BIPM.RI(II)-K1.F-18, BIPM.RI(II)-K4.F18, CCRI(II)-K3.F-18 and APMP.RI(II)-K3.F-18

BIPM.RI(II)-K1.F-18, BIPM.RI(II)-K4.F18, CCRI(II)-K3.F-18 and APMP.RI(II)-K3.F-18 MEASURAND : Equivalent activity of 18 F Key comparison BIPM.RI(II)-K1.F-18 result of measurement carried out in the SIR for the sample submitted by laboratory i Lab i x i u i Date of / kbq / kbq measurement IRA 15312 57 2001-09-21 BEV 15390 160 2002-11-12 CIEMAT 15216 97 2004-05-13 PTB 15316 50 2005-04-13 LNE-LNHB 15203 62 2010-07-05 Key comparison BIPM.RI(II)-K4.F-18 result of measurement carried out in the SIR for the sample submitted by laboratory i Lab i x i u i Date of / kbq / kbq measurement VNIIM 15197 97 June 2014 NPL 15311 52 Sept. 2014 ENEA-INMRI 15368 49 Oct. 2014 NMISA 15328 96 Nov. 2015 The BIPM key comparison database, December 2016 1/5

Key comparison CCRI(II)-K3.F-18 result of measurement carried out at laboratory i converted to the equivalent activity through the NPL Lab i x i u i Measurement / kbq / kbq report date ANSTO 15150 240 2001-03-15 CMI-IIR 15010 120 2001-03-29 NIST 14670 160 2001-03-21 Key comparison APMP.RI(II)-K3.F-18 result of measurement carried out at laboratory i converted to the equivalent activity through the NPL Lab i x i u i Measurement / kbq / kbq report date INER 15130 150 2001-01-11 The BIPM key comparison database, December 2016 2/5

BIPM.RI(II)-K1.F-18, BIPM.RI(II)-K4.F18, CCRI(II)-K3.F-18 and APMP.RI(II)-K3.F-18 MEASURAND : Equivalent activity of 18 F Key comparison BIPM.RI(II)-K1.F-18 Key comparison reference value: the SIR reference value for this radionuclide x R is 15 276 kbq, with a standard uncertainty u R = 24 kbq (see Final Report). The value xi is the equivalent activity for laboratory i. The degree of equivalence of each laboratory with respect to the reference value is given by a pair of terms: D i = (x i - x R ) where w i, its expanded uncertainty (k = 2), both expressed in MBq, and U i = 2[(1-2/n )u i 2 + (1/n 2 )Su i 2 ] 1/2 where w i is the weight of laboratory i contributing to the calculation of x R. Linking BIPM.RI(II)-K4.F-18 to BIPM.RI(II)-K1.F-18 The value x i is the SIRTI equivalent activity for laboratory i participant in BIPM.RI(II)-K4.F-18 multiplied by the linking factor to BIPM.RI(II)-K1.F-18 (see Final Report). The degree of equivalence of laboratory i participant in BIPM.RI(II)-K4.F-18 with respect to the key comparison reference value is given by a pair of terms: D i = (x i - x R ) and U i, its expanded uncertainty (k = 2), both expressed in MBq. The approximation U i = 2(u i 2 + u R 2 ) 1/2 is used in the following table as none of these laboratories contributed to the KCRV. Linking CCRI(II)-K3.F-18 to BIPM.RI(II)-K1.F-18 The value x i is the equivalent activity for laboratory i participant in CCRI(II)-K3.F-18 having been normalized to the value of the NPL and the LNE-LNHB combined as the link. The degree of equivalence of laboratory i participant in CCRI(II)-K3 with respect to the key comparison reference value is given by a pair of terms: D i = (x i - x R ) and U i, its expanded uncertainty (k = 2), both expressed in MBq. The approximation U i = 2(u i 2 + u R 2 ) 1/2 is used as none of these laboratories contributed to the computation of the key comparison reference value as none of these laboratories contributed to the KCRV. The BIPM key comparison database, December 2016 3/5

Linking APMP.RI(II)-K3.F-18 to BIPM.RI(II)-K1.F-18 The value x i is the equivalent activity for laboratory i participant in APMP.RI(II)-K3.F-18 having been normalized to the value of the NPL and the LNE-LNHB combined as the link. The degree of equivalence of laboratory i participant in APMP.RI(II)-K3.F-18 with respect to the key comparison reference value is given by a pair of terms: D i = (x i - x R ) and U i, its expanded uncertainty (k = 2), both expressed in MBq. The approximation U i = 2(u i 2 + u R 2 ) 1/2 is used as this laboratory did not contribute to the computation of the key comparison reference value as none of these laboratories contributed to the KCRV. These statements make it possible to extend the BIPM.RI(II)-K1.F-18 matrices of equivalence to all participants in the CCRI(II)-K3.F-18, the APMP.RI(II)-K3.F-18 and the BIPM.RI(II)-K4.F-18 comparisons. Degrees of Equivalence between BIPM.RI(II)-K1.F-18, BIPM.RI(II)-K4.F-18, CCRI(II)-K3.F-18 and APMP.RI(II)-K3.F-18 Lab i D i U i / MBq IRA 0.04 0.10 BEV 0.11 0.32 CIEMAT -0.06 0.18 PTB 0.04 0.09 LNE-LNHB -0.07 0.11 VNIIM -0.08 0.20 NPL 0.04 0.11 ENEA-INMRI 0.09 0.11 NMISA 0.05 0.20 ANSTO -0.13 0.48 CMI-IIR -0.27 0.24 NIST -0.61 0.32 INER -0.15 0.30 The BIPM key comparison database, December 2016 4/5

[D i = (x i - x R )] / (MBq) [D i / x R ] / (kbq / MBq) BIPM.RI(II)-K1.F-18, BIPM.RI(II)-K4.F-18, CCRI(II)-K3.F-18 and APMP.RI(II)-K3.F-18 Degrees of equivalence for equivalent activity of 18 F 1.0 65 0.8 52 0.6 39 0.4 26 0.2 13 0.0 0-0.2-13 -0.4-26 -0.6-39 -0.8-52 -1.0 IRA BEV CIEMAT PTB LNE- LNHB VNIIM NPL ENEA- INMRI NMISA ANSTO CMI-IIR NIST INER -65 Red diamonds: participants in BIPM.RI(II)-K1.F-18 Pink squares: participants in BIPM.RI(II)-K4.F-18 Blue circles: participants in CCRI(II)-K3.F-18 only Green triangle: participant in APMP.RI(II)-K3.F-18 only Note: One interval of 0.2 MBq on the y axis represents approximately 1.3 % of the key comparison reference value. Right-hand axis shows approximate values only. The BIPM key comparison database, December 2016 5/5