Hsin-Hung Chou, Ph.D.

Transcription

1 Hsin-Hung Chou, Ph.D. Assistant Professor Department of Life Science Genome & Systems Biology Degree Program National Taiwan University A: 1, Section 4, Roosevelt Rd, Taipei, TW T: E: W: choulab.wordpress.com ORCID: Research Interests Evolution & Synthetic Biology, in particular: High-throughput screening of biomolecules with novel functions Epistasis its molecular basis and impact on evolution Functional promiscuity and diversification of proteins Education Ph.D. in Biology, Harvard University B.S. in Plant Pathology, National Taiwan University Appointments Since 2015/8 Assistant Professor, National Taiwan University 2013/3-2015/2 Marie Curie Fellow, University of Cambridge 2012/ /2 HFSP Fellow, University of Cambridge 2010/9-2012/11 EMBO Long-Term Fellow, ETH Zürich 2010/1-2010/6 Postdoctoral Researcher, Harvard University Honors and Awards Ministry of Science and Technology Award for Outstanding Junior Faculty Marie Curie International Incoming Fellowship HFSP Long-Term Fellowship EMBO Long-Term Fellowship 2009 Poster Award, Gordon Research Conference in Microbial Population Biology 2006 Summer Institute in Statistical Genetics Scholarship, University of Washington President's Awards (6 semesters), National Taiwan University Scholarships of Tai-Power Co. (3 academic years) 1998 Scholarship of Mr. Lin Hsiung-Chen 1998 Scholarship of No-Yu Seed and Stock Co Undergraduate Research Grant, National Science Council of Taiwan

2 Publications (*first author; #corresponding author) 1. Chou HH*#, Marx CJ, Sauer U (2015) Transhydrogenase promotes the robustness and evolvability of E. coli deficient in NADPH production. PLoS Genet. 11(2): e (SCI IF: 8.167; 14 th in Genetics & Heredity) 2. Chou HH*, Delaney NF, Draghi JA, Marx CJ (2014) Mapping the fitness landscape of gene expression uncovers the cause of antagonism and sign epistasis between adaptive mutations. PLoS Genet. 10(2): e (SCI IF: 8.167; 14 th in Genetics & Heredity) 3. Chou HH*, Marx CJ (2012) Optimization of gene expression through divergent mutational paths. Cell Reports 1: (SCI IF: 7.207; 32 th in Cell Biology) 4. Chou HH*, Chiu HC, Delaney NF, Segre D, Marx CJ (2011) Diminishing returns epistasis among beneficial mutations decelerates adaptation. Science 332: (SCI IF: ; 2 th in Multidisciplinary Sciences) 5. Chou HH*, Berthet J, Marx CJ (2009) Fast growth increases the selective advantage of a mutation arising recurrently during evolution under metal limitation. PLoS Genet. 5(9): e (SCI IF: 8.167; 14 th in Genetics & Heredity) 6. Lee MC, Chou HH, Marx CJ (2009) Asymmetric, bimodal trade-offs during adaptation of Methylobacterium to distinct growth substrates. Evolution 63: (SCI IF: 4.659; 9 th in Evolution) 7. Pan YW, Chou HH, You EN, Yu HT (2004) Isolation and characterization of 23 polymorphic microsatellite markers for diversity and stock analysis in tiger shrimp (Penaeus monodon). Mol. Ecol. Notes 4: (SCI IF: 2.384; 48 th in Ecology) 8. Chou HH*, Wu WS (2002) Phylogenetic analysis of internal transcribed spacer regions of the genus Alternaria, and the significance of filament-beaked conidia. Mycol. Res. 106: (SCI IF: 2.809; 5 th in Mycology) 9. Wu WS, Chou HH, Lin SM, Wu HC (2001) The effect of seed-borne pathogens on emergence of globe amaranth, calendula and tagetes and the methods of control. J. Phytopathol. 149: (SCI IF: 0.921; 126 th in Plant Sciences) 10. Chou HH*, Wu WS (2000) The occurrence and control of leaf spot on globe amaranth. Plant Pathol. Bulletin 9: Reviewer for: Journals Nature Communications, Evolution, FEBS Letters, Communications Biology mbio, Applied Microbiology and Biotechnology Research Grant Wellcome Trust Swiss National Science Foundation Netherlands Organization for Scientific Research Ministry of Science and Technology, Taiwan

