Keith John CARPENTER Ph.D., F.R.Eng., F.I.Ch.E., C.Eng., M.ACS

Transcription

1 ICES

2 Keith John CARPENTER Ph.D., F.R.Eng., F.I.Ch.E., C.Eng., M.ACS Executive Director Institute of Chemical and Engineering Sciences Block 28 Ayer Rajah Crescent, Unit # Singapore Phone: / keith_carpenter@ices.a-star.edu.sg MAJOR RESEARCH INTERESTS 1. Crystallisation and particle science Our focus is mainly on techniques to measure and to control form, shape, size and physical properties of complex organic materials for purification and formulation as pharmaceuticals, fine chemicals and personal care products. In particular we are interested in the effects of impurities, especially where these are very similar molecules, even stereo isomers and tautomers of the main compound. Understanding nucleation and growth are fundamental to controlling the product properties. A wide range of skills and disciplines interact including process engineering, organic chemistry, physical chemistry, characterisation and analysis. 2. Interface science The interaction between surfaces and molecules in solution controls the stability of many formulated products, including emulsions, dispersions and agglomerates. Understanding and controlling the nature of interfaces is a key element in controlling product properties. 3. Chemical Reactions and Reaction engineering In many chemical processes the reaction and the reactor are at the heart of the process and determine the cost effectiveness. Techniques to control yield and selectivity both by controlling the reaction and by better engineering are key aspects of this work. RECENT REPRESENTATIVE PUBLICATIONS 1. J.H. Atherton and K.J. Carpenter, Process Development: Physicochemical Concepts, Oxford University Primer series 79, Oxford University Press, K.J. Carpenter, Chemical Engineering in Product Development the application of engineering science, Invited plenary lecture to ECCE2, Entropie, 223, 4, K.J. Carpenter, Chemical Engineering in Product Development, Chemical technology for a sustainable future, Invited Keynote lecture to CHISA 2000 August, K.J. Carpenter, Chemical Reaction Engineering Aspects of Fine Chemicals Manufacture, Invited plenary lecture to ISCRE 16, Chem. Eng. Sci., 56, , L.K. Saw, B.W. Brooks, K.J. Carpenter and D.V. Keight, Different dispersion regions during the phase inversion of an ionomeric polymer-water system, J. Colloid and Interface Science, 257, , P.E. Bonnett, K.J. Carpenter, S Dawson and R.J. Davey, Solution crystallization via a submerged liquid-liquid phase boundary: oiling out, Chem. Commun., (6), ,

3 MAJOR RESEARCH INTERESTS CHING Chi Bun PhD (University of Aston, UK, 1978) 1. Deputy Director Institute of Chemical and Engineering Sciences 2. Professor National University of Singapore 1 Institute of Chemical and Engineering Sciences Ayer Rajah Crescent Block 28, # Singapore Phone: ching_chi_bun@ices.a-star.edu.sg 2 National University of Singapore Department of Chemical and Environmental Engineering 10 Kent Ridge Crescent Singapore Room E Phone: / checcb@nus.edu.sg 1. Development of Novel Chiral Stationary Phase & Process for resolving pharmaceutical optical isomer drugs and intermediates. 2. Study on Liquid Chromatographic Evaluation of Equilibrium and Kinetic Parameters for Single, Binary, Multi-Absorbate Chiral Systems. 3. Large Scale Chiral Separation Technology ie Simulated Moving Bed (SMB) cum Chiral Crystallization Process and SMB Chromatography Reactor incorporating Asymmetric Synthesis. 4. Study of Enzymatic biotransformation Kinetics & Flow Dynamics of Immobilized Enzyme Reactors for the resolution of chiral compounds. 5. Organic Synthesis under ionic liquid medium. RECENT REPRESENTATIVE PUBLICATIONS 1. Madhav, M V and C B Ching, Study on the enzymatic hydrolysis of racemic methyl ibuprofen ester (Editorial section). Journal of Chemical Technology and Biotechnology, 76, 9 (September 2001): (United States). 2. Yu, H W and C B Ching, Kinetic and equilibrium study of the enantioseparation of fluoxetine on a new β-cyclodextrin column by HPLC. Chromatographia (2001). (Germany). 3. Venu, M and C B Ching, Study on the enzymatic hydrolysis of racemic methyl ibuprofen ester. Journal of Chemical Technology and Biotechnology, 76, 9 (2001): (United Kingdom). 4. Ching, C B and Y X Wu, Study of feed-temperature control of chromatography using computational fluid dynamics simulation (Editorial section). Journal of Chromatography A, 945, 1-2 (2001): (The Netherlands)

