ROADSHOW CANCER NOUVELLE-AQUITAINE A NEW HIGH PERFORMANCE ALGORITHM FOR MODERN TREATMENT PLANNING SYSTEMS G. BIRINDELLI (1), J. CARON (1,2), B. DUBROCA (1), J.-L. FEUGEAS (1), G. PH. NICOLAÏ (1), J. PAGE (1), G. KANTOR (2), V. TIKHONCHUK (1) (1) CENTRE LASERS INTENSES ET APPLICATIONS (CELIA) UNIVERSITÉ DE BORDEAUX, FRANCE (2) INSTITUT BERGONIÉ DE BORDEAUX, FRANCE Roadshow 2017-2018, le cancer, de la recherche à la prise en charge du patient Limoges, 12 et 13 décembre 2017
Présentation du Projet RESEARCH PROGRAM POPRA : MAINLY FOUNDED BY AQUITAINE REGIONAL COUNCIL AND EUROPEAN FUND FOR REGIONAL DEVELOPMENT POPRA - PROGRAMME OPTIQUE, PHYSIQUE ET RADIOTHÉRAPIE EN AQUITAINE 5 YEARS 2014-2019 Multi-laboratories, Multi-institutions Comprehensive Cancer Center - Institut Bergonié, Bordeaux University Hospital (CHU) Academic research units on Talence campus CELIA, CENBG, IMB, LABRI Multi-disciplinaries oncology, radiotherapy, theoretical physics, medical physics, applied mathematics, IT developments S 2 MAIN AXES NEW SOURCES OF PROTONS SUITABLE FOR RADIOTHERAPY HIGH INTENSITY LASERS ACCELERATION AND TRANSPORT NEW ALGORITHMS FOR TREATMENT PLANNING SYSTEMS TRANSVERSAL PROGRAM OF SCIENTIFIC RESEARCH WITH A MISSION OF VALORIZATION
Offres de service & produits marchés visés New algorithms fast and accurate for modern TPS External radiotherapy, Brachytherapy, Radiopharmaceutical Therapy as an alternative to fast or accurate existing algorithms Ad-hoc modelling Robust and rapid Lack of precision for complex geometries Inadequate for modern requirements (MRI ) Monte-Carlo Statistical methods Robust and referent Slow calculation speed Inadequate for treatments requirement New proposals Fast MC What about MRI guided radiotherapy? Deterministic modelling Evaluation of performances in progress IS THERE A PLACE FOR A FAST AND ACCURATE ALGORITHM ABLE TO MEET THE CHANGING NEEDS?
Entropic moment methods The dose calculation is based on the resolution of the Linearized Boltzmann Transport Equation (LBTE) which requires discretization of all phase space (angle and energy) and physical space (position): 1keV Energy Space 1MeV The system of equations is closed by using the Boltzmann entropy maximization principle Resolution of the angular moments LBTE is solved on a reduced phase space Angle Attractive properties Distribution function: non negative Mathematical hyperbolicity: efficient numerical methods Continuity of moments equations: derivability for inverse problem resolution All particles treated - photons, positrons, electrons, primary, scattered or secondary LESS UNKNOWNS GREATER EFFICIENCY SHORTER COMPUTATIONAL TIME AND SMALLER MEMORY SPACE REQUIRED WHAT ABOUT ACCURACY?
ENTROPIC ALGORITHM VALIDATION External radiotherapy (electrons, photons, protons) measured pencil beam Monte-Carlo entropic closure spine bone bone bone bone trachea : air water electrons, 9 MeV 10 10 cm 2 EXPERIMENTAL AND NUMERICAL (MONTE-CARLO) QUALITATIVE AND QUANTITATIVE COMPELLING COMPARISONS PROMISING ALGORITHM TO ADDRESS THE PRECISION LEVEL OF MODERN TPS
MRI-guided radiotherapy ENTROPIC ALGORITHM VALIDATION 1T SIMULATIONS OF EFFECTS OF ELECTROMAGNETIC FIELDS B=0,35T B=1,5T EXPERIMENTAL AND NUMERICAL (MONTE-CARLO) water air water water air water water air water PROMISING ALGORITHM TO ADDRESS THE NEW CHALLENGES OF THE MODERN TPS DEDICATED TO RECENT FACILITIES OF IMAGING/TREATMENT
Brachytherapy ENTROPIC ALGORITHM VALIDATION DENSITY AND CHEMICAL COMPOSITION EFFECTS EXPERIMENTAL AND NUMERICAL (MONTE-CARLO) PROMISING ALGORITHM TO ADDRESS THE RECENT RECOMMENDATIONS (TG-186) FOR BRACHYTHERAPY
PROMISING ALGORITHM TO RESPOND TO REAL TIME COMPUTATION AND PRECISION REQUIREMENTS
Contacts gabriele.birindelli@u-bordeaux.fr jean-luc.feugeas@u-bordeaux.fr philippe.nicolai@u-bordeaux.fr