Section 8.1 Def. and Examp. Systems

Size: px
Start display at page:

Download "Section 8.1 Def. and Examp. Systems"

Transcription

1 Section 8.1 Def. and Examp. Systems Key Terms: SIR Model of an epidemic o Nonlinear o Autonomous Vector functions o Derivative of vector functions Order of a DE system Planar systems Dimension of a system Reduction of higher order DEs to systems of first order DEs

2 We investigate systems of differential equations. Initially we discuss definitions and examples. Naturally we will be able to model many more applications using systems. Then we examine ways to visualize solutions and make geometrical interpretations of a system. A system of differential equations is a set of one or more equations, involving one or more unknown functions. In many applications there are several interrelated quantities changing with respect to an independent variable, often time. Modeling such an application leads to a system of differential equations. We start with a model. The SIR model of an epidemic We start by modeling an epidemic. Suppose we have a population of N individuals that is subject to a communicable disease. We will assume the following facts about the disease: The disease is of short duration and rarely fatal. The disease spreads through contact between individuals. Individuals who have recovered from the disease are immune. These features are present in measles, the mumps, and in the common cold.

3 We divide the population into three groups. The susceptible, S(t), are those individuals who have never had the disease. The infected, I (t), are those who are currently ill with the disease. The recovered, R(t), are those who have had the disease and are now immune. The total population is the sum of these three, N = S + I + R. We must compute the rate of change for each of these subpopulations. Since the disease is of short duration and rarely fatal, we may ignore deaths and births. This means that the total population N is a constant. It also implies that S(t), the number of susceptibles, changes only because some of them catch the disease and pass into the infected population. Since the disease spreads through contacts between susceptible and infected individuals, the rate of change is proportional to the number of contacts. Assuming that the two populations are randomly distributed over area, the number of contacts is proportional to the product SI of the two populations. Thus there is a positive constant a such that ds = -asi

4 The number of infected individuals, I(t), changes in two ways. First, it increases as susceptible individuals get sick. Assuming that there is a fairly standard time in which a recovery takes place, the rate of recovery is proportional to the number of infected. So there is a positive constant b such that the rate of recoveries is bi. Putting these together, we see that di = asi - bi The number of recovered individuals, R(t), increases as those who are infected are cured so dr = bi ds = -asi Thus we have a system of 3 DEs: di = asi - bi This called the SIR model. It is nonlinear (note the products of unknown functions S and I). It is autonomous. dr = bi A solution to the SIR model is a triple of functions S(t), I (t), and R(t), which satisfy the equations the three DES.

5 We cannot solve the system explicitly, but we can compute numerical solutions. To do this we need to select initial conditions and values for the rate constants a and b. Let S(0) = 4, I (0) = 0.1, and R(0) = 0 and a = b = 1. So we have IVP ds = -SI di = SI - I dr =I S(0) = 4 I (0) = 0.1 R(0) = SIR EXAMPLE from text S(t) I(t) R(t) 1.5 A 4 th order Runge-Kutta Method was used with h = The number of infected individuals starts small, rises quickly, and then falls off. Interestingly, almost the entire population eventually gets the disease.

6 Although the SIR model as originally set up involves three equations and three unknowns, the last equation is not really needed. Remember that part of our model requires that the total population N = S + I + R is constant. If we add the equations we get dn/ = 0, which serves as verification. In addition, the first two equations form a planar, autonomous system. If we were to solve only these equations for S and I, we could compute the number of recovered individuals from the equation R = N S I. In this way, we get the system Sꞌ = asi, I ꞌ = asi bi, which is also referred to as the SIR model.

7 Vector Notation We will use vector notation when dealing with first-order systems of DEs. Often it easiest to relabel dependent variables using subscripted names. For example the SIR system can put into vector notation as follows. ds Let u 1 (t) = S(t), u 2 (t) = I(t), and u 3 (t) = R(t). Then system = -asi is equivalent to uꞌ 1 = au 1 u 2 uꞌ 2 = au 1 u 2 bu 2 uꞌ 3 = bu 2. We now introduce the vector-valued function and then the derivative of u is If we define vector function u' 1(t) -au1u 2 u'(t) = = u' 2(t) au1u 2 - bu2 u' 3(t) bu2 -au1u 2 f(u) = au u - bu bu di = asi - bi dr = bi u 1(t) St () u(t) = = It () u 2(t) u 3(t) Rt () Most software for approximating systems of DEs using this format of input. then the system is given by uꞌ = f(u).

8 IVP in vector formulation System u' 1(t) -au1u 2 u'(t) = u' 2(t) = f(u) = au1u 2 - bu2 u' 3(t) bu2 requires 3 initial condition at initial time t 0, S(t 0 ) = S 0, I(t 0 ) = I 0, and R(t 0 ) = R 0 then the IVP is expressed as uꞌ = f(u) u(t 0 ) = u 0 = (S 0 I 0, R 0 ) T Terminology The SIR model involves only first-order derivatives of the unknown functions S, I, and R. For that reason it is called a first-order system. The order of a system of differential equations is the highest derivative that occurs in the system The general first-order system of two equations has the form xꞌ = f (t, x, y), yꞌ = g(t, x, y), where f and g are functions of the three variables t, x, and y. A solution to the system is a pair of functions x(t) and y(t) that satisfies xꞌ(t) = f (t, x(t), y(t)), yꞌ(t) = g(t, x(t), y(t)), for t in some interval.

