/ ) (log Pow) 7)

Similar documents
Substance name: Lead chromate EC number: CAS number:

KATE2017 on NET beta version Operating manual

Mode of action approaches to mixtures. Joop Hermens Institute for Risk Assessment Sciences Utrecht University

External Validation of Common Aquatic Toxicity Prediction Tools:

AND INHIBITION OF REPRODUCTION OF DAPHNIA MAGNA

Nano-Ecotoxicology Assessment of Potential Effects of Engineered Nanomaterials in the Environment

Environmental quality standards for priority pesticides relevant in the aquatic environment in Slovak Republic

Prediction and QSAR Analysis of Toxicity to Photobacterium phosphoreum for a Group of Heterocyclic Nitrogen Compounds

Author's personal copy

Screening and prioritisation of substances of concern: A regulators perspective within the JANUS project

Determining the suitability of Ceriodaphnia rigaudii as a toxicity test species

TECHNICAL BASIS FOR NARCOTIC CHEMICALS AND POLYCYCLIC AROMATIC HYDROCARBON CRITERIA. I. WATER AND TISSUE

BASF DocID 2010/

Toxicity Assessment of Hydragyp. VGT Pty Ltd. Test Report

ESSENTIAL TOXICOLOGY An Educational Resource

QMRF# Title. number and title in JRC QSAR Model Data base 2.0 (new) number and title in JRC QSAR Model Data base 1.0

ADSORPTION OF SUBSTITUTED AROMATIC COMPOUNDS BY POWDERED ACTIVATED CARBON: A MECHANISTIC APPROACH TO QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS

Announcement ECB-Workshop on Biology-Based Modelling

ACUTE AND CHRONIC TOXICITY OF IMIDAZOLIUM-BASED IONIC LIQUIDS ON DAPHNIA MAGNA

PREDICTING THE TOXICITY OF NEAT AND WEATHERED CRUDE OIL: TOXIC POTENTIAL AND THE TOXICITY OF SATURATED MIXTURES

EVALUATION OF SILVER NANOPARTICLES ECOTOXICITY IN SILVER CARP (HYPOPHTHALMICTHYS MOLITRIX) AND GOLDFISH (CARASSIUS AURATUS)

Annual Review MIXTURE TOXICITY AND ITS MODELING BY QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS

Introduction to Ecotoxicology. Ludek Blaha, Jakub Hofman, Klara Hilscherova & co.

Sub-lethal effects of acetone on Daphnia magna

Toxic Effect of Silver and Platinum Nanoparticles Toward the Freshwater Microalga Pseudokirchneriella subcapitata

Procedure for New Chemicals

4. CHEMICAL AND PHYSICAL INFORMATION

Toxicity Assessment of Environmentally Relevant Pollutant Mixtures Using a Heuristic Model

Safety Data Sheet. QHA036/20LT INTERZINC 22???????? Version 1 Revision Date 10/21/13

Mechanism-based Molecular Design of Chemicals with Low Carcinogenicity Potential

IFE Foam Conference: Foam Under Fire!

Ecological Risk Assessment of Pollutant Chemicals: Extinction Risk Based on Population-Level Effects

A biology-based dynamic approach for the reconciliation of acute and chronic toxicity tests: Application to Daphnia magna

FERTILIZATION OF FRESHWATER FISH PONDS WITH COBALT AND ITS ADSORPTION AND DESORPTION IN THE POND SEDIMENT

Substance name: 2,4 - Dinitrotoluene EC number: CAS number: MEMBER STATE COMMITTEE SUPPORT DOCUMENT FOR IDENTIFICATION OF

Toxicity Assessment of Triple Strike. VGT Pty Ltd. Test Report

Project Summary. Title: Effect of Clean and Polluted Groundwater on Reproduction and Development of Daphnia

_!M Ry=- EB7 (7 R $U $7E $7= $7XU EB7 NO jhu %,% $=- C8 % C< $ 7. Using Rainbow Trout to Measure Arsenic Toxicity in Water

Nanoparticles and the environment: behaviour, ecotoxicity and fate

1.QSAR identifier 1.1.QSAR identifier (title): QSAR model for Fish, early-life stage toxicity test 1.2.Other related models:

Safety Data Sheet. EGA870 INTERZONE 505 OFF WHITE PART A Version No. 2 Revision Date 09/27/17

Safety Data Sheet. TLA754 INTERLINE 961 GREY BASE Version No. 1 Revision Date 11/09/13

Assessment? Does Ecotoxicology Inform ECOLOGICAL RISK VIEWPOINT. Some argue that ecotoxicology is too simplistic to do the job effectively.

