Alexander R. Lippert, Ph.D.
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1 Alexander R. Lippert, Ph.D. Department of Chemistry and Center for Drug Discovery, Design, and Delivery (CD4), Southern Methodist University 3215 Daniel Avenue, Dallas, TX TEL: URL: Education and Training University of California, Berkeley, Berkeley, California Postdoctoral Studies in Chemical Biology Advisor: Prof. Christopher J. Chang University of Pennsylvania, Philadelphia, Pennsylvania Ph.D. in Synthetic Chemistry Advisor: Prof. Jeffrey W. Bode University of California, Santa Barbara, Santa Barbara, California Ph.D. candidate in Synthetic Chemistry Advisor: Prof. Jeffrey W. Bode California Institute of Technology, Pasadena, California B.S. in Chemistry Advisor: Prof. Linda Hsieh-Wilson Positions 2012 present Southern Methodist University, Dallas, Texas Assistant Professor of Chemistry Publications and Patents Affiliated with Southern Methodist University (17) Bruemmer, K. J.; Merrikhihaghi, S.; Lollar, C. T.; Morris, S. N. S.; Bauer, J. H.; Lippert, A. R. "19F Magnetic Resonance Probes for Detecting Peroxynitrite in Living Cells Using an Oxidative Decarbonylation Reaction." Chem. Commun. 2014, accepted. doi: /C4CC04292A. (16) Krenek, K. M; Lippert, A. R. Composition, Device and Imaging System for Analysis Using Chemiluminescent Probes, U.S. provisional patent, filed June, (15) Lollar, C. T.; Krenek, K. M.; Bruemmer, K. J.; Lippert, A. R. "Ylide Mediated Carbonyl Homologations for the Preparation of Isatin Derivatives." Org. Biomol. Chem. 2014, 12, doi: /C3OB42024H. (14) Lippert, A. R. "Designing Reaction-Based Probes for the Selective Detection of Hydrogen Sulfide." J. Inorg. Biochem. 2014, 133, (13) Lin, V. S.; Lippert, A. R.; Chang, C. J. Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling: Imaging H 2 O 2 -dependent H 2 S production. Proc. Natl. Acad. Sci. USA 2013, 110,
2 Unaffiliated with Southern Methodist University (12) Lippert, A. R.; Chang, C. J. Compositions and Methods for Imaging, accepted U.S. Patent 13/816,620, filed August 22, 2011, projected U.S. publication date of August 15, (11) Michel, B. W.; Lippert, A. R.; Chang, C. J. A Reaction-Based Fluorescent Probe for Selective Imaging of Carbon Monoxide in Living Cells Using a Palladium-Mediated Carbonylation. J. Am. Chem. Soc. 2012, 124, (10) Lippert, A. R.; Lin, V.; Chang, C. J. Fluorescent Probes for Reactive Sulfur Species, U.S. provisional patent, filed June, (9) Lippert, A. R.; Van De Bittner, G. C.; Chang, C. J. Boronate Oxidation as a Bioorthogonal Reaction Approach for Studying the Chemistry of Hydrogen Peroxide in Living Systems. Acc. Chem. Res. 2011, 44, (8) Lippert, A. R.; New, E. J.; Chang, C. J. Reaction-Based Fluorescent Probes for the Selective Imaging of Hydrogen Sulfide in Living Cells. J. Am. Chem. Soc. 2011, 133, (7) Lippert, A. R.; Keshari, K. R.; Kurhanewicz, J.; Chang, C. J. A Hydrogen Peroxide-Responsive Hyperpolarized 13 C MRI Contrast Agent. J. Am. Chem. Soc. 2011, 133, (6) Lippert, A. R.; Naganawa, A.; Keleshian, V. L.; Bode, J. W. Synthesis of Phototrappable Shapeshifting Molecules for Adaptive Guest Binding. J. Am. Chem. Soc. 2010, 132, (5) Lippert, A. R.; Gschneidtner, T.; Chang, C. J. Lanthanide-Based Luminescent Probes for Selective Time-Gated Detection of Hydrogen Peroxide in Water and Living Cells. Chem. Commun. 