9 Example: Show that the pair x 1 (t) = -t and x 2 (t) = -1 form a solution of the system x' = 1, x = 1 ==> x' = x x' 1 = x2 x' = -x x - x Just substitute in each side and show the results are equal. x' = 0, -x x -x = ( t)( 1) ( t) = t + t = 0, ==> x' =-x x -x General systems of DEs; Systems of n equations with n unknowns. If the unknown functions are x 1 (t), x 2 (t),..., and x n (t), then the system has the form xꞌ 1 = f 1 (t, x 1, x 2,..., x n ), xꞌ 2 = f 2 (t, x 1, x 2,..., x n ),... xꞌ n = f n (t, x 1, x 2,..., x n ), We will always require that the number of equations is equal to the number of unknowns, and this number is called the dimension of the system. A system of dimension 2 is called a planar system. The SIR model in the form Sꞌ = asi, I ꞌ = asi bi is a planar system and so is x' 1 = x2 x' = -x x - x

10 Reduction of higher-order equations and systems to first-order systems An application involving a higher-order equation (that is, a DE with second derivative or higher) has an equivalent model using a first-order system. Most numerical solvers are written to solve first-order systems. To solve a higher-order equation, it is necessary to use the equivalent first-order system. Example: Find a first-order system equivalent to the third-order, nonlinear equation xꞌꞌꞌ + xxꞌꞌ = cos t. The idea is to introduce new dependent variables for the unknown function and each derivative up to one less than the order of the equation. Hence, we introduce u 1 = x, u 2 = xꞌ, and u 3 = xꞌꞌ. Then differentiate each of the new variables. Finally solve the original DE for the highest derivative, and use the definitions of the new variables. We get the first-order system uꞌ 1 = u 2 uꞌ 2 = u 3 uꞌ 3 =xꞌꞌꞌ = u 1 u 3 + cos t.

Systems of Differential Equations

Systems of Differential Equations WWW Problems and Solutions 5.1 Chapter 5 Sstems of Differential Equations Section 5.1 First-Order Sstems www Problem 1. (From Scalar ODEs to Sstems). Solve each linear ODE; construct and solve an equivalent

More information

Spotlight on Modeling: The Possum Plague

Spotlight on Modeling: The Possum Plague 70 Spotlight on Modeling: The Possum Plague Reference: Sections 2.6, 7.2 and 7.3. The ecological balance in New Zealand has been disturbed by the introduction of the Australian possum, a marsupial the

More information

Applications in Biology

Applications in Biology 11 Applications in Biology In this chapter we make use of the techniques developed in the previous few chapters to examine some nonlinear systems that have been used as mathematical models for a variety

More information

Introduction to SEIR Models

Introduction to SEIR Models Department of Epidemiology and Public Health Health Systems Research and Dynamical Modelling Unit Introduction to SEIR Models Nakul Chitnis Workshop on Mathematical Models of Climate Variability, Environmental

More information

Mathematical Analysis of Epidemiological Models: Introduction

Mathematical Analysis of Epidemiological Models: Introduction Mathematical Analysis of Epidemiological Models: Introduction Jan Medlock Clemson University Department of Mathematical Sciences 8 February 2010 1. Introduction. The effectiveness of improved sanitation,

More information

Analysis of Numerical and Exact solutions of certain SIR and SIS Epidemic models

Analysis of Numerical and Exact solutions of certain SIR and SIS Epidemic models Journal of Mathematical Modelling and Application 2011, Vol. 1, No. 4, 51-56 ISSN: 2178-2423 Analysis of Numerical and Exact solutions of certain SIR and SIS Epidemic models S O Maliki Department of Industrial

More information

We have two possible solutions (intersections of null-clines. dt = bv + muv = g(u, v). du = au nuv = f (u, v),

We have two possible solutions (intersections of null-clines. dt = bv + muv = g(u, v). du = au nuv = f (u, v), Let us apply the approach presented above to the analysis of population dynamics models. 9. Lotka-Volterra predator-prey model: phase plane analysis. Earlier we introduced the system of equations for prey

More information

Modelling of the Hand-Foot-Mouth-Disease with the Carrier Population

Modelling of the Hand-Foot-Mouth-Disease with the Carrier Population Modelling of the Hand-Foot-Mouth-Disease with the Carrier Population Ruzhang Zhao, Lijun Yang Department of Mathematical Science, Tsinghua University, China. Corresponding author. Email: lyang@math.tsinghua.edu.cn,

More information

APPM 2360 Lab 3: Zombies! Due April 27, 2017 by 11:59 pm

APPM 2360 Lab 3: Zombies! Due April 27, 2017 by 11:59 pm APPM 2360 Lab 3: Zombies! Due April 27, 2017 by 11:59 pm 1 Introduction As you already know, in the past month, zombies have overrun much of North America, including all major cities on both the East and

More information

Mathematical Epidemiology Lecture 1. Matylda Jabłońska-Sabuka

Mathematical Epidemiology Lecture 1. Matylda Jabłońska-Sabuka Lecture 1 Lappeenranta University of Technology Wrocław, Fall 2013 What is? Basic terminology Epidemiology is the subject that studies the spread of diseases in populations, and primarily the human populations.

