Bhupesh Goyal, Ph.D.

Transcription

1 Bhupesh Goyal, Ph.D. Assistant Professor Department of Chemistry, School of Basic and Applied Sciences, Sri Guru Granth Sahib World University, Fatehgarh Sahib , Punjab, India. Mobile: EDUCATION Bhupesh Goyal, Ph.D. (IIT Bombay) Degree Institute/University Year Result/ Details Ph.D. (Bio-organic Chemistry) M.Sc. (Honours School) Chemistry B.Sc. (Honours School) Chemistry Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India Department of Chemistry, Panjab University, Chandigarh, India Department of Chemistry, Panjab University, Chandigarh, India 2012 CPI 9.33, Awarded with coursework % % RESEARCH TRAINING/FELLOWSHIPS Position Institute/University Year Details Indian Academy of Sciences Summer Research Fellow M.Sc. Research Project Trainee Research Chemist CSIR-UGC Junior Research Fellow (Council of Scientific and Industrial research, Govt. of India) Indian Institute of Technology Kanpur, India Panjab University, Chandigarh, India Ranbaxy Research Laboratories, Gurgaon, India Indian Institute of Technology Bombay, Mumbai, India Topic: C-Glycosyl Amino Acids. Supervisor: Prof. Y. D. Vankar Topic: Design and Synthesis of Sulfur Analogs of Nimesulide a COX-2 selective drug. Supervisor: Prof. M. L. Sharma Topic: Design and synthesis of biologically active small molecules using parallel synthesis. Topic: Protein Folding and Enzyme Catalysis: Computational and Experimental Studies of Peptide Models. Supervisor: Prof. S. Durani

2 CSIR-UGC Senior Research Fellow (Council of Scientific and Industrial research, Govt. of India) Postdoctoral Research Associate Indian Institute of Technology Bombay, Mumbai, India Department of Chemistry & Biochemistry, Arizona State University, Tempe, USA Topic: Protein Folding and Enzyme Catalysis: Computational and Experimental Studies of Peptide Models. Supervisor: Prof. S. Durani Topic: De novo design of functional membrane proteins Supervisor: Prof. Giovanna Ghirlanda RESEARCH INTERESTS/SPECIALIZATION Computational scrutiny of protein folding and dynamics. Active site design and functional re-engineering of enzymes using computational methods. Molecular docking and dynamics simulations on protein kinases and inhibitor designing. Protein folding and misfolding, Molecular modeling and Drug design. RESEARCH FUNDING RECEIVED IN THE PAST AND/ONGOING PROJECTS Awarded a research proposal of Rs lakhs on the Computational Scrutiny of the Mechanism of Amyloid -Peptide Aggregation under the Start-Up Research Grant (Young Scientists) Scheme by the Science and Engineering Research Board (SERB), Govt. of India. Award Number: SB/FT/CS-013/2014 Awarded postdoctoral research fellowship at the Center for Bio-inspired Solar Fuel Production, an Energy Frontier Research Center sponsored by the U.S. Department of Energy, at Department of Chemistry & Biochemistry, Arizona State University, Tempe, USA during Awarded senior research fellowship by Council of Scientific & Industrial Research (CSIR), New Delhi in 2009 at Department of Chemistry, IIT Bombay, Mumbai. Award Number: File Number 10-2(5)/2005(ii)-E.U.II TEACHING EXPERIENCE (SUBJECTS/COURSES TAUGHT) Name of the Institution Sri Guru Granth Sahib World University Fatehgarh Sahib, Punjab Position From To Subjects/courses taught Assistant Professor, Department of Chemistry August 2013 Continuing Topics in Chemistry, Organic Reaction Mechanism & Stereochemistry, Organic Reactions & Rearrangements, Bio-organic Chemistry, Applied Chemistry & Applied Chemistry lab 2