Environmental Risk Assessment of Nanomedicines

Chemical Oxidation Overview. Jim Jacobs Tel:

The BEAM-project: Prediction and Assessment of Mixture Toxicities in the Aquatic Environment

Prediction of Acute Toxicity of Emerging Contaminants on the Water Flea Daphnia magna by Ant Colony Optimization - Support Vector Machine QSTR models

User manual Strategies for grouping chemicals to fill data gaps to assess acute aquatic toxicity endpoints

Recommendation of the BPC Working Groups

Accurately Densities, Dielectric Constants and Volumes of Mixed Formamide (FA) Water at K

Standards for Green Solvents; an example using ionic liquids

GPS Safety Summary. 1. NAME OF SUBSTANCE Sulfuric acid.

Substance Name: 2,2-bis(4'-hydroxyphenyl)-4- methylpentane EC Number: CAS Number: SUPPORT DOCUMENT FOR IDENTIFICATION OF

Medicinal Chemistry/ CHEM 458/658 Chapter 3- SAR and QSAR

Product Properties Test Guidelines OPPTS Dissociation Constants in Water

Dose-Response Analysis in Animal

1.QSAR identifier 1.1.QSAR identifier (title): QSAR for female rat carcinogenicity (TD50) of nitro compounds 1.2.Other related models:

Predicting the synergy of multiple stress effects

Safety Data Sheet. HRM230 INTERFINE 629 CLAY BROWN (RAL8003)PT A Version No. 1 Revision Date 11/09/13. For professional use only.

Background Document Biology-Based Methods

QMRF identifier (JRC Inventory): QMRF Title: QSAR model for female rat carcinogenicity (TD50) of nitro compounds Printing Date:21.01.

Ecotoxicological impacts of microplastics on marine organisms, including species providing a source of food

Exploration of alternative methods for toxicity assessment of pesticide metabolites

The Biotechnology Education Company. Toxicity Detection of Pollutants in Freshwater. See Page 3 for storage instructions. EXPERIMENT OBJECTIVE:

The Ability of Daphnia magna to Maintain Homeostasis Despite Varying Toxicity Levels of Surrounding Environments

OECD QSAR Toolbox v.4.1. Tutorial on how to predict Skin sensitization potential taking into account alert performance

How to decide whether a substance is a polymer or not and how to proceed with the relevant registration

Item #9: Amphipod Tox Proposal Modification Page 1 of 9

Global Harmonization System:

Estimation of Hazardous Phenolic Compounds in Industrial Wastewater

Toxicity of Seven Herbicides to the Three Cyanobacteria Anabaena flos-aquae, Microcystis flos-aquae and Mirocystis aeruginosa

REVIEW OF TITANIUM DIOXIDE NANOPARTICLE PHOTOTOXICITY: DEVELOPING A PHOTOTOXICITY RATIO TO CORRECT THE ENDPOINT VALUES OF TOXICITY TESTS

Annex IX: Risks for PolyChlorinated Biphenyls (PCBs)

SAFETY DATA SHEET CON DET

ACUTE AQUATIC TOXICITY OF GOLD NANOPARTICLES TO FRESHWATER GREEN ALGAE

OECD QSAR Toolbox v.4.1. Tutorial of how to use Automated workflow for ecotoxicological prediction

Higher Alkenyl Succinic Anhydride (ASA) CATEGORY JUSTIFICATION and TEST PLAN

Environmental Toxicology of 2,4-D

Safety Data Sheet. HRXG21 INTERFINE 629 G21 JADE PART A Version No. 1 Revision Date 11/09/13. For professional use only.

- A7/13 - PART 2. Matrix Analyte(s) Method LOQ Reference. HPLC with fluorescence detection after acid hydrolysis

Biology 5868 ID Exam 2 April 6, 2007

Background 3. Regulatory History for Assessments of Ethers 5

TOXICITY OF, AND DEVELOPMENT OF PREDICTIVE MODELS FOR, SUBSTITUTED PHENOLS TO CERIODAPHNIA CF. DUBIA AND VIBRIO FISCHERI

Reference M atm -1 H / R,

Adverse Outcome Pathways in Ecotoxicology Research

METHOD 9034 TITRIMETRIC PROCEDURE FOR ACID-SOLUBLE AND ACID INSOLUBLE SULFIDES

Biocidal Products Committee (BPC)

