Fabrication and Biomedical Applications of Ⅱ-Ⅵ Core-shell Quantum Dots

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1 33 1 Vol. 33 No SHANGHAI NONFERROUS METALS March Ⅱ-Ⅵ Ⅱ-Ⅵ CdSe Ⅱ-Ⅵ Ⅱ-Ⅵ CdSe TN A Fabrication and Biomedical Applications of Ⅱ-Ⅵ Core-shell Quantum Dots GE Mei-ying WEI Diao-xing WU Jie SUN Yan National Laboratory for Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai China Abstract Ⅱ-Ⅵ quantum dots showed specific optical properties comparing to the convertional fluorescent dye due to strong quantum confined effect. They high quantum yield broad absorption with narrow symmetric photoluminescence PL spectra high resistance to photobleaching and exceptional resistance to photo-and chemical degradation. Here we report the synthesis and optical characterization of CdSe quantum dots as well as the surface modification and photochemical instability. At last we introduce the potential application in fluorescent biological lables. Key words Ⅱ-Ⅵ quantum dots CdSe core-shell quantum dots fluorescent biological labels Tel myge@ mail. sitp. ac. cn

2 1 Ⅱ-Ⅵ 21 Ⅱ-Ⅵ CdSe CdS ZnS TEM 2 CdSe CdSe TEM 1. 1 Ⅱ-Ⅵ Murray 23 Peng CdO Cd AC 2 Ⅱ-Ⅵ CdSe 1996 Hines 32 ZnS CdSe /ZnS 1 10% 50% 1 a ~ e 5 15 s 30 s 60 s 90 s 120 s 535 nm nm nm 1 30 nm nm 1. 2 / Peng 28 CdS CdSe /CdS CdS CdSe CdS ZnS CdSe CdSe 2004 Talapin 36 CdS ZnSe CdSe / ZnSe /ZnS CdSe /CdS /ZnS 70% 2005 Xie CdSe 38 CdSe /

3 22 33 CdS /Cd 0. 5 Zn 0. 5 S /ZnS 70% 3 CdSe CdSe / CdS 2 / ZnS CdSe 578 nm 587 nm 5% 30% 1998 Alivisatos Nie 4 42 Nie 3 CdSe CdSe / CdS 2 / ZnS 2 CdSe /ZnS CdSe /CdS CdSe / ZnSe 31 CdSe /ZnS CdS /ZnS CdSe / ZnSe /ZnS 36 CdSe /CdS /ZnS 36 CdSe /CdS / Zn 0. 5 Cd 0. 5 S / ZnS 37 Zn x Cd 1 - x Se /ZnS 38 / CdSe R6G 540 ~ nm 1. 3 domain PG-zb MBP-zb DNA Johns Hopkins University Wang 44 - FRET Cy5 DNA FRET 10 nm FRET QD-FRET DNA 2 Alivisatos 4 3T3 - CdSe /ZnS IgG IgG IgG Mattoussi 43 CdSe- ZnS Fc

4 1 Ⅱ-Ⅵ 23 Chem Soc Hodes G. Porous Nanocrystalline Liquid Junction Solar Cells 4. 8 fm Chem C pm 44 3 Nanocrystal Quantum Dot Solids J Polymer J. Nature 1994 Devices J 1 Alivisatos A P. Semiconductor Clusters Nanocrystals and Quantum Dots J. Science Michalt X Pinaud F F Bentolila L A et al. Quantum Dots for Live Cells in Vivo Imaging and Diagnostics J. Science Medintz I L Uyeda H T Goldman E R et al Quantum Dot Bioconjugates for Imaging Labelling and Sensing J. Nat Mater Bruchez Marcel Jr Moronne Mario Gin P et al. Semiconductor Nanocrystals as Fluorescent Biological Labels J. Science Klein D L Roth R Lim A K L et al. A Single-electron Transistor Made from a Cadmium Selenide Nanocrystal J. Nature Sheldon M T Trudeau P E Mokari T et al. Enhanced Semiconductor Nanocrystal Conductance via Solution Grown Contacts J. Nano Lett Weiss E A Chiechi R C Geyer S M et al. Size-dependent Charge Collection in Junctions Containing Single-size and Multi-size Arrays of Colloidal CdSe Quantum Dots J. J Am Comparison of Dye and Semiconductor-sensitized J. J Phys 10 Klimov V I Mikhailovsky A A Xu S et al. Optical Gain and Stimulated Emission in Nanocrystal Quantum Dots J. Science Malko A V Mikhailovsky A A Petruska M A et al. From Amplified Spontaneous Emission to Microring Lasing Using. Appl Phys Lett Klimov V I Ivanov S A Nanda J et al. Single-exciton Optical Gain in Semiconductor Nanocrystals J. Nature 13 Colvin V L Schlamp M C Alivisatos A P. Light-emitting Diodes Made from Cadmium Selenide Nanocrystals and a Semiconducting Coe S Woo W K Bawendi M et al. Electroluminescence from Single Monolayers of Nanocrystals in Molecular Organic. Nature Rogach A L Gaponik N Lupton J M et al. Light-emitting Diodes with Semiconductor Nanocrystals J. Angew Chem Int Edit Cushing B L Kolesnichenko V L O' Connor C J. Recent Advances in the Liquid-phase Syntheses of Inorganic Nanoparticles J. Chem Rev Gao M Kirstein S Mohwald H et al. Strongly Photoluminescent CdTe Nanocrystals by Proper Surface Modification J. J Phys Chem B Rossetti R Ellison J L Gibson J M et al. Size Effects in the Excited Electronic States of Small Colloidal CdS Crystallites J. J Chem Phys Li L Qian H F Ren J C. Rapid Synthesis of Highly Luminescent CdTe Nanocrystals in the Aqueous Phase by Microwave Irradiation with Controllable Temperature J. Chem Commun Lemon B I Crooks R M. Preparation and Characterization of Dendrimer-encapsulated CdS Semiconductor Quantum Dots J. J Am Chem Soc Peng X G Manna L Yang W D et al. Shape Control of CdSe Nanocrystals J. Nature Gur I Fromer N A Geier M L et al. Air-stable All-inorganic 22 Yin Y Alivisatos A P. Colloidal Nanocrystal Synthesis and the Nanocrystal Solar Cells Processed from Solution J. Science Organic-inorganic Interface J. Nature Murray C B Norris D J Bawendi M G. Synthesis and Characterization of Nearly Monodisperse CdE E = sulfur selenium tellurium Semiconductor Nanocrystallites J. J

