Dr., Ph.D. Assistant Professor GITAM University Bengaluru Karnata-562163, India. Phone: +91 7896156247 E-mail: s.alla@iitg.ernet.in santhoshalla@gmail.com EDUCATI 2010-2016 Ph.D., rganic Chemistry, India. Thesis Title: Studies Toward Metal-Free Synthesis of Benzofuzed Azoles Using Hypervalent Iodine Supervisor: Prof. Tharmalingam Punniyamurthy 2007-2009 M.Sc., rganic Chemistry, CPI 8.80 Andhra University, India. 2002-2005 B.Sc., Mathematics, Chemistry and Industrial Chemistry, 74% of Marks Andhra University, India. Undergone ne Month Project in Quality Control Laboratory, M/s Hindustan Petroleum Corporation Limited, Visakh Refinery, Visakhapatnam. RESEARCH 2012-2016 Senior Research Fellow,, India. 2010-2012 Junior Research Fellow,, India. ACHIEVEMETS AD AWARDS Graduate Aptitude Test (GATE), February, 2010, Chemistry Ministry of Human Resource Development, Government of India.
PRFESSIAL EXPERIECE 2016-Till Date Assistant Professor,. GITAM University, Bengaluru, India. 2010-2016 Teaching Assistantship, B. Tech and M. Sc., India. CH223, Chemical Technology Lab CH110, General Chemistry Lab CH101, Tutorial, rganic Chemistry and Exam Duties. 2009-2010 Lecturer, Chemistry, M.Sc., and B.Sc. M.V.R P.G. College, Visakhapatnam, India. M. Sc. (Final): rganic Chemistry Lab, Photochemistry, Reaction Mechanisms and atural Products M. Sc. (Previous): rganic Chemistry Lab, Inorganic Chemistry Lab, Mass Spectrometry and atural Products B.Sc: Electrochemistry SKILLS Research Instrumental Expertise in design and execution of multistep organic reactions from milligram to gram scale, handling air and moisture sensitive compounds using protective atmosphere (Schlenk line, Glove box) and crystallization techniques. perated both Varian (400 MHz) and Bruker (600 MHz) MR instruments and well versed with 1 H, 13 C techniques and their interpretation. perated Perkin Elmer FTIR Spectrophotometer. perated both Agilent and Waters-QTF mass spectrometers. Technical MS ffice Chemdraw MestReova familiar with SciFinder Scholar
PUBLICATIS 1. Iodobenzene Catalyzed C-H Amination of -Substituted Amidines using m-chloroperbenzoic Acid, Rapolu Kiran Kumar, Pradeep Sadhu and Tharmalingam Punniyamurthy. rg. Lett. 2013, 15, 1334. Impact Factor: 6.364. 2. rganocatalytic Syntheses of Benzoxazoles and Benzothiazoles Using Aryl Iodide and xone via C-H Functionalization and C-/S Bonds Formation Santhosh Kumar Alla, Pradeep Sadhu and Tharmalingam Punniyamurthy. J. rg. Chem. 2014, 79, 7502. Impact Factor: 4.721. 3. Pd(II)-Catalyzed Aminotetrazole-Directed rtho-selective Halogenation of Arenes Pradeep Sadhu, and Tharmalingam Punniyamurthy. J. rg. Chem. 2013, 78, 6104. Impact Factor: 4.721. 4. Room-Temperature Cu(II)-Catalyzed Chemo- and Regioselective rtho-itration of arenes via C-H Functionalization Pradeep Sadhu, and Tharmalingam Punniyamurthy. J. rg. Chem. 2015, 80, 8245. Impact Factor: 4.721. CFERECE ATTEDED 1., Rapolu Kiran Kumar, Pradeep Sadhu and Tharmalingam Punniyamurthy, Iodobenzene Catalyzed C-H Amination of -Substituted Amidines Using m-chloroperbenzoic Acid, 9 th J-ST Conference organized by IISER, Bhopal ovember, 2013. 2., Rapolu Kiran Kumar, Pradeep Sadhu and Tharmalingam Punniyamurthy, Iodobenzene Catalyzed C-H Functionalizaton of -Substituted Amidines Using m-chloroperbenzoic Acid, 16 th CRSI ational Symposium in Chemistry organized by IITB, Mumbai February, 2014. 3., Pradeep Sadhu and Tharmalingam Punniyamurthy, rganocatalytic Syntheses of Benzoxazoles and Benzothiazoles Using Aryl Iodide and xone via C-H Functionalization and C-/S Bonds Formation, 3 rd ational Conference on Frontiers in Chemical Sciences organized by IITG, Guwahati December, 2014. 4. and Tharmalingam Punniyamurthy, rganocatalysis: Iodine(III) Catalyzed Syntheses of Heterocyclic Compounds via xidative C-H Functionalization/ Carbon-Heteroatom Bond Formation, Chem Convene 2015, organized by IITG, Guwahati April, 2015.
