Department of Chemistry
|
|
- Joshua Waters
- 5 years ago
- Views:
Transcription
1 West Virginia University Department of Chemistry rganic Division April 4 th, 2012 Cumulative Exam # 378 X. Michael Shi rganic Cumulative Examination #378 ame Question # 1 (29 points): Question # 2 (34 points): Question # 3 (40 points): Total (103 points):
2 Question 1. Some fundamental terms involved carbene chemistry a) Give an example of Setter reaction and draw detailed electron-pushing mechanism. (5 points) b) Draw the detailed structures of Grubbs I, Grubbs II, Hoveyda-Grubbs catalysts (6 points) c) Schrock entered the metathesis field in 1979 and extending the work on Tantalum and Tungsten complexes. The Tantalum complex suffered from catalyst turnover as the reaction shown below. Provide the product (2 points) Cl Cp Ta Cl pentane, 25 o C The Tungsten complexes became Schrock catalyst, which was commercialized starting in Provide the detailed structure of this catalyst (2 points). In addition, Schrock further developed this system to asymmetric catalyst in Provide the chiral Schrock catalyst (2 points). 1
3 d) Another major area in carbene catalysis was the application of dirhodium complexes for the activation of stabilized carbene. Provide the product for the following reaction. (2 point) 2 dirhodium catalyst CbZ DCE, 60 o C Provide detailed electron-pushing mechanism. ote: for the metal catalysis, there are several different argument regarding the mechanism, you will receive full credit if you can provide any of the reasonable plausible mechanism regarding this transformation with all details provided. (4 points) e) Two more terms: 1) draw examples of Breslow intermediate (2 point); 2) Draw examples of Fisher carbene and Schrock carbene, CLEARLY explain the difference (4points) 2
4 Question 2. Carbene catalysis a) For the following reaction first reported by Jeff Bode. H + Ts 10% Detailed electron-pushing reaction mechanism (6 points); structure of DBU (1 point), Mes (1 point). Mes Cl - 15% DBU, 0.1 M EtAc, rt H Ts b) Draw the detailed electron pushing for the following reaction reported by Tom Rovis (6 points) H 3 C Br H + BnH Et3, Tol H 3 C Br Bn 3
5 c) For the following reaction reported by Hoveyda. Provide detailed electron-pushing reaction mechanism (6 points). Predict the stereochemistry of the product (> 98:2 d.r.). Draw the transition-state that account for the formation of the r corresponding stereochemistry (4 points). + CH 2.5% Cy BF Cy 2.5% at-bu, B 2 (pin) 2, THF, rt H B d) Draw the detailed electron pushing mechanism for the following catalytic kinetic resolution (8 points). What is the other major product (2 points) Mes 0.5 eq H + H 1 eq + H 10% 10% Cl 4 - Mes Mes 4
6 Question 3. Carbene metal complexes/catalysts a) In 2010, Huw Davis reported the reaction carbene annulation with Indole. Me 2 C H 2 C 2 Me A Rh 2 (S-DSP) 4 Rh 2 (S-DSP) 4 1) Draw detailed electron-pushing mechanism for the formation of A (5 points) 2) What is the structure of B (2 points). Wish identical di-rh catalyst, predict the stereochemistry of B (2 points) B b) Recently (ACIE, 2012, 2939), Rai-Shung Liu reported the following reaction. Provided the detailed electron pushing mechanism (5 points). Draw the structure of IPr (2 points) IPrAuCl/AgTf 2 5
7 c) In 2011, Jianbo Wang reported the following reaction 2 Me + H 2 2.5% Pd 2 (dba) 3 K 3 P eq. C 1atm Me, 60 o C H 1) Structure of dba? (2 points) structure of Pd 2 (dba) 3? (2 points) 2) Mechanism? (6 points) Me d) Professor Peter Zhang developed a porphyrin-based Co(II) catalysts that has been used in nitrene and carbene chemistry. 1) See the simplified Co-P catalyst. Provide electron counting of Co (2 points). 2) Draw the d-electrons distribution. Hint: different energy of the d-orbitals (2 points) 3) Provide the detailed electron pushing for the following reaction (5 points) Co 3 2 S H Co cat S H H 6
8 e) Valery Fokin reported the following transformation. Draw the detailed electron pushing mechanism (5 points) H + Tf 2 (1 eq) CH 1% Rh 2 (Ac) 4 CH 2 Cl 2 t-bu t-bu The end. 7
Lecture 6: Transition-Metal Catalysed C-C Bond Formation
Lecture 6: Transition-Metal Catalysed C-C Bond Formation (a) Asymmetric allylic substitution 1 u - d u (b) Asymmetric eck reaction 2 3 Ar- d (0) Ar 2 3 (c) Asymmetric olefin metathesis alladium π-allyl
More informationCEM 852 Final Exam. May 6, 2010
CEM 852 Final Exam May 6, 2010 This exam consists of 7 pages. Please make certain that your exam has all of the necessary pages. Total points possible for this exam are 150. n answering your questions,
More informationOrganic Tutorials 3 rd Year Michaelmas Transition Metals in Organic Synthesis: (General paper level) ! 1! Reading
rganic Tutorials 3 rd Year Michaelmas 2010 Transition Metals in rganic Synthesis: (General paper level) Reading 1. Lecture Course, and suggested references from this. 2. Clayden, Greaves, Warren and Wothers.
