Institute of Organic Chemistry with Centre of Phytochemistry Bulgarian Academy of Sciences

Institute of Organic Chemistry with Centre of Phytochemistry Bulgarian Academy of Sciences

Institute of Organic Chemistry with Centre of Phytochemistry The Institute was established in 1960. The Centre of Phytochemistry was founded in 1977, within a joint project of the Bulgarian Government, UNDP and UNESCO for scientific and applied research and training of specialists.

Research Areas New Materials Organic Analyses Natural Products Computational Chemistry

Natural Products

Natural Products Characterization of the chemical diversity and health promoting potential of Bulgarian flora Isolation of new biologically active natural compounds (alkaloids, terpenoids, flavonoids and other phenolics) Development of methods for standardization and quality control of Bulgarian medicinal plants and propolis

Natural Bioactive Products Studies of pectic substances and other bioactive polysaccharides Investigation of the antioxidant properties of fruits, vegetables, herbs and mushrooms. Development of new technologies for functional foods (Through contract with the small enterprise VITANEA )

Organic synthesis and Stereochemistry Equipment for organic and organometallic transformations; synthesis of natural compound analogues and pharmaceutical ingredients

Organic synthesis and Stereochemistry Rational design of chiral ligands based on readily available natural chiral sources Development of metal-mediated and organocatalytic systems for enantioselective transformations and synthesis of terapeuticaly relevant structures Investigation of the stereochemical course of selective transformations and configuration determinations Contract research collaborations with pharmaceutical companies design and synthesis of compound-libraries for development of drug candidates

Organic Analysis Labs Bulgarian NMR Centre Laboratory Mass spectrometry & Instrumental chromatography Electronic and vibrational spectroscopy Elemental analysis

NMR Spectrometer Bruker Avance II+ 600 MHz

NMR Spectrometer Bruker DRX 250 MHz

NMR Spectroscopy Structural analysis and stereochemistry - small and medium size molecules conformation and configuration, mixture analysis Molecular mobility - classic dynamic NMR, nuclear relaxation methods, DOSY spectroscopy Supramolecular aggregates and complexes - molecular recognition with cyclodextrines; structure and composition of surfactant solutions; colloid and water soluble polymers as drug delivery systems; Computer programs and spectral databases

Mass spectrometry & Instrumental chromatography High resolution magneto-sector mass spectrometer DFS HRGC/HRMS/DS (CI, EI, ESI. APCI)

Organic Analysis - Analysis of new compounds, mixtures, composits of natural and synthetic origin - New methods for determination of composition, quality and authenticity of foods - Expert evaluation of identity, purity and quality parameters of chemical and pharmaceutical products

Most important ongoing projects: Chiral Cations and Ligands with Tunable Properties for Asymmetric Synthesis and Catalysis (project funded by Swiss National Science Foundation, collaboration IOCCP-BAS and Department of Organic Chemistry, University Geneva) Bees in Europe and the decline of bee colonies (search for natural products active against bee pathogens) BEEDOC (project funded by FP-7) Innovative Chiral Catalysts Based on Auxiliaries from the Chiral Pool (project funded by Bulgarian National Science Fund) Infraspecific diversity, biologically active substances, selection of perspective habitats, cultivation and sustainable use of Tribulus terrestris L. for the pharmaceutical industry (project funded by Bulgarian National Science Fund) Design, synthesis and photophysical investigations of self organized nanoassemblies of noble metal nanoparticles and organic luminophores (project funded by Swiss National Science Foundation, collaboration IOCCP-BAS and Department Physical Chemistry, University Geneva)

Most important ongoing projects: Fluorophore modified noble metal nanoparticles new materials for bio- and chemical sensors (project funded by Bulgarian National Science Fund) Study of the pharmacological potential of Bulgarian medicinal plants to treat experimental osteoporosis: taxonomic, phytochemical and in vivo/in vitro biomedical research (project funded by Bulgarian National Science Fund) Bulgarian NMR Centre Development of Advanced and Effective Research Infrastructure for NMR Analysis of Bio- and Nanomaterials (project funded by Bulgarian National Science Fund) Enhancing Access and Services To East European users towards an efficient and coordinated pan-european pool of NMR capacities to enable global collaborative research and boost technological advancements EAST-NMR (FP7 INFRA2008-1.1.1) European Phosphorus Sciences Network (PhoSciNet) COST CM0802

Existing national co-operations Joint Genomic Centre Molecular biology Biodiversity IOCCP Microbiology Polymers Sofia Medical University Sofia University

Existing international co-operations University of Athens University of Geneva University of Skopje University of Malta IOCCP Slovak Acad. Sci. Vrije Universiteit Brussel Romanian Acad. Sci.