Nizar A. Al-Shar'i, PhD

Transcription

1 Nizar A. Al-Shar'i, PhD Assistant professor, Medicinal Chemistry and Computer Aided Drug Design Personal profile I am Nizar Ali Al-Shar i, born in Rhaba, Irbid, Jordan in 1978, married with one boy. I am a pharmacist with a PhD in medicinal chemistry and computer aided drug design. Currently I am an assistant professor and the chair of the Medicinal Chemistry and Pharmacognosy Department in the at. In terms of research, I am interested in drug discovery by applying Computer Aided Drug Design (CADD) and in Molecular Dynamics (MD) Simulation. The combination of experimental and theoretical approaches often provides unique insight into the systems being studied. Address Department of Medicinal Chemistry and Pharmacognosy Phone: + (962) Ext Mobile: + (962) nashari@just.edu.jo Office location: P2 level -1 Education PhD in Computer Aided Drug Design University of Strathclyde 161 Cathedral Street, Glasgow, G4 0RE, Glasgow, Scotland, UK Thesis Title: A computational method for identifying allosteric binding sites in kinases MSc in Medicinal Chemistry Dept. of Medicinal Chemistry and Pharmacognosy, Thesis title: Synthesis and characterization of azole containing sulfonamides and evaluating their activity against Candida albicans. BSc in pharmacy P a g e

2 Experience-Academic Lecturer 3/2007-7/2009 Pharmacy department International Academy for Health Sciences, Hafr El Batin - Saudi Arabia. Full time lecturer 2/2013-4/2013 Dept. of Medicinal Chemistry and Pharmacognosy Assistant professor 4/2013-present Dept. of Medicinal Chemistry and Pharmacognosy Experience- Administrative Department head 9/2014-present Department of medicinal chemistry and pharmacognosy Assistant Dean of Pharmacy for Postgraduate Students Affairs and Quality Control 9/2013-9/2014 Department head 3/2007-7/2009 Pharmacy department, International Academy for Health Sciences, Hafr El Batin - Saudi Arabia. Experience- other Liaison officer 9/2013-9/2014 Liaison officer between Jordan Pharmaceutical Association and the, Jordan University of Science and Technology (JUST). Teaching Teaching courses for BSc, PharmD, and MSc levels. Medicinal Chemistry I-III Computer Aided Drug Design 2 P a g e

3 Graduate students Co-supervisor: Katreen Ali Banisalman: Design, Synthesis and Biological Evaluation of Novel Zinc Binders Targeting Human Glyoxalase-I; A Validated Target for Cancer Treatment Examiner: Munia F. Sowaileh Mohamad A. Al-Fandi Ghazi AlJabal Rajaa Badarnih MSc, 2013 MSc, 2014 MSc, 2015 MSc, 2015 Research High experience in Computer Aided Drug Design. High experience in running Molecular Dynamics Simulations. High experience in organic synthesis. Good experience in performing in-vitro antifungal activity of pharmaceutical compounds. Good experience in performing in-vitro enzyme inhibition assays of pharmaceutical compounds. Good command in using FT-IR spectrophotometer as well as interpreting its spectra. Familiar with MS and NMR instruments, with an ability to interpret their spectra. Computer skills High experience in using MS Windows and Linux operating systems and their applications. Excellent knowledge of the Internet. Professional software Discovery Studio (Biovia ) DS Pipeline Pilot (Biovia ) AMBER (a molecular dynamics package) Principle Component Analysis (PCA) SPSS Chemdraw ChemSketch PyMol (a molecular visualization system) Visual Molecular Dynamics (VMD), a molecular visualization program for displaying, animating, and analyzing large biomolecular systems GraphPad Prism MATLAB Professional memberships Member in the Jordan Pharmaceutical Association, since January Registered as a professional pharmacist from the Saudi Commission for Health Specialties, March 9 th, P a g e

4 Publications 1. Nizar A. Al-Shar i, Mohammad Hassan, Qosay Al-Balas, and Ammar Almaaytah. "Identification of Possible Glyoxalase II Inhibitors as Anticancer Agents by a Customized 3D Structure-Based Pharmacophore Model", Jordan Journal of Pharmaceutical Sciences, vol. 8, no. 2, pp , Ammar Almaaytah, Shadi Tarazi, Mohammad Al-Fandi, Ahmad Abuilhaija, Nizar Al-shar i, Qosay Al-Balas, and Aymen Abu-Awad. "The Design and Functional Characterization of the Antimicrobial and Antibiofilm Activities of BMAP27-Melittin, a Rationally Designed Hybrid Peptide", International Journal of Peptide Research and Therapeutics, vol. 21, no. 2, pp , Ammar Almaaytah, Shadi Tarazi, Ahmad Abu-Alhaijaa, Yara Altall, Nizar Al-shar i, Khaldon Bodoo, and Qosay Al- Balas. "Enhanced Antimicrobial Activity of AamAP1-Lysine, a Novel Synthetic Peptide Analog Derived from the Scorpion Venom Peptide AamAP1", Pharmaceuticals, vol. 7, no. 5, pp , Al-Shar'i, N, Al-Jaidi, B, Johnston, BF, Robertson, MN, Mackay, SP and Clark, RL, The drug discovery portal library: a unique resource to enhance drug discovery in academia, Journal of Pharmacy and Pharmacology, vol 62, no. 10, special issue, pp , Amjad M. Qandil, Mohammad A. Hassan, Nizar A. Al-Shar'i. "Synthesis and Anticandidal Activity of Azole- Containing Sulfonamides," Archiv der Pharmazie, vol. 341, no. 2, pp , Conferences and workshops 1. ICH-GCP Good Clinical Practice workshop, Pfizer, Jordan University of Science and Technology, November 19 th, Zarqa University Second Scientific Day, March 4 th, 2014, Zarqa University, Zarqa, Jordan. Nizar Al-Shar i, Bioinformatics in Computer-Aided Drug Design: The impact of molecular dynamics simulations. 3. Cancer Research UK Medicinal Chemistry Workshop, November 13 th, 2012, Newcastle University, Newcastle, UK. 4. Allosteric Mechanisms in Protein Regulation, July 18 th, 2012, Koc University, Istanbul, Turkey th Drug Design and Medicinal Chemistry Conference. June 7-8 th, 2012, San Diago, Calefornia, USA. 6. Exploiting New Computer Architectures in Molecular Dynamics Simulations workshop, March 23, 2011, School of Oriental and African Studies, University Of London, London. UK. References Dr. Amjad Qandil Pharmaceutical Sciences Dept. College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences (KSAU HS) P. O. Box 22490, Mail Code 3160, Riyadh 11481, Saudi Arabia. Phone: + (966) , Ext , Qandila@ksau-hs.edu.sa 4 P a g e

5 References (continued ) Prof. Mohammad A. Hassan Department of Medicinal Chemistry and Pharmacognosy Phone: + (962) , Ext , hassan-m@just.edu.jo Prof. Simon Mackay University Of Strathclyde 161 Cathedral Street, Glasgow, G4 0RE Phone : +44(0) , Ext. 2866, simon.mackay@strath.ac.uk Dr. Blair Johnston University Of Strathclyde 161 Cathedral Street, Glasgow, G4 0RE Phone : +44(0) , Ext. 5756, blair.johnston@strath.ac.uk 5 P a g e