SIAM 23, October 2006 SIDS INITIAL ASSESSMENT PROFILE

Toluene Biogenesis in Peatlands:

OECD QSAR Toolbox v.3.3. Predicting skin sensitisation potential of a chemical using skin sensitization data extracted from ECHA CHEM database

Investigating Potamopyrgus antipodarum as suitable test species for ecotoxicology testing of surface water

Chemical Control Legislation In Japan

Things we didn t know we had to worry about : Frank Skee Pretreatment Coordinator City of Greensboro December 4, 2014

해양녹조류 Tetraselmis suecica, 규조류 Ditylum brightwellii, 와편모조류 Prorocentrum minimum 에대한 Aroclor 1016 과비스페놀 A 의독성효과. Article

INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES

Ecorisk Dilemma. ES/RP 532 Applied Environmental Toxicology. EPA Approach. EPA Objective. Hazard Identification. Hazard ID

OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters (as revised in 2012)

Overview. Database Overview Chart Databases. And now, a Few Words About Searching. How Database Content is Delivered

Assessing Atmospheric Releases of Hazardous Materials

Integrated Approaches to Testing and Assessment in Developmental Toxicology

Transcription:

CAS 79-01-6 C 2 HCl 3 131.4 1) -84.7 2) 87.2 2) 1.4642(20/4) 3) 69mmHg(25) 4) 1ppm=5.46mg/m 3 (20 ) 5) n- / 2.61 6) (log Pow) 7) 5) 1,280mg/L(25) 8) OH BOD 2.4 2 30mg/L 100mg/L 9) 44-1

BCF 4.317.0(6 70µg/L)4.016.0( 6 7µg/L) 9) 12 80,047t 26,555.667t 1,234.204t 1) 54,725.537t OECD 10,000t ( )() 1) 95 EUSES 2.1 2,400km 2 800 1 99.9 0.0002 0.0 0.0 2.2 44-2

44-3 µg/l µg/l µg/g µg/g 2.3 PEC 7mg/L 2mg/L µg/l µg/l µg/l µg/l µg/l µg/l µg/l 1 95 2 3.1

[µg/l] [] a b c No. 36,000Selenastrum capricornutum NOEC BMS 3 74,000Selenastrum capricornutum NOEC GRO 3 83,000Selenastrum capricornutum EC 50 BMS 3 95,000Skeletonema costatum EC 50 POP 4 15005 100,000Selenastrum capricornutum EC 50 GRO 3 175,000Selenastrum capricornutum NOEC GRO 4 10574 450,000Scenedesmus abundans EC 50 GRO 4 11677 2,100Daphnia magna NOEC REP 21 7,750Daphnia magna EC 50 IMM 2 11926 11,000Daphnia magna EC 50 IMM 2 14,000Mysidopsis bahia LC 50 MOR 4 15005 18,000Daphnia magna LC 50 MOR 2 5184 42,000Daphnia magna LC 50 MOR 2 2017 45,000Daphnia pulex LC 50 MOR 2 2017 57,000Daphnia cucullata LC 50 MOR 2 2017 1,900Oryzias latipes LC 50 MOR 2 12513 28,280Jordanella floridae LC 50 MOR 4 140 38,000Oryzias latipes LC 50 MOR 4 1,700Dugesia japonica LC 50 MOR 7 12513 1,700Dugesia japonica EC 50 GRO 7 12513 9,500Xenopus laevis EC 50 DEV 4 14733 45,000Xenopus laevis LC 50 MOR 2 9740 48,000Ambystoma mexicanum LC 50 MOR 2 9740 1,200,000Entosiphon sulcatum TT POP 3 5303 PNEC PNEC EC 50 Median Effective Concentration LC 50 Median Lethal Concentration NOEC No Observed Effect Concentration Toxicity Threshold) BMSBiomass: DEVDevelopment: GROGrowth IMM Immobilization MORMortality POPPopulation REPReproduction: PNEC Selenastrum capricornutum 72 EC 50 83,000 µg/l Daphnia magna 48 EC 50 11,000 µg/l Jordanella floridae 96 LC 50 28,280 µg/l Xenopus laevis 96 EC 50 9,500 µg/l 3 100 44-4