More information

A Note on the Spread of Infectious Diseases. in a Large Susceptible Population

A Note on the Spread of Infectious Diseases. in a Large Susceptible Population International Mathematical Forum, Vol. 7, 2012, no. 50, 2481-2492 A Note on the Spread of Infectious Diseases in a Large Susceptible Population B. Barnes Department of Mathematics Kwame Nkrumah University

More information

Social Influence in Online Social Networks. Epidemiological Models. Epidemic Process

Social Influence in Online Social Networks. Epidemiological Models. Epidemic Process Social Influence in Online Social Networks Toward Understanding Spatial Dependence on Epidemic Thresholds in Networks Dr. Zesheng Chen Viral marketing ( word-of-mouth ) Blog information cascading Rumor

More information

Module 02 Control Systems Preliminaries, Intro to State Space

Module 02 Control Systems Preliminaries, Intro to State Space Module 02 Control Systems Preliminaries, Intro to State Space Ahmad F. Taha EE 5143: Linear Systems and Control Email: ahmad.taha@utsa.edu Webpage: http://engineering.utsa.edu/ taha August 28, 2017 Ahmad

More information

SIR Epidemic Model with total Population size

SIR Epidemic Model with total Population size Advances in Applied Mathematical Biosciences. ISSN 2248-9983 Volume 7, Number 1 (2016), pp. 33-39 International Research Publication House http://www.irphouse.com SIR Epidemic Model with total Population

More information

Dynamical models of HIV-AIDS e ect on population growth

Dynamical models of HIV-AIDS e ect on population growth Dynamical models of HV-ADS e ect on population growth David Gurarie May 11, 2005 Abstract We review some known dynamical models of epidemics, given by coupled systems of di erential equations, and propose

More information

ACM/CMS 107 Linear Analysis & Applications Fall 2016 Assignment 4: Linear ODEs and Control Theory Due: 5th December 2016

ACM/CMS 107 Linear Analysis & Applications Fall 2016 Assignment 4: Linear ODEs and Control Theory Due: 5th December 2016 ACM/CMS 17 Linear Analysis & Applications Fall 216 Assignment 4: Linear ODEs and Control Theory Due: 5th December 216 Introduction Systems of ordinary differential equations (ODEs) can be used to describe

More information

Thursday. Threshold and Sensitivity Analysis

Thursday. Threshold and Sensitivity Analysis Thursday Threshold and Sensitivity Analysis SIR Model without Demography ds dt di dt dr dt = βsi (2.1) = βsi γi (2.2) = γi (2.3) With initial conditions S(0) > 0, I(0) > 0, and R(0) = 0. This model can

More information

U(s) = 0 + 0s 3 + 0s 2 + 0s + 125

U(s) = 0 + 0s 3 + 0s 2 + 0s + 125 THE UNIVERSITY OF TEXAS AT SAN ANTONIO EE 5143 LINEAR SYSTEMS AND CONTROL H O M E W O R K # 2 Andres Rainiero Hernandez Coronado September 6, 2017 The objective of this homework is to test your understanding

More information

Mathematical Modeling and Analysis of Infectious Disease Dynamics

Mathematical Modeling and Analysis of Infectious Disease Dynamics Mathematical Modeling and Analysis of Infectious Disease Dynamics V. A. Bokil Department of Mathematics Oregon State University Corvallis, OR MTH 323: Mathematical Modeling May 22, 2017 V. A. Bokil (OSU-Math)

More information

Three Disguises of 1 x = e λx

Three Disguises of 1 x = e λx Three Disguises of 1 x = e λx Chathuri Karunarathna Mudiyanselage Rabi K.C. Winfried Just Department of Mathematics, Ohio University Mathematical Biology and Dynamical Systems Seminar Ohio University November

More information

Math 216 Final Exam 14 December, 2012

Math 216 Final Exam 14 December, 2012 Math 216 Final Exam 14 December, 2012 This sample exam is provided to serve as one component of your studying for this exam in this course. Please note that it is not guaranteed to cover the material that

More information

Section 9.3 Phase Plane Portraits (for Planar Systems)

Section 9.3 Phase Plane Portraits (for Planar Systems) Section 9.3 Phase Plane Portraits (for Planar Systems) Key Terms: Equilibrium point of planer system yꞌ = Ay o Equilibrium solution Exponential solutions o Half-line solutions Unstable solution Stable

More information

A NEW SOLUTION OF SIR MODEL BY USING THE DIFFERENTIAL FRACTIONAL TRANSFORMATION METHOD

A NEW SOLUTION OF SIR MODEL BY USING THE DIFFERENTIAL FRACTIONAL TRANSFORMATION METHOD April, 4. Vol. 4, No. - 4 EAAS & ARF. All rights reserved ISSN35-869 A NEW SOLUTION OF SIR MODEL BY USING THE DIFFERENTIAL FRACTIONAL TRANSFORMATION METHOD Ahmed A. M. Hassan, S. H. Hoda Ibrahim, Amr M.

More information

MULTIOBJECTIVE DESIGN OF VACCINATION CAMPAIGNS WITH A STOCHASTIC VALIDATION

MULTIOBJECTIVE DESIGN OF VACCINATION CAMPAIGNS WITH A STOCHASTIC VALIDATION MULTIOBJECTIVE DESIGN OF VACCINATION CAMPAIGNS WITH A STOCHASTIC VALIDATION André Rodrigues da Cruz Universidade Federal de Minas Gerais Master Student in Electrical Engineering andrercruz@cpdee.ufmg.br

More information

Age-dependent branching processes with incubation

Age-dependent branching processes with incubation Age-dependent branching processes with incubation I. RAHIMOV Department of Mathematical Sciences, KFUPM, Box. 1339, Dhahran, 3161, Saudi Arabia e-mail: rahimov @kfupm.edu.sa We study a modification of

More information

Figure The Threshold Theorem of epidemiology

Figure The Threshold Theorem of epidemiology K/a Figure 3 6. Assurne that K 1/ a < K 2 and K 2 / ß < K 1 (a) Show that the equilibrium solution N 1 =0, N 2 =0 of (*) is unstable. (b) Show that the equilibrium solutions N 2 =0 and N 1 =0, N 2 =K 2

