Biography: Peter Schoenmakers obtained a Masters Degree in chemical engineering from the Technical University of Delft, The Netherlands in 1977. After a research project on reversed-phase liquid chromatography that included a year at Northeastern University (Boston, MA, USA) with Professor Barry Karger, he obtained his Ph.D. from Professor Leo de Galan in Delft (1981). After fulfilling his military service, he had a career in industrial R&D, first at Philips (Eindhoven, NL; 1983-1992) and subsequently at Shell (Amsterdam, NL and Houston, TX, USA; 1992-2002). In 1998 he became a part-time professor in Polymer Analysis at the University of Amsterdam. Since 2002 he is a fulltime professor. Since 2009 he holds the chair of Analytical Chemistry, including its applications in Forensic Science. He teaches analytical chemistry to students in the BSc chemistry and MSc analytical sciences programs, as well as to students in forensic science and art conservation. His research interests include analytical separations (chromatography and mass spectrometry) and their applications to large molecules. A specific focus in recent years has been on the theory and application of comprehensive two-dimensional liquid chromatography. Peter Schoenmakers is active in the organization of several successful symposium series. He is a member of the permanent scientific committee of the HPLC series of conferences and chairman of the symposia on the Separation and Characterization of Natural and Synthetic Macromolecules (SCM) and Hyphenated Techniques in Chromatography (HTC). He has been editor of the Journal of Chromatography A since 2003. Abstract: LIQUID CHROMATOGRAPHY: 2D or not 2D? Peter Schoenmakers Analytical Chemistry / Forensic Science Group, Van 't Hoff Institute for Molecular Science (HIMS), Faculty of Science, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV, Amsterdam, The Netherlands There are two reasons to perform comprehensive two-dimensional liquid chromatography. The first is to increase the number of components that may possibly be separated. The peak capacity of LC systems has been increased significantly by the advances in instrumentation and column technology. Many hundreds of peaks can be accommodated in a single LC run. Patient researchers may even reach a peak capacity of 1000 (in about a day). While impressive, these results are still well short of the most ambitious targets. For example, the human proteome is assumed to contain some 50,000 proteins. Comprehensive two-dimensional liquid chromatography (LC_LC) constitutes a significant step in the right direction. Using this technique a peak capacity of several thousand can be achieved within a reasonable time (one or two hours). The second reason why LC_LC may be advantageous is the possibility to generate structure chromatograms, which can be readily and rigorously interpreted. This is true for samples of polymers, which have a limited sample dimension, implying that only a few characteristics (e.g. molecular weight, end groups) differ between the different molecules
in the sample. It may also be true in other situations, such as the oxidative stability of pharmaceutical preparations. In this lecture the potential and practical performance of one-dimensional LC and LC_LC will be compared. Different ways of performing LC_LC will be discussed and we will take a peek into the future. Is LC_LC_LC a realistic option? Professional titles CURRICULUM VITAE Peter J. Schoenmakers Professor and group leader Editor Analytical Chemistry including its applications in forensic science University of Amsterdam, Faculty of Science, van t Hoff Institute for Molecular Sciences (HIMS) Adress: Nieuwe Achtergracht, 1018 WV Amsterdam, The Netherlands 020-5256642 or 6515 Fax 020-5256638 E-mail P.J.Schoenmakers@uva.nl Journal of Chromatography A (including electrophoresis, mass spectrometry and other separation and detection methods), Published by Elsevier Science Biographic highlights Born June 17 th, 1954 in Schiedam, The Netherlands. Resident of Oudkarspel, The Netherlands. Married (1984) to Dana W.Conron of New Canaan, CT, USA. One daughter (Bonnie, 1990). Higher education 1971-1977 Technical University of Delft (The Netherlands), Department of Chemical Engineering. Masters thesis: Possibilities for describing chromatographic selectivity using solubility parameters.
1977-1982 Technical University of Delft (The Netherlands), graduate studies in analytical chemistry (Prof.L.de Galan). Ph.D. thesis: A systematic approach to mobile-phase effects in reversed-phase liquid chromatography. 1978 Northeastern University, Boston, MA, USA, Institute of Chemical Analysis, Applications and Forensic Science (presently Barnett Institute). Nine months of research in chromatography with Prof.B.L.Karger. Industrial occupation 1983-1992 Philips Research Laboratories, Eindhoven, The Netherlands. 1983-1989 Research Chemist 1989-1992 Head of Organic-Analytical-Chemistry Group 1992-2002 Koninklijke/Shell Laboratorium, Amsterdam, The Netherlands (since 1996: Shell Research and Technology Centre, Amsterdam) 1992-1994 Senior Research Chemist 1994-1996 Group Leader, Chromatography Group (size ca. 16), Analytical Department 1996-1997 Shell Westhollow Technology Center, Houston, TX, USA Exchange Scientist (12 months) 1997-2000 Principal Research Chemist, Analytical-Separations Department 2000-2002 Principal Scientist and member of the Leadership Team Analytical-Chemistry Department. Academic occupation 1998- Professor and group leader Polymer-analysis group, University of Amsterdam 1998-2002 Part-time (50%) 2002- Full-time Main courses taught General Chemistry (1 st year B.Sc.) Analytical Chemistry (2 nd year B.Sc.) Nanomaterials (3 rd year B.Sc.) (Analytical) Separation Science (1 st year M.Sc.) Industrial Analysis (1 st /2 nd year M.Sc.) Café (Chemical Analysis and Forensic Evidence, 2 nd year M.Sc.) Polymer separations (External) Method development in chromatography (External) Two-dimensional liquid-phase separations (External)
Main research area: Polymer separations Size-Exclusion Chromatography (Interactive) Liquid Chromatography Comprehensive Two-Dimensional Liquid Chromatography Molecular-topology fractionation Matrix-Assisted Laser-Desorption/Ionization Mass Spectrometry Pyrolysis gas chromatography mass spectrometry Applications in polymer science and technology Analytical separation science Preparation and application of monolithic columns Nanotechnology (chip-based separations) Optimization of one-dimensional and two-dimensional separations Spatial separations Data handling and chemometrics Research area in development Forensic analytical chemistry Editorship 2003- Editor of The Journal of Chromatography A (including electrophoresis, mass spectrometry and other separation and detection methods), Published by Elsevier Science Publications (Co-)author of more than 150 papers on chromatography and other areas within analytical chemistry (list of publications available). (Co-)author of several patents on instrumentation and software for chromatography and FTIR spectroscopy. Author of a book on Optimization of Chromatographic Selectivity (Elsevier, 1986); Contributing author and (co-) editor of several other books. Editorial and advisory boards Analytical Chemistry (A page panel 1996 2000; Editorial Board 2001 2003) Chromatographia Journal of Separation Science Chromatography Monograph series of the Royal Chemical Society LC-GC Magazine and LC-GC International Polymer Chemistry Chromedia (Web-based community publishing)
Symposium organization (highlights) Chairman of the organizing committee of the series of International Symposia on the Separation and Characterization of Natural and Synthetic Macromolecules, (SCM series; Amsterdam, 2003; 2005; 2007; 2009) Chairman of the organizing committee of Hyphenated Techniques in Chromatography (HTC-11, Bruges, Belgium, 2010). Member of the Permanent Scientific Committee of the symposium series on High- Performance Liquid-Phase Separations and Related techniques (HPLC Series) Chairman of the organizing committee of the International Symposium on High- Performance Liquid-Phase Separations ( HPLC 2013, June 13 th - 18 th 2013, Amsterdam, NL). Member of the organizing committee of the 25 th International Symposium on High- Performance Liquid-Phase Separations ( HPLC 2001, Maastricht, NL).