HCC Houston Community College COURSE TITLE BIOLOGY 1406 GENERAL BIOLOGY I CREDIT 4 SEMESTER HOURS (3 hours lecture; 3 hours lab.) COURSE INTENT LIFE SCIENCE MAJOR TEXTBOOK Campbell, Neil, Reece, Jane, with Urry, Lisa, Cain, Michael, Wasserman, Steven, Minorsky, Peter, and Jackson, Robert Biology, 9 th Edition, Volume I prepared specially for Houston Community College Pearson Education, Inc., publishing as Pearson Benjamin Cummings, 2009. LEARNING SUPPLEMENT BUNDLED WITH VOLUME I Garrett, Lori K. Get Ready for Biology Pearson Education, Inc., publishing as Pearson Benjamin Cummings, 2007. LABORATORY MANUAL Loesh, Tom; Mishra, Jasleen; Palmer, William; Sawant, Leena; Schwart, David; Shah, Nimish; Wiersema, Donna; Editors. Biology 1406 Laboratory Manual. Bluedoor Publishing, 2011. TESTING/GRADING It is recommended that a minimum of 4 examinations (including the final) be given in the course of the semester. This should make up approximately 75% to 80% of the course grade. There should be at least one laboratory practical examination (ideally two) and about 20% to 25% of the course grade should be allocated to laboratory performance, based on the practical examination(s) and the written laboratory reports.
2 TOPICS TO BE COVERED PAGES 2-449 Chapter 1. Introduction: Themes in the Study of Life 2. The Chemical Context of Life 3. Water and the Fitness of the Environment 4. Carbon and the Molecular Diversity of Life 5. The Structure and Function of Large Biological Molecules 6. A Tour of the Cell 7. Membrane Structure and Function 8. An Introduction to Metabolism 9. Cellular Respiration: Harvesting Chemical Energy 10. Photosynthesis 11. Cell Communication 12. The Cell Cycle 13. Meiosis and Sexual Life Cycles 14. Mendel and the Gene Idea 15. The Chromosomal Basis of Inheritance 16. The Molecular Basis of Inheritance 17. From Gene to Protein 18. Regulation of Gene Expression 19. Viruses 20. Biotechnology 21. Genomes and Their Evolution LABORATORY EXERCISES in various college specific laboratory manuals 1. Preface: Laboratory Safety 2. Basic Chemistry 3. Biochemistry: Detection of Biological Molecules, The Scientific Method and Experimental Design 4. The Care and Feeding of the Microscope 5. Cell Structure 6. Diffusion and Osmosis 7. Enzymes 8. Respiration and Fermentation 9. Photosynthesis and Spectrophotomery 10. Cell 11. Genetics 12. DNA to Protein 13. Biotechnology and DNA Extraction SUGGESTED WEBSITES 1. www.masteringbiology.com for BioFlix, 3-D animations,
3 MP3 tutors, videos, practice tests, practice problems and ebook. 2. http://www.lcusd.net/lchs/mewoldsen/ebiolink.htm for Dr. E s biology links. Several hundred biology related links on this webpage for any subject in biology. 3. http://multimedia.mcb.harvard.edu/media.html for the award winning video The Inner Life of a Cell. Superb animations demonstrate the operation of many of the cellular components discussed in Chapter 6 of Campbell. Choose the Super Speed version for the largest display. 4. http://multimedia.mcb.harvard.edu/anim_atpase3_flv.html for a detailed look at the operation of the F 0 F 1 ATPase of the inner mitochondrial membrane. How ATP is made by a rotating protein structure. (There are underscores after anim and 3) SUGGESTED COMPUTER CDs and DVDs Campbell and Reese 9 th Edition Visual Instructor Resources 1. DVD 1 Chapters 1 through 21 chapter specific videos, animations, activities, on-line labs, investigations, Powerpoint step edit art. 2. Quickstart CD Powerpoint Images and Art all chapters 3. Test Bank CD all chapters SESSION 1 TOPICS TO BE COVERED Chapter 1 Introduction - General considerations of the course. REFERENCE(S) pp. 1 27, Campbell and Reese pp. 1 87, Garrett (Study Skills and Basic Math ongoing through semester) pp. 133 161, Garrett (Biology Basics specific to session 1) Hand out lecture and lab schedules. Organizational session. Mastering Biology activities The Levels Of Life Card Game, Energy Flow And Chemical Cycling, Form Fits Function, Comparing Prokaryotic And Eukaryotic Cells, Negative And Positive Feedback, Classification Schemes, Heritable Information DNA
4 To present the overall view of the course. To orient students in the studies of life science. To introduce students to evolutionary principles and to the scientific method SESSION 2 TOPIC TO BE COVERED Chapter 2 The Chemical Context of Life REFERENCE(S) pp. 30 45, Campbell and Reese pp. 89 132, Garrett (Biological Terminology ongoing through semester) pp. 163 199, Garrett (Chemistry Basics specific to session 2) Lab Exercise 1 Mastering Biology, 9th Edition einstruction clicker PRS Q and A Mastering Biology activities Structure Of The Atomic Nucleus, Electron Arrangement, Build An Atom, Covalent Bonds, Nonpolar And Polar Molecules, Ionic Bonds, Hydrogen Bonds. To acquaint students with the importance of chemistry. To review basic chemistry. To review chemical bonds. SESSION 3 TOPIC TO BE COVERED Chapter 3 Water and the Fitness of the Environment REFERENCE(S) pp. 46 57 Lab Exercise 2 Mastering Biology, 9th Edition einstruction clicker PRS Q and A Mastering Biology activities The Polarity Of Water, Cohesion Of Water, Dissociation Of Water Molecules, Acids, Bases, and ph. To discuss the importance of water as a life sustaining medium.
