The concentration of a drug in blood. Exponential decay. Different realizations. Exponential decay with noise. dc(t) dt.

Similar documents
Stochastic differential equation models in biology Susanne Ditlevsen

Stochastic Differential Equations.

I forgot to mention last time: in the Ito formula for two standard processes, putting

Introduction to Diffusion Processes.

PROBABILITY: LIMIT THEOREMS II, SPRING HOMEWORK PROBLEMS

Stochastic Integration and Stochastic Differential Equations: a gentle introduction

Stochastic Calculus February 11, / 33

MA8109 Stochastic Processes in Systems Theory Autumn 2013

Stochastic Differential Equations

Lecture 4: Ito s Stochastic Calculus and SDE. Seung Yeal Ha Dept of Mathematical Sciences Seoul National University

PROBABILITY: LIMIT THEOREMS II, SPRING HOMEWORK PROBLEMS

Numerical methods for solving stochastic differential equations

Mathematical Methods for Neurosciences. ENS - Master MVA Paris 6 - Master Maths-Bio ( )

Stochastic Integration and Continuous Time Models

1. Stochastic Process

Lecture 4: Introduction to stochastic processes and stochastic calculus

MFE6516 Stochastic Calculus for Finance

SDE Coefficients. March 4, 2008

Lecture 12: Diffusion Processes and Stochastic Differential Equations

Bernardo D Auria Stochastic Processes /12. Notes. March 29 th, 2012

Verona Course April Lecture 1. Review of probability

Exercises. T 2T. e ita φ(t)dt.

The multidimensional Ito Integral and the multidimensional Ito Formula. Eric Mu ller June 1, 2015 Seminar on Stochastic Geometry and its applications

The Wiener Itô Chaos Expansion

n E(X t T n = lim X s Tn = X s

Stochastic Differential Equations

Itô s formula. Samy Tindel. Purdue University. Probability Theory 2 - MA 539

ELEMENTS OF PROBABILITY THEORY

Some Tools From Stochastic Analysis

Numerical Integration of SDEs: A Short Tutorial

Stochastic Calculus. Kevin Sinclair. August 2, 2016

Introduction. Stochastic Processes. Will Penny. Stochastic Differential Equations. Stochastic Chain Rule. Expectations.

Malliavin Calculus: Analysis on Gaussian spaces

Stochastic Modelling in Climate Science

Man Kyu Im*, Un Cig Ji **, and Jae Hee Kim ***

MATH4210 Financial Mathematics ( ) Tutorial 7

Nonlinear representation, backward SDEs, and application to the Principal-Agent problem

Clases 11-12: Integración estocástica.

Stochastic Calculus and Black-Scholes Theory MTH772P Exercises Sheet 1

B8.3 Mathematical Models for Financial Derivatives. Hilary Term Solution Sheet 2

Stochastic Calculus for Finance II - some Solutions to Chapter VII

Stochastic Differential Equations. Introduction to Stochastic Models for Pollutants Dispersion, Epidemic and Finance

Theoretical Tutorial Session 2

1. Stochastic Processes and filtrations

Continuous Time Finance

1 Brownian Local Time

Bernardo D Auria Stochastic Processes /10. Notes. Abril 13 th, 2010

p 1 ( Y p dp) 1/p ( X p dp) 1 1 p

Brownian motion. Samy Tindel. Purdue University. Probability Theory 2 - MA 539

Topics in fractional Brownian motion

HJB equations. Seminar in Stochastic Modelling in Economics and Finance January 10, 2011

Brownian Motion. 1 Definition Brownian Motion Wiener measure... 3

Stochastic contraction BACS Workshop Chamonix, January 14, 2008

Stochastic Calculus Made Easy

Tools of stochastic calculus

Fast-slow systems with chaotic noise

Week 9 Generators, duality, change of measure

Discretization of SDEs: Euler Methods and Beyond

A Short Introduction to Diffusion Processes and Ito Calculus

Introduction to numerical simulations for Stochastic ODEs

Question 1. The correct answers are: (a) (2) (b) (1) (c) (2) (d) (3) (e) (2) (f) (1) (g) (2) (h) (1)

Some Terminology and Concepts that We will Use, But Not Emphasize (Section 6.2)

Derivation of Itô SDE and Relationship to ODE and CTMC Models

Example 4.1 Let X be a random variable and f(t) a given function of time. Then. Y (t) = f(t)x. Y (t) = X sin(ωt + δ)

Finite element approximation of the stochastic heat equation with additive noise

Gaussian, Markov and stationary processes

B. LAQUERRIÈRE AND N. PRIVAULT

Interest Rate Models:

Brownian Motion. Chapter Definition of Brownian motion

Solutions to the Exercises in Stochastic Analysis

A Concise Course on Stochastic Partial Differential Equations

Backward martingale representation and endogenous completeness in finance

Rough paths methods 4: Application to fbm

3. WIENER PROCESS. STOCHASTIC ITÔ INTEGRAL

Functional Limit theorems for the quadratic variation of a continuous time random walk and for certain stochastic integrals

An Introduction to Malliavin calculus and its applications

Stochastic Calculus (Lecture #3)

Universal examples. Chapter The Bernoulli process

Exact Simulation of Multivariate Itô Diffusions

The Smoluchowski-Kramers Approximation: What model describes a Brownian particle?

