Chemistry of Heterocyclic Compounds
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1 Chemistry of Heterocyclic Compounds
2 What s Heterocyclic Compound? A heterocyclic compound is one that contain rings made up, in addition to carbon, one or more heteroatoms like 0,N,S,P. etc.
3 Heterocyclic compounds can be classified into 1)aliphatic heterocycles:: Examples
4 Heterocyclic compounds can be classified into 2)Aromatic heterocycles: Examples
5 NOMENCULATURE OF HETEROCYCLES
6 NOMENCULATURE OF HETEROCYCLES a- Trivial names: b- Generic names, and Trade names: C- IUPAC (or systemic or chemical name):
7 B-Nomenclature of non Fused Heterocycles Prefix + Stem + Suffix
8 1- The Prefix It indicates the type of the heteroatom, their numbers and their positions. (Table I): When two or more heteroatom of same type are present, the prefix di, tri,...etc. is used. If the heteroatoms are different, their order of citation start with the heteroatomof as high a group in the periodic table and as low an atomic number in thatgroup. Thus the order of naming will be: O > S > Se >N > P > Si > B > Hg etc (see table I):
9 A Reference book of such IUPAC nomenclature.outlined here is: CRC Handbook of Chemistry and Physics by Robert. C.W and Melvin. J. A. 60th edition p. (C33-C44
10 2-The stem It determines the ring-size from 3 membered ring to 10 membered ring.
11 3- The Suffix It determines the state of saturation or unsaturation which depends upon (i) the presence or absence of N and (ii) the ring size.
12 saturation or unsaturation state
13 Table III (cont): a: The complete saturation is indicated by prefixing "perhydro " added before the total name of the unsaturated state. b: no suffix c: no stem N.B: If the ring size is more than 10, use the carbocyclic monocyclic name and the heteroatom is indicated by prefixes: Oxa, thic, aza
14 Example
15 Manner of numbering of the monocyeles
16 Rule 1 Monocyles containing one heteroatom, are numbered beginning at the heteroatom and the substituents takes the least possible number:
17 Rule 2 Cycles containing more than one different heteroatoms the numbering begins at the atoms of the higher order of priority (shown in table I) and proceeds round the ring in order to give other heteroatoms the least possible numbers without regards to the substituents;
18 Rule 2
19 Nomenclature of Partially Saturated Ring
20 Rule 1 If the number of double bonds is less than the maximum, prefix dihydro tetrahydro,. etc are added to the same name of unsaturated state. The saturated positions are given the least numbers after the hetero atom:
21 Rule 1
22 Rule 2 - Obligatory saturation of a single position is indicated by a symbol 1H, 2H, 3H... etc. according to the position of the saturated atom
23 Rule 2
24 Rule 3 In case of 4 & 5 membered rings with partial saturation (i.e) contain only one double bond. The suffix will be (ine) when N is present and (ene) when N is absent, and indicate the position of the double bond over A symbol.
25 Rule 3
26 The following are the IUPAC and trivial names of most monocycles
27 The following are the IUPAC and trivial names of most monocycles
28 The following are the IUPAC and trivial names of most monocycles
29 The following are the IUPAC and trivial names of most monocycles
30 B-Nomenclature of Fused Heterocycles
31 B-Nomenclature of Fused Heterocycles (B I) Carbocycle fused with heterocyclic system. (B II) Heterocycle fused with another heterocyclic system
32 I-Nomenclature of Carbocycle fused with Heterocycles IUPAC name: 1. The Parent name (written at the end) is the name of the heterocyclic ring. 2. The fused name (written at first) is the name of the fused benzene called (Benzo).
33 I-Nomenclature of Carbocycle fused with Heterocycles IUPAC name: 3. The Side of fusion of the parent ring with the fused benzene ring is indicated by alphabetical numbering and put such letter (a, b, c,... etc) between square brackets in between the prefix and parent name. In this case the parent ring is numbered as usual (p 5 ) and the sides 1,2, take letter (a), side 2,3 takes letter (b), side 3, 4 takes letter (c),... etc
34 I-Nomenclature of Carbocycle fused with Heterocycles IUPAC name:
35 I-Nomenclature of Carbocycle fused with Heterocycles IUPAC name: 4- The total numbering of the complete fused system in done to determine the positions of saturations or substitutions according to the following rules: a- The fused system is oriented so that: The greatest number of ring is in a horizontal row, and the remaining rings above the right of this horizontal row.