3 Central University of Punjab, Bathinda, Punjab Indian Institute of Technology Bombay, Mumbai Assistant Professor (contractual), Centre for Computational Sciences Teaching Assistant, Department of Chemistry April 2013 July 2008 August 2013 November 2009 Contributed in the drafting of syllabus for M.Sc. in Computational Sciences B. Tech. Theory Course CH- 102 T (Organic)" & B. Tech. Laboratory Course CH-117 L EXPERIMENTAL SKILLS Synthesis: Solid Phase Peptide Synthesis using Fmoc-Chemistry. Instruments used: Automated Peptide Synthesizer, Lyophilizer, Centrifuge, Mass spectrometer, MALDI, HPLC, NMR, CD, ATR-FTIR, ITC, UV-Visible Spectrophotometer, Spectroflourimeter. COMPUTATIONAL SKILLS Molecular Dynamics: GROMACS simulation package. Quantum Mechanics: GAUSSIAN03, GAUSSIAN09. Molecular Modeling: CAPM, PDBmake (In-house software). Docking and Scoring: AutoDock, PatchDock, igemdock etc. Visualization Tools: VMD, Viewerlite Pro, Rasmol, MOLMOL, Swiss-PDB, Pymol, Molden etc. AWARDS AND RECOGNITIONS Nominated by Indian Science Congress Association (ISCA), Patiala-Chapter for a poster presentation on the topic entitled Present scenario and recent developments in Alzheimer s disease research in the Science Communicators Meet (9 th Rastriya Vigyan Sancharak Sammelan) during 103 rd Session of the Indian Science Congress at University of Mysore, Mysuru, Jan 3 7, Invited Lecture on the topic Understanding the role of molecular dynamics simulations in computer-aided drug design during the 46 th workshop entitled Application of Molecular Dynamics Simulation in Molecular Modelling & Drug Designing, at Biotech Park in Biotechnology City, Lucknow, promoted by Department of Biotechnology, Govt. of India and Department of Science & Technology, Govt. of U.P. during Feb 26 28, Selected for Winter School on Computational Chemistry conducted by UGC-Networking Resource Centre, School of Chemistry, University of Hyderabad during Dec 29, 2014 Jan 10, Selected for the Science Academies Refresher Course on "Bioinformatics in Modern Biology" during May 5 17, 2014 at School of Life Sciences, Manipal University, Manipal. Awarded Start-Up Research Grant (Young Scientists) of Rs lakhs on the Computational Scrutiny of the Mechanism of Amyloid -Peptide Aggregation by Science and Engineering Research Board (SERB), Govt. of India in March,

4 Awarded postdoctoral research fellowship sponsored by the U.S. Department of Energy, at Department of Chemistry & Biochemistry, Arizona State University, Tempe, USA during Awarded Foreign Travel Grant from DST, CSIR and DBT, New Delhi, India for a poster presentation in 242 nd American Chemical Society National Meeting & Exposition, Denver, Colorado, USA during Aug. 28 Sept. 01, Awarded Senior Research fellowship (SRF) by CSIR-UGC, New Delhi, India in Awarded Junior Research fellowship (JRF) by CSIR-UGC, New Delhi, India in Selected as a Summer visiting student-fellow of the Indian Academy of Sciences under the supervision of Prof. Y. D. Vankar, Department of Chemistry, IIT Kanpur, India. (May 2005 July 2005). Rank 1 in B.Sc. (Honours School) IIIrd year at Department of Chemistry, Panjab University, Chandigarh, India during Merit Certificate under National Scholarship Scheme in March PEER REVIEWD PUBLICATIONS Bhupesh Goyal, Anil Kumar, Kinshuk Raj Srivastava and Susheel Durani. Computational scrutiny of the effect of N-terminal proline and residue stereochemistry in the nucleation of -helix fold. RSC Advances 2016, 6, (IF: 3.289) Bhupesh Goyal, Anil Kumar, Kinshuk Raj Srivastava and Susheel Durani. Scrutiny of chain-length and N-terminal effects in α-helix folding: A molecular dynamics study on polyalanine peptides. Journal of Biomolecular Structure and Dynamics 2016, DOI: / (IF: 2.300) Bhupesh Goyal, Kinshuk Raj Srivastava, Kirti Patel and Susheel Durani. Modulation of -hairpin peptide self-assembly: A twenty-residue poly-l -hairpin modified rationally as a mixed-l,d hydrolase. ChemistrySelect 2016, 1, Bhupesh Goyal, Kirti Patel, Kinshuk Raj Srivastava and Susheel Durani. De novo design of stereochemically-bent sixteen-residue -hairpin as a hydrolase mimic. RSC Advances 2015, 5, (IF: 3.289) Sandip Shinde, Jennifer Binder, Bhupesh Goyal, Brian Woodrum, Sonia De Munari, Marcia Levitus and Giovanna Ghirlanda. A Designed Buried Salt Bridge Modulates Heterodimerization of a Membrane Peptide. Biopolymers (Peptide Science) 2014, 106, (6), (IF: 2.879) Kinshuk Raj Srivastava, Anil Kumar, Bhupesh Goyal and Susheel Durani. Stereochemistry and Solvent Role in Protein Folding: Spectroscopic and Molecular Dynamics Studies of poly-l and alternating-l,d Homopolypeptides in DMSO. Journal of Physical Chemistry B 2011, 115, (20), (IF: 3.187) Kirti Patel, Bhupesh Goyal, Anil Kumar, Nand Kishore and Susheel Durani. Cured of Stickiness, Poly-L β-hairpin is Promoted with LL-to-DD Mutation as a Protein and a Hydrolase Mimic. Journal of Physical Chemistry B 2010, 114 (50), (IF: 3.187) 4

