyagi, J. B. Leão, and X.-Q. Chu *, The Effects of Pressure on the Dynamics of an Oligomeric Protein from Deep-sea Hyperthermophile, Proc. Natl. Acad. Sci. U.S.A.(PNAS), 112 (45) (2015). 5. G. Dhindsa, M. S. Tyagi, and X.-Q. Chu*, Temperature-dependent Dynamics of Dry and Hydrated β-casein Studied by Quasielastic Neutron Scattering, J. Phys. Chem. B 118, (2014). 6. X.-Q. Chu*, E. Mamontov, H. O Neill, and Q. Zhang, Temperature Dependence of Logarithmic-like Relaxational Dynamics of Hydrated trna, J. Phys. Chem. Lett. 4, (2013). 7. X.-Q. Chu, M. Gajapathy, K. L. Weiss, E. Mamontov, J. D. Ng and L. Coates, Dynamic behavior of oligomeric inorganic pyrophosphatase explored by quasielastic neutron scattering, J. Phys. Chem. B 116, (2012). 8. E. Mamontov and X.-Q. Chu, New opportunities for probing protein dynamics in aqueous solutions at low to physiological temperatures, Physical Chemistry Chemical Physics 14, (2012). (Perspective Article) 9. X.-Q. Chu, E. Mamontov, H. O Neill, and Q. Zhang, Apparent decoupling of the dynamics of a protein from the dynamics of its aqueous solvent, J. Phys. Chem. Lett. 3, (2012). 10. X.-Q. Chu, G. Ehlers, E. Mamontov, A. Podlesnyak, W. Wang, and D. J. Wesolowski, Diffusion Processes in Water on Oxide Surfaces: Quasielastic Neutron Scattering Study of Hydration Water in Rutile Nano-Powder, Phys. Rev. E 84, (2011). 11. M. Li, X.-Q. Chu, E. Fratini, P. Baglioni, A. Alatas, E. Alp, and S.-H. Chen, Phonon-like Excitation in Secondary and Tertiary Structure of Hydrated Protein Powders, a Communication in Soft Matter 7, (2011). 12. X.-Q. Chu, K.-H. Liu, M. S. Tyagi, C.-Y. Mou, and S.-H. Chen, Low Temperature Dynamics of Water Confined in a Hydrophobic Mesoporous Material, Phys. Rev. E 82, (2010). (Rapid Communication) 13. X.-Q. Chu, M. Lagi, E. Mamontov, E. Fratini, P. Baglioni, and S.-H. Chen, Experimental Evidence of Logarithmic Relaxation in Single-particle Dynamics of Hydrated Protein Molecules, Soft Matter 6, (2010). (Communication) 14. S.-H. Chen, M. Lagi, X.-Q. Chu, Y. Zhang, C. Kim, A. Faraone, E. Fratini, and P. Baglioni, Dynamics of a globular protein and its hydration water studied by neutron scattering and MD simulations, a Feature Article in Spectroscopy: Biomedical Applications 24, 1-24 (2010). 15. S.-H. Chen, Y. Zhang, M. Lagi, X.-Q. Chu, L. Liu, A. Faraone, E. Fratini, and P. Baglioni, The Dynamic Response Function χ T (Q,t) of Confined Supercooled Water and its Relation to the Dynamic Crossover Phenomenon, Z. Phys. Chem. 224, (2010). 16. X.-Q. Chu, A. Faraone, C. Kim, E. Fratini, P. Baglioni, J. B. Leao, and S.-H. Chen, Proteins Remain Soft at Lower Temperatures under Pressure, a Letter in J. Phys. Chem. B 113, 5001 (2009). 17. G. Franzese, K. Stokely, X.-Q. Chu, P. Kumar, M. G. Mazza, S.-H. Chen and H. E. Stanley, Pressure effects in supercooled water: comparison between a 2D model of water and experiments for Xiang-qiang (Rosie) Chu 4/5

5 surface water on a protein, J. Phys.: Condens. Matter 20, (2008). 18. D. Liu, X.-Q. Chu, M. Lagi, Y. Zhang, E. Fratini, P. Baglioni, A. Alatas, A. Said, E. Alp, and S.-H. Chen, Studies of Phonon-like Low Energy Excitations of Protein Molecules by Inelastic X-ray Scattering, Phys. Rev. Lett. 101, (2008). 19. M. Lagi, X.-Q. Chu, C. Kim, F. Mallamace, P. Baglioni and S.-H. Chen, The Low-Temperature Dynamic Crossover Phenomenon in Protein Hydration Water: Simulations vs Experiments, J. Phys. Chem. B, 112, 1571 (2008). 20. X.-Q. Chu, E. Fratini, P. Baglioni, A. Faraone, and S.-H. Chen, Observation of a Dynamic Crossover in RNA Hydration Water which Triggers the Dynamic Transition in the Biopolymer, Phys. Rev. E 77, (2008). 21. X.-Q. Chu, A. I. Kolesnikov, A. P. Moravsky, V. Garcia-Sakai, and S.-H. Chen, Observation of a Dynamic Crossover in Water Confined in Double-Wall Carbon Nanotubes, Phys. Rev. E 76, (2007). 22. S.-H. Chen, L. Liu, X.-Q. Chu, Y. Zhang, E. Fratini, P. Baglioni, A. Faraone, and E. Mamontov, Experimental Evidence of Fragile-to-Strong Dynamic Crossover in DNA Hydration Water, J. Chem. Phys. 125, (2006). Xiang-qiang (Rosie) Chu 5/5