P h a r m a c e u t i c a l I n t e r m e d i a t e s & C h e m i c a l s
Modepro is a privately held ISO9001:2008 certified company specializing in Pharmaceutical intermediates & fine chemicals. Our company is today widely acknowledged for its abilities in product development & process technology. Modepro is the preferred source for many multinational companies for their product development & outsourcing requirements. Our infrastructure is very versatile & is specially designed to address the requirements of carrying out complex & hazardous chemical processes safely & efficiently. Our personnel are highly skilled at handling different kinds of products & operating specialized & hazardous processes. The plant has been successfully audited by several multinational companies for compliance to the guidelines of the quality system recommended by the ICHQ7 standard. Manufacturing facility The production unit located near Mumbai is a multipurpose facility equipped with highly versatile infrastructure which gives us the ability to carry out various types of chemical processes under different operating conditions. Quality Assurance & Quality control The Q/A team ensure the implementation of the quality management system & actively monitors its effectiveness. The quality management system is based on the ISO9001:2008 standard & includes all relevant elements specified by the ICHQ7 standard. The Quality Control department is extensively equipped with modern analytical instrumentation and is staffed with trained analysts with supporting facilities. It generates the required analytical data for all quality related issues like routine analysis, investigations, validations, method development, compliance with guidelines like ICH, etc. R&D The Modepro R&D Center provides process research of APIs and intermediates involving multi-step synthesis. We have a successful track record in developing noninfringing processes and scaling up from kilo to multi-tons on schedule. Our team of researchers has developed several innovative and cost effective processes for producing intermediates of several well known API s. Environment We at Modepro recognise our responsibilities to the environment & are committed to implementing practises that will promote environmental compatibility. Special care is taken to develop processes that minimize effluents & are thereby environmentally friendly..
Brinzolamide Intermediates 3-Bromoacetyl-5-chlorothiophene-2-sulphonamide [CAS No. 160982-11-6] 6-Chloro-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-4-one-1,1-dioxide [CAS No. 174139-69-6] 6-Chloro-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-4-ol-1,1-dioxide[CAS No. 171274-01-4] 3-(Bromoacetyl)thiophene-2-sulfonamide[CAS No. 154127-28-3] 3,4-Dihydro-2H-thieno[3,2-e][1,2]thiazin-4-one-1,1-dioxide 3,4-Dihydro-2H-thieno[3,2-e][1,2]thiazin-4-ol-1,1-dioxide [ CAS No. 138890-97-8] Dorzolamide Intermediates 5,6-Dihydro-6-methylthieno[2,3-b] thiopyran-4-one [CAS No. 120279-85-8] 5,6-Dihydro-6-methyl-4-oxothieno[2,3-b]thiopyran-2-sulphonamide [CAS No. 120279-88-1] 5,6-Dihydro-4-hydroxy-6-methyl-4H-thieno [2,3-b]thiopyran-2-sulphonamide-7,7-dioxide [CAS No. 154802-22-9] 5,6-Dihydro-6-methyl-4-oxothieno[2,3-b]thiopyran-2-sulphonamide-7,7-dioxide 5,6-Dihydro-6-methyl-4-acetylamido-4H- thieno[2,3-b]thiopyran-2-sulphonamide-7,7-dioxide [CAS No. 120298-38-6] 5,6-Dihydro-(6S)-6-methylthieno[2,3-b]thiopyran-4-one (4S,6S)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-ol-7,7-dioxide 5,6-Dihydro-(6S)-6-methyl-4-oxothieno[2,3-b]thiopyran-2-sulfonamide Glimepiride Intermediates trans-4-methylcyclohexyl amine [CAS No. 2523-55-9] trans-4-methylcyclohexyl isocyanate [CAS No. 32175-00-1] 3-Ethyl-4-methyl-2-oxo-N-[2-(4-sulfamoylphen-yl)ethyl]-2,5-dihydro-1H-pyrrole-1- carboxamide [CAS No. 119018-29-0]