MA50251: Applied SDEs

Brownian Motion and Poisson Process

Problem 1. Construct a filtered probability space on which a Brownian motion W and an adapted process X are defined and such that

APPLICATION OF THE KALMAN-BUCY FILTER IN THE STOCHASTIC DIFFERENTIAL EQUATIONS FOR THE MODELING OF RL CIRCUIT

From Random Variables to Random Processes. From Random Variables to Random Processes

Simulation and Parametric Estimation of SDEs

MATH 56A SPRING 2008 STOCHASTIC PROCESSES 197

Tyler Hofmeister. University of Calgary Mathematical and Computational Finance Laboratory

A NOTE ON STATE ESTIMATION FROM DOUBLY STOCHASTIC POINT PROCESS OBSERVATION. 0. Introduction

Malliavin Calculus in Finance

A Class of Fractional Stochastic Differential Equations

MSH7 - APPLIED PROBABILITY AND STOCHASTIC CALCULUS. Contents

An Overview of the Martingale Representation Theorem

The Pedestrian s Guide to Local Time

Session 1: Probability and Markov chains

Controlled Diffusions and Hamilton-Jacobi Bellman Equations

On pathwise stochastic integration

Lecture 12. F o s, (1.1) F t := s>t

13 The martingale problem

Stochastic Lagrangian Transport and Generalized Relative Entropies

Transcription:

The concentration of a drug in blood Exponential decay C12 concentration 2 4 6 8 1 C12 concentration 2 4 6 8 1 dc(t) dt = µc(t) C(t) = C()e µt 2 4 6 8 1 12 time in minutes 2 4 6 8 1 12 time in minutes 1 2 Exponential decay with noise Different realizations C12 concentration 2 4 6 8 1 dc(t) = µc(t)dt + σc(t)dw (t) C(t) = C() exp ( (µ + 1 2 σ2 )t + σw (t) ) C12 concentration 2 4 6 8 1 dc(t) = µc(t)dt + σc(t)dw (t) C(t) = C() exp ( (µ + 1 2 σ2 )t + σw (t) ) 2 4 6 8 1 12 time in minutes 2 4 6 8 1 12 time in minutes 3 4

Dynamic noise Motivating example: Population Dynamics Deterministic vs stochastic models A simple population growth model: Dynamic vs measurement noise Is the system deterministic or stochastic in nature? Irrelevant! N t : a t : dn t dt size of population at time t = a t N t ; N() = N (e.g. size of a tumor or concentration of a drug in blood) relative rate of growth (or decay) at time t 5 6 If a t = a is constant: N t = N e at Stochastic extension 2 N(t) 15 1 a> Maybe a t is not completely known, but subject to some random environmental effects: 5 a t a t + noise 5 1 15 2 time a< E.g. noise = σw t, W t = white noise, σ constant, a t = a constant 7 8

If a t = a + σw t : dn t = an t dt + σn t dw t or N t = N exp{(a σ 2 /2)t + σw t } sigma =.1 If a t = a + σw t : dn t = an t dt + σn t dw t or N t = N exp{(a σ 2 /2)t + σw t } sigma =.3 N(t) 4 6 8 1 12 N(t) 4 6 8 1 12 14 16 18 5 1 15 2 time 5 1 15 2 time 9 1 dn t dt = a t N t = (a + σw t )N t = an t + σn t W t Randomization of parameters Random variation in a parameter a: a a + σ noise We can write for a zero mean noise process. N t = N + an s ds + σn s dw s } {{ }?? A stochastic process: dx t dt = b(t, X t ) + σ(t, X t ) noise 11 12

Natural requirements: dx t dt = b(t, X t ) + σ(t, X t ) W t (1) Let = t < t 1 < < t n = t. Discretization of equation 1: W t1 and W t2 are independent for t 1 t 2 W t is a stationary process E[W t ] = for all t X k+1 X k = b(t k, X k ) t k + σ(t k, X k )W k t k This leads us to a white noise process where X j = X(t j ), W k = W (t k ), t k = t k+1 t k Replace W k t k by V k = V k+1 V k where {V t } t is a suitable stochastic process. 13 14 Our discretized version becomes: V t should have stationary, independent increments with mean. If we require V t to be continuous it turns out that only one solution exists: Brownian Motion B t k 1 k 1 X k = X + b(t j, X j ) t j + σ(t j, X j ) B j j= Is there a limit when t j? If so: j= Thus V t = B t. X t = X + b(s, X s )ds + σ(s, X s )db s } {{ }?? 15 16

