M. Pharmacy I Semester (Suppl.) Examination, November 2015 (Common To All) Subject: Pharmaceutical Analytical Techniques Code No. 6001 / S 1 a) Describe the instrumentation and applications of UV-visible spectrophotometer. 7 b) Discuss Woodward-Fieser rules for calculating the max for conjugated dienes by taking suitable example. 7 2 a) Discuss the principle, instrumentation along with a sketch diagram and applications of Fourier Transform Infra Red) (FTIR) spectrometer. 7 b) Draw schematic IR spectra for the following compounds and write the interpretation i) C 2 H 5 COCH 3 ii) C 6 H 5 -CH 2 COOH iii) C 6 H 5 -CHO 7 3 a) Write the theory and principle of proton NMR spectroscopy. Write about shielding and deshielding effects in NMR spectrum. 7 b) Discuss the effect of spin-spin coupling and explain how it is useful in structure elucidation of a compound with the help of a schematic NMR spectrum of a suitable compound. 7 4 a) Write a detailed account on various ionization techniques in Mass Spectrometry. 7 b) Discuss the fragmentation patterns and fragment characteristics in relation to parent structure and functional groups by taking suitable examples from straight chain and cyclic compounds containing hetero atoms. 7 5 a) Discuss various stationary phases and their applications in HPLC. 7 b) Write the instrumentation and applications of HPTLC. 7 OU - 1701 OU - 1701 6 Write notes on: 2x7 a) Derivatisation methods in GC b) Gel permeation chromatography 7 a) Write about preparative electrophoresis. 7 b) Write the principle and applications of capillary electrophoresis. 7 8 Write notes on: 2x7 a) Radioimmuno assay b) Chiral chromatography.
Code No. 6002 / S M. Pharmacy (Ph. Chem.) I Semester (Supplementary) Examination, November 2015 Subject: Advanced Pharmaceutical Organic Chemistry I 1 a) Discuss the various elements symmetry. 7 b) Explain cis-trans isomerism with examples. 7 2 Write the definition, stability, structure and reactivity of i) Carbanions ii) Carbenes 7+7 3 Discuss the mechanism of the following organic reactions: i) Electrophilic addition reaction 7 ii) Nucleophilic addition reaction 7 4 a) What is sigmatropic rearrangement? Explain with suitable examples: i) Sigmatropic migrations of hydrogen ii) Sigmatropic migrations of carbon 7 b) Discuss Diels Alder reaction with the help of FMO method. 7 5 a) Discuss the R and S system of designating configuration of compounds containing more than one asymmetric centre. 7 b) Explain stereoselective synthesis with suitable examples. 7 6 Explain the mechanism of the following: i) Wagner Meerwin rearrangement 7 ii) Hoffman rearrangement 7 7 Explain the mechanism of the following: i) Beckmann rearrangement 7 ii) Benzil benzilic acid rearrangement 7 OU - 1701 OU - 1701 8 a) Differentiate between SN 1 and SN 2 reactions. Discuss the role of solvents in nucleophilic substitution reactions. 7 b) Discuss the orientation and reactivity of monosubstituted benzene with suitable examples. 7
Code No. 6004 / S M. Pharmacy (Ph.Chem. / Ph.cognosy) I Semester (Supplementary) Examination, November 2015 Subject: Advanced Chemistry of Natural Products 1 a) Discuss the role of natural products in development of new drugs with suitable examples. 8 b) Discuss the sources, chemistry, structural modifications and uses of Rauwolfia. 6 2 Write the sources, structural features and elucidate the structure of Morphine. 14 3 a) Describe the problems in synthesis of peptides and systematically synthesize any one tripeptide. 8 b) Write the structural features and mechanism action of artemisicin. 4 4 Write about: a) Discuss the basic chemistry and structural features of a steroids. 7 b) Write about the structural modifications of steroids to develop into anti-inflammatory and antifertility agents. 7 5 Write structural features and modifications, mechanism of action and therapeutic uses of i) Gymnemic acids ii) Taxanes 14 6 Give the color reactions of steroids and elucidate the structure of cholesterol. 14 7 a) Discuss the chemistry of insulin. 7 b) Write about primary, secondary and tertiary structure of proteins. 7 8 a) Write about the criteria in selection of lead. 5 b) Define and classify alkaloids and write a note on general methods of structure elucidation. 9 OU - 1701 OU - 1701
Code No. 6003 / S M. Pharmacy (Ph. Chem.) I Semester (Supplementary) Examination, November 2015 Subject: Advanced Medicinal Chemistry I 1 Write a note on the following: i) Rate theory 7 ii) Induced fit theory 7 2 a) Discuss the major pathways for oxidative metabolism with suitable examples. 8 b) Write a note on bioprecursors. 6 3 Write a note on the following by taking suitable examples: a) Serendipity 7 b) Random screening 7 4 Discuss the targets for the development of i) Anti-inflammatory agents 7 ii) Anti-ulcer agents 7 5 a) Write in detail the applications of prodrug approach. 8 b) Explain glucuronic acid conjugation with examples. 6 6 a) Discuss the factors influencing enzyme induction and inhibition. 6 b) Explain with examples how enzyme inhibitors are developed as drugs using rational drug design. 8 7 a) Write an account of natural products as leads in drug design. 7 b) Explain how the stereochemical aspects of drugs affect the biological activity of a drug. 7 8 a) Explain with appropriate examples how the side effects of a known drug could lead to the development of other therapeutic classes. 6 b) Write a note on ion channel blockers. 8 OU - 1701 OU - 1701
