Index. 2,2 -Azobis(2-amidinopropane dihydrochloride) (V50), 164, 165, 289, 300, 301, 329

Transcription

1 Index A AAPBA. See 3-Acrylamidophenylboronic acid (AAPBA) Acidic hydrolysis, 186 Acid-triggered burst release, 180, Acid-triggered decomposition, 183 Acid-triggered self-bursting, 172, 184, 188 Acrylamide (AAM), 112, 165, Acrylamidophenylboronic acid (AAPBA), 264, , , 292 Acryloyl chloride, 206, 217, 266, 267 Actuators, 7, 15, 25, 56, 124, 193, 230, 236, 258, 263, 281, 283, 287, 288, 300, 308, 309, 313, 319, 320, 324, 328, 338, 360, 372 Adsorbents, 3, 108, 304 Allyl-group-containing mono-(6-nallylamino-6-deoxy)- -cyclodextrin (ACD), 349 Ammonium peroxide, 267 Ammonium persulfate (APS), 4, 5, 8, 10, 35, 38, 41, 43, 50, 55, 60, 68, 93, 101, 195, 196, 206, 208, 218, 266, Anilino-1-naphthalenesulfonic acid ammonium salt (ANS), 344, , Anodic aluminum oxide (AAO), 111, 128, 129 APS. See Ammonium persulfate (APS) Association constants (K s ), 352, 353, 355, 356, 360 Atom transfer radical polymerization (ATRP), 52, 53, 55, 56, 111, 112, 128, 130, 131, 184, ATRP. See Atom transfer radical polymerization (ATRP) 2,2 -Azobis(2-amidinopropane dihydrochloride) (V50), 164, 165, 289, 300, 301, 329 B Ba 2C -recognition, 304, 336, 337 Ba 2C -triggered swelling behaviors BDK. See 2,2-Dimethoxy-2- phenylacetophenone (BDK) Benesi-Hildebrand equation, 352, 355 Benzo-15-crown-5-acrylamide (B 15 C 5 Am), 314, Blood glucose concentration, 264, 269, 290 BMA. See Butyl methacrylate (BMA) Boronate anion, 287 Boronic acid, 264 Bovine serum albumin (BSA), 127, 128, Bromoisobutyryl bromide (BIBB), 52, 184, 246 BSA. See Bovine serum albumin (BSA) Bursting-release characteristics, 136 Butyl methacrylate (BMA), 32, 34, 112, 113, , 241, C Ca-alginate capsule, 140, 141 Capillary microfluidic device, 44, 93, 101, 102, 157, 164, 165, 180, 289 Capillary microfluidic technique, 136 Carbodiimide method, 277, 284 Catalysis, 25, 59 Cationic hydrogels, Cationic ph-responsive microgels, 156, , 169 L.-Y. Chu et al., Smart Hydrogel Functional Materials, DOI / , Chemical Industry Press, Beijing and Springer Berlin Heidelberg

2 376 Index CD. See -Cyclodextrins (CD) CD/ANS complex, 347 CDDS. See Controlled drug delivery systems (CDDS) CD/NS complex, 347, 372 CF. See Controlled factor (CF) Chemical separations, 25, 59, 124, 193 Chitosan microcapsules, 158, 160, 169, Chitosan microspheres, , 169, 172, Chlorotrimethylsilane (CTMS), 77, 78, 158 CLSM. See Confocal laser scanning microscope (CLSM) Coefficient of variation (CV), 52, 141 Co-extrusion minifluidic approach, 140 Coil-to-globule transition, 236, 238, 241, 243, 250, 345, 352 Comb-type grafted hydrogels, 7, 8, 10, 204, 217, 225, Comb-type hydrogels, 217, 223, 229, 230, Compression resistance, 16 Confocal laser scanning microscope (CLSM), 36, 37, , 159, 160, , Contact angle, 78, 79, 118, 127, 362 Controlled drug delivery systems (CDDS), 160, 323 Controlled factor (CF), 125, Controlled release, 15, 16, 23, 112, 120, 125, 126, 132, , 140, 142, 145, , 155, , 268, , 313, , 338, 339, 374 Core-shell microcapsules, 92, 106, 169, 172, 180, , 329, 338 Core-shell microspheres, 27 30, 34, 52, 55 Critical alcohol response concentrations, 