POTENTIAL BIOLOGICAL ACTIVITY OF CHALCONES : A REVIEW
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1 Int. J. Chem. Sci.: 11(), 201, ISS X PTETIAL BILGICAL ACTIVITY F ALCES : A EVIEW JAMPAIAH AMAAGATI and. J. P. SUBHASHII * Department of Chemistry, University College of Technology, smania University, HYDEABAD (A.P.) IDIA ABSTACT Chalcones are 1,-diphenyl-2-propene-1-one, consist of two aromatic rings linked by a three carbon α,β-unsaturated carbonyl system. The chemistry of chalcones has generated intensive scientific studies throughout the world. In these our aim to summarize chalcones biological activities likes anticancer, antimicrobial, analgesic and antiviral activities etc. Key words: Chalcones, Anticancer,, Antiviral, Anti-inflammatory. ITDUCTI Chalcones considered as the precursors of flavonoids and isoflavonoids, are products of condensation of aromatic aldehydes with acetophenones in the presence of alkali. Chalcones, which can be found in plants as secondary metabolites. Derivatives of those may possess variety of biological activities such as anti-inflammatory, antibacterial, antiviral, antituberculoid, antifungal, antimalarial, antitumor, and antioxidant activities. Table 1: Various pharmacological activities of 1,-diphenyl-2-propene-1-one derivatives o. 1 T. K. Marek S Antitumor 1 * for correspondence; jamgn11@gmail.com
2 16 J. Amanaganti and. J. P. Subhashini: Potential Biological Activity. o. 2 K.. Yerra 1 2 Antitumor 2 Echeverria H 1 et al 2 4 Antitumor 4 4 Anindra H Anticancer 4 5 Tribhuvan Singh Ar Anti-inflammatory 5 6 Y. ajendra Prasad H 2 Ar Anti-inflammatory and antimicrobial 6 7 Jae-Ho Jeon Me Anti-inflammatory 7 Me 8 A. Foroumadi Me Antileishmanial 8
3 H C H C 2 Int. J. Chem. Sci.: 11(), o. 9 M. M. H. Bhuiyan Ar Ar I. Habib 1 H 10 H 2 11 Thanh-Dao Tran M. A. Kadhim 12 1 T.. Doan H Antioxidant and antimicrobial 1 14 D. Anastasia 1 4 H 5 Antioxidant C. Govindaraju Antiviral 15 1 X 2 16 E. Seguin Me Me Me Me Cytotoxic and inhibition of tubulin polymerization 16
4 H C 18 J. Amanaganti and. J. P. Subhashini: Potential Biological Activity. o. 17 C. Jen-Hao S Cytotoxic, antiinflammatory, and anti-oxidant Zohreh Cl Antileishmanial M. A. Julio 1 2 Antiparasitic H. Tanvir Antifungal B. Amit Antimalarial 21 Cl 22 D. Lorena Cl H H Anti-nociceptive 22 2 L. Xiaoling Antiproliferative 2 H C
5 H C Int. J. Chem. Sci.: 11(), o. 24 J. ishida H H H Tyrosinase inhibitor 24 H H 25. aghav 1 Effect on bovine Serum albumin 25 CCLUSI In conclusion, we have described the biological applications of 1,-diaryl α,βunsaturated derivatives. From the review of the various results shown by active compounds, we can find out that 1,-diaryl α,β-unsaturated derivatives showed a promising results in most of the pharmacological. EFEECES 1. T. K. Marek, K. Wojciech, Micha, Andrzej, oland, E. A. Wakiec and Z. Zofia, Eur. J. Med. Chem., 42, (2007). 2. K.. Yerra, F. Shih-Hua and T. Yew-Min, Bioorg. Med. Chem., 17, (2009).. C. Echeverria, J. Francisco Santibañez,. Donoso-Tauda, Carlos A. Escobar and.. Tagle, Int. J. Mol. Sci., 10, (2009). 4. Anindra, C. Bandana, P. G. Munna, A. Jawed, K. ituraj and P. T. ama, Bioorg. Med. Chem., 18, (2010) 5. T. Singh,. Lavanya, Merugu, P. Sudhakar and Sana Yasmeen, Int. es. J. Pharm., (7), (2012). 6. Y. ajendra Prasad, A. Srinivasa ao and. ambabu, Asian J. Chem., 21(2), (2009). 7. Jae-Ho Jeon, Si-Jun Kim, Cheol Gi Kim, Jin-Kyung Kim, Jong-Gab Jun and Bull. Korean Chem. Soc., (), (2012).
6 140 J. Amanaganti and. J. P. Subhashini: Potential Biological Activity. 8. A. Foroumadi, Emami, M. Sorkhi, M. akhjiri, Z. azarian, Heydari, K. Ardestani, F. Poorrajab and A. Shafiee, Chem. Biol. Drug Des., 75, (2010). 9. M. M. H. Bhuiyan, M. I. Hossain, M. M. Mahmud and Mohammad Al-Amin, Chem. Journal, 1(1), (2011). 10. I. Habib, P. Kumar and A. Kulkarni, Der Pharm. Lett., 5(2), (201). 11. Thanh-Dao Tran, Thao-hu guyen, Tuong-Ha Do, Khac-Minh Thai and Cat-Dong Tran, Inter. Ele. Conf. Syn. rg. Chem.., 15, 1-5 (2011). 12. M. A. Kadhim, J. Uni. Anbar. Pure. Sci., 4(), 1-4 (2010). 1. T.. Doan and D. T. Tran, Pharmacology & Pharmacy, 2, (2011). 14. D. Anastasia, M. Maya, A. K. Christos, H. Dimitra, K. Panagiotis, Bioorg. Med. Chem., 17, (2009). 15. C. Govindaraju, D. aj, B. K. Sarojini, Hegde, Sreenivasa, Y. Siddappa, avikumar, Veerakyathappa, Bhanuprakash, Y. evanaiah,. agavendra, Med. Chem. es., 22, (201). 16. E. Seguina, A. Elomria, P. Magiatisb, Alexios-leandros Skaltsounisb, L.. Chaoc and F.. Tillequinc, at. Prod. Lett., 16(), (2002). 17. C. Jen-Hao, H. Chi-Feng, Y. Shyh-Chyun, W. Jih-Pyang, W. Shen-Jeu and L. Chun- an, Bioorg. Med. Chem., 16, (2008) Zohreh, E. Saeed, H. Samaneh, K.A. Sussan,. Maryam, P. Fatemeh, Abbas, F. Alireza, Eur. J. Med. Chem., 45, (2010). 19. M. A. Julio, P. Sylvia, C. Diaz, Josefina, D. V. Francisco and I. A. ivero, Bioorg. Med. Chem., 17, (2009). 20. H. Tanvir, L. Hamid, Z.. Muhammad, M. Y. Muhammad and P. Masood, Eur. J. Med. Chem. 44, (2009). 21. B. Amit, C. M. Lokesh, Manish, K. A. Satish and K. B. Virendra, Eur. J. Med. Chem., 44, 88-9 (2009). 22. D. Lorena, A. L. Luise, C. Valdir, C. ogerio, D. C. Fatima and J.. icardo, Bioorg. Med. Chem., 16, (2008). 2. L. Xiaoling, G. Mei-Lin, Bioorg. Med. Chem., 15, (2007).
7 Int. J. Chem. Sci.: 11(), J. ishida, H. Gao, J. Kawabata, Bioorg. Med. Chem., 15, (2007) aghav and P. Malik, Adv. Appl. Sci. es., 2(5) (2011). evised : Accepted :
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