More informationOrganocatalytic Umpolung via N- Heterocyclic Carbenes. Qinghe Liu Hu Group Meeting August 20 th 2015
rganocatalytic Umpolung via N- Heterocyclic Carbenes Qinghe Liu Hu Group Meeting August 20 th 2015 Contents Part 1: Introduction Part 2: N-Heterocyclic carbene-catalyzed umpolung: classical umpolung, conjugated
More informationWilkinson s other (ruthenium) catalyst
Wilkinson s other (ruthenium) catalyst Cl 3 ; 2 h 3, reflux 3h h 3 Cl h 3 h Cl 3 Good catalyst especially for 2 1-alkenes 2, base toluene Cl h 3 h 3 h 3 Et 3 Cl h 3 Cl h 3 h 3 R h 3 h 3 Cl h 3 R RC 2 C
More informationIridium-Catalyzed Hydrogenation with Chiral P,N Ligands
Iridium-Catalyzed Hydrogenation with Chiral P, Ligands 贾佳 utline Brief Introduction Hydrogenation of C=C Bonds Hydrogenation of C= Bonds Hydrogenation of C= Bonds Conclusion Brief Introduction First example
More informationCEM 852 Exam LDA, THF, 0 C, 15 min; then
CEM 85 Exam- April, 005 This exam consists of 5 pages. Please write ALL your answers in the answer books. Please write legibly and draw all structures clearly. Good luck. 1. Provide examples of the following
More informationOC 2 (FS 2013) Lecture 3 Prof. Bode. Redox Neutral Reactions and Rearrangements
C 2 (F 203) Lecture 3 Prof. Bode edox eutral eactions and earrangements Types of edox eutral rganic eactions. eactions with no external reducing or oxidizing agent In this case, one part of the starting
More informationCatalytic Asymmetric [4+1] Annulation of Sulfur Ylides with Copper Allenylidene Intermediates. Reporter: Jie Wang Checker: Shubo Hu Date: 2016/08/02
Catalytic Asymmetric [4+1] Annulation of Sulfur Ylides with Copper Allenylidene Intermediates Reporter: Jie Wang Checker: Shubo Hu Date: 2016/08/02 Xiao, W.-J. et al. J. Am. Chem. Soc. 2016, 138, 8360.
More informationYou may write your answers in the space provided and/or on additional pages.
Name: 1 CHEM 633: Advanced rganic Chemistry: Physical Midterm 2 Please answer the following questions clearly and concisely. You may write your answers in the space provided and/or on additional pages.
More informationSpiro Monophosphite and Monophosphoramidite Ligand Kit
Spiro Monophosphite and Monophosphoramidite Ligand Kit metals inorganics organometallics catalysts ligands custom synthesis cgm facilities nanomaterials 15-5162 15-5150 15-5156 15-5163 15-5151 15-5157
More informationdeactivation or decomposition is therefore quantified using the turnover number.
A catalyst may be defined by two important criteria related to its stability and efficiency. Name both of these criteria and describe how they are defined with respect to stability or efficiency. A catalyst
More informationThere are 15 total pages to this exam. Please be sure your copy has 15 pages before you begin.