4 5. Wang, X and C B Ching, Kinetic and equilibrium study of the separation of three chiral center drug nadolol by HPLC on a novel perphenyl carbamoylated β-cd bonded chiral stationary phases. Separation Science and Technology, 37, 11 (2001). 6. Ng, S C, L Chen and C B Ching, Facile preparative HPLC enantioseparation of racemic drugs using chiral stationary phases based on mono-6(a)-azido6(a)-deoxy-perphenylcarbamoylated betacyclodextrin immobilized on silica gel. Tetrahedron Letters, 43, 4 (21 January 2002): (United Kingdom). 7. Wu, Y, X Wang and C B Ching, Computational fluid dynamics simulation of the adsorption separation of three components in high performance liquid chromatography. Chromatographia, 55, 7/8 (April 2002). (Germany). 8. Chen, L, L F Zhang and C B Ching, Synthesis and chromatographic properties of a novel chiral stationary phase derived from heptakis (6-azido-6-deoxy-2,3-di-O-phenyl carbamoylated)-betacyclodextrin immobilized onto amino-functionalized silica gel via multiple urea linkages (Editorial section). Journal of Chromatography A, 950, 1-2 (15 May 2002): (The Netherlands). 9. Wang, X, X J Wang and C B Ching, Solubility metastable zone width and racemic characterization of propranolol hydrochloride. Chirality, 14, 4 (20 May 2002): (United States). 10. Ng, S C, T T Ong, P Fu and C B Ching, Enantioseparation of flavour and fragrance compounds by HPLC using novel-urea-covalent bonded methylated-β-cyclodextrins on silica. Journal of Chromatography A, 968, 1-2 (30 August 2002): (The Netherlands). 11. Velmurugan, T, C B Ching, S C Ng, Z W Bai and T T Ong, Optimization of the reversed-phase high-performance chromatographic separation of the enantiomers of a carbonic chiral drug (tolperisone) on a heptakis (6-azido-6-deoxy) perphenyl carbonated β-cyclodextrin columns. Chromatographia, 56, 3-4 (August 2002): (Germany). 12. Yu, H W, P Fu, C B Ching and S C Ng, Enantioseparation of fluoxetine on a new β-cyclodextrin column by HPLC. Separation Science and Technology, 37, 6 (2002): (United States). 13. Ching, C B, Y Wu, M Lisso, G Wozny, T Laiblin and W Arlt, The study of feed temperature control of chromatography using CFD simulation. Journal of Chromatography A, 945 (2002): (The Netherlands). 14. Yu, H W and C B Ching, Optimization of simulated moving bed based on an approximated Langmuir model. AIChE Journal, 48, 10 (2002): Wang, X and C B Ching, Liquid chromatographic retention behavior and enantiomeric separation of three chiral center β-block drug (Nadolol) using heptakis (6-azido-6-deoxy-2,3-di-Ophenylcarbamoylated) β- cyclodextrin bonded chiral stationary phase. Chirality, 14 (2002): (United States). 16. Zaher, Z M A, H Y Shen, C B Ching, L C Feng and S Selvaratnam, A facile and efficient nucleophilic displacement reaction at room temperature in ionic liquids. Tetrahedron Letters, 43 (2002): (United Kingdom). 17. Zaher, M A J, C B Ching, J Bu and A McCluskey, The first Bischler-Napieralski cyclization in a room temperature ionic liquid. Tetrahedron Letters, 43 (2002): Shen, H Y, M A J Zaher and C B Ching, Selective alkylation of phenol with tert-butyl alcohol catalyzed by [6min] PF6. Tetrahedron Letters, 43 (2002). 19. Bu, J, Z M A Judeh, C B Ching and S Kawi, Epoxidation of define catalyzed by Mn(II) salen complex anchored on PAMAN-SiO 2 dendrimer. Catalysis Letters, 85, 3-4 (2003):

5 20. Hong Wei Yu, Yan Xia Wu and Chi Bun Ching, Determination of the adsorption isotherm of fluoxetine by adjustable factor h-root method (AF-HRM), CHROMATOGRAPHIA, 57 (3-4): (2003). 21. Wang Xiu Juan, Wiehler Harald and Ching Chi Bun, A study of the characterization and the crystallization of 4-hydroxy-2-pyrrolidone, Pharmaceutical Research. (In Press) 22. Wang Xiu Juan, Wiehler Harald and Ching Chi Bun, A study of the physicochemical properties and the crystallization thermodynamics of the pure enantiomers and the racemate for N- methylephedrine, Journal of Chemical and Engineering Data (In Press)