236, 252, 254, 255, 258 Critical deswelling temperature (CDT), 270 Cross-linked network structure, 123, 303 Cross-linked PNIPAM grafted membrane, 120, Crown-5, 308, 309, , 320, Crown-6, 300, , 319, 336 Crown ether, 299, 300, 302, 303, , 314, 318, 319, 324, 326, 327, 334, 336, 338, 360 Crown ether/metal ion complexes, 302, 318, 319 CTMS. See Chlorotrimethylsilane (CTMS) -Cyclodextrins (CD), 343, 344, , 354, 356, , 367, 368, 370, D DDS. See Drug delivery systems (DDS) Deprotonation, 161, 177 Diabetes, 60, 263, 275, 288, 292, 293 Differential scanning calorimetry (DSC), Diffusional permeability, 114, 115, , 130, 141, 276, 280, 293, Diffusion-controlled transport, 194 Diffusion thermo-responsive coefficient (R D ), 114, , 137, 142, 371 2,2-Dimethoxy-2-phenylacetophenone (BDK), 35, 38, 101, 164, 165, 290, 329 N,N -Dimethylacrylamide (DMAA), , 241, 242, (3-Dimethyl-aminopropyl)-3- ethylcarbodiimide hydrochloride N,N-Dimethylformamide, 267 D,L-tryptophan, Double emulsions, 156, 164, 165, 182, 183, 253, 289, 290, 329, 334 Drug delivery systems (DDS), 7, 25, 26, 60, 74, 124, 126, 135, 136, 151, 158, 160, 172, 193, 205, 263, 271, 273, 275, 308, 313, 319, 320, 323 D-tryptophan (D-Trp), 365 Dynamic phase transition, 11, 105, 108 E ECD. See Mono-6-deoxy-6-ethylene diamino- -cyclodextrin (ECD) EG. See Ethyl gallate (EG) Electrostatic repulsion, 166, 177, 180, 184, 213, 214, 220, 221, 277, 279, , 286, 303, 306, 318 Elongations and compressions, 16 Emulsification, 26, 34 42, 49, 52, 56, 136, 142, 143, 253, 283 Emulsifier, 101, 208, 283, 329 Emulsions, 26 31, 35, 36, 38, 43, 49, 50, 52, 53, 56, 69, 93, 101, 102, 136, 142, 143, 145, 146, 149, , , 169, 180, 182, 183, 207, 253, 283, 289, 290, 329, 331, 334, 335 Enantiomeric excess (e.e.), Enzyme immobilization, 25, 59 Equilibrium phase transition, 108 Equilibrium swelling ratio (ESR), 14, 219, 270, 271, 350, 351 Equilibrium thermo-responsive phase transition, 4 6, 100, 102 ESR. See Equilibrium swelling ratio (ESR)

3 Index 377 Ethanol-responsive characteristics, , 247 Ethanol-responsive smart gating membrane, Ethylene diamine, 283 Ethyl gallate (EG), 91, 92, F Flow characteristics, 59 77, 80, 82, 88 Flux thermo-responsive coefficient (R J ), 114, 116, 117 Fourier transform infrared spectra (FT-IR), 206, 217, 350, 367 Freely mobile ends, 8, 25, 172, 196, 198, 205, 206, 211, 213, , 220, 223, 264, 272, 359 Free radical polymerization, 4, 30, 31, 34, 36, 37, 52, 55, 56, 112, 131, 143, 169, 241, 266, 349 Freeze-drying, 32, 38 42, 194, 205, 283 FT-IR. See Fourier transform infrared spectra (FT-IR) Functional materials, 3, 319, 356 Functional membranes with thermo-responsive hydrogel gates, , , Functional pump, 172, 180 Functional valves, 125, 172, 178, 180 G Gating membrane, 117, , 132, , 236, , 258, , 324, 360, 370 Gel permeation chromatography (GPC), 195, 206, 217, 268 Glass-capillary microfluidic device, 289 Globule-to-coil transition, 236, 241, 243, 250, 345, 352 Gluconic acid, 277, 281, 283 Glucose, , , , 290, 292, 293 Glucose oxidase (GOD), , Glucose response, 264, 276, 286, 287, Glucose responsibility, 268, 269 Glucose-responsive gates, 276, 293 Glucose-responsive hydrogel, 290 Glucose-responsive