Initials: 1 ame: Chem 633: Advanced rganic Chemistry Midterm 2 Please answer the following questions clearly and concisely. Write your answers in the space provided. Write your initials on each page you
More informationChiral Diol Promoted Boronates Addi3on Reac3ons. Lu Yan Morken Group Boston College
Chiral Diol Promoted Boronates Addi3on Reac3ons Lu Yan Morken Group Boston College Main Idea R R B or R R B Ar * exchange B * * or B Ar R 1 R 1 R 2 R 1 R 2 Products not nucleophilic enough nucleophilic
More information- Overview of polymeriza1on catalysis
- verview of polymeriza1on catalysis Different coordina-on polymeriza-on mechanisms: RP, RMP, (meth)acrylate polymeriza6on, olefin polymeriza6on. Different catalysts: Metal- based catalysts, organic catalysts
More informationFinal Exam /340 ( CHEM 6352 Fall %) Name
Final Exam /340 ( CEM 6352 Fall 2012 %) Name Dec. 15 th, 2012 9:30-13:45 You may NT use any references or aids to complete the following with the exception of a chemical model set and the scrap paper that
More informationCEM 852 Final Exam. May 5, 2011
CEM 852 Final Exam May 5, 2011 This exam consists of 8 pages. Please make certain that your exam has all of the necessary pages. Total points possible for this exam are 150. In answering your questions,
More informationStrategies for Stereocontrolled Synthesis
Chemistry. Synthetic rganic Chemistry II Lecture 3 March, 2007 Rick L. Danheiser Massachusetts Institute of Technology! Thermodynamic Control Strategies! Kinetic Control Strategies! Strategies for the
More informationShi Asymmetric Epoxidation
Shi Asymmetric Epoxidation Chiral dioxirane strategy: R 3 + 1 xone, ph 10.5, K 2 C 3, H 2, C R 3 formed in situ catalyst (10-20 mol%) is prepared from D-fructose, and its enantiomer from L-sorbose oxone,
More informationCEM 852 Exam What is the ratio of (S) / (R) alcohol formed during this reaction? (2 pts) baker's yeast. H 2 O, sucrose 25 C
CEM 852 Exam-1 February 19, 2005 This exam consists of 5 pages. Please write ALL your answers in the answer books. Please write legibly and draw all structures clearly. Good luck. 1. What is the ratio
More informationNucleophilic Heterocyclic Carbene Catalysis. Nathan Werner Denmark Group Meeting September 22 th, 2009
Nucleophilic Heterocyclic Carbene Catalysis Nathan Werner Denmark Group Meeting September 22 th, 2009 Thiamine Thiamine Vitamin B 1 The first water-soluble vitamin described Is naturally synthesized by
More informationConcise, Asymmetric, Stereocontrolled Total Synthesis of Stephacidins A, B and Notoamide B
Concise, Asymmetric, Stereocontrolled Total Synthesis of Stephacidins A, B and otoamide B (+)-avrainvillamine (+)-notoamide B 20 51 21 55 (-)-stephacidin B In 2002, Bristol-Myers Squibb reported the biologically
More informationPART I: CARBENES and NITRENES
ACS Group eting Problem Session Feb/Mar 2009 Mahesh Mohan Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ Reactive Intermediates in rganic Synthesis PART I: CARBEES
More informationInitials: 1. Chem 633: Advanced Organic Chemistry 2011 Final Exam
Initials: 1 ame: Chem 633: Advanced rganic Chemistry 2011 Final Exam Please answer the following questions clearly and concisely. In general, use pictures and less than 10 words in your answers. Write
More informationAsymmetric Catalysis by Lewis Acids and Amines
Asymmetric Catalysis by Lewis Acids and Amines Asymmetric Lewis acid catalysis - Chiral (bisooxazoline) copper (II) complexes - Monodentate Lewis acids: the formyl -bond Amine catalysed reactions Asymmetric
More informationO + k 2. H(D) Ar. MeO H(D) rate-determining. step?
ame: CEM 633: Advanced rganic Chem: ysical Problem Set 6 (Due Thurs, 12/8/16) Please do not look up references until after you turn in the problem set unless otherwise noted. For the following problems,
More informationRhodium Catalyzed Alkyl C-H Insertion Reactions
Rhodium Catalyzed Alkyl C-H Insertion Reactions Rh Rh Jeff Kallemeyn 5/17/05 1. Cyclopropanation The Versatile and Reactive Rhodium Carbene R + Et Rh 2 (Ac) 4 R C 2 Et N 2 2. [2,3] sigmatropic rearrangement
More informationDr. P. Wipf Page 1 of 5 10/7/2009. Cl Ru. Kingsbury, J. S.; Harrity, J. P. A.; Hoveyda, A. H. J. Am. Chem. Soc. 1999, 121, 791.
Dr. P. Wipf Page 1 of 5 10/7/2009 Alkene Metathesis Grubbs II published The Catalysts Me Mo F 3C CF3 Me F 3C CF3 C(Me) 2 chrock, R. R.; Murdzek, J..; Bazan, G. C.; Robbins, J.; DiMare, M.; 'Reagan, M.
More informationCEM 852 Exam-2 April 11, 2015
CEM 852 Exam-2 April 11, 2015 This exam consists of 6 pages. Please make certain that your exam has all of the necessary pages. Total points possible for this exam are 100. In answering your questions,
More informationName: CHEM 633: Advanced Organic Chemistry: Physical Final Exam. Please answer the following questions clearly and concisely.