5 24 33 Am Chem Soc Qu L Peng Z A Peng X. Alternative Routes toward High Quality CdSe Nanocrystals J. Nano Lett Peng Z A Peng X. Formation of High-quality CdTe CdSe and CdS Nanocrystals Using CdO as Precursor J. J Am Chem Soc Bryant G W Jaskolski W. Surface Effects on Capped and Uncapped Nanocrystals J. J Phys Chem B Dayal S Burda C. Surface Effects on Quantum Dot-based Energy Transfer J. J Am Chem Soc Peng X G Schlamp M C Kadavanich A V et al. Epitaxial Growth of Highly Luminescent CdSe / CdS Core / shell Nanocrystals with Photostability and Electronic Accessibility J. J Am Chem Soc Li J J Wang Y A Guo W et al. Large-scale Synthesis of Nearly Monodisperse CdSe / CdS Core / shell Nanocrystals Using Air-stable Reagents via Successive Ion Layer Adsorption and Reaction J. J Am Chem Soc Mekis I Talapin D V Kornowski A et al. One-pot Synthesis of Highly Luminescent CdSe / CdS Core-shell Nanocrystals via Organometallic and Greener Chemical Approaches J. J Phys Chem B Reiss P Bleuse J Pron A. Highly Luminescent CdSe /ZnSe Core /shell Nanocrystals of Low Size Dispersion J. Nano Lett Hines M A Guyot-Sionnest P Synthesis and Characterization of Strongly Luminescing ZnS-capped CdSe Nanocrystals J. J Phys Chem Dabbousi B O Rodriguez-Viejo J Mikulec F V et al. CdSe ZnS Core-shell Quantum Dots Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites J. J Phys Chem B Steckel J S Zimmer J P Coe-Sullivan S et al. Blue Luminescence from CdS ZnS Core-shell Nanocrystals J. Angew Chem Int Edit Protiere M Reiss P. Facile Synthesis of Monodisperse ZnS Capped CdS Nanocrystals Exhibiting Efficient Blue Emission J. Nanoscale Res Lett Talapin D V Mekis I Gotzinger S et al. CdSe /CdS /ZnS and CdSe /ZnSe /ZnS Core-shell-shell Nanocrystals J. J Phys Chem B Xie R Kolb U Li J et al. Synthesis and Characterization of Highly Luminescent CdSe-core CdS/Zn 0. 5 Cd 0. 5 S /ZnS Multishell Nanocrystals J. J Am Chem Soc Protiere M Reiss P. Highly Luminescent Cd 1 - x Zn x Se /ZnS Core Shell Nanocrystals Emitting in the Blue-green Spectral Range J. Small Gerion D Pinaud F Williams S C et al. Synthesis and Properties of Biocompatible Water-soluble Silica-coated CdSe / ZnS Semiconductor Quantum Dots J. J Phys Chem B Dubois F Mahler B Dubertret B et al. A Versatile Strategy for Quantum Dot Ligand Exchange J. J Am Chem Soc Pong B K Trout B L Lee J Y. Modified Ligand-exchange for Efficient Solubilization of CdSe /ZnS Quantum Dots in Water a Procedure Guided by Computational Studies J. Langmuir Chan W C W Nie S. Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection J. Science Goldman E R Clapp A R Anderson G P et al. Multiplexed Toxin Analysis Using Four Colors of Quantum Dot Fluororeagents J. Anal Chem Zhang C Y Yeh H C Kuroki M T et al. Single-quantum-dotbased DNA Nanosensor J. Nat Mater