5 To discuss the properties of water and the concept of ph and buffers. SESSION 4 TOPIC TO BE COVERED Chapter 4 Carbon and the Molecular Diversity of Life REFERENCES pp. 58 67 Lab Exercise 3 Biochemistry: Detection of Biological Molecules To discuss carbon chemistry To discuss the functional groups in organic molecules SESSION 5 Topic to be Covered Reference(s) Suggested Activities First Lecture Exam Instructional Objectives SESSION 6 TOPIC TO BE COVERED Chapter 5 The Structure and Function of Macromolecules 1. Carbohydrates 2. Lipids 3. Proteins 4. Nucleic acids REFERENCE(S) pp. 68 91 Lab Exercise 4 Care and Feeding of the Microscope
6. To study the chemistry of carbohydrates, lipids, proteins, and nucleic acids. To discuss the importance of these biological molecules to life, both structurally and functionally. SESSION 7 TOPICS TO BE COVERED REFERENCE (S) Chapter 6, A Tour of the Cell pp. 94 124 Campbell and Reese First Laboratory Exam To discuss how cells are studied. To discuss the differences between prokaryotic and eukaryotic cells. To identify organelles (nucleus, mitochondria, Golgi apparatus, etc.) and discuss their specific functions. To point out similarities and differences between an animal and a plant cell. To discuss the cell surface. SESSION 8 TOPIC TO BE COVERED Chapter 7 Membrane Structure and Function REFERENCE (S) pp. 125 141 Discuss the models of membrane structure. Examine the movement of small molecules across the plasma membrane. Discuss endocytosis and exocytosis.
7 SESSION 9 TOPIC TO BE COVERED Chapter 8 An Introduction to Metabolism REFERENCE(S) pp. 142 161 Lab Exercise 5 Discuss energy, especially chemical energy, Discuss ATP structure and function in cells. Discuss how enzymes are essential as Biological catalysts SESSION 10 Second Lecture Exam SESSION 11 TOPIC TO BE COVERED Chapter 9 Cellular Respiration: Harvesting Chemical Energy REFERENCE(S) pp. 162 184 Lab Exercise 6 To discuss how cells make ATP. To discuss catabolism. To discuss redox reactions in metabolism. To examine glycolysis in terms of energy yield to the cell, and glycolytic end products. To define fermentation and discuss its products in plants and animal cells. To consider aerobic metabolism: citric acid cycle, electron transport, oxidative phosphorylation, and chemiosmosis. To determine overall energy yield and products of glucose metabolism. SESSION 12 TOPIC TO BE COVERED Chapter 10 Photosynthesis REFERENCE(S) pp. 185 205
8 To define photosynthesis and show the components involved in the process. To discuss how light energy is trapped, funneled into high energy compounds, and to discuss the relationship of this process to chloroplast structure. To discuss cyclic and non-cyclic photophosphorylation. To discuss how carbon dioxide is reduced during the dark reaction. To compare C 3 and C 4 plants in terms of structure, as well as carbon fixation. SESSION 13 TOPIC TO BE COVERED Chapter 12 The Cell Cycle REFERENCE (S) pp.228 245 Models: Mitosis Lab Exercise 7 To describe the various stages of the cell cycle. To describe the process of mitosis and cytokinesis. To compare normal and abnormal cell division. To describe regulation of the cell cycle SESSION 14 TOPIC TO BE COVERED Chapter 13 Meiosis and Sexual Life Cycles REFERENCE (S) pp. 248-261 Introduce general concepts in genetics. Compare asexual versus sexual reproduction. Discuss meiosis and compare this process with mitosis. Describe the source of genetic variation due to crossing over during meiosis.