Name: 1 CEM 633: Advanced rganic Chemistry: Physical Final Exam Please answer the following questions clearly and concisely. You may write your answers in the space provided and/or on additional pages.
More informationOrganic Chemistry Laboratory Summer Lecture 6 Transition metal organometallic chemistry and catalysis July
344 Organic Chemistry Laboratory Summer 2013 Lecture 6 Transition metal organometallic chemistry and catalysis July 30 2013 Summary of Grignard lecture Organometallic chemistry - the chemistry of compounds
More informationIonic Liquids (IL s): An Ionic Liquid-Supported Ruthenium Carbene Complexes for RCM in Ionic Liquids
Ionic Liquids (IL s): An Ionic Liquid-Supported Ruthenium Carbene Complexes for RCM in Ionic Liquids J. Am. Chem. Soc. 2003, 125, 9248-49 Angew. Chem. Int. Ed. 2003, 42, 3395-3398 Literature presentation
More informationFinal Exam April 30, 2014
Bennett Department of Chemistry Chemistry 234 Final Exam April 30, 2014 ame: This exam is a closed book, closed notes. Calculators and a molecular model set are allowed. You must show your work in order
More informationMODULE CODE: CHEM10003 ORGANIC CHEMISTRY 4 EXAM
School of Science and Sport Physical Sciences, Chemistry Paisley Campus Session 2014-15 Trimester 2 MDULE CDE: CHEM10003 RGANIC CHEMISTRY 4 EXAM Date: 15th May 2015 Time: 10.00am 12.00pm Attempt THREE
More informationTotal Syntheses of Minfiensine
Total Syntheses of Minfiensine Douany, A. B.; umphreys, P. G.; verman, L. E.*; Wrobelski, A. D., J. Am. Chem. Soc. 2008, ASAP. D: 10.1021/ja800163v Shen, L.; Zhang, M.; Wu, Y.; Qin, Y.*, Angew. Chem. nt.
More informationPartial Periodic Table
Easily Legible Printed Name: CHEM 3451, Spring 2018 Professor Walba Second Hour Exam March 13, 2018 scores: 1) 2) 3) 4) 5) CU Honor Code Pledge: On my honor, as a University of Colorado at Boulder Student,
More informationOrganocatalysis Enabled by N-Heterocyclic Carbenes
rganocatalysis Enabled by -eterocyclic Carbenes Acyl Anions X Y omoenolates Acylazolium Azolium enolate Base Catalysis Jiaming Li 2018/04/27 tability of -heterocyclic Carbenes 2p x,y,z p π 2p x,y,z p π
More informationOrganic Cumulative Exam January 26, 2017
rganic Cumulative Exam January 26, 2017 Answer only three the six questions. o more than three question answers will be graded any work not to be considered must be clearly marked as such. Clearly indicate
More informationMulticatalyst Promoted Asymmetric Tandem Reactions
Literature presentation Kishor Mohanan Multicatalyst Promoted Asymmetric Tandem Reactions Features of Tandem Catalysis Reduces the yield losses associated with the purification of intermediates, Save time,
More informationBasics of Catalysis and Kinetics
Basics of Catalysis and Kinetics Nobel laureates in catalysis: Haber (1918) Ziegler and Natta (1963) Wilkinson, Fischer (1973) Knowles, Noyori, Sharpless (2001) Grubbs, Schrock, Chauvin (2006) Ertl (2007)
More informationSteric and Electronic Controllers in Ring-Closing Metathesis Reactions. Jennifer E. Farrugia October 29, 2003
Steric and Electronic Controllers in Ring-Closing Metathesis Reactions Jennifer E. Farrugia October 29, 2003 Steric and Electronic Controllers How do substrate sterics affect the reactivity/ selectivity
More informationWhen something goes wrong. Goya: Mother showing her derformed child to two women Louvre, Paris
1 ew Catalytic Asymmestric eactions Karl Anker Jørgensen Danish ational eserach Foundation: Center for Catalysis Department of Chemistry, Aarhus University Denmark kaj@chem.au.dk When something goes wrong
More informationElectrophilic Carbenes
Electrophilic Carbenes The reaction of so-called stabilized diazo compounds with late transition metals produces a metal carbene intermediate that is electrophilic. The most common catalysts are Cu(I)
More informationShort Literature Presentation 10/4/2010 Erika A. Crane
Copper-Catalyzed Enantioselective Synthesis of trans-1- Alkyl-2-substituted Cyclopropanes via Tandem Conjugate Additions-Intramolecular Enolate Trapping artog, T. D.; Rudolph, A.; Macia B.; Minnaard, A.