materials, 263 Glucose-responsive microcapsules, 276, Glucose-responsive sensors, 273, 293 Glucose-responsive swelling/shrinking behaviors, 265, , 288, Glucose-sensitive controlled release, Glucose-sensitive microcapsule, Glucose sensitivity, 268, 293 Glucose sensor, 281, 283, 287, 288 GOD. See Glucose oxidase (GOD) GPC. See Gel permeation chromatography (GPC) Grafted dangling chains, 14 Grafted polymer chains, 128, 372 Grafted side chains, , 272 Grafting yield, , 122, 123, , , 151, 174, 246, , 293, 362, 363, 365, Graft polymerization, 12, 27, 28, , 139, 174, 277, 283, 325, 360, 367 Graft-type microgels, Graft-type poly(nipam-co-aac) microgel, Guest ion signal, 325 H Hagen-Poiseuille s law, 115, 118, 175 Heavy metal ions, , Heterogeneous internal microstructure, 4, 6, 7, 12, 15, 49 Hollow microcapsules, 35, 143, 164, 276, 283, 286, 293 Homogeneous internal microstructure, 7, 15, 23, 49 Honeycomb-like network, 7 Host-guest complex, 300, , 311, 314, 315, , 328, 329, 334, 336, 355 Hydrodynamic diameters, 28, 29, 32 34, 161, 162, 164 Hydrogen bonding, 30, 31, 33, 34, 97, 100, 103, 108, 210, 235, 237, 309, 343 Hydrophilic groups, 29, 70, 241 Hydrophobic groups, 220, 241 Hydrophobic interaction, 10, 34, 37, 72, 91, 98, 100, 103, 108, 198, 211, 220, 225, 237, 345, 347, 355 Hyperglycemic limit, 270 Hyperlipidemia, 60 Hypoglycemic limit, 269 Hysteresis circle, 20 I IEP. See Isoelectric point (IEP) Instantaneous deswelling percentage (DP i ), 272

4 378 Index Insulin, 263, 264, Intact-to-broken transformation behaviors, Interfacial polymerization, 38, 136, 139, 142, 283, 284, 325 Internal microstructures, 4 23, 44, 49, 50 Interpenetrating polymer networks (IPN), 30 34, 123, 124 Ion-imprinted hydrogel, 314, 315, 320 Ion receptor, 304 Ion-recognition behaviors, 302, 306, 327, 335 Ion-recognition receptor, 300, 319, 320, 324, 338 Ion-recognizable controlled-release behaviors, 325, 327 Ion-recognizable gates, 325, 338 Ion-recognizable gating membrane, 324 Ion-recognizable hydrogels, , Ion-recognizable microcapsules, Ion-responsibility, 304 Ion-signal sensor, 300 IPN. See Interpenetrating polymer networks (IPN) Isoelectric point (IEP), 156, 161, 162 Isothermal phase transition, 94 98, 100, 102, 108, 372 Isothermal shrinkage behavior, 311, 315 Isothermal volume change, 94, 318 Isothermal volume phase transition, 93 98, 255, 334 K K C -induced release, K C -induced shrinkage, 312 K C -recognition, 308, 309, 311, 317, , 338 K C -recognizable materials, 308 K C -recognizable systems, 308 K C -triggered isothermal shrinking behaviors, 315 K C -triggered isothermal volume shrinkage, 331 L Laminar flow, 61, 63, 69, 80 Lead ions, 300 Ligand, 300, 308, 309, 319, 320 Lipophilic drug, 148, 180, 181, 184, 188 Lower critical alcohol response concentration (C c1 ), 236, 252, 254, 255 Lower critical solution temperature (LCST), 3, 29, 61, 94, 112, 137, 197, 236, 264, 300, 345, 360 L-tryptophan (L-Trp), 365 M MBA. See N,N -Methylenebisacrylamide (MBA) MCG. See Microgel-crosslinked hydrogel (MCG) Mechanical properties, 4, 15, 22, 34 Mechanical strength, 4, 15 23, 34, 126, 145, 148, 186, 329 Membrane emulsification, 26, 34 42, 56, 136, 142, 143 Membranes, 