Ezetimibe Intermediates 1-(4-Fluorophenyl)-5-(2-oxo-(4S)-4-phenyloxazolidin-3-yl)pentane-1,5-dione [CAS No. 189028-93-1] 3-[5-(4-Fluorophenyl)-(5S)-5-hydroxy-pentanoyl]-(4S)-4-phenyloxazolidin-2-one [CAS No. 189028-95-3] Methyl (3R,4S)-1-(4-flurophenyl)-2-oxo-4-[4-(benzyloxy)phenyl]-3-azetidin-3-yl-propionate [CAS No. 204589-80-0] (4S)-4-benzyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-pentanoyl]-1,3-oxazolidin-2-one [CAS No. 852148-49-3] (3R,4S) 1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(benzyloxy) phenyl]azetidin-2-one [CAS No. 163222-32-0] (3-[{2-{(S)-(4-Benzyloxyphenyl)(4-fluoro-phenylamino)methyl}-5-(4-fluorophenyl)- (5S)-5-trimethylsilanoyloxypentanoyl]-(4S)-4-phenyl-1,3-oxazolidin-2-one Intermediate for Tiagabine 4-Bromo-1,1-bis(3-methyl-2-thienyl)-1-butene [CAS No. 109857-81-0] Intermediate for Famciclovir 2-[(Acetyloxy)methyl]-4-(2-amino-6-chloro-9H-purin-9-yl)butylacetate [CAS No. 97845-60-8] Intermediate for Tioconazole 2-Chloro-3-methylthiophene [CAS No. 14345-97-2] Intermediate for Lornoxicam Ethyl 6-chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1, 1-dioxide Intermediate for Alfuzosin 2-Chloro-6,7-dimethoxyquinazolin-4-amine [CAS No. 23680-84-4] Piperidine derivatives 4-Methylpiperidine [CAS No. 626-58-4]
4- Benzylpiperidine [CAS No. 31252-42-3] 2-(1-Piperidinyl)ethanol [CAS No. 3040-44-6] 4-[2-(1-Piperidinyl)ethoxy]benzoic acid.hcl [CAS No. 84449-80-9] N-(2-Chloroethyl)piperidine.HCl (PIPEC) [CAS No. 2008-75-5] cis 2,6-dimethylpiperidine [CAS No. 766-17-6] Pyridine derivatives 2-Benzoylpyridine[CAS No. 91-02-1] 2-Benzylpyridine [CAS No. 101-82-6] 4-Benzoylpyridine [CAS No. 14548-46-0] 4-Benzylpyridine [CAS No. 2116-65-6] 1-Methyl-1-phenyl-1-(2-pyridyl)methanol.HCl [CAS No. 19478-81-0] N,N-Dimethyl-2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethanamine [CAS No. 469-21-6] Thiophene derivatives 2-Cyanothiophene [CAS No. 1003-31-2] 3-Cyanothiophene [CAS No. 1641-09-4] 2-Chlorothiophene [CAS No. 96-43-5] 3-Chlorothiophene [CAS No. 17249-80-8] 2-Bromothiophene [CAS No. 1003-09-4]
Thiophene derivatives 3-Bromothiophene [CAS No. 872-31-1] 2,5-Dibromothiophene [CAS No. 3141-27-3] Ethyl-5-chlorothiophene-2-yl sulfonyl carbamate [CAS No. 849793-87-9] Thiophene-2-carboxylic acid [CAS No. 527-72-0] 3-Chlorothiophene-2-carboxylic acid [CAS No. 59337-89-2] 5-Chlorothiophene-2-carboxylic acid [CAS No. 24065-33-6] 5-Bromothiophene-2-carboxylic acid [CAS No. 7311-63-9] 5-Formylthiophene-2-carboxylic acid [CAS No. 4565-31-5] Sodium thiophene-2-carboxylate [CAS No. 25112-68-9] 2,5-dichlorothiophene-3-carboxylic acid [CAS No. 36157-41-2] 2-Acetylthiophene [CAS No. 88 15-3] 3-Acetyl-2,5-dichlorothiophene [CAS No. 36157-40-1] 2-Chloro-3-methylthiophene [ CAS No. 14345-97-2] 2-Bromo-3-methylthiophene [CAS No. 14282-76-9] 5-Bromothiophene-2-carboxaldehyde [CAS No. 4701-17-1] 5-Acetylthiophene-2-carboxamide [CAS No. 68257-89-6] 5-Chlorothiophene-2-yl sulfonamide [CAS No. 53595-66-7]
Technical capabilities Process Bromination Chiral synthesis Chlorination Description Liquid bromine, HBr We regularly perform chiral synthesis of several intermediate for API s. Chlorine gas, Thionyl chloride, HCl Concentrated peroxides Perform oxidation using H 2 O 2 Cyclopropanation Diazo Compounds Elemental reactive metals Hydrogenation Lithiation Optical resolution Oxidation Phosgenation Reduction Using Ethyl Diazoacetate EDA Expertise with Sodium, Magnesium, Zinc etc. Using noble metal catalysts like Pd/C, Pt/C, Ru/C etc. Lithiation using n-buli, LDA Chiral resolution using enzymes Jone s, Swen s, Prinz, KMnO 4, MnO 2, NaOCl, Oxone etc. Using Triphosgene Metal ammonia, sodium borohydride,
Corporate Office 409, Bezzola Complex, Sion Trombay Road, Chembur, Mumbai - 400 071. India. Tel.: +91-22- 2522 1698, +91-22- 2523 4659, Fax : +91-22- 2529 9389 Email: info@modepro.com Factory D-16/2, TTC Area,Turbhe MIDC, Navi Mumbai - 400 705. India www.modepro.com