More informationCarbenes and Carbene Complexes I Introduction
Carbenes and Carbene Complexes I Introduction A very interesting (honest) class of radical-like molecules Steadily becoming more important as they find far more synthetic applications We will primarily
More informationHomogeneous Catalysis - B. List
omogeneous Catalysis - B. List 2.2.2 Research Area "rganocatalytic Asymmetric α-alkylation of Aldehydes" (B. List) Involved:. Vignola, A. Majeed Seayad bjective: α-alkylations of carbonyl compounds are
More informationOrganometallics: Hard to define usefully and completely at the same time, but generally: Compounds containing metal-carbon bond(s).
eady; Catalysis rganometallics: Definitions rganometallics: ard to define usefully and completely at the same time, but generally: Compounds containing metal-carbon bond(s). C C C C C C K 3 o question:????
More informationCopper-Catalyzed Synthesis of Esters from Ketones. Alkyl Group as a Leaving Group.
Copper-Catalyzed Synthesis of Esters from Ketones. Alkyl Group as a Leaving Group. akatani, Y.; Koizumi, Y.; Yamasaki, R.; Saito, S. rg. Lett. 2008, 10, 2067-2070. An Annulation Reaction for the Synthesis
More informationTotal Synthesis of the Chartellines
Total Synthesis of the Chartellines X Y chartelline A, X = Y = chartelline B, X =, Y = chartelline C, X = Y = Mariam Shamszad ovember 1, 2006 Background Chartellines A, B, and C were isolated in the 1980s
More informationPartial Periodic Table
Easily Legible Printed Name: CHEM 3351 (100), Fall 2016 Professor Walba Second Hour Exam October 18, 2016 CU Honor Code Pledge: On my honor, as a University of Colorado at Boulder Student, I have neither
More informationChapter 8 Alkenes: Reactions
Chamras Glendale Community College Organic Chemistry 105 Chapter 8 Alkenes: Reactions Name Type 1. alo-hydrogenation (Ionic & Radical) Electrophilic Addition 2. ydration (Acid-Catalyzed) Electrophilic
More informationSonogashira Couplings of Aryl Bromides: Room Temperature, Water Only, No Copper
Sonogashira Couplings of Aryl omides: Room Temperature, Water nly, o Copper uce. Lipshutz, David W. Chung, and ian Rich rg.lett. ASAP Article Presentation By ora Jameson Current Lit 08/30/2008 ora Jameson
More informationStrained Molecules in Organic Synthesis
Strained Molecules in rganic Synthesis 0. Introduction ~ featuring on three-membered rings ~ Tatsuya itabaru (M) Lit. Seminar 08068 for cyclobutadienes : see Mr. Yamatsugu's Lit. Sem. 069 eat of Formation
More informationAsymmetric Nucleophilic Catalysis
Asymmetric ucleophilic Catalysis Chiral catalyst X 2 Chiral catalyst X = alkyl, X 1 2 1 Vedejs, E.; Daugulis,. J. Am. Chem. Soc. 2003, 125, 4166-4173 Shaw, S. A.; Aleman,.; Vedejs, E. J. Am. Chem. Soc.
More informationChem 112A: Final Exam
Chem 112A: Final Exam December 15th, 2010 Please provide all answers in the spaces provided. You are not allowed to use a calculator for this exam, but you may use molecular model kits. nly cyclohexane
More informationFirst Midterm Exam Monday, October 16, You may use model kits but no other material with chemical information without instructor approval.
CH 334 Form B First Midterm Exam Monday, October 16, 2017 Name KEY You may use model kits but no other material with chemical information without instructor approval. Please do not use any electronic devices
More informationNOT TO BE REMOVED FROM THE EXAMINATION HALL
A copy of the Level III (FHEQ Level 6) Equation and Data Sheet booklet is provided. The use of hand-held, battery-operated, electronic calculators will be permitted subject to the regulations governing
More informationMassachusetts Institute of Technology. Chemistry 5.43 February 28 th, Exam #1. Question 1a /4 points Question 2b /10 points
Massachusetts Institute of Technology Chemistry 5.43 February 28 th, 2007 Professor M. Movassaghi Exam #1 Question 1a /4 points Question 2b /10 points Question 1b /2 points Question 2c /6 points Question
More informationBasic Arrow-Pushing & Energy Concepts - Key Problem Set 1 Due Tuesday, 10/4/16
asic ArrowPushing & Energy Concepts Key Problem Set 1 Due Tuesday, 10/4/16 1. For each compound, identify the atom most likely to be attacked first by a nucleophile and identify the unoccupied frontier
More informationInitials: 1. Chem 633: Advanced Organic Chemistry 2016 Final Exam
Initials: 1 ame: Chem 633: Advanced rganic Chemistry 2016 Final Exam This exam is closed note, closed book. Please answer the following questions clearly and concisely. In general, use pictures and less
More informationSp 3 C-H Bond Activation Catalyzed by Transition Metal. Reporter: Wan Xiaobing Supervisor: Prof. Shi Zhangjie
Sp 3 C- Bond Activation Catalyzed by Transition Metal Reporter: Wan Xiaobing Supervisor: Prof. Shi Zhangjie Academic: high bond energy Practical: abundant, cheap, clean 2 hv C n 2n+2 Cl 2 C n 2n+2-m Cl
More informationKinetic Resolutions. Some definitions and examples Resolution: A process leading to the separation of enantiomers, or derivatives thereof.