26, 111, 135, 165, 172, 235, 264, 275, 308, 323, 359 Metal ions, , 318, 319, 324, 325, N,N -Methylenebisacrylamide (MBA), 4, 5, 8, 17, 30, 32 34, 38, 41, 43, 50, 60, 68, 93, 101, 120, , 174, 177, 179, 195, 206, 218, 223, 289, 300, 301, 316, 318, 329, 335 Microcapsules, 26, 92, 126, 135, 156, 172, 236, 264, 275, 323 Microchannel, 48, 49, 60, 68 89, 143, 150, 158 Microfluidic approaches, 50, 52, 93, 172, 180, 329 Microfluidic device, 42 44, 68 69, 93, 101, 102, 143, 145, 150, , 164, 165, 180, 289, 290, 329 Microfluidic emulsification, 52, 56, 143, 253 Microforge, 101, 289 Microgel-crosslinked hydrogel (MCG), 11 17, 19, 20, 22, 23 Microgels, 5, 25, 60, 92, 126, 135, 156, 171, 194, 236, 264, 275 Micropuller, 101, 289 Microspheres, 25, 59, 101, 135, 156, 172, 316 Microstructures, 4 23, 44, 49, 50, 56, 117, 122, 131, 174, 207 M n. See Number average molecular weight (M n ) Mono-6-deoxy-6-ethylene diamino- - cyclodextrin (ECD), 344, 360, 367, 372 Mono-6-deoxy-6-hexane diamino- - cyclodextrin (HCD), 344 Monodisperse microgels, 25 56, 92, 93,

5 Index 379 Monodispersity, 12, 26, 28, 30, 32, 35, 42, 52, 59, 142, 165, (N-Morpholino)ethanesulfonic acid (MES), 278, 284 N Nanoparticles, 77 79, 126, 139, , Naphthalenesulfonic acid (NS), 344, 347, 348, 356, Negative thermo-responsive model, 131 Normal-type hydrogel, 203, 204, 218, 220, 223, , 265, 269, 272 NS. See 2-Naphthalenesulfonic acid (NS) Number average molecular weight (M n ), 195, 268 Nylon-6 (N6), 112, 244, 360 O Oil-in-water (O/W) emulsions, 136, 158, 283 Oleic acid (OA), 139 On-off switches, 25 Operation temperature, 106, 107, 114, 236, , 255, 307, 320, 328, 331, , 367, 373 Optimal Pb 2C -responsive concentration, 307 Osmotic pressure, 186, 220, 302, 304, 307, 318, 319, 336, 338 O/W/O double emulsions, 164, 180, 182, 289, 290, 329, 334 P Particle size dispersal coefficient ( ), 143 PBA. See Phenylboronic acid (PBA) Pb 2C -adsorption, 305 Pb 2C -adsorption capacity, 305 Pb 2C -recognition, 304, 307 PC. See Polycarbonate (PC) PE. See Polyethylene (PE) Peracid groups, 11, 12 Phase transition, 3, 29, 60, 91, 124, 138, 172, 193, 236, 264, 287, 300, 325, 344, 360 Phenylboronic acid (PBA), , 275, 276, 287, 288, 290 Phenylboronic acid-glucose complex, 287 ph-responsive composite membranes, 172, 188 ph-responsive controlled-release, 171, 173, , ph-responsive core-shell microcapsules, , 329 ph-responsive gates, 178, 277, 280, 281 ph-responsive hydrogels, 155, 173, ph-responsive microgels, ph-responsive phase transition, 172 ph-responsive self-bursting controlled release, 188 Physiological blood glucose concentration, 269, 290, 293 Physiological ph, 219, 264 Physiological temperature, 147, , 276, 287, Plasma-graft pore-filling polymerization, 173, 174, 277, 283, 325 Plasma-induced pore-filling graft polymerization, 112, 117, 123, 131, 136, 139, 360, 367, 373 Poly(2-hydroxyethyl methacrylate) (PHEMA), Poly(acrylamide) (PAAM), 30 Poly(acrylamide-co-styrene) (poly(aam-co- St)), 30, 31 Poly(acrylic acid) (PAAC), 30, 34, 123, 124, 156, , 293 Poly(dimethylsiloxane) (PDMS), 48, 49 Poly(glycidyl methacrylate/mono-6-deoxy- 6-ethylene diamino- -cyclodextrin) (PG-ECD), , 367 Poly(N,N-dimethylaminoethyl