DaNa 2.0 Communication platform for safety research on nanomaterials

Transcription

1 B. Mathes DaNa 2.0 Communication platform for safety research on nanomaterials Webinar, July Supported by Supported by

2 DECHEMA - Link between disciplines and organisations Non-profit scientific-technological society More than 5,800 members (including more than 650 companies) Honorary service of far more than 1,000 high-ranking experts from research institutions and industry About 100 working groups on scientific issues Together with DECHEMA Ausstellungs-GmbH we are the organizers of ACHEMA, the world forum for the process industry 1

3 2 History

4 Nanomaterial safety research in Germany Discussion in DECHEMA workgroups Announcement of BMBF* funding 2006 Project 2009 Project 2013 Project *BMBF = German Federal Ministry of Education and Research 3

5 Roots of DaNa 2.0 Project NanoCare ( ) - largest project on (human-)toxicology of nanomaterials - 11 on the market substances examined (19 variations) - Public dialogue: Website: Knowledge Base Nanoparticles (today: nanoobjects) - SOPs (standard operation procedures) introduced For nanomaterials Reproduceable Available at 4

6 German national funding (2008 ff) BMBF* funding actions (2008) - NanoCare (this time as the name of a funding action) Human toxicology of nanomaterials - NanoNature Nanomaterials for and in Nature (Ecotoxicology) 18 projects and 1 accompanying: DaNa Database Nanomaterials (i.e. DaNa1.0) *BMBF = German Federal Ministry of Education and Research 5

7 6 DaNa

8 Motivation for the knowledge base Nanotechnology in applications and consumer products Different nanomaterials used (individual and in combinations) When in textiles, food supplements, cosmetics: Safety concerns among consumers Source: Nature

9 Target groups Interested laymen Journalists Politicians NGOs Scientists but non-toxicologists Complete content is available in German and English Picture: 8

10 Aims of DaNa/DaNa 2.0 Central component of DaNa: Communication of research on safety of nanomaterials Website (German/English) Brochure, Flyer Other Media (lectures, ) No active research but assessment of literature and projects 9

11 Central issues of DaNa/DaNa 2.0 Impartial information on nanomaterials for objectification of public discussion Support of German funded projects e.g. project information, SOP template, cluster meetings, 10

12 11 Website

13 12 Correlation Materials Application

14 13 Correlation Materials Application

15 14 Material + application specific information

16 15 Material + application specific information

17 In-depth information on each nanomaterial Material / Applications Exposure / Uptake / Behaviour Human toxicology / Eco-toxicology 16

18 Increasing depth of details 1 summary 2 main results known in the field 3 Link to scientific literature 17

19 Nanotoxicology literature Increasing numbers of publications # of Nanotoxicology Papers published per year. Columns for 2010 and 2011 were added by H.F.Krug and C.Steinbach. (modified from original: C.L. Haynes: The emerging field of nanotoxicology. Anal. Bioanal. Chem 398, , 2010). 18

20 Usability of nanotoxicology papers An actual publication showed: for titaniumdioxide only ~32%, and for Zinkoxide even only 13% of the published data are suitable for risk assesment (Hristozov et al. 2012). Today about 2000 publications / year => in maximum ~600 useable! Need to be sorted out! 19

21 pdf form for download 20

22 Example project page

23 Development of a harmonized SOP template

24 Glossary german/ english

25 FAQ

26 Risk assessment for nanomaterials What is risk? Risk = f (Exposure; Hazard) Exposure Risk Hazard 25

27 Risk assessment for nanomaterials Important Hazard potentials and exposure have to be determined case-bycase Conclusions by analogy for substance characteristics not possible 26

28 Short risk assessment for nanomaterials TiO 2 (nano) in sunscreens Positive prospects: - effective sunblock - yearly tens of thousands skin cancer diagnoses less Real: - better sun protection - less use of chemical UV block substances Still open - epidemiology of incidence of skin cancer by TiO 2 - sunscreens Negative prospects: - permeation into the body - negative impact of nano particles in human body Real: - good protection via healthy skin Still open - research with injured skin Conclusion: - better sun protection - good protection via healthy skin - more information needed for injured skin 27

29 Direct link to Consumers Contact:

30 Contact! Dr. Björn Mathes DECHEMA e.v