Angela Carrillo Alocén

Transcription

1 Literature Presentation Angela Carrillo Alocén 9/15/10

2 Functional and Structural Analysis of a Key Region of the Cell Wall Inhibitor Moenomycin Fuse, S, Tsukamoto, H; Yuan, Y; Wang, T-S; Zhang, Y; Bolla, M; Walker, S; Sliz, P; Kahne, D, ACS Chem. Biol., 2010, 5 (7), Moenomycin (MmA) inhibits PG biosynthesis times more potent than Vancomycin against Gram-positive. It binds to the PG glycosyltransferases. Poor physicochemical properties. How MmA binds to its targets? Angela Carrillo Alocén, Sept 15 th

3 Functional and Structural Analysis of a Key Region of the Cell Wall Inhibitor Moenomycin Fuse, S, Tsukamoto, H; Yuan, Y; Wang, T-S; Zhang, Y; Bolla, M; Walker, S; Sliz, P; Kahne, D, ACS Chem. Biol., 2010, 5 (7), Angela Carrillo Alocén, Sept 15 th

4 Functional and Structural Analysis of a Key Region of the Cell Wall Inhibitor Moenomycin Fuse, S, Tsukamoto, H; Yuan, Y; Wang, T-S; Zhang, Y; Bolla, M; Walker, S; Sliz, P; Kahne, D, ACS Chem. Biol., 2010, 5 (7), The carboxylate of Moenomycin plays an important role in binding through a favorable electrostatic interaction with a Lysine in the active site. Any reduction of the size of the lipid chain increases the importance of maintaining appropriate polar active site contacts. Angela Carrillo Alocén, Sept 15 th

5 Traceless Ligation of Cysteine Peptides Using Selective Deselenization Metanis, N; Keinan, E; Dawson, P, Ang. Chem. Int. Ed. 2010, 49 (39), Native chemical ligation (NCL) of Sec-peptide 1 and thioester peptide 2 at an Ala site. TCEP Proposed Mechanism Angela Carrillo Alocén, Sept 15 th

6 Traceless Ligation of Cysteine Peptides Using Selective Deselenization Metanis, N; Keinan, E; Dawson, P, Ang. Chem. Int. Ed. 2010, 49 (39), Deselenization Deselenization of peptides in phosphate buffered D 2 O by TCEP Dehydroalanine formation Deselenization occurs with complete retention of stereoselectivity Angela Carrillo Alocén, Sept 15 th

7 Traceless Ligation of Cysteine Peptides Using Selective Deselenization Metanis, N; Keinan, E; Dawson, P, Ang. Chem. Int. Ed. 2010, 49 (39), Selective reduction of selenocysteine to alanine in the presence of unprotected cysteine by TCEP Is highly chemo- and enantioselective. Angela Carrillo Alocén, Sept 15 th

8 Synthesis of the Lantibiotic Lactocin S Using Peptide Cyclizations on Solid Phase Ross, A; Liu, H; Pattabiraman, V.R.; Vederas, J.C; J. Am. Chem. Soc., 2010, 132 (2), Lactocin S 37-residue lantibiotic discovered in Lactobacillus sakei. First solid-supported tdsynthesis of a natural llantibiotic. Angela Carrillo Alocén, Sept 15 th

9 Synthesis of the Lantibiotic Lactocin S Using Peptide Cyclizations on Solid Phase Ross, A; Liu, H; Pattabiraman, V.R.; Vederas, J.C; J. Am. Chem. Soc., 2010, 132 (2), Pentafluoropropanamide methyl esters of lanthionine. Activity assay. HPLC trace for Natural and Synthetic Lactocin S Angela Carrillo Alocén, Sept 15 th

10 Literature Presentation Dan Meyers 9/15/10

11 A novel catalytic decarbonylative Heck type reaction and conjugate addition of aldehydes to unsaturated carbonyl compounds. Luo Yang, Camille A. Correia, Xiangyu Guo, Chao Jun Li. McGill University Tetrahedron Letters 51 (2010)

12 A novel catalytic decarbonylative Heck type reaction and conjugate addition of aldehydes to unsaturated carbonyl compounds. Luo Yang, Camille A. Correia, Xiangyu Guo, Chao Jun Li. McGill University Tetrahedron Letters 51 (2010)

13 Palladium Catalyzed Carbonylative Heck Type Reactions of Alkyl Iodides Kayla S. Bloome and Erik J. Alexanian. UNC Chapel Hill J. Am. Chem. Soc. ASAP, 2010.

14 Cyano Diels Alder and Cyano Ene Reactions. Applications in a Formal [ ] Cycloaddition Strategy for the Synthesis of Pyridines. Takeo Sakai and Rick L. Danheiser. Massachusetts Institute of Technology J. Am. Chem. Soc. ASAP, 2010.

15 Cyano Diels Alder and Cyano Ene Reactions. Applications in a Formal [ ] Cycloaddition Strategy for the Synthesis of Pyridines. Takeo Sakai and Rick L. Danheiser. Massachusetts Institute of Technology J. Am. Chem. Soc. ASAP, 2010.

16 Literature Presentation Pablo García Reynaga 9/15/10

17 A Strategy for the Synthesis of Well Defined Iron Catalysts and Application to Regioselective Diene Hydrosilylation Jessica Y Wu Benjamin N Stanzl and Tobias Ritter Jessica Y. Wu, Benjamin N. Stanzl and Tobias Ritter, J. Am. Chem. Soc., Article ASAP

18 Silver Catalyzed Late Stage Fluorination Pingping Tang, Takeru Furuya and Tobias Ritter J. Am. Chem. Soc., 2010, 132 (34), pp

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20 Asymmetric Alkyl Alkyl Cross Couplings of Unactivated Secondary Alkyl Electrophiles: Stereoconvergent Suzuki Reactions of Racemic Acylated Halohydrins Nathan A. Owston and Gregory C. Fu, J. Am. Chem. Soc., 2010, 132 (34), pp

21 Asymmetric Alkyl Alkyl Cross Couplings of Unactivated Secondary Alkyl Electrophiles: Stereoconvergent Suzuki Reactions of Racemic Acylated Halohydrins Nathan A. Owston and Gregory C. Fu, J. Am. Chem. Soc., 2010, 132 (34), pp

22 Literature Presentation Seth Carmody 9/15/10

23 A Bacteriophage-Based Platform for Rapid Trace Detection of Proteases Dickerson, T.J. et al JACS 2010 ASAP Dept. of Chemistry and Worm Institute of Research and Medicine, The Scripps Research Institute 23

24 Polar Sequestration of Excess MurG May Regulate Enzyme Function Gitai, Z. et al J. Bacteriol. 2010, 192, Dept. of Molecular Biology, Princeton 24

25 Photo-click Spatiotemporal Imaging of Newly Sythesized Proteins Lin, Q. et al. ACS Chemical Biology 2010 ASAP Dept. of Chemistry and Dept. of Pharmaceutical Sciences, SUNY Buffalo 25

26 Photo-click Spatiotemporal Imaging of Newly Sythesized Proteins Lin, Q. et al. ACS Chemical Biology 2010 ASAP Dept. of Chemistry and Dept. of Pharmaceutical Sciences, SUNY Buffalo 26