methacrylate) (PDM), 156, , , , 188 Poly(N-isopropylacrylamide) (PNIPAM), 3 8, 10, 15 17, 19, 20, 22, 23, 26 30, 34 43, 47 56, 60 78, 80 89, , 112, , , , , 172, , 193, 194, 196, 198, 203, 216, , 264, 265, 268, 270, 271, 287, 288, 290, 300, 306, 307, 309, 310, 312, 313, , 324, 328, , 338, , , 360, 361, , 367, 370, Poly(N-isopropylacrylamide-co-acrylamide) (PNA), 113, 208, , Poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AAc)), 8 14, 16, 23, , , 229 Poly(N-isopropylacrylamide-co-benzo-15- crown-5-acrylamide), 308, 330 Poly(N-isopropylacrylamide-co-benzo-18- crown-6-acrylamide), 300, 324 Poly(N-isopropylacrylamide-co-butyl methacrylate) (PNB), 113, 237, 238, 241, , 306, 307, 310

6 380 Index Poly(N-isopropylacrylamide-co-N,Ndimethylacrylamide) (PND), 237, 238, , 246 Poly(N-isopropylacrylamide-co-N,N - dimethylamino ethyl methacrylate) (poly(nipam-co-dmaema)), 194, , 229 Poly(N-isopropylacylamide-co-glycidyl methacrylate) (PNG), , 360, 367, 368, 372 Poly(N-isopropylacylamide-co-glycidyl methacrylate/mono-6-deoxy-6-ethylene diamino- -cyclodextrin) (PNG-ECD), 344, 349, 356, 360, Poly(vinyl pyrrolidone) (PVP), , 169 Poly(vinylidene fluoride) (PVDF), 112, 113, , 125, 126, , 178, 179, 276, 277, 279, 280 Polycarbonate (PC), 112, 115, 117, 118 Polyethylene (PE), 49, 50, 112, 115, , 195, 218, 360 Polyethylene terephthalate (PET) track-etched membranes, 360 Polyglycerol polyricinoleate (PGPR 90), 43, 50, 68, 93, 101, 206, 207, 290 Polyphenols, Polyvinyl alcohol (PVA), 52, 53, 55 Porous membrane, 35, 117, 128, , 172, 179, 180, 276, Porous microcapsule, 126, 139, 283, 325 Positive LCST shift, 304 Positive thermo-responsive model, 118 Potassium ion, Precipitation polymerization, 316, 318 Protonation, 156, 158, 161, 162, 165, 166, 169, 181, 281 Pumping effects, 172, 173, 178, 180 Pumping element, 172 PVA. See Polyvinyl alcohol (PVA) R Redox initiator system, 4 Repeated elongations and compressions, 16 Response interval of ethanol concentration (C E2 -C E1 ), 248 Response rate, 7, 11, 15, 16, 20, 23, 47, 95, 177, 194, 199, 216, 225, 264, 272, 273, 314, 315 Response temperature of the membranes, Restoration, 22 Reversible addition-fragmentation chain transfer (RAFT) polymerization, 111 Reversible ion-responsive release characteristics, 327 Reversible volume-phase change, Reynolds number, 61, 69 71, 73, 75 77, 80 S Salting-out effect, 307, 318, 337 Sandwich host-guest complex, 300, 303, 308, 329 Scanning electron microscopy (SEM), 4, 5, 11, 13, 17, 20, 25, 27, 28, 31, 32, 36 39, 122, 174, 182, 183, 278, 279, 284, 285, 316, 350, 351, 362, 367 Schiff base bonding, 156, 158, 160 SDS. See Sodium dodecyl sulfate (SDS) Self-assembly, 77, 78 Self-bursting controlled release, 188 Self-regulated conformational change, 334 Self-regulated drug delivery systems, 264, 271, 273 Self-regulated insulin delivery systems, 263 SEM. See Scanning electron microscopy (SEM) Sensors, 15, 25, 56, 59, 107, 108, 124, 126, 135, 140, 151, 193, 230, 236, 258, 271, 273, 275, 281, 283, 287, 288, 293, 300, 308, 309, 313, 319, 320, 328, 339, 344, 356, 359, 360 Sharp temperature jump, 348, 349 Shear focusing flow-focus device, 159 Shirasu porous glass (SPG), 34 38, 112, , 