ADDENBROOKE'S COGNITIVE EXAMINATION - ACE-R Final Revised Version C (2005)

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Final Revised Version C (2005) Name : Date of birth : Hospital no. : O R I E N T A T I O N Ask: What is the Ask: Which R E G I S T R A T I O N Register number of trials Day Building Addressograph Date Floor A T T E N T I O N & C O N C E N T R A T I O N Date of testing: Tester's name: Age at leaving full-time education: Occupation: Handedness: Month Town Year County Season Country Ask the subject: ' could you take 7 away from a 100? After the subject responds, ask him or her to take away another 7 to a total of 5 subtractions. If subject make a mistake, carry on and check the subsequent answer (i.e. 93, 84, 77, 70, 63 -score 4) Stop after five subtractions (93, 86, 79, 72, 65). Ask: 'could you please spell WORLD for me? Then ask him/her to spell it backwards: M E M O R Y - Recall Ask: 'Which 3 words did I ask you to repeat and remember?' M E M O R Y - Anterograde Memory Tell: ' I'm going to give you a name and address and I'd like you to repeat after me. We'll be doing that 3 times, so you have a chance to learn it. I'll be asking you later' Score only the third trial John Marshall 24 Market Street Spilsby Tell: 'I'm going to give you three words and i'd like you to repeat after me: lemon, key and ball'. After subject repeats, say 'Try to remember them because i'm going to ask you later'. Score only the first trial (repeat 3 times if necessary). Lincolnshire M E M O R Y - Retrograde Memory 1 st Trial 2 nd Trial 3 rd Trial Name of current Prime Minister Name of the woman who was Prime Minister Name of the USA president Name of the USA president who was assassinated in the 1960's [Score 0-3] (for the best performed task) [Score 0-3] [Score 0-7] [Score 0-4] A T T E N T I O N & O R I E N T A T I O N M E M O R Y

Final Revised Version (2005) V E R B A L F L U E N C Y - Letter 'P' and animals Letters Say: I m going to give you a letter of the alphabet and I d like you to generate as many words as you can beginning with that letter, but not names of people or places. Are you ready? You ve got a minute and the letter is P Animals Say: Now can you name as many animals as possible, beginning with any letter? [Score 0-7] >17 7 14-17 6 11-13 5 8-10 4 6-7 3 4-5 2 2-3 1 <2 0 total correct [Score 0-7] >21 7 17-21 6 14-16 5 11-13 4 9-10 3 7-8 2 5-6 1 <5 0 total correct F L U E N C Y L A N G U A G E - Comprehension Show written instruction: Close your eyes 3 stage command: 'Take the paper in your right hand. Fold the paper in half. Put the paper on the floor' L A N G U A G E - Writing Ask the subject to make up a sentence and write it in the space below: Score 1 if sentence contains a subject and a verb (see guide for examples) [Score 0-3] L A N G U A G E

L A N G U A G E - Repetition Ask the subject to repeat:' hippopotamus'; 'eccentricity; 'unintelligible'; 'statistician' Score 2 if all correct; 1 if 3 correct; 0 if 2 or less. Final Revised Version (2005) [Score 0-2] Ask the subject to repeat: Above, beyond and below Ask the subject to repeat: No ifs, ands or buts L A N G U A G E - Naming Ask the subject to name the following pictures: [Score 0-2] pencil + watch [Score 0-10] L A N G U A G E L A N G U A G E - Comprehension Using the pictures above, ask the subject to: Point to the one which is associated with the monarchy Point to the one which is a marsupial Point to the one which is found in the Antarctic Point to the one which has a nautical connection [Score 0-4]

L A N G U A G E - Reading Ask the subject to read the following words: [Score 1 only if all correct] V I S U O S P A T I A L A B I L I T I E S Ov erlapping pentagons: sew pint soot dough height Ask the subject to copy this diagram: Wire cube : Ask the subject to copy this drawing (for scoring, see instructions guide) Clock: Ask the subject to draw a clock face with numbers and the hands at ten past five. (for scoring see instruction guide: circle = 1, numbers = 2, hands = 2 if all correct) Final Revised Version (2005) [Score 0-2] L A N G U A G E V I S U O S P A T I A L

P E R C E P T U A L A B I L I T I E S Final Revised Version (2005) Ask the subject to count the dots without pointing them [Score 0-4] V I S U O S P A T I A L

P E R C E P T U A L A B I L I T I E S Final Revised Version C (2005) Ask the subject to identify the letters [Score 0-4] R E C A L L Ask Now tell me what you remember of that name and address we were repeating at the beginning John Marshall 24 Market Street Spilsby Lincolnshire R E C O G N I T I O N This test should be done if subject failed to recall one or more items. If all items were recalled, skip the test and score 5. If only part is recalled start by ticking items recalled in the shadowed column on the right hand side. Then test not recalled items by telling ok, I ll give you some hints: was the name X, Y or Z? and so on. Each recognised item scores one point which is added to the point gained by recalling. [Score 0-7] John Simons John Marshall Joseph Marshall recalled 42 28 24 recalled Market Street High Street Market Square recalled Spilsby Horncastle Sleaford recalled Northamptonshire Lincolnshire Leicestershire recalled General Scores MMSE /30 ACE-R /100 Subscores Attention and Orientation /18 Memory /26 Fluency /14 Language Visuospatial /26 /16 S C O R E M E M O R Y V I S U O S P A T I A L Normative values based on 63 controls aged 52-75 and 142 dementia patients aged 46-86 Cut-off <88 gives 94% senstivity and 89% specificity for dementia Cut-off <82 gives 84% sensitivity and 100% specificity for dementia