2010, 46, (4) Lippert, A. R.; Keleshian, V. L.; Bode, J. W. Dynamic Supramolecular Complexation by Shapeshifting Organic Molecules. Org. Biomol. Chem. 2009, 7, (3) Ju, L.; Lippert, A. R.; Bode, J. W. Stereoretentive Synthesis and Chemoselective Amide-Forming Ligations of C-Terminal Peptide α-ketoacids. J. Am. Chem. Soc. 2008, 130, (2) Lippert, A. R.; Kaeobamrung, J.; Bode, J. W. Synthesis of Oligosubstituted Bullvalones: Shapeshifting Molecules Under Basic Conditions. J. Am. Chem. Soc. 2006, 128, (1) Khidekel, N.; Arndt, S.; Lamarre-Vincent, N.; Lippert, A.; Poulin-Kerstien, K. G.; Ramakrishnan, B.; Qasba, P. K.; Hsieh-Wilson, L. C. A Chemoenzymatic Approach toward Rapid and Sensitive Detection of O-GlcNAc Posttranslational Modifications. J. Am. Chem. Soc. 2003, 125, Presentations and Conference Abstracts Invited Talks (5) BME-Cancer Imaging Program Seminar Series, Invited Speaker, UT Southwestern (April 2014) "Reaction-based chemical probes for biologically generated sulfur, oxygen, and nitrogen species." Alexander R. Lippert. (4) Keck Seminar Series, Invited Speaker, Rice University (April 2014) "Reaction-based chemical probes for biologically generated sulfur, oxygen, and nitrogen species." Alexander R. Lippert.
3 (3) American Chemical Society Southwest Regional Meeting in Waco, Invited Speaker (November 2013) "Reaction-based molecular imaging probes for visualizing disease biomarkers." Alexander R. Lippert. (2) Center for Drug Design, Discovery, and Delivery, SMU, Invited Speaker (March 2013). Chemical Probes for Imaging Hydrogen Sulfide and Peroxynitrite in Living Systems. Alexander R. Lippert. (1) American Peptide Symposium, Invited Speaker, Young Investigator Lecture (June 2011). Hydrogen Peroxide Responsive Hyperpolarized 13 C MRI Contrast Agents. Alexander R. Lippert and Christopher J. Chang. Other Talks and Posters (8) American Chemical Society National Meeting in San Francisco (August 2014). Small Molecule Imaging Probes for Reactive Sulfur, Oxygen, and Nitrogen Species. Alexander R. Lippert. (7) Bioorganic Gordon Conference in Proctor Academy (June 2014). Small Molecule Imaging Probes for Reactive Sulfur, Oxygen, and Nitrogen Species. Kevin J. Bruemmer, Jian Cao, Katherine M. Krenek, Christina T. Lollar, Sara Merrikhihaghi, Siti Nur Sarah Morris, Jock Thacker, Alexander R. Lippert. (6) Bioorganic Gordon Conference in Proctor Academy (June 2013). New Fluorescence and Magnetic Resonance Probes for ONOO. Kevin J. Bruemmer, Christina T. Lollar, Julian L. Spearman, Alexander R. Lippert. (5) UT Southwestern Symposium and Training XXI: Frontiers in Molecular Imaging (May 2013). "Magnetic Resonance Detection of Peroxynitrite Using the Oxidative Decarbonylation of Isatin Derivatives." Kevin J. Bruemmer, Katherine M. Krenek, Alexander R. Lippert. (4) Bioorganic Gordon Research Conference (June 2010). New Reaction-Based Probes for H 2 O 2 and O 2. Alexander R. Lippert, Tina Gschneidtner, and Christopher J. Chang. (3) American Chemical Society National Meeting in San Francisco (March 2010). Lanthanide-based luminescent probes for hydrogen peroxide. Alexander R. Lippert, Tina Gschneidtner, and Christopher J. Chang. (2) American Chemical Society