More information

Non-Linear Models Cont d: Infectious Diseases. Non-Linear Models Cont d: Infectious Diseases

Non-Linear Models Cont d: Infectious Diseases. Non-Linear Models Cont d: Infectious Diseases Cont d: Infectious Diseases Infectious Diseases Can be classified into 2 broad categories: 1 those caused by viruses & bacteria (microparasitic diseases e.g. smallpox, measles), 2 those due to vectors

More information

Mathematical modelling and controlling the dynamics of infectious diseases

Mathematical modelling and controlling the dynamics of infectious diseases Mathematical modelling and controlling the dynamics of infectious diseases Musa Mammadov Centre for Informatics and Applied Optimisation Federation University Australia 25 August 2017, School of Science,

More information

6. Age structure. for a, t IR +, subject to the boundary condition. (6.3) p(0; t) = and to the initial condition

6. Age structure. for a, t IR +, subject to the boundary condition. (6.3) p(0; t) = and to the initial condition 6. Age structure In this section we introduce a dependence of the force of infection upon the chronological age of individuals participating in the epidemic. Age has been recognized as an important factor

More information

POPULATION DYNAMICS: TWO SPECIES MODELS; Susceptible Infected Recovered (SIR) MODEL. If they co-exist in the same environment:

POPULATION DYNAMICS: TWO SPECIES MODELS; Susceptible Infected Recovered (SIR) MODEL. If they co-exist in the same environment: POPULATION DYNAMICS: TWO SPECIES MODELS; Susceptible Infected Recovered (SIR) MODEL Next logical step: consider dynamics of more than one species. We start with models of 2 interacting species. We consider,

More information

Math 310: Applied Differential Equations Homework 2 Prof. Ricciardi October 8, DUE: October 25, 2010

Math 310: Applied Differential Equations Homework 2 Prof. Ricciardi October 8, DUE: October 25, 2010 Math 310: Applied Differential Equations Homework 2 Prof. Ricciardi October 8, 2010 DUE: October 25, 2010 1. Complete Laboratory 5, numbers 4 and 7 only. 2. Find a synchronous solution of the form A cos(ωt)+b

More information

ECS 289 / MAE 298, Lecture 7 April 22, Percolation and Epidemiology on Networks, Part 2 Searching on networks

ECS 289 / MAE 298, Lecture 7 April 22, Percolation and Epidemiology on Networks, Part 2 Searching on networks ECS 289 / MAE 298, Lecture 7 April 22, 2014 Percolation and Epidemiology on Networks, Part 2 Searching on networks 28 project pitches turned in Announcements We are compiling them into one file to share

More information

The SIR Disease Model Trajectories and MatLab

The SIR Disease Model Trajectories and MatLab The SIR Disease Model Trajectories and MatLab James K. Peterson Department of Biological Sciences and Department of Mathematical Sciences Clemson University November 17, 2013 Outline Reviewing the SIR

More information

Section 2.4 Linear Equations

Section 2.4 Linear Equations Section 2.4 Linear Equations Key Terms: Linear equation Homogeneous linear equation Nonhomogeneous (inhomogeneous) linear equation Integrating factor General solution Variation of parameters A first-order

More information

István Faragó, Róbert Horváth. Numerical Analysis of Evolution Equations, Innsbruck, Austria October, 2014.

István Faragó, Róbert Horváth. Numerical Analysis of Evolution Equations, Innsbruck, Austria October, 2014. s István, Róbert 1 Eötvös Loránd University, MTA-ELTE NumNet Research Group 2 University of Technology Budapest, MTA-ELTE NumNet Research Group Analysis of Evolution Equations, Innsbruck, Austria 14-17

More information

An Introduction to Stochastic Epidemic Models

An Introduction to Stochastic Epidemic Models An Introduction to Stochastic Epidemic Models Linda J. S. Allen Department of Mathematics and Statistics Texas Tech University Lubbock, Texas 79409-1042, U.S.A. linda.j.allen@ttu.edu 1 Introduction The

More information

Section 2.1 Differential Equation and Solutions

Section 2.1 Differential Equation and Solutions Section 2.1 Differential Equation and Solutions Key Terms: Ordinary Differential Equation (ODE) Independent Variable Order of a DE Partial Differential Equation (PDE) Normal Form Solution General Solution

More information

Stochastic modelling of epidemic spread

Stochastic modelling of epidemic spread Stochastic modelling of epidemic spread Julien Arino Centre for Research on Inner City Health St Michael s Hospital Toronto On leave from Department of Mathematics University of Manitoba Julien Arino@umanitoba.ca

More information

Homework #4 Solutions

Homework #4 Solutions MAT 303 Spring 03 Problems Section.: 0,, Section.:, 6,, Section.3:,, 0,, 30 Homework # Solutions..0. Suppose that the fish population P(t) in a lake is attacked by a disease at time t = 0, with the result

More information

Hepatitis C Mathematical Model

Hepatitis C Mathematical Model Hepatitis C Mathematical Model Syed Ali Raza May 18, 2012 1 Introduction Hepatitis C is an infectious disease that really harms the liver. It is caused by the hepatitis C virus. The infection leads to

More information

Epidemics in Networks Part 2 Compartmental Disease Models

Epidemics in Networks Part 2 Compartmental Disease Models Epidemics in Networks Part 2 Compartmental Disease Models Joel C. Miller & Tom Hladish 18 20 July 2018 1 / 35 Introduction to Compartmental Models Dynamics R 0 Epidemic Probability Epidemic size Review