3 Research Grant High-throughput approach to explore the sequence space and ligand selectivity of the metal binding domain in the MerR protein family. Ministry of Science and Technology, Taiwan: MOST B MY High-throughput approaches to explore the sequence space of ribosome binding sites and the impact of antibiotic resistance mutations on translation initiation. Ministry of Science and Technology, Taiwan: MOST B MY2. Teaching LS7034 Seminar in Adaptive Evolution LS5085 Synthetic Biology - Engineering, Evolution, and Design LS3020 Microbiology LS3031 Project-Orientated Microbiology Laboratory Practical LS1007 General Biology Administrative Service 2017 Admissions Committee, Department of Life Science, NTU Research Safety Committee, College of Life Science, NTU Curriculum Committee, Genome and Systems Biology Program, NTU 2016 Research and Development Committee, Department of Life Science, NTU 2015 Student Affair Committee, Department of Life Science, NTU Outreach Activities 2016/08 What do biologists do? Chunghwa Postal Museum, Taipei, Taiwan 2016/03 Career library of life science. Taipei Chenggong High School, Taipei, Taiwan 2015/12 Workshop and consultation on education abroad. National Taiwan University, Taipei, Taiwan Career Development 2014/2 EMBO laboratory management course European Molecular Biology Organization, Heidelberg, Germany 2013/8 Protein Crystallography Summer School University of St. Andrews. St. Andrews, UK 2008/7 Workshop on Molecular Evolution Marine Biological Laboratory. Woods Hole, USA 2006/6 Summer Institute in Statistical Genetics

4 University of Washington, Seattle, USA Invited Seminars 2017/09 High-throughput mapping of the sequence space of bacterial ribosome binding sites. College of Life Sciences, Jiangsu Normal University, Xuzhou, China 2017/06 High-throughput mapping of the sequence space of biomolecules. Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, USA 2017/05 High-throughput mapping of the sequence space of biomolecules. AGRO x BIOMED x CHIP Symposium, Taipei, Taiwan 2016/11 Robustness and evolvability of metabolic network. International Symposium on Evolutionary Genomics and Bioinformatics, Kaohsiung, Taiwan 2016/08 Transhydrogenase promotes the robustness and evolvability of metabolic network. The 21 st Conference on Bacteriology, Taipei, Taiwan 2016/02 Experimental evolution of bacteria deficient in NADPH production. 2 nd NIG-NTU Joint Symposium, Jinshan, Taiwan 2016/02 Evolution of metabolic networks. Department of Life Science, National Taiwan Normal University, Taipei, Taiwan 2015/11 Evolutionary biology from a molecular perspective. Department of Entomology, National Taiwan University, Taipei, Taiwan 2014/12 Molecular mechanisms of adaptive evolution. Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan 2014/10 Exploring the genetic and physiological basis of adaptation. National Tsing Hua University, Hsinchu, Taiwan 2011/6 The fitness landscape of gene expression. University of Cambridge, Cambridge, UK 2010/7 Genetic and physiological basis of adaptation in microbial evolution experiments. College of Life Science, National Taiwan University. Taipei, Taiwan 2010/3 Optimization of gene expression Lessons from microbial evolution experiments. Microbial Sciences Initiative, Harvard University, Cambridge, USA 2009/4 Adaptation to metal limitation. Biodiversity Research Center, Academia Sinica, Taipei, Taiwan 2008/3 Parallel transpositions of an IS element lead to enhanced cobalt-uptake capability of Methylobacterium extorquens AM1 in a metal-limited environment. Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan Conference Presentations Talks 2011/8 Stabilizing selection reverses fitness effects of adaptive mutations. ESEB Annual Meeting. University of Tübingen.

5 2008/6 Dissecting the genetic basis and molecular mechanism of parallel evolution of microbial populations evolved under metal limitation. Evolution Conference. University of Minnesota. 2008/6 Genetic and physiological basis of adaptation to metal limitation. Boston Bacterial Meeting. Harvard University. 1999/12 Etiology and control of leaf spot disease of globe amaranth. Chinese Plant Pathology Conference. Taiwan Agricultural Chemicals and Toxic Substances Research Institute. Posters 2017/6 High-throughput exploration of the sequence space of ribosome binding sites. Gordon Research Conference on Molecular Mechanisms in Evolution. Easton, USA. 2016/7 Balancing redox disturbance through experimental evolution. Synthetic Biology Conference (SEED). Chicago, USA. 2009/7 Optimizing gene expression via convergent evolution. 2008/6 Parallel transpositions of an IS element lead to enhanced cobalt-uptake capability in a metal-limited environment. ASM 108 th General Meeting. Boston, USA. 2007/7 Evolutionary perspective: currency exchange mechanism in the cellular economy. 2006/10 Adaptation of a bacterium-plasmid system. Harvard Initiative of Life Science Symposium. Harvard University. 2006/6 Using experimental evolution to address the adaptation of horizontal gene transfer recipients. Boston Bacterial Meeting. Tufts University. 2005/7 Adaptation of experimental populations bearing a foreign central metabolic module. Academic Referees Postdoc supervisors Dr. Uwe Sauer sauer@imsb.biol.ethz.ch Institute of Molecular Systems Biology ETH Zürich PhD advisor Dr. Christopher J. Marx cmarx@uidaho.edu Department of Biological Sciences University of Idaho PhD committee Dr. Scott V. Edwards sedwards@fas.harvard.edu Department of Organismic and Evolutionary Biology Harvard University