National Meeting in Philadelphia (August 2008). Functionalized bullvalenes: Adaptive organic molecules. Alexander R. Lippert and Jeffrey W. Bode. (1) American Chemical Society National Meeting in San Francisco (September 2006). Polysubstituted bullvalone: A base triggered adaptive organic molecule. Alex R. Lippert and Jeffrey W. Bode. Honors, Awards, and Affiliations (5) Member, Global Health Services Research Cluster, Southern Methodist University (2014 present) (4) Member, Biopsychosocial Research Cluster, Southern Methodist University (2013 present) (3) Member, Center for Drug Discovery, Design, and Delivery (CD4), Southern Methodist University (2012 present) (2) Robert H. De Wolfe Teaching Fellowship (2007) (1) Member, American Chemical Society (2004 present) Manuscript Review
4 (1) Journal of the American Chemical Society, Chemical Communications, Organic Letters, ACS Chemical Neuroscience, Chemical Science, Free Radicals in Biology and Medicine, Sensors and Actuators B: Chemical, Textile Research Journal, Analytical Chemistry, ChemBioChem, Biochimica et Biophysica Acta, Acta Chimica Acta Courses Taught at Southern Methodist University (2) Organic Chemistry I CHEM 3371 Fall 2013, Spring 2013, Fall 2014 (1) Modern Aspects of Chemistry CHEM 6220 Fall 2012, Fall 2013, Fall 2014 Students Mentored at Southern Methodist University (7) Sara Alsultan, 1st year Master's Student (6) Maha Aljowni, 1st year PhD student (5) Weiwei An, 1st year PhD student (4) Kenneth Bethel, 1st year PhD student (3) Siti Nur Sarah Morris, 1st year Master's student (2) Sara Merrikhihaghi, 2nd year PhD student Pharm. D., Tehran University (1) Jian Cao, 2nd year PhD student B.S. Pharmacy, Jiangsu University (9) Audrey Reeves, Sophomore (8) Miguel Quimbar, Sophomore (7) Edward Allegra, Junior (6) Genevieve Luseesa, Senior (5) Marielle Ngoue, Senior (4) Camille Baird, Senior Joint Student with Prof. Peng Tao (3) Jock Thacker, Senior Current Graduate Students Current Undergraduate Students (2) Kevin Bruemmer, Senior Hamilton Undergraduate Research Scholar, Provost Scholar, Lazenby Scholar, Engaged Learning
5 (1) Christina Lollar, Senior Hamilton Undergraduate Research Scholar, President's Scholar, Engaged Learning Alumni (1) Katherine Krenek, Medical School at UT Southwestern Medical Center
Affiliated with Southern Methodist University (Underline = undergraduate; * = Corresponding author)
Alexander R. Lippert, Ph.D. Department of Chemistry, Center for Drug Discovery, Design, and Delivery (CD4), and Center for Global Health Impact (CGHI), Southern Methodist University 3215 Daniel Avenue,
Alexander Ryan Lippert, Ph.D.
Alexander Ryan Lippert, Ph.D. Department of Chemistry, Center for Drug Discovery, Design, and Delivery (CD4), and Center for Global Health Impact (CGHI), Southern Methodist University 3215 Daniel Avenue,
(6) Member, Cognitive Science Research Cluster, Southern Methodist University (2015-present)
Alexander Ryan Lippert, Ph.D. Department of Chemistry, Center for Drug Discovery, Design, and Delivery (CD4), and Center for Global Health Impact (CGHI), Southern Methodist University 3215 Daniel Avenue,
Colorado Springs, CO B.A., Chemistry GPA: 3.73 May 2009 Research Advisor: Dr. Rongson Pongdee
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