More information

Introduction to Epidemic Modeling

Introduction to Epidemic Modeling Chapter 2 Introduction to Epidemic Modeling 2.1 Kermack McKendrick SIR Epidemic Model Introduction to epidemic modeling is usually made through one of the first epidemic models proposed by Kermack and

More information

Section 9.8 Higher Order Linear Equations

Section 9.8 Higher Order Linear Equations Section 9.8 Higher Order Linear Equations Key Terms: Higher order linear equations Equivalent linear systems for higher order equations Companion matrix Characteristic polynomial and equation A linear

More information

ME 406 S-I-R Model of Epidemics Part 2 Vital Dynamics Included

ME 406 S-I-R Model of Epidemics Part 2 Vital Dynamics Included ME 406 S-I-R Model of Epidemics Part 2 Vital Dynamics Included sysid Mathematica 6.0.3, DynPac 11.01, 1ê13ê9 1. Introduction Description of the Model In this notebook, we include births and deaths in the

More information

GEMF: GENERALIZED EPIDEMIC MODELING FRAMEWORK SOFTWARE IN PYTHON

GEMF: GENERALIZED EPIDEMIC MODELING FRAMEWORK SOFTWARE IN PYTHON GEMF: GENERALIZED EPIDEMIC MODELING FRAMEWORK SOFTWARE IN PYTHON HEMAN SHAKERI Network Science and Engineering Group (NetSE) Department of Electrical and Computer Engineering Kansas State University Manhattan,

More information

Section 7.4 Runge-Kutta Methods

Section 7.4 Runge-Kutta Methods Section 7.4 Runge-Kutta Methods Key terms: Taylor methods Taylor series Runge-Kutta; methods linear combinations of function values at intermediate points Alternatives to second order Taylor methods Fourth

More information

On the Spread of Epidemics in a Closed Heterogeneous Population

On the Spread of Epidemics in a Closed Heterogeneous Population On the Spread of Epidemics in a Closed Heterogeneous Population Artem Novozhilov Applied Mathematics 1 Moscow State University of Railway Engineering (MIIT) the 3d Workshop on Mathematical Models and Numerical

More information

Fixed Point Analysis of Kermack Mckendrick SIR Model

Fixed Point Analysis of Kermack Mckendrick SIR Model Kalpa Publications in Computing Volume, 17, Pages 13 19 ICRISET17. International Conference on Research and Innovations in Science, Engineering &Technology. Selected Papers in Computing Fixed Point Analysis

More information

VERIFIED SOLUTION OF NONLINEAR DYNAMIC MODELS IN EPIDEMIOLOGY

VERIFIED SOLUTION OF NONLINEAR DYNAMIC MODELS IN EPIDEMIOLOGY Int. J. Appl. Math. Comput. Sci.,, Vol., No., DOI: VERIFIED SOLUTION OF NONLINEAR DYNAMIC MODELS IN EPIDEMIOLOGY JOSHUA A. ENSZER, MARK A. STADTHERR Department of Chemical and Biomolecular Engineering

More information

CS224W: Analysis of Networks Jure Leskovec, Stanford University

CS224W: Analysis of Networks Jure Leskovec, Stanford University Announcements: Please fill HW Survey Weekend Office Hours starting this weekend (Hangout only) Proposal: Can use 1 late period CS224W: Analysis of Networks Jure Leskovec, Stanford University http://cs224w.stanford.edu

More information

On a stochastic epidemic SEIHR model and its diffusion approximation

On a stochastic epidemic SEIHR model and its diffusion approximation On a stochastic epidemic SEIHR model and its diffusion approximation Marco Ferrante (1), Elisabetta Ferraris (1) and Carles Rovira (2) (1) Dipartimento di Matematica, Università di Padova (Italy), (2)

More information

Stability of SEIR Model of Infectious Diseases with Human Immunity

Stability of SEIR Model of Infectious Diseases with Human Immunity Global Journal of Pure and Applied Mathematics. ISSN 0973-1768 Volume 13, Number 6 (2017), pp. 1811 1819 Research India Publications http://www.ripublication.com/gjpam.htm Stability of SEIR Model of Infectious

More information

Stochastic Differential Equations in Population Dynamics

Stochastic Differential Equations in Population Dynamics Stochastic Differential Equations in Population Dynamics Numerical Analysis, Stability and Theoretical Perspectives Bhaskar Ramasubramanian Abstract Population dynamics in the presence of noise in the

More information

MODELING AND ANALYSIS OF THE SPREAD OF CARRIER DEPENDENT INFECTIOUS DISEASES WITH ENVIRONMENTAL EFFECTS

MODELING AND ANALYSIS OF THE SPREAD OF CARRIER DEPENDENT INFECTIOUS DISEASES WITH ENVIRONMENTAL EFFECTS Journal of Biological Systems, Vol. 11, No. 3 2003 325 335 c World Scientific Publishing Company MODELING AND ANALYSIS OF THE SPREAD OF CARRIER DEPENDENT INFECTIOUS DISEASES WITH ENVIRONMENTAL EFFECTS

More information

Today. Logistic equation in many contexts

Today. Logistic equation in many contexts Today Logistic equation in many contexts Classic example of the power of mathematics - one unifying description for many apparently unrelated phenomena. Rates of change that are proportional to two things

More information

Kasetsart University Workshop. Mathematical modeling using calculus & differential equations concepts