11,000 µg/l PNEC 110 PNEC 95µg/L Selenastrum capricornutum 72 NOEC 36,000 µg/l Daphnia magna 21 NOEC 2,100 µg/l 2 100 2,100 µg/l PNEC 21 µg/l PNEC 100 21 µg/l PECPNEC PEC/ PNEC µg/l µg/l 21 0.3 (1.8) µg/l µg/l µg/l µg/l µg/l0.095 1 95 2 3 4 3µg/L PEC 7µg/L 2 µg/l PEC PNEC 0.3 1998 2000 1.8 1) (2002)14102 2) Lide, D.R. (ed.). CRC Handbook of Chemistry and Physics. 79th ed. Boca Raton, FL: CRC Press Inc., 1998-1999.,p. 3-164. [Hazardous Substances Data Bank ( HSDB)] 44-5

3) Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996. 1643. [HSDB] 4) Boublik, T., Fried, V., and Hala, E., The Vapour Pressures of Pure Substances. Second Revised Edition. Amsterdam: Elsevier, 1984. 87. [HSDB] 5) (1997) ( ) 6) Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995. 4. [HSDB] 7),, (1984).;,, (1995). [ (1997) ( ) ] 8) Horvath AL et al; J Phys Chem Ref Data 28: 449 (1999). [HSDB] 9),,, (1992). 10) BUA Report 95 (1991). [ (1997) ( ) ] 11) IPCS, Environmental Health Criteria, 50 (1985). [ (1997) ( ) ] 2 1: 12 2: 3: 4: 2000 5: 2 3 U.S.EPAAQUIRE Ref. No. 140 : Smith, A.D., A. Bharath, C. Mallard, D. Orr, K. Smith, J.A. Sutton, J. Vukmanich, L.S. McCarty, and G.W. Ozburn (1991) : The Acute and Chronic Toxicity of Ten Clorinated Organic Compounds to the American Flagfish (Jordanella floridae). Arch. Environ. Contam. Toxicol. 20(1):94-102. 2017 : Canton, J.H., and D.M.M. Adema (1978) : Reproducibility of Short-Term and Reproduction Toxicity Experiments with Daphnia magna and Comparison of the Sensitivity of Daphnia magna with Daphnia pulex and Daphnia cucullata in Short-term Experiments. Hydrobiologia 59(2):135-140. 5184 : LeBlanc, G.A. (1980) : Acute Toxicity of Priority Pollutants to Water Flea (Daphnia magna). Bull.Environ.Contam.Toxicol. 24(5):684-691. 44-6

5303 : Bringmann, G., and R. Kuhn (1980) : Comparison of the Toxicity Thresholds of Water Pollutants to Bacteria, Algae, and Protozoa in the Cell Multiplication Inhibition Test. Water Res. 14(3):231-241. 9740 : Slooff, W., and R. Baerselman (1980) : Comparison of the Usefulness of the Mexican Axolotl (Ambystoma mexicanum) and the Clawed Toad (Xenopus laevis) in Toxicological Bioassays. Bull.Environ.Contam.Toxicol. 24(3):439-443. 10574 : Slooff, W., J.H. Canton, and J.L.M. Hermens (1983) : Comparison of the Susceptibility of 22 Freshwater Species to 15 Chemical Compounds. I.(Sub)Acute Toxicity Tests. Aquat. Toxicol. 4(2):113-128. 11677 : Geyer, H., I. Scheunert, and F. Korte (1985) : The Effects of Organic Environmental Chemicals on the Growth of the Alga Scenedesmus subspicatus: A Contribution to Environmental Biology. Chemosphere 14(9):1355-1369. 11926 : Abernethy, S., A.M. Bobra, W.Y. Shiu, P.G. Wells, and D. MacKay (1986) : Acute Lethal Toxicity of Hydrocarbons and Chlorinated Hydrocarbons to Two Planktonic Crustaceans: The Key Role of Organism-Water Partitioning. Aquat.Toxicol.8(3):163-174. 12513 : Yoshioka, Y., Y. Ose, and T. Sato (1986) : Correlation of the Five Test Methods to Assess Chemical Toxicity and Relation to Physical Properties. Ecotoxicol.Environ.Saf. 12(1):15-21. 14733 : Fort, D.J., E.L. Stover, J.R. Rayburn, M. Hull, and J.A. Bantle (1993) : Evaluation of the Developmental Toxicity of Trichloroethylene and Detoxification Metabolites Using Xenopus. Teratog.Carcinog.Mutagen. 13(1):35-45. 15005 : Ward, G.S., A.J. Tolmsoff, and S.R. Petrocelli (1986) : Acute Toxicity of Trichloroethylene to Saltwater Organisms. Bull.Environ.Contam.Toxicol. 37(6):830-836. (1996) 7 44-7