Material outline: For the Scientist in you: Definitions Theoretical treatment Kinetic esolutions General eferences: Vedejs, ACIEE, 2005, 3974 Jacobsen, Adv. Syn. Cat. 2001, 5 Kagan, Topics in Stereochemistry,
More informationReporter: Yue Ji. Date: 2016/12/26
Literature Report (11) Total Synthesis of Rubriflordilactone B Reporter: Yue Ji Checker: Mu-Wang Chen Date: 2016/12/26 Yang, P.; Yao, M.; Li, J.; Li, Y.; Li, A.* Angew. Chem. Int. Ed. 2016, 55, 6964. Laboratory
More informationCHE Organic Chemistry Exam 4, May 4, 2004
CE 232 - rganic Chemistry Exam 4, May 4, 2004 ame KEY Student ID o. Before you begin this exam: First: You are allowed to have a simple model set at your seat. Please put away all other materials. Second:
More informationOrganic Chemistry CHM 224
rganic Chemistry CHM 224 Exam I Review Questions This set of questions is a compilation of old exams and additional questions, and does not represent the typical length of an exam - this is WAY longer!
More informationName: CHEM 633: Advanced Organic Chem: Physical Problem Set 5 Due 11/10/17
ame: CEM 633: Advanced rganic Chem: ysical Problem Set 5 Due 11/10/17 Please do not look up references until after you turn in the problem set unless otherwise noted. For the following problems, please
More informationHOMEWORK PROBLEMS: ALKYNES. 1. Provide the complete IUPAC name for the following compounds:
CEM 31 MEWRK PRBLEMS: ALKYNES 1. Provide the complete IUPAC name for the following compounds: 2. When the compound below is treated with one equivalent of B 3, where does it react Explain. Where would
More informationShort Access to (+)-Lupinine and (+)-Epiquinamide via Double Hydroformylation
Short Access to (+)-Lupinine and (+)-Epiquinamide via Double Hydroformylation Kai Gao Checker: Changbin Yu Mann, A.* et al rg. Lett. 2009, ASAP Strategy for the formation of quinolizidine alkaloids R H
More informationScission of Dinitrogen by a Molybdenum(III) Xylidene Complex. CHM 5.33 Fall 2005
Scission of Dinitrogen by a Molybdenum(III) Xylidene Complex CHM 5.33 Fall 2005 Introduction The experiment is based on research performed in the laboratory of Professor Cummins during the early 90 s.
More informationPartial Periodic Table
Printed ame: CEM 3371, Spring 2015 Professor Walba First our Exam March 10, 2015 CU onor Code Pledge: n my honor, as a University of Colorado at Boulder Student, I have neither given nor received unauthorized
More informationTotal Synthesis of (+/-)-Goniomitine via a Formal Nitrile/Donor-Acceptor Cyclopropane [3 + 2] Cyclization
Total Synthesis of (+/-)-Goniomitine via a Formal itrile/donor-acceptor Cyclopropane [3 + 2] Cyclization (-)-Goniomitine Christian L. Morales and Brian Pagenkopf* rganic Letters, ASAP Current Literature
More informationIntramolecular Ene Reactions Utilizing Oxazolones and Enol Ethers Fisk, J.S. and Tepe, J..J J. Am. Chem. Soc., 2007, 129,
Intramolecular Ene Reactions Utilizing xazolones and Enol Ethers Fisk, J.S. and Tepe, J..J J. Am. Chem. Soc., 2007, 129, 3058-3059 - versus -Arylation of Aminoalcohols: rthogonal Selectivity in Copper-Based
More information"-Amino Acids: Function and Synthesis
"-Amino Acids: Function and Synthesis # Conformations of "-Peptides # Biological Significance # Asymmetric Synthesis Sean Brown MacMillan Group eting ovember 14, 2001 Lead eferences: Cheng,. P.; Gellman,
More informationH H H OH OH H OH H O 1 CH 2 OH
Name 215 F07-Exam No. 3 Page 2 I. (29 points) Streptomycetes are soil-dwelling, filamentous, Gram-positive saprophytic bacteria. They are responsible for over 50% of the known microbial metabolites, including
More informationLiterature Report III
Literature Report III Regioselective ydroarylation of Alkynes Reporter: Zheng Gu Checker: Cong Liu Date: 2017-08-28 Cruz, F. A.; Zhu, Y.; Tercenio, Q. D.; Shen, Z.; Dong, V. M. J. Am. Chem. Soc. 2017,
More informationChem 6 sample exam 1 (100 points total)
Chem 6 sample exam 1 (100 points total) @ This is a closed book exam to which the Honor Principle applies. @ The last page contains several equations which may be useful; you can detach it for easy reference.