Kasetsart University Workshop. Mathematical modeling using calculus & differential equations concepts Kasetsart University Workshop Mathematical modeling using calculus & differential equations concepts Dr. Anand Pardhanani Mathematics Department Earlham College Richmond, Indiana USA pardhan@earlham.edu

More information

Markov Chains and Pandemics

Markov Chains and Pandemics Markov Chains and Pandemics Caleb Dedmore and Brad Smith December 8, 2016 Page 1 of 16 Abstract Markov Chain Theory is a powerful tool used in statistical analysis to make predictions about future events

More information

Derivation of Itô SDE and Relationship to ODE and CTMC Models

Derivation of Itô SDE and Relationship to ODE and CTMC Models Derivation of Itô SDE and Relationship to ODE and CTMC Models Biomathematics II April 23, 2015 Linda J. S. Allen Texas Tech University TTU 1 Euler-Maruyama Method for Numerical Solution of an Itô SDE dx(t)

More information

Stochastic Models. John M. Drake & Pejman Rohani

Stochastic Models. John M. Drake & Pejman Rohani Epidemiological data are noisy Two types of noise: Observation error: the data are probabilistically related to the true state of the system Process noise: the system progresses probabilistically Environmental

More information

University of Leeds. Project in Statistics. Math5004M. Epidemic Modelling. Supervisor: Dr Andrew J Baczkowski. Student: Ross Breckon

University of Leeds. Project in Statistics. Math5004M. Epidemic Modelling. Supervisor: Dr Andrew J Baczkowski. Student: Ross Breckon University of Leeds Project in Statistics Math5004M Epidemic Modelling Student: Ross Breckon 200602800 Supervisor: Dr Andrew J Baczkowski May 6, 2015 Abstract The outbreak of an infectious disease can

More information

Inferring the origin of an epidemic with a dynamic message-passing algorithm

Inferring the origin of an epidemic with a dynamic message-passing algorithm Inferring the origin of an epidemic with a dynamic message-passing algorithm HARSH GUPTA (Based on the original work done by Andrey Y. Lokhov, Marc Mézard, Hiroki Ohta, and Lenka Zdeborová) Paper Andrey

More information

MAS1302 Computational Probability and Statistics

MAS1302 Computational Probability and Statistics MAS1302 Computational Probability and Statistics April 23, 2008 3. Simulating continuous random behaviour 3.1 The Continuous Uniform U(0,1) Distribution We have already used this random variable a great

More information

Problem set 3: Solutions Math 207A, Fall where a, b are positive constants, and determine their linearized stability.

Problem set 3: Solutions Math 207A, Fall where a, b are positive constants, and determine their linearized stability. Problem set 3: s Math 207A, Fall 2014 1. Fin the fixe points of the Hénon map x n+1 = a x 2 n +by n, y n+1 = x n, where a, b are positive constants, an etermine their linearize stability. The fixe points

More information

Supplement to TB in Canadian First Nations at the turn-of-the twentieth century

Supplement to TB in Canadian First Nations at the turn-of-the twentieth century Supplement to TB in Canadian First Nations at the turn-of-the twentieth century S. F. Ackley, Fengchen Liu, Travis C. Porco, Caitlin S. Pepperell Equations Definitions S, L, T I, T N, and R give the numbers

More information

Simulating stochastic epidemics

Simulating stochastic epidemics Simulating stochastic epidemics John M. Drake & Pejman Rohani 1 Introduction This course will use the R language programming environment for computer modeling. The purpose of this exercise is to introduce

More information

LAW OF LARGE NUMBERS FOR THE SIRS EPIDEMIC

LAW OF LARGE NUMBERS FOR THE SIRS EPIDEMIC LAW OF LARGE NUMBERS FOR THE SIRS EPIDEMIC R. G. DOLGOARSHINNYKH Abstract. We establish law of large numbers for SIRS stochastic epidemic processes: as the population size increases the paths of SIRS epidemic

More information

Delay SIR Model with Nonlinear Incident Rate and Varying Total Population

Delay SIR Model with Nonlinear Incident Rate and Varying Total Population Delay SIR Model with Nonlinear Incident Rate Varying Total Population Rujira Ouncharoen, Salinthip Daengkongkho, Thongchai Dumrongpokaphan, Yongwimon Lenbury Abstract Recently, models describing the behavior

More information

Introduction to Stochastic SIR Model

Introduction to Stochastic SIR Model Introduction to Stochastic R Model Chiu- Yu Yang (Alex), Yi Yang R model is used to model the infection of diseases. It is short for Susceptible- Infected- Recovered. It is important to address that R

More information

Chapter 5 Exercises. (a) Determine the best possible Lipschitz constant for this function over 2 u <. u (t) = log(u(t)), u(0) = 2.

Chapter 5 Exercises. (a) Determine the best possible Lipschitz constant for this function over 2 u <. u (t) = log(u(t)), u(0) = 2. Chapter 5 Exercises From: Finite Difference Methods for Ordinary and Partial Differential Equations by R. J. LeVeque, SIAM, 2007. http://www.amath.washington.edu/ rjl/fdmbook Exercise 5. (Uniqueness for

More information

Global Analysis of an Epidemic Model with Nonmonotone Incidence Rate

Global Analysis of an Epidemic Model with Nonmonotone Incidence Rate Global Analysis of an Epidemic Model with Nonmonotone Incidence Rate Dongmei Xiao Department of Mathematics, Shanghai Jiaotong University, Shanghai 00030, China E-mail: xiaodm@sjtu.edu.cn and Shigui Ruan

More information

Endemic persistence or disease extinction: the effect of separation into subcommunities