5 Bhupesh Goyal, Kinshuk Raj Srivastava, Anil Kumar, G. Naresh Patwari and Susheel Durani. Stereochemistry and Protein-Folding Physics: Study of Electrostatics of Peptides External to Peptide Hydrogen Bond. (manuscript under preparation) PAPERS PRESENTED IN INTERNATIONAL CONFERENCES 1. Bhupesh Goyal and Susheel Durani, De Novo design of stereochemically-bent sixteen-residue - hairpin as a hydrolase mimic. 6 th International Symposium Current Trends in Drug Discovery & Research (CTDDR-2016) at CSIR-Central Drug Research Institute, Lucknow, Feb 25 28, Bhupesh Goyal, Molecular docking analysis of the mechanism of inhibition of amyloid -peptide aggregation in Alzheimer s disease. International Conference on Molecular Pharmacology, Drug Discovery and Nanopharmaceuticals (MPDDNP-2015) at Chitkara College of Pharmacy, Chitkara University, Punjab, March 27 28, (Oral Presentation) 3. Bhupesh Goyal, Susheel Durani, Scrutiny of Chain-Length and N-Terminal Effects in Oligoalanines Using Molecular Dynamics Simulations. Indo-US Conference on Molecular Modeling and Informatics in Drug Design, NIPER Mohali, Punjab, Nov. 3 6, Bhupesh Goyal, Kinshuk Raj Srivastava and Susheel Durani, Conformational Analysis of Nonapeptides of Poly-L and Alternating-L,D Stereochemistry Containing N-Terminus Diproline Segments. 3 rd Indo-German Symposium on Frontiers of Chemistry, IIT Bombay, Sept , Bhupesh Goyal, Kirti Patel and Susheel Durani, Protein Design in Sequence Space of L- and D-- Amino Acids: A Sixteen Residue Poly-L β-hairpin Modified Rationally as a Mixed-L,D Hydrolase. 242 nd American Chemical Society National Meeting & Exposition held at Denver, Colorado, USA, Aug. 28 Sept. 1, Bhupesh Goyal, Kirti Patel and Susheel Durani, Protein Design over L- and D-α-Amino-Acid Alphabet: Canonical β-hairpin Reprogrammed as a Hydrolase Mimic. Indo-US Symposium/Workshop on Modern Trends in Macromolecular Structures Feb 21 24, 2011 at Department of Chemistry, IIT Bombay. 7. Anil Kumar, Bhupesh Goyal, and Susheel Durani, The Stereochemical bias of Nature: Enquiries of its Relevance to Protein Folding. RSC/IIT Bombay Symposium on the Chemical Sciences Celebrating the IIT Bombay Golden Jubilee on Feb 3, 2009 at IIT Bombay. PAPERS PRESENTED IN NATIONAL CONFERENCES 1. Bhupesh Goyal, Computational scrutiny of the mechanism of inhibition and binding modes of inhibitors of Amyloid β-peptide aggregation in Alzheimer s disease. 19 th Punjab Science Congress at SUS Group of Institutions, Tangori, S.A.S. Nagar (Mohali), Feb 7 9, Bhupesh Goyal, Present scenario and recent developments in Alzheimer s disease research. 9 th Science Communicators Meet (Rastriya Vigyan Sancharak Sammelan) of 103 rd Session of the Indian Science Congress at University of Mysore, Jan 3 7,