RESEARCH ITERESTS Methodology Development in rganic Synthesis Transition-Metal Catalysis rganocatalysis atural Product Synthesis RESEARCH SUMMARY Transition metal free carbon-heteroatom bond formation reactions using hypervalent iodine have experienced impressive progress in recent times owing to their environmentally benign properties, efficiency and low cost. During my doctoral studies, we have mainly focused on the catalytic application of hypervalent iodine for the design of newer metal-free protocols for the synthesis of benzofuzed azole compounds by carbon-heteroatom bond formation reactions. First, we developed iodobenzene catalyzed synthesis of 2-substituted -sulfonyl benzimidazoles and -aryl benzimidazoles by oxidative C-H amination from ''-aryl-'- tosyl/'-methyl sulfonylamidines and,'-bis(aryl)amidines in the presence of mcpba as a terminal oxidant at room temperature in 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as solvent. This reaction is based on the involvement of hypervalent iodine generated insitu from iodobenzene and mcpba and afford the target products in moderate to good yield (Scheme 1). R " 20 mol % PhI R ' 1.5 equiv mcpba R ' H R"' HFIP, rt, 2-12 h R"' R ' = H, Alkyl, Halogen yields upto 93% R " = Alkyl, Aryl R"' = Aryl, Ts, Ms Scheme 1: Synthesis of substituted benzimidazoles In continuation of our research for the synthesis of oxygen analogous starting from alkyl/arylanilides, we describe a simple, transition metal-free protocol for the synthesis of 2- alkyl/arylbenzoxazoles catalyzed by 1-iodo-4-nitrobenzene and oxone as an inexpensive and environmentally safe terminal oxidant at room temperature under air via oxidative C-H functionalization and C- bond formation. The scope of the reaction was carried out with different substituted anilides and the desired products were obtained in moderate to high yields (Scheme 2). R "
H R" = EWG, EDG R" = Alkyl, Aryl 20 mol % 4-2 C 6 H 4 I 1.5 equiv oxone 3.0 equiv TfH HFIP, rt, 3-24 h yields upto 91% R" Scheme 2: Synthesis of substituted benzoxazoles After successful implementation of 1-iodo-4-nitrobenzene/oxone catalytic reaction for the synthesis of substituted benzoxazoles, we described the scope and utility of this protocol for the synthesis of substituted benzothiazoles from alkyl/arylthioanilides. The reactions readily occurred to give the desired 2-alkyl/2-arylbenzothiazoles with enhanced yields (Scheme 3). H R" S = EWG, EDG R" = Alkyl, Aryl 20 mol % 4-2 C 6 H 4 I 1.5 equiv oxone 3.0 equiv TfH HFIP, rt, 3-24 h S yields upto 95% R" Scheme 3: Synthesis of substituted benzothiazoles In addition to the synthesis of heterocyclic compounds by organocatalysis, we have also developed [bis(trifluoroacetoxy)iodo]benzene mediated synthesis of benzimidazol-2-ones using stoichiometric amounts of iodine(iii) under base-free conditions at room temperature in 2,2,2-Trifluoroethanol (TFE) as solvent (Scheme 4). '' H 1.2 equiv PhI(CCF 3 ) 2 TFE, rt, 1-2 h '' ', ' = Alkyl, Halogen R"' = Me, Et, Allyl ' yields upto 88% Scheme 4: Synthesis of benzimidazol-2-one derivatives In conclusion, we have developed metal-free protocols for the synthesis of various substituted benzofuzed azoles, namely benzimidazoles, benzoxazoles, benzothiazoles and benzimidazol-2-ones using catalytic and stoichiometric hypervalent iodine. These reactions done at ambient temperatures, with broad substrate scope and high level of functionality contribute a great deal of potential towards the synthesis of library of important heterocyclic compounds.
PERSAL DETAILS ame: Father s ame: Lakshmana Rao Birth Date: 01 August, 1985 ationality: Indian Marital Status: Single Permanent Address: Door o.44-5-7, Flat o. 104, Sai Sravanthi Elegance, Thatichetlapalem, Visakhapatnam, Andhra Pradesh-530016, India. REFERECES Dr. Tharmalingam Punniyamurthy Professor orth Guwahati, Assam, India. Phone: +91-361-2582309 Fax: +91-361-2690762 Email: tpunni@iitg.ernet.in Dr. G. Krishnamoorthy Professor orth Guwahati, Assam, India. Phone: +91-361-2582315 Email: gkrishna@iitg.ernet.in Dr. Bhubaneswar Mandal Associate Professor orth Guwahati, Assam, India. Phone: +91-361-2582319 Fax: +91-361- 2582349 Email: bmandal@iitg.ernet.in Dr. Arun Goyal Professor Department of Biosciences and Bioengineering orth Guwahati, Assam, India. Phone: +91-361-2582208 Fax: +91-361-2582249 Email: arungoyl@iitg.ernet.in