Endemic persistence or disease extinction: the effect of separation into subcommunities Mathematical Statistics Stockholm University Endemic persistence or disease extinction: the effect of separation into subcommunities Mathias Lindholm Tom Britton Research Report 2006:6 ISSN 1650-0377 Postal

More information

Epidemic model for influenza A (H1N1)

Epidemic model for influenza A (H1N1) Epidemic model for influenza A (H1N1) Modeling the outbreak of the pandemic in Kolkata, West Bengal, India, 2010 Sandipan Dey India July 8, 2017 2 Summary In this report, the spread of the pandemic influenza

More information

Stochastic modelling of epidemic spread

Stochastic modelling of epidemic spread Stochastic modelling of epidemic spread Julien Arino Department of Mathematics University of Manitoba Winnipeg Julien Arino@umanitoba.ca 19 May 2012 1 Introduction 2 Stochastic processes 3 The SIS model

More information

Research Article Optimal Control of an SIR Model with Delay in State and Control Variables

Research Article Optimal Control of an SIR Model with Delay in State and Control Variables ISRN Biomathematics Volume, Article ID 4549, 7 pages http://dx.doi.org/.55//4549 Research Article Optimal Control of an SIR Model with Delay in State and Control Variables Mohamed Elhia, Mostafa Rachik,

More information

SIR model. (Susceptible-Infected-Resistant/Removed) Outlook. Introduction into SIR model. Janusz Szwabiński

SIR model. (Susceptible-Infected-Resistant/Removed) Outlook. Introduction into SIR model. Janusz Szwabiński SIR model (Susceptible-Infected-Resistant/Removed) Janusz Szwabiński Outlook Introduction into SIR model Analytical approximation Numerical solution Numerical solution on a grid Simulation on networks

More information

2015 Holl ISU MSM Ames, Iowa. A Few Good ODEs: An Introduction to Modeling and Computation

2015 Holl ISU MSM Ames, Iowa. A Few Good ODEs: An Introduction to Modeling and Computation 2015 Holl Mini-Conference @ ISU MSM Ames, Iowa A Few Good ODEs: An Introduction to Modeling and Computation James A. Rossmanith Department of Mathematics Iowa State University June 20 th, 2015 J.A. Rossmanith

More information

Stability of a Numerical Discretisation Scheme for the SIS Epidemic Model with a Delay

Stability of a Numerical Discretisation Scheme for the SIS Epidemic Model with a Delay Stability of a Numerical Discretisation Scheme for the SIS Epidemic Model with a Delay Ekkachai Kunnawuttipreechachan Abstract This paper deals with stability properties of the discrete numerical scheme

More information

SI j RS E-Epidemic Model With Multiple Groups of Infection In Computer Network. 1 Introduction. Bimal Kumar Mishra 1, Aditya Kumar Singh 2

SI j RS E-Epidemic Model With Multiple Groups of Infection In Computer Network. 1 Introduction. Bimal Kumar Mishra 1, Aditya Kumar Singh 2 ISSN 1749-3889 (print), 1749-3897 (online) International Journal of Nonlinear Science Vol.13(2012) No.3,pp.357-362 SI j RS E-Epidemic Model With Multiple Groups of Infection In Computer Network Bimal Kumar

More information

Linear Variable coefficient equations (Sect. 2.1) Review: Linear constant coefficient equations

Linear Variable coefficient equations (Sect. 2.1) Review: Linear constant coefficient equations Linear Variable coefficient equations (Sect. 2.1) Review: Linear constant coefficient equations. The Initial Value Problem. Linear variable coefficients equations. The Bernoulli equation: A nonlinear equation.

More information

Coordinate Curves for Trajectories

Coordinate Curves for Trajectories 43 The material on linearizations and Jacobian matrices developed in the last chapter certainly expanded our ability to deal with nonlinear systems of differential equations Unfortunately, those tools

More information

The death of an epidemic

The death of an epidemic LECTURE 2 Equilibrium Stability Analysis & Next Generation Method The death of an epidemic In SIR equations, let s divide equation for dx/dt by dz/ dt:!! dx/dz = - (β X Y/N)/(γY)!!! = - R 0 X/N Integrate

More information

Final Project Descriptions Introduction to Mathematical Biology Professor: Paul J. Atzberger. Project I: Predator-Prey Equations

Final Project Descriptions Introduction to Mathematical Biology Professor: Paul J. Atzberger. Project I: Predator-Prey Equations Final Project Descriptions Introduction to Mathematical Biology Professor: Paul J. Atzberger Project I: Predator-Prey Equations The Lotka-Volterra Predator-Prey Model is given by: du dv = αu βuv = ρβuv

More information

MATHEMATICAL MODELS Vol. III - Mathematical Models in Epidemiology - M. G. Roberts, J. A. P. Heesterbeek

MATHEMATICAL MODELS Vol. III - Mathematical Models in Epidemiology - M. G. Roberts, J. A. P. Heesterbeek MATHEMATICAL MODELS I EPIDEMIOLOGY M. G. Roberts Institute of Information and Mathematical Sciences, Massey University, Auckland, ew Zealand J. A. P. Heesterbeek Faculty of Veterinary Medicine, Utrecht

More information

EG4321/EG7040. Nonlinear Control. Dr. Matt Turner

EG4321/EG7040. Nonlinear Control. Dr. Matt Turner EG4321/EG7040 Nonlinear Control Dr. Matt Turner EG4321/EG7040 [An introduction to] Nonlinear Control Dr. Matt Turner EG4321/EG7040 [An introduction to] Nonlinear [System Analysis] and Control Dr. Matt