36 I-Nomenclature of Carbocycle fused with Heterocycles IUPAC name: b- The numbering starts from the atom next to the fusion giving the hetero atom the least possible numbering and continue numbering in clockwise direction (whenever possible) and the fused carbons are given the same previous number adding to it letters (a, b, c, etc). c- In case of poly cycles, the parent name is given to the largest heterocycles containing many rings (provided it has a famous trivial name).
37
38 The following are the agreed trivial and IUPAC names of the some of the famous carbocycles fused with hetero cycl :
39 The following are the agreed trivial and IUPAC names of the some of the famous carbocycles fused with hetero cycl :
40 The following are the agreed trivial and IUPAC names of the some of the famous carbocycles fused with hetero cycl :
41 (II) Nomenclature of Heterocycle fused with another Heterocycles The IUPAC rules for naming such systems are also composed of 4 points: The Parent name given to the more prior heterocycle(s), is used as suffix. The fussed ring (s) name is the less prior rings and is used as prefix. The side of fusion for both rings. The numbering of the total system.
42 1. The selection of the parent ring(s) (as suffix) should be according to the following order of preferences i- The Nitrogen containing ring must be taken as a parent ring:
43 ii- If no Nitrogen, the ring contain the more prior heteratom (according to table l), is considered as a parent ring:
44 iii) The largest ring size is taken as a parent ring if the two rings contain N or does not contain N.
45 iv) The largest number of rings with famous trivial name is always used as parent name:
46 v) The ring containing the greatest number of hetero atoms or greatest varieties of heteroatoms is the parent ring: N d 2 4 c N 3 b a N H N N d c 1 S a b N 3 2 pyrido(2,3-d)pyrimidine imidazo(4,5-d)thiazole
47 vi) A component ring having the more prior heteroatom(according table I) is the parent ring: 2 3 H N Se d c 1 S N 3 a b selenazolo(5,4-d)thiazole 2
48 vii) The parent ring is the ring containing a more number of carbon atoms adjacent to the fusion: N N d 3 5 c 3 N 6 b a 2 N 1 pyrazino(2,3-d)pyrimidine N N d 3 5 c 3 6 b a N 2 N 1 pyrazino(2,3-d)pyridazine
49 2- The naming of the prefix of fused (less prior) heterocycles is given as such: Furan = furo Thiophene = thieno Pyridine = pyrido Pyrrole = pyrrolo Imidazole = imidazo Quinoline = quino
50 3- Determination of the sides of fusion for both sides of the two fused heterocycles as such: a- The side of fusion with the parent ring is numbered alphabetically and the letter of fusion is placed between square brackets at its end. b- The side of fusion of the prefix ring is indicated by two numbers denoting the two positions of fusion with the parent ring, these twonumbers are also placed at first in the square brackets. The order of writing these two numbers conforms the direction of lettering of the parent ring.
51 3- Determination of the sides of fusion for both sides of the two fused heterocycles as such: 1 N a b 4 3 N 2 7 N a b 5 1 S 2 5 S 1 thiazolo(4,5-b)pyridine 4 N H 3 thiazolo(5,4-b)pyridine
52 4-The peripheral numbering of the total heterocyclic fused molecule is by the same discussed rule (page 5), and considering the following other rules A)Give the lowest number to the more prior heteroatom (according to table I) especially when present just after fusion. But, if the more prior hetero atom is not the nearest to the fusion side the other nearest heteroatoms after fusion must take the least possible numbering regardless of priority of table I.
53 7 Br 11 O 2 N N 5 7- nitro-[1,4]oxathiino[3,2-b]pyridine O S O a a b 1 N 7-bromo pyrano93,4-b)pyrrole 3 2
54 b)the hetero atoms in the fusion side are numbered according to the sequence of numbering, but when carbon atoms in the fusion take the previous number plus letter a, b, c,...etc. and also such carbon atom follow the least possible numbering:
55 e.g N b a 1 N 3 4a 5 N 4 NH amino pyrolo91,2-b)[1,2,4]triazine
56 c) The saturated atoms take the least possible numbering before other substitutents.
57 Radicals Derived from Heterocyclic Compounds
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