More informationHydroformylation. Organometallic Chemistry and Homogeneous Catalysis. Homogeneous catalysis with transition metal complexes
Organometallic Chemistry and Homogeneous Catalysis Dr. Alexey Zazybin Lecture N10 Kashiwa Campus, January 8, 2010 R Hydroformylation Rh or Co + CO + H 2 H O Aldehydes R + H * O R linear (normal) branched
More informationAziridine Carboxylates, Carboxamides and Lactones: New Methods for Their Preparation and Their Transformation into α- and β-amino Acid Derivatives
Molecules 2000, 5 293 Aziridine Carboxylates, Carboxamides and Lactones: ew Methods for Their Preparation and Their Transformation into α- and β-amino Acid Derivatives obert H. Dodd Institut de Chimie
More informationMidterm Exam 1. Chem 3B, Fall 2016 Thursday, September 29, :00 9:00 pm. Name. Student ID
Midterm Exam 1 Chem 3B, Fall 2016 Thursday, September 29, 2016 7:00 9:00 pm ame Student ID You have 120 minutes to complete this exam. Please provide all answers in the space provided. Work drawn in the
More informationSynthetic Methodology. Using Tertiary Phosphines. as Nucleophilic Catalysts
Synthetic Methodology Using Tertiary osphines as Nucleophilic Catalysts 1 3 2 u 2 (P 3 ) 3 4 1 2 D. Ma, X. Lu 1988 1 2 Pd 2 (dba) 3.CCl 3 /P 3 /Ac or Pd(Ac) 2 /P 3 1 2 B. M. Trost 1988 1 3 2 u 2 (P 3 )
More informationFinal Exam /415 ( CHEM 6352 Fall %) Name
Final Exam /415 ( CEM 6352 Fall 2011 %) Name Dec. 15 th, 2011 8:00-12:00 You may NT use any references or aids to complete the following with the exception of a chemical model set and the scrap paper that
More informationChem 232. Problem Set 4. Table. Substrate Types and the Choice of S N 1 of S N 2
Chem 232 D. J. Wardrop wardropd@uic.edu Problem et 4 Does the nucleophilic substitution of substrate X proceed via an N 2 or N 1 mechanism? is a perennial question in rganic Chemistry. Use the table below
More informationOC IV: Organic Photochemistry Exercise 1 Exercise class Page 1 of 11. Exercise 1: Fundamentals, H-Abstraction reactions
C IV: rganic otochemistry Exercise 1 Exercise class Page 1 of 11 Exercise 1: Fundamentals, -Abstraction reactions 1. Draw the energy potential curve of the ground state and the first two excited states
More informationLecture 17 February 14, 2013 MH + bonding, metathesis
Lecture 17 February 14, 2013 MH + bonding, metathesis Nature of the Chemical Bond with applications to catalysis, materials science, nanotechnology, surface science, bioinorganic chemistry, and energy
More informationScandium-Catalyzed Asymmetric Reactions
Scandium-Catalyzed Asymmetric eactions Jimmy Wu Evans Group Seminar February 11, 2005 I. Background II. eutral BIL Ligands III. Anionic BIL Ligands IV. Pybox Ligands V. Bip yridine Ligands VI. rganop hosp
More informationCarbenes and Olefin Metathesis
arbenes and Olefin etathesis Peter H.. Budzelaar etal-carbon multiple bonds any transition metals form not only - single bonds but also = and (more rare) even bonds. omplexes containing an = bond are called
More informationDevelopment of Chiral Phosphine Olefin Ligands and Their Use in Asymmetric Catalysis
Development of Chiral osphine lefin Ligands and Their Use in Asymmetric Catalysis 2 Wei-Liang Duan July 31, 2007 Research Works in Hayashi Group, Kyoto University (ct, 2003 Mar, 2007) Conventional Chiral
More information1. Determine the oxidation state of the metal centre and count the number of electrons.