More information

The Spreading of Epidemics in Complex Networks

The Spreading of Epidemics in Complex Networks The Spreading of Epidemics in Complex Networks Xiangyu Song PHY 563 Term Paper, Department of Physics, UIUC May 8, 2017 Abstract The spreading of epidemics in complex networks has been extensively studied

More information

Homogeneous Linear Systems and Their General Solutions

Homogeneous Linear Systems and Their General Solutions 37 Homogeneous Linear Systems and Their General Solutions We are now going to restrict our attention further to the standard first-order systems of differential equations that are linear, with particular

More information

Dynamic pair formation models

Dynamic pair formation models Application to sexual networks and STI 14 September 2011 Partnership duration Models for sexually transmitted infections Which frameworks? HIV/AIDS: SI framework chlamydia and gonorrhoea : SIS framework

More information

dy dt = a by y = a b

dy dt = a by y = a b 12.3 Euler s method and numerical solutions First-Order Linear Differential Equation with y(0) = y 0 given. dy dt = a by Steady state solutions: 0 = dy dt = a by y = a b 12.3 Euler s method and numerical

More information

Lecture 10. Under Attack!

Lecture 10. Under Attack! Lecture 10 Under Attack! Science of Complex Systems Tuesday Wednesday Thursday 11.15 am 12.15 pm 11.15 am 12.15 pm Feb. 26 Feb. 27 Feb. 28 Mar.4 Mar.5 Mar.6 Mar.11 Mar.12 Mar.13 Mar.18 Mar.19 Mar.20 Mar.25

More information

Nonlinear Control Systems

Nonlinear Control Systems Nonlinear Control Systems António Pedro Aguiar pedro@isr.ist.utl.pt 3. Fundamental properties IST-DEEC PhD Course http://users.isr.ist.utl.pt/%7epedro/ncs2012/ 2012 1 Example Consider the system ẋ = f

More information

SYMBIOTIC MODELS WITH AN SIR DISEASE

SYMBIOTIC MODELS WITH AN SIR DISEASE SYMBIOTIC MODELS WITH AN SIR DISEASE A Thesis Presented to the Faculty of California State Polytechnic University, Pomona In Partial Fulfillment Of the Requirements for the Degree Master of Science In

More information

The integrating factor method (Sect. 1.1)

The integrating factor method (Sect. 1.1) The integrating factor method (Sect. 1.1) Overview of differential equations. Linear Ordinary Differential Equations. The integrating factor method. Constant coefficients. The Initial Value Problem. Overview

More information

Exam 2. Principles of Ecology. March 25, Name

Exam 2. Principles of Ecology. March 25, Name Exam 2. Principles of Ecology. March 25, 2009. Name N t = N o λ t N t = N o e rt N t+1 = N t + r o N t (1-N t /K) N t = K/(1 + [(K N o )/N o ] * e rt ) dn/dt = rn(1-n/k) N captured and marked initially

More information

Models of Infectious Disease Formal Demography Stanford Summer Short Course James Holland Jones, Instructor. August 15, 2005

Models of Infectious Disease Formal Demography Stanford Summer Short Course James Holland Jones, Instructor. August 15, 2005 Models of Infectious Disease Formal Demography Stanford Summer Short Course James Holland Jones, Instructor August 15, 2005 1 Outline 1. Compartmental Thinking 2. Simple Epidemic (a) Epidemic Curve 1:

More information

Math 308 Week 8 Solutions

Math 308 Week 8 Solutions Math 38 Week 8 Solutions There is a solution manual to Chapter 4 online: www.pearsoncustom.com/tamu math/. This online solutions manual contains solutions to some of the suggested problems. Here are solutions

More information

Available online at J. Math. Comput. Sci. 2 (2012), No. 6, ISSN:

Available online at   J. Math. Comput. Sci. 2 (2012), No. 6, ISSN: Available online at http://scik.org J. Math. Comput. Sci. 2 (2012), No. 6, 1671-1684 ISSN: 1927-5307 A MATHEMATICAL MODEL FOR THE TRANSMISSION DYNAMICS OF HIV/AIDS IN A TWO-SEX POPULATION CONSIDERING COUNSELING

More information

A New Mathematical Approach for. Rabies Endemy

A New Mathematical Approach for. Rabies Endemy Applied Mathematical Sciences, Vol. 8, 2014, no. 2, 59-67 HIKARI Ltd, www.m-hikari.com http://dx.doi.org/10.12988/ams.2014.39525 A New Mathematical Approach for Rabies Endemy Elif Demirci Ankara University

More information

Solving systems of ODEs with Matlab

Solving systems of ODEs with Matlab Solving systems of ODEs with Matlab James K. Peterson Department of Biological Sciences and Department of Mathematical Sciences Clemson University October 20, 2013 Outline 1 Systems of ODEs 2 Setting Up

More information

STABILITY ANALYSIS OF A GENERAL SIR EPIDEMIC MODEL

STABILITY ANALYSIS OF A GENERAL SIR EPIDEMIC MODEL VFAST Transactions on Mathematics http://vfast.org/index.php/vtm@ 2013 ISSN: 2309-0022 Volume 1, Number 1, May-June, 2013 pp. 16 20 STABILITY ANALYSIS OF A GENERAL SIR EPIDEMIC MODEL Roman Ullah 1, Gul

More information

Differential Equations with Boundary Value Problems

Differential Equations with Boundary Value Problems Differential Equations with Boundary Value Problems John Polking Rice University Albert Boggess Texas A&M University David Arnold College of the Redwoods Pearson Education, Inc. Upper Saddle River, New

More information