6 3. Bhupesh Goyal and Susheel Durani, Computational design of monomeric -hairpin peptide as a hydrolase mimic. 7 th National Seminar on Synergistic Aspects of Chemical and Other Sciences (SACOS-2015) at Department of Chemistry, Punjabi University, Patiala, Feb 19 20, Bhupesh Goyal and Susheel Durani, Modulation of -Hairpin Peptide Self-Assembly: Computational Design of Monomeric -Hairpin Peptide. National Conference on New Frontiers in Chemical Sciences organized by PG Department of Chemistry, G.S.S.D.G.S. Khalsa College, Patiala, Nov 15, Bhupesh Goyal, Kinshuk Raj Srivastava and Susheel Durani, Influence of Homochiral and Heterochiral Pro-Pro Segments on the Conformational Stability of Short Alanine-Based Peptides. National Symposium on New Horizons in Chemistry organized by Department of Chemistry, Indian Institute of Technology Bombay, Oct 3 4, Bhupesh Goyal, Kirti Patel and Susheel Durani, Protein Design in Sequence Space of L- and D-- Amino Acids: A Sixteen Residue Poly-L β-hairpin Modified Rationally as a Mixed-L,D Hydrolase. In-House Symposium organized by Department of Chemistry, Indian Institute of Technology Bombay, Feb 26, Bhupesh Goyal, Anil Kumar, G. Naresh Patwari and Susheel Durani, Stereochemistry and the Energetics of Protein Conformation: Combined Quantum and Statistical Mechanical Studies of Tetrapeptides Diastereomeric in Structure. Symposium on Recent Trends in Biophysics organized by Department of Physics, Banaras Hindu University, Varanasi under the aegis of Indian Biophysical Society, Feb 13 15, Bhupesh Goyal, Anil Kumar, G. Naresh Patwari and Susheel Durani, Stereochemistry and the Conformational Landscapes of Polypeptide Structure: A Combined DFT and Molecular Dynamics Study of Tetrapeptide Models. Symposium on Frontiers on Computational Biology organized by C-DAC, Pune, India, July 23 24, PARTICIPATION IN CONFERENCES/WORKSHOPS 1. Participated in the Refresher course in Basic and Applied Science conducted by UGC-HRDC, Panjab University, Chandigarh, May 26 June 15, Participated in the V th National Symposium on Advances in Chemical Sciences, at Department of Chemistry, Center for Advanced Studies, Guru Nanak Dev University, Amritsar, Punjab, Feb 2 3, Participated in the Professor Ram Chand Paul National Symposium on Innovations in Chemical Sciences organized by Department of Chemistry & Centre of Advanced Studies in Chemistry, Punjab University, Chandigarh, March 20 21, Participated in the 7 th National Conference on Recent Advances in Chemical, Biological and Environmental Sciences (RACES-2015) organized by Department of Biotechnology & Chemistry, Multani Mal Modi College, Patiala, Jan 30 31,

7 5. Participated in the Post-conference workshop on Molecular Modeling in Drug Design held at National Institute of Pharmaceutical Education & Research (NIPER) Mohali, Punjab, November 7, Participated in the Pre-conference workshop on Informatics in Drug Design held at National Institute of Pharmaceutical Education & Research (NIPER) Mohali, Punjab, November 3, Participated in the UGC-Sponsored 21 st Orientation Programme held at Academic Staff College, Punjabi University, Patiala, June 2 28, Participated in the workshop on Patent Searching & Drafting organized by IPR cell, SJM School of Management, IIT Bombay, January & January 22 23, Participated in the workshop of six weekends on Intellectual Property Rights Fundamentals organized by IPR cell, SJM School of Management, IIT Bombay, August 14 October 10, Participated in the workshop on Emerging Techniques of Biophysics organized by Department of Physics, Banaras Hindu University, Varanasi, February 16, Participated in the workshop on Open Source Drug Discovery organized by IPR cell, IIT Bombay on April 25, Participated in the workshop on Advances in Computer Aided Drug Discovery and Design Methods held at Dr. D. Y. Patil University, Navi Mumbai, October Participated in a two-day international seminar-cum-workshop on Computational Drug Discovery in Pharma R & D at SVKM s NMIMS University, Mumbai, August Participated in a two-day Linux Workshop conducted by Department of Computer Science & Engineering, IIT Bombay, Aug 18-19, ADMINISTRATIVE DUTIES/ACTIVITIES Centre Superintendent during end-semester final examination at Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab during Teacher Coordinator in the Poster Making Event on Green Technology at PARGAAS- ENLIGHTENMENT, The Youth Fest-2014 held at Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab, Feb 13, Executive Secretary in organizing conference on Emerging Horizons in Science & Technology in collaboration with Punjab Academy of Sciences at Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab, Jan 17 18, Departmental level organizer in R&D exhibition at Techfest 2011, IIT Bombay. Department Representative during in Research Scholar s Forum, IIT Bombay. Member of organizing team of National level Winter School in Bio-inorganic Chemistry 2007, IIT Bombay. 7

8 PERSONAL DETAIL Nationality: Indian Date of birth: Oct 22, 1982 Sex: Male Languages Known: English, Hindi, and Punjabi Martial Status: Married PROFESSIONAL MEMBERSHIPS Life member of Indian Biophysical Society (IBS), Tata Institute of Fundamental Research, Mumbai, India. Life member of Indian Society of Chemists and Biologists (ISCB), CDRI-Lucknow, India. Life member of Indian Science Congress Association (ISCA), Kolkata, India. Life member of The Society of Biological Chemists India (SBCI), Indian Institute of Science, Bangalore, India. Life member of Punjab Academy of Sciences, Punjabi University, Patiala, Punjab, India. Life member of IIT Bombay Alumini Association, IIT Bombay, Mumbai, India. Member, Panjab University Chemical Society, Panjab University, Chandigarh, India. 8