9 Discuss the variety of sexual life cycles among Plants, animals, and fungi. SESSION 15 TOPIC TO BE COVERED Third Lecture Exam REFERENCE(S) Lab Exercise 8 SESSION 16 TOPIC TO BE COVERED Chapter 14 Mendel and the Gene Idea REFERENCE(S) pp. 262 283 Lab Exercise 9 To introduce the Mendelian Theory of Inheritance based on Mendel's studies with garden peas. To describe the concepts of: alleles, dominance, recessive traits, and the use of Punnett squares to determine probable results of genetic crosses. To discuss monohybrid and dihybrid inheritance including genotypes, phenotypes, homozygosity, heterozygosity, and expected types of ratios from genetic crosses, as well as the role of a test cross. To introduce concepts on the use of statistics in genetics. SESSION 17 TOPIC TO BE COVERED Chapter 15 The Chromosomal Basis of Inheritance REFERENCE(S) pp.286 302 To introduce the general concepts on the chromosomal basis of heredity. To discuss linked genes and crossing over. To describe the formulation of genetic maps based
10 on mutations and crossover rates. To describe sex-linked inheritance. To discuss chromosomal alterations, their potential consequences, and extranuclear inheritance. SESSION 18 TOPIC TO BE COVERED Chapter 16 The Molecular Basis of Inheritance REFERENCE(S) pp. 305 324 Second Laboratory Exam To introduce the historical perspective of the DNA molecule. To describe semi conservative replication, including the functions of DNA polymerase, replication forks, and repair mechanisms. To compare alternate forms of the DNA molecule. To describe the organization of the DNA molecule in eukaryotic chromosomes. SESSION 19 TOPIC TO BE COVERED Chapter 17 From Gene to Protein REFERENCE(S) pp. 325-350 INSTRUCTIONAL ACTIVITIES Mastering Biology activities Overview Of Protein Synthesis, Transcription, RNA Processing, Translation Discuss the interrelationships between genes and metabolism. Describe the process of transcription in protein synthesis. Discuss the different types of RNA, the genetic code and their role in protein synthesis. Discuss the process of translation by presenting the initiation, elongation and termination of protein synthesis. Compare the different types of mutations and their effects on protein synthesis.
11 SESSION 20 TOPIC TO BE COVERED Lecture Exam 4 REFERENCES Lab Exercise 10 and 11 SESSION 21 TOPIC TO BE COVERED Chapter 18 Regulation of Gene Expression REFERENCE(S) pp. 351 380 Lab Exercise 12 To describe gene regulation in bacteria by inducible and repressible operons. To describe modification in the eukaryotic chromosomes. To discuss mechanisms of transcriptional and translational regulation in eukaryotes. To discuss the processes involved in eukaryotic development. differentiation and regeneration. To discuss proto oncogenes and carcinogenesis SESSION 22 TOPIC TO BE COVERED Chapter 19 Viruses REFERENCES pp. 381 395 Mastering Biology, 9th Edition Instruction clicker PRS Q and A Mastering Biology activities Simplified Viral Reproductive Cycle, Phage Lytic Cycle, Phage Lysogenic And Lytic Cycles, Retrovirus(HIV) Reproductive Cycle
12 To discuss the structure, properties, and types of viruses. To describe the lytic and lysogenic cycles of bacteriophages. To describe the life cycles of animal viruses To discuss plasmids and prions. SESSION 23 TOPIC TO BE COVERED Chapter 20 Biotechnology REFERENCE(S) pp. 396 425 Lab Exercise 13 To describe the procedures used in gene manipulation and cloning. To discuss the various applications of biotechnology. SESSION 24 TOPIC TO BE COVERED Chapter 21 Genomes and Their Evolution (optional for Bio 1406) REFERENCE(S) pp.426 449 To describe cell differentiation and morphogenesis. To discuss transposons To describe transcriptional regulation of cytoplasm and signals from other cells To discuss the various applications of cell signaling and transcriptional regulation. SESSION 25 TOPIC TO BE COVERED REFERENCE(S)
13 REVIEW FOR FINAL EXAM THIRD LABORATORY EXAM MELVIN BRANCH, INSTRUCTOR Email: melvin.branch@hccs.edu