Exercise sheet : Organometallic chemistry Gunnar Bachem 1. Determine the oxidation state of the metal centre and count the number of electrons. 2. The metal fragment 1 reacts with the amine to give a carbene
More informationChiral Catalyst II. Palladium Catalysed Allylic Displacement ( -allyl complexes) 1. L n Pd(0) 2. Nuc
Chiral Catalyst II ast lecture we looked at asymmetric catalysis for oxidation and reduction Many other organic transformations, this has led to much investigation Today we will look at some others...
More informationParallel Kinetic Resolution. Group Meeting Timothy Chang
Parallel Kinetic Resolution (PKR) Group Meeting 09 29 2009 Timothy Chang Vedejs, E.; Chen, X. J. Am. Chem. Soc. 1997, 119, 2584. Tanaka, K.; Fu, G. C. J. Am. Chem. Soc. 2003, 125, 8078. KR versus PKR The
More informationN-Heterocyclic Carbene Catalysis via Azolium Dienolates: An Efficient Strategy for Enantioselective Remote Functionalizations
Angew. Chem. Int. Ed. 2017, 10.1002. 1 N-Heterocyclic Carbene Catalysis via Azolium Dienolates: An Efficient Strategy for Enantioselective Remote Functionalizations Reporter: En Li Supervisor: Prof. Yong
More informationName: CHEM 633/634 Problem Set 1: Review Due Tues, Aug 29, 2017 (First Lecture!)
ame: CEM 633/634 Problem Set 1: Review Due Tues, Aug 29, 2017 (First Lecture!) Please print this problem set. Answers must be in the spaces or boxes provided to receive full credit. You may work in groups,
More informationProblem session (3) Daiki Kuwana. Please fill in the blank and explain reaction mechanisms and stereoselectivities.
Problem session (3) Daiki Kuwana Please fill in the blank and explain reaction mechanisms and stereoselectivities. 1. 1-1 1. (Ac) 2 (10 mol%), DPEphos (20 mol%) Et 3, toluene, 90 C 2. s 4 (14 mol%), M;
More information[3,3]-Sigmatropic rearrangements
1 [3,3]-Sigmatropic rearrangements heat R 1 R 3 R 1 R 3 R 1 R 3 A class of pericyclic reactions whose stereochemical outcome is governed by the geometric requirements of the cyclic transition state Reactions
More informationSECTION 12. «POT-POURRI» in Organic Synthesis (2018)
SECTIN 12 «PT-PURRI» in rganic Synthesis (2018) 1 Total Synthesis of Erythromycin A via a Spiroketal ERYTRMYCIN A DESLNGCAMPS et al. Can. J. Chem. 1985, 63, 2810-2820. 2 Tetrahydropyran Derivative as Starting
More informationAsymmetric Copper-Catalyzed Synthesis of α-amino Boronate Esters from N-tert- Butanesulfinyl Aldimines
Asymmetric Copper-Catalyzed Synthesis of α-amino Boronate Esters from -tert- Butanesulfinyl Aldimines R BR 2 J. Am. Chem. Soc. 2008, 130, 6910. Melissa A. Beenen, Chihul An, and Jonathan A. Ellman rrent
More informationA Tandem Semipinacol Rearrangement/Alkylation of a-epoxy Alcohols: An Efficient and Stereoselective Approach to Multifunctional 1,3-Diols
A Tandem Semipinacol Rearrangement/Alkylation of a-epoxy Alcohols: An Efficient and Stereoselective Approach to Multifunctional 1,3-Diols B() 2 H H B() 2 H H Hu, X.-D.; Fan, C.-A.; Zhang, F.-M.; Tu, Y.
More informationAsymmetric Lewis Base Strategies for Heterocycle Synthesis
Asymmetric Lewis Base trategies for eterocycle ynthesis Dr Andrew mith EatCEM, chool of Chemistry, University of t Andrews 1st cottish-japanese ymposium of rganic Chemistry, University of Glasgow Friday
More informationA Highly Efficient Organocatalyst for Direct Aldol Reactions of Ketones and Aldehydes
A ighly Efficient rganocatalyst for Direct Aldol Reactions of Ketones and Aldehydes Zhuo Tang, Zhi-ua Yang, Xiao-ua Chen, Lin-Feng Cun, Ai-Qiao Mi, Yao-Zhong Jiang, and Liu-Zhu Gong Contribution from the
More information2311A and B Practice Problems to help Prepare for Final from Previous Marder Exams.
2311A and B Practice Problems to help Prepare for Final from Previous Marder Exams. Disclaimer.: Use only to help learn what you need to know and don t expect the final to be in the same form. 1 1. Short
More information