132, 136, 142 Silica nanoparticles, 77, 78 Site-specific targeting, 68, 74, 84, 85, 87, 89, 148 Size-matching interaction, 315 Smart functional membranes with alcoholresponsive characteristics, Smart functional membranes with molecularrecognizable properties, Sodium dodecyl sulfate (SDS), 19, 69, 70, 72, 80, 81, 325 Sol-gel method, 77, 78 SPG. See Shirasu porous glass (SPG) SPG membrane emulsification, 34, 35, 136, 142 Squirting release function, 328 Stokes-Einstein equation, 29, 129 Structure-function relationship, 3 23 Sugar-responsive systems, 275 Supramolecular host-guest complexation, 304 Surface wettability, 60, 80 84, 86 88, 127, 158

7 Index 381 Surfactant-free emulsion polymerization, 26 29, 56 Swelling/deswelling equilibrium, Swelling/deswelling transition, 265 Swelling/shrinking behaviors, 56, 265, 288, , 306, 312, 315 Swelling/shrinking volume change, 287, 291 T TA. See Tannic acid (TA) Tannic acid (TA), , 108 Target drug delivery systems, 193 Temperature-dependence, 6, 14, 32, 33, , 270, 303, 305, 306, 344, 350, Tensile properties, 16 Terephthalaldehyde, , , 186 Terephthaloyl dichloride, 283 N,N,N,N -tetramethylethylenediamine (TEMED), 4, 43 Thermo-/pH-dual-responsive hydrogels, Thermo-responsive affinity membrane, Thermo-responsive coefficient of membrane pore size (Rd), 114, 116 Thermo-responsive controlled-release, 15, 16, 23, 120, 125, 132, 137, 138, 140, 150, 151 Thermo-responsive diffusional permeability, , 130, Thermo-responsive gating coefficient, 114, 116, 121, 364, 365, 371, 373 Thermo-responsive hydraulic permeability, Thermo-responsive hydrogel gates, Thermo-responsive hydrogels, 3 23, 26, 34 42, 56, , , , Thermo-responsive microcapsules, , 139, , 150 Thermo-responsive microgels, 25 56, 59 89, 141 Thermo-responsive phase transition, 4 15, 75, , Thermo-responsive polymer, 91, Thermo-responsive volume changes, 23, 49, 268, 311 Thermo-triggered squirting microcapsule, 145 Three-dimensional stereo restraint, 7 Triple stimuli-responsive gating functions, 370, 373 U UCST. See Upper critical solution temperature (UCST) Uniform-sized emulsions, 156, 180 Unit adsorption amount (Q m ), 368 Unit equilibrium adsorption amount (Q m ), 368 Upper critical alcohol response concentration (C c2 ), 236 Upper critical solution temperature (UCST), 30 33, 124 UV-initiated polymerization, 142, 165, 169, 253, 289, 335 UV irradiation, 35, 38, 48, 102, 165, 290 UV-visible spectrophotometer, 345, 348 V Venus flytraps, 308, 309 Vitamin B12 (VB12), 125, 126, 128, 130, 137, 138, , , 228, 229, 284, 286, 312, 313, , Volume phase transition, 6, 7, 13, 14, 29, 42 48, 50, 61, 62, 93 98, 124, 130, 141, 148, 172, 177, 193, 255, 264, , 302, 309, 330, 334, 335, 373 Volume phase transition temperature (VPTT), 3, 52, , 106, 107, 130, , , 253, 255, 287, 288, 290, 331, 334, 336, , W Water-in-oil (W/O) emulsions, 35, 36, 38, 52, 69, 93, 101, 102, 142, 143, 145, 146, Water-in-oil-in-water-in-oil (W/O/W/O) triple emulsion, 143 Water-soluble carbodiimide (WSC), 278, 284 Weight average molecular weight (M w ), 268 WSC. See Water-soluble carbodiimide (WSC) X XPS. See X-ray photoelectron spectroscopy (XPS) X-ray photoelectron spectroscopy (XPS), 175, 362