Curriculum Vitae (CV) Personal Information Name: Seyed Ahmad Ebadi Nationality: Iranian Date of Birth: 14/4/1984 Place of birth: Tehran Marital Status: Married Affiliation: Hamadan University of Medical Sciences Academic position: Assistant Professor Address Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran Tel: +988138381590 E-mail: a.ebadi@umsha.ac.ir & ahmadebadie@gmail.com Education Ph.D. in Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, 2009-2014 Dissertation Title: Synthesis and molecular modeling of novel nonpeptidic small molecules as p38mapk inhibitors and evaluation of TNF-α production in a cell model Supervisors: Prof. Miri R. & Prof. Firouzi O., Advisors: Prof. Javidnia K. & Prof. Ghahramani M. H. M.Sc. in Organic chemistry, Faculty of Chemistry, K. N. Toosi University of Technology, 2007-2009 Thesis Title: Design and Synthesis of Novel Peptides as Anti-Cancer Agents Supervisor: Prof. Balalaie S., Advisor: Prof. Davoodi J. B.S. in Applied Chemistry, Faculty of Science, K. N. Toosi University of Technology, 2002-2007
Research Interests: Molecular Dynamics Simulation Study on Specific System Such as Protein Kinase Computational Chemistry Virtual Screening and Molecular Modeling Synthesis of Peptide and Peptidomimetic Molecules Synthesis of Novel Bioactive Heterocyclic Molecules Research Experience Solid & Solution Phase Peptide Synthesis Multicomponent Reaction (Ugi, Biginelli ) Molecular Modeling of Protein Kinase (Molecular Dynamic & ab initio Methods) Virtual Screening and Design of p38 MAPK Inhibitors Theoretical Study on Reaction Mechanism (ab Initio Method) Teaching Interests Organic Chemistry Computational Chemistry and Molecular Modeling Medicinal Chemistry Computer Skills Operating Systems: Windows, Linux Office Applications: Microsoft PowerPoint, Excel, Word. Docking: AutoDock, AutoDock Vina MD Simulation: GROMACS, SIESTA Ab Initio: GAMESS, ORCA Publications 1. Razzaghi-Asl, N., Shahabipour, S., Ebadi, A., Bagheri, A. Quantum chemical analysis of potential anti-parkinson agents. Journal of Chemical Sciences. 2015, 127, 1211-20. 2. Ebadi, S.A., Razzaghi-Asl, N., Khoshneviszadeh, M., Miri, R. Detailed atomistic molecular modeling of a potent type ΙΙ p38α inhibitor. Structural Chemistry. 2015, 26, 1125-37. 3. Razzaghi-Asl, N., Sepehri, S., Ebadi, A., Miri, R. Effect of Biomolecular Conformation on Docking Simulation: A Case Study on a Potent HIV-1 Protease Inhibitor. Iranian Journal of Pharmaceutical Research. 2015, 14, 785-802.
4. Razzaghi-Asl, N., Sepehri, S., Ebadi, A., Miri, R., Shahabipour, S. Molecular docking and quantum mechanical studies on biflavonoid structures as BACE-1 inhibitors. Structural Chemistry. 2015, 26, 607-21. 5. Razzaghi-Asl, N., Hemmateenejad, B., Ebadi, A., Miri, R. A new insight into computational molecular design: a case study on BACE-1 inhibitors. Journal of Computational Methodes in Science and Engineering. 2014, 14, 315-25. 6. Nikkhoo, A.R., Miri, R., Arianpour, N., Firuzi, O., Ebadi, A., Salarian, A.A. Cytotoxic activity assessment and c-src tyrosine kinase docking simulation of thieno [2, 3-b] pyridinebased derivatives. Medicinal Chemistry Research. 2014, 23, 1225-33. 7. Ebadi, A., Razzaghi-asl, N., Shahabipour, S., Miri, R. Ab-Initio and Conformational Analysis of a Potent VEGFR-2 Inhibitor: A Case Study on Motesanib. Iranian Journal of Pharmaceutical Research. 2014, 13, 405-15. 8. Razzaghi-Asl, N., Ebadi, A., Edraki, N., Shahabipour, S., Miri, R. Ab initio modeling of a potent isophthalamide-based BACE-1 inhibitor: amino acid decomposition analysis. Medicinal Chemistry Research. 