Pymetrozine: An essential component of insect pest management in European oilseed rape production.

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Pymetrozine: An essential component of insect pest management in European oilseed rape production. Russell Slater, Christoph Vock, Torsten Block EPPO Workshop on integrated management of insect pests in oilseed rape. 20th 22 nd September 2017

Code number CGA 21944 Trade name Formulation Common name Chemical class Mode of action IRAC MoA code Molecular structure Actvitiy PLENUM 0% WG Pymetrozine Pyridine azomethine Chordotonal organ TRPV channel modulator 9 B Contact Ingestion Systemic Pymetrozine works on the sensillae in the chordotonal organ and blocks the nerve impulse to the brain. This results in a constant stretching of the legs. Chordotonal-Sensillae Femur Extensor Flexor Joint Lower leg Spectrum Other insecticides with same mode of action Aphids Whitefly Planthoppers Mealybugs Beetles & Weevils Pyrifluquinazon Afidopyrafen Lower leg Femur

Pymetrozine symptomology Beetle starts to lose control of legs and starts intensive grooming behaviour Uncontrolled extension of hind legs. Normal behaviour Easy prey for predators Total loss of co ordination and balance Beetle falls to the ground

Pymetrozine Use in OSR BBCH 9 Pollen beetle Aphids 10 11 18 32 1 3 7 61 6 Unique mode of action in oilseed rape. Rapid effects: stops feeding quickly. Reliable performance: shown to provide pest control under varible environmental conditions Both high and low temperatures.

Efficacy against pollen beetle in winter OSR n = 31 (DE, CH, FR, PL, CZ, DK) 90 80 70 60 Efficacy % 0 40 30 20 10 0 4-7-8 10 Tage Days after nach application Applikation Plenum 10 g/ha VM NNI (NCI) 300 300 ml/ha ml/ha

Resistance status of major OSR pests to registered insecticides modes of action. Chemical subgroup IRAC MoA A.I. Examples Pollen Beetle (Meligethes aeneus) Rape Stem Weevil (Ceutorhynchus napi) Cabbage seed weevil (C.assimilis/Obstrictus) Cabbage Stem Weevil (C.pallidactylus) Rape winter stem weevil (C.picitarsis) Cabbage stem flea beetle (Psylliodes chrysocephala) Brassica pod midge (Dasineura brassicae) Green peach aphid (Myzus persicae) Pyrethroids 3A L cyhalothrin Deltamethin Cyfluthrin Pyrethroids 3A Tau fluvalinate Bifenthrin Etofenprox Organophosphates 1B Chlorpyrifos Phosmet Neonicotinoids 4A Thiacloprid Acetamiprid Thiamethoxam Pyridine azomethine 9B Pymetrozine Oxadiazines 22A Indoxacarb Carbamates 1A Pirimicarb Green = No known cases of resistance, Yellow = localised shifts in sensitivity or localised resistance hotspots Orange = Resistance reported in several regions with significant impact on pest control, Red = widespread resistance.

MoA s available across important OSR producing region for controlling pollen beetles Today 4 No. of MoA s today in average: 3 3 Pyrethroides 4 3 6 4 4 3 4 Neonicotinoides Organophosphates Pymetrozine Indoxacarb Spinosad (CH only) Maintaining as many MoA as possible is key!

Pollen beetle: MoA situation & outlook in Europe MoA groups registered availability in countries today Outlook Pyrethroids (3A) Everywhere Restistance selection increasing (not all SPI s similar affected) : UNDER THREAT Neonicotinoids (4A) Everywhere (almost) Regulatory pressure high: COMPLETE BAN? Pyridine azomethine derivates: Pymetrozine (9B) Oxadiazines: Indoxacarb (22A) Organophosphates (1B) Everywhere Mostly available (not in HR, SL, SE, NL) BE, FR, AT, PL, CZ, HR, HU, CH (not in DK, GB, DE, SL, NL, SE) Regulatory pressure: UNCERTAIN Remains? Regulatory pressure high Further PHASE OUT? Spinosyns: Spinosad () CH only (not in EU) Potential in other countries? New / alternative MoA Regulatory reuquirements often compromise registrability success chance or effectiveness

MoA s available across important OSR producing region for controlling pollen beetles Future? Pyrethroids 1 0-1 2-3 0 0-1 0-1 Pyrethroids not affected by resistance or reduced rates (Except DK, SE) Neonicotinoids Organophosphates Pymetrozine Indoxacarb Spinosad (CH only) Maintaining as many MoA as possible is key!

Maintaining diversity of modes of action & learning lessons from the past. 100 90 80 70 60 0 40 30 20 10 0 Percentage of pyrethroid resistant beetle populations in Germany 2001 201 2001 2002 2004 2006 2007 2008 2009 2010 2011 2012 2013 2014 201 2001 2006 based on Syngenta data, 2007 201 IRAC data* The lack of available alternatives and repetitive over use of pyrethroids is one of the key factors in the evolution of pyrethroid resistant oilseed rape pests. Response from industry has been to register alternative modes of action from their existing portfolio of products. However many of those alternatives are under threat from regulatory challenge. Discovery, development and registration of new active substances (especially new MoA) extremely challenging, particularly in Europe Don t expect unlimited supply! Critical to maintain diversity of modes of action and implement resistance management in practice in order to prevent or delay resistance and repeat events of the past. * www.irac online org

Unique mode of action for oilseed rape pest control. Highly active against aphids & pollen beetle. No known resistance in oilseed rape pests. An important resistance management tool. A critical need to maintain diversity of modes of action.