Code No. 8001 / M M. Pharmacy (Common to All) I-Semester (Main) Examination, April 2015 Subject: Pharmaceutical Analytical Techniques 1 (a) Write a detailed account of various types of electronic transitions induced by the interaction of UV radiation with organic molecules. 7 (b) Explain the effect of solvent and ph on the UV absorption maxima of organic molecules. 7 2 (a) Write about the fundamental principles of NMR. Explain the instrument used in NMR by means of a neat sketch. 8 (b) Discuss applications of 1 H-NMR in structure elucidation. 6 3 (a) Explain the basic principles involved in mass spectrometry. Discuss the construction of a mass spectrometer in detail. 8 (b) Give a detailed account of fragmentation patterns for carboxylic acids and alcohols. 6 4 (a) Write in brief about the basic principles involved in HPLC. Enlist various stationary phases used in HPLC. 6 (b) In HPLC, explain how do you increase the resolution of compounds in a given mixture. 8 5 Write about: (a) Finger print region in IR spectroscopy. 7 (b) Mc Lafferty rearrangement in mass spectrometry. 7 6 Write an account of: (a) Principle and Applications of Radioimmuno Assay Methods 7 (b) Principles, Instrumentation and Applications of Zone electrophoresis. 7 7 (a) What is necessary criterion for absorption to occur in the IR region? What types of molecular vibrations are associated with IR absorption? 7 (b) Compare and contrast between conventional IR and FTIR spectrophotometer with respect to working principle, sensitivity and instrumentation. 7 OU - 1705 OU - 1705 8 (a) Discuss about various derivatisation methods in gas chromatographic analysis. 6 (b) Explain in detail the principle and working of any three detectors in GC. 8
Code No. 8004 / M M. Pharmacy (Pharm.Chem./ Pharmacognosy) I-Semester (Main) Examination, April 2015 Subject : Advanced Chemistry of Natural Products Time : 3 hours Max. Marks : 70 Note : Answer any FIVE questions. All questions carry equal marks. 1 a) Discuss the approaches for drug discovery from natural products. b) What is the lead and write the methods for the selection of lead? 8+6 2 Explain the general methods of peptide synthesis and give the preparation of any one tripeptide. 14 3 a) Give the sources and color reactions of steroids. b) Elucidate the structure of cholesterol. 4+10 4 Write about a) Structure and mechanism action of artemisicin and reserpine b) Sources and chemistry of insulin 7+7 5 a) What are alkaloids, classify and give the color reactions? b) Elucidate the structure of morphine. 4+10 6 Give an informative note on a) Stereochemistry of steroids b) Morphine analogs and antagonists 6+8 7 a) Give the sources, chemistry, structural modifications and mechanism action of vincristine. b) Structures and structural features of anti-inflammatory agents. 6+8 8 Discuss about a) Tertiary and quaternary structures of proteins b) End group analysis of proteins 7+7 OU - 1705 OU - 1705 **
Code No. 8002 / M M. Pharmacy (Ph.Chem.) I Semester (Main) Examination, April 2015 Subject : Advanced Pharmaceutical Organic Chemistry I Time : 3 hours Max. Marks : 70 Note : Answer any FIVE questions. All questions carry equal marks. 1 a) Explain the illustrate the centre of symmetry, plane of symmetry, enantiomers and diastereoisomers with examples. 8 b) Discuss the optical isomerism of Biphenyl derivatives. 6 2 Discuss the generation, stability and reactivity of i) Free radicals 5 ii) Carbocations 5 iii) Nitrenes 4 3 a) Explain the Nucleophilic reactions with suitable examples. 7 b) Explain mechanism of i) Electrophilic substitution 4 ii) E 1 Elimination 3 4 a) What do you understand by pericyclic reactions? Discuss various types of pericyclic reactions. 6 b) Write short notes on : i) Huckel and Mobius molecular orbital system 4 ii) Sigmatropic rearrangement 4 5 a) Describe the mechanism of following : 7 i) Pinacol Pinacolone rearrangement ii) Benzil benzilic acid rearrangement b) Give the mechanism of following : 7 i) Hoffman rearrangement ii) Lossen rearrangement 6 Discuss the mechanism and applications of the following : i) Claisen rearrangement 5 ii) Beckmann rearrangement 5 iii) Bayer Villiger rearrangement 4 7 a) What are the important methods of resolving recemic mixtures? 8 b) Write a note on stereoselective synthesis with an example. 6 8 a) Give the mechanism of following : 7 i) Curtius rearrangement ii) rearrangement of hydro peroxides b) Write short notes on : 7 i) CON rotation ii) DIS rotation OU - 1705 OU - 1705 **
Code No. 8003 / M M. Pharmacy (Pharm. Chem.) I Semester (Main) Examination, April 2015 Subject : Advanced Medicinal Chemistry - I Time : 3 hours Max. Marks : 70 Note : Answer any FIVE questions. All questions carry equal marks. 1 a) Write a note on the following theories of drug-receptor interaction. i) Induced fit theory ii) Macromolecular perturbation theory 4+4 b) Explain the drug development of cimetidine. 6 2 Discuss targets for the development of i) Anti-inflammatory agents 7 ii) Anti-hypertensive agents 7 3 a) Define the term prodrugs and write a note on bioreversible derivatives for various functional groups. 7 b) Write a note on applications of prodrugs. 7 4 Explain the following in detail by taking suitable examples. i) Glucuronic acid conjugation 8 ii) Glutathione conjugation 6 5 a) Write a note on ion channel blockers. 7 b) Discuss about phase-i biotransformation of drugs with suitable examples. 7 6 Write a note on the following : i) Serendipity 7 ii) Molecular modification of known drugs 7 7 Write a note on the following : a) Rational drug design 8 b) Random screening 6 OU - 1705 OU - 1705 8 Write a note on the following : i) Occupancy theory 7 ii) Soft drugs 7 **