2013, 22, 3259-69. 9. Razzaghi-Asl, N., Ebadi, A., Edraki, N., Shahabipour, S., Miri, R. Fragment-based Binding Efficiency Indices in Bioactive Molecular Design: A Computational Approach to BACE-1 Inhibitors. Iranian Journal of Pharmaceutical Research. 2013, 12, 423-36. 10. Ebadi, A., Razzaghi-Asl, N., Khoshneviszadeh, M., Miri, R. Comparative amino acid decomposition analysis of potent type I p38alpha inhibitors. DARU Journal of Pharmaceutical Sciences. 2013, 21, 41. 11. Razzaghi-Asl, N., Ebadi, A., Edraki, N., Mehdipour, A., Shahabipour, S., Miri, R. Response surface methodology in docking study of small molecule BACE-1 inhibitors. Journal of Molecular Modeling. 2012, 18, 4567-76. 12. Asl, R., Miri, R., Ebadi, A., Edraki, N., Shahabipour, S. Theoretical binding efficiencies in bioactive molecular design: a case study on BACE-1 inhibitors. Research in Pharmaceutical Sciences. 2012, 7, 614. 13. Salami, M., Moosavi-Movahedi, A.A., Ehsani, M.R., Yousefi, R., Haertle, T., Chobert, J.M., Razavi, S.H., Henrich, R., Balalaie, S., Ebadi, S.A. Improvement of the Antimicrobial and Antioxidant Activities of Camel and Bovine Whey Proteins by Limited Proteolysis. Journal of agricultural and food chemistry. 2010, 58, 3297-302. 14. Balalaie, S., Ebadi, S.A., Arabanian, A., Davoodi, J., Ahangarian, B. Design and Synthesis of Novel Peptidic Apoptosis Mimetics. In: Journal of Peptide Science, 2010, Vol. 16, p. 166.
Conference Papers 1. Karimi, A., Ebadi, A., Dastan, D., Virtual Screening for BRD4 Bromodomain Inhibitors: 2- hydroxynaphthalen-1(4h)-one as New Scaffold. 19 th Iranian Pharmacy Students, Shiraz, Iran, October 2015 2. Abbasnia, M., Ebadi, A., Dastan, D., Homology Modeling of C-C Chemokine Receptor Type 2. 19 th Iranian Pharmacy Students, Shiraz, Iran, October 2015 3. Jalilian, M., Dastan, D., Ebadi, A. Chemical composition, antioxidant and antimicrobial activities of Eremurus spectabilis essential oil and extracts from Iran. 19 th Iranian Pharmacy Students, Shiraz, Iran, October 2015 4. Ebadi, S. A., Ebrahimi, M., Homology Modeling and Molecular Dynamic Simulation of PLA 2 form Vipera Lebetina. The 1 st Poisoning, Tehran, Iran, October 2014 National Congress of Toxicology and Animal 5. Ebadi, S. A., Arbanian, A., Davoodi, J., Ahangharian, B., Balalaie, S. Design and Efficient Synthesis of Novel Peptidic Apoptosis Mimetics. 16th Iranian Conference of Organic Chemistry, Zanjan, Iran, August 2009 Thesis Design and synthesis of novel 3,4-dihydropyrimidine-2-one derivatives; 2014 Supervisors: Prof. Miri R. & Dr. Sadeghpour H., Advisor: Ebadi A. Public URL Google Scholar: http://scholar.google.com/citations?user=nsziepkaaaaj References Prof. Ramin Miri Ph. D. Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, PO Box 3288-71345 mirir@sums.ac.ir +989171131602 Prof. Saeed Balalaie Ph. D. Department of Chemistry - K.N.Toosi University of Technology, P.O. Box 15875-4416, Tehran Iran balalaie@kntu.ac.ir +989123332851
باظم تعالی کاروام ظ ابق آم زؼی پصي ؽی ي اجرایی: اطالعات ؼخصی وام: ظیذ احمذ وام خاو ادگی: عبادی داوؽکذ : ؼمار تلفه محل کار: 0813831590 آدرض پعت الکتريویکی: a.ebadi@umsha.ac.ir & ahmadebadie@gmail.com تلفه مرا یا تلفه تماض: 09124668571 ظ ابق تحصیلی رؼت تحصیلی گرایػ رؼت تحصیلی درج علمی داوؽگا محل تحصیل ؼ ر محل تحصیل کؽ ر محل تحصیل زمان فارغ التحصیل 1393 PhD ؼیمی داريیی داوؽگا عل م پسؼکی ؼیراز ؼیراز ایران 1388 ؼیمی ؼیمی آلی کارؼىاظی ارؼذ داوؽگا صىعتی خ اج وصیر الذیه ط ظی ت ران ایران 1386 ؼیمی ؼیمی کاربردی کارؼىاظی داوؽگا صىعتی خ اج وصیر الذیه ط ظی ت ران ایران
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