Basic properties I Basic properties II B t is a Gaussian process: B t has independent increments: For all t 1 t k the random variable Z = (B t1,..., B tk ) has a multinormal distribution, and B t1, B t2 B t1,..., B tk B tk 1 E[B t ] = B ; Var[B t ] = t. are independent for all t 1 t k. 17 18 We also call it a standard Wiener process: W = {W t } t, Basic properties III a Gaussian process with independent increments for which W = w.p. 1, E[W t ] =, Var[W t W s ] = t s There exists a continuous version, so we simply assume that B t is such a continuous version. for all s t. It can be shown that any continuous time stochastic process with independent increments and finite second moments E[X 2 t ] for all t, is a Gaussian process if X t is Gaussian. 19 2

Construction of the Itô integral We will define Let us try the usual tricks from ordinary calculus: or more generally for S T. S f(s) dw s f(s) dw s define the integral for a simple class of functions extend by some approximation procedure to a larger class of functions 21 22 Assume f is a step-function of the form: f(t) = a j I {j/2 n,(j+1)/2 n }(t) j Then it will be natural to define S f(t) dw t = j a j [W tj+1 W tj ] Example: We want to calculate Problems!!! W t dw t Choose two different, but reasonable approximations: where k/2 n if S k/2 n T t k = S if k/2 n < S T if k/2 n > T f 1 (t) = j W tj I {j/2 n,(j+1)/2 n }(t) (Left end point) f 2 (t) = j W tj+1 I {j/2 n,(j+1)/2 n }(t) (Right end point) 23 24

But [ ] T E f 2 (t)dw t = j E[W tj+1 (W tj+1 W tj )] Then [ ] T E f 1 (t)dw t = j E[W tj (W tj+1 W tj )] = = E[W tj+1 (W tj+1 W tj )] j E[W tj (W tj+1 W tj )] j = j E[(W tj+1 W tj ) 2 ] since W t has independent increments. = j (t j+1 t j ) = T 25 26 It is natural to approximate a given function f(t) by a step-function of the form: The variations of the paths of W (t) are too big to define the integral in the ordinary sense. The problem is that a Wiener process W (t) is nowhere differentiable. Worse still: the sample paths have unbounded variation on any bounded time interval. f(t) f(t j ) I {tj,t j+1}(t) j where the points t j belong to the interval [t j, t j+1 ]. Define S f(t)dw (t) = lim n j f(t j ) [W tj+1 W tj ] 27 28

We just saw - unlike ordinary integrals - that it makes a difference what t j we choose!!! Two useful and common choices: The Itô integral: t j = t j, the left end point. The Stratonovich integral: t j = (t j + t j+1 )/2, the mid point. Heuristics Mathematics Itô vs Stratonovich integrals 29 3 Stochastic Differential Equations The process X solves dx t = b(x t, t)dt + σ(x t, t)dw t, X = U if dx t = b(x t, t)dt + σ(x t, t)dw t, W t = W (1) t.. W (m) t X t = b : R d R + R d σ : R d R + R d m X = U X (1) ṭ. X (d) t X (i) t = U (i) + for all i = 1,, d and t >. Necessary condition: for all t > ; σ 2 = tr σσ T. b i (X s, s)ds + m j=1 { b(x s, s) + σ(x s, s) 2 }ds < T denotes transposition of vectors and matrices. σ i,j (X s, s)dw (j) s 31 32

The Ito integral (Ω, F, {F t }, P ) Z stochastic process adapted to the filtration {F t }: Z t is F t -measurable for all t > W Wiener process with respect to {F t } W t is F t -measurable for all t > For t > s, W t W s is independent of {F s } and N(, t s)-distributed (W = ) Random adapted step function = t < t 1 < < t n = T partition of [, T ] Z t = A i for t i t < t i+1, i =,..., n 1 where A i is an F ti -measurable random variable, i =,..., n 1 E(A 2 i ) <, i =,..., n 1 Z t dw t = n Z ti 1 (W ti W ti 1 ) i=1 How can an integral Z t dw t be defined? 33 34 Z continuous adapted process It is not difficult to prove that ( ) T E Z t dw t = ( E ) 2 Z t dw t = n E(Zt 2 i 1 )(t i t i 1 ) i=1 Z s dw s is an {F t }-martingale E(Z 2 t )dt < = t (n) < t (n) 1 < < t (n) n = T a sequence of partitions of [, T ] satisfying that ( ) max t (n) j t (n) j 1 as n 1 j n Define an adapted step function by Z (n) t = Z t (n) i for t (n) i t < t (n) i+1, i =,..., n 1 Z (n) t dw t = n i=1 Z t (n) i 1 ( ) W (n) t W (n) i t i 1 35 36

The mean square limit of Z(n) t dw t as n exists and is almost surely unique. This limit defines the Ito integral Z (n) t dw t L 2 Z t dw t ( E ) 2 Z t dw t ( ) T E Z t dw t = =lim n n i=1 = ( ) ( E Z 2 t (n) t (n) i i 1 E(Z 2 t )dt Z s dw s is an {F t }-martingale t Z s dw s is continuous ) t (n) i 1 37 38 Some names In order to define the Ito integral it is sufficient that Z t dw t ( ) T P Zt 2 dt < = 1 In general the Ito integral is a local martingale only We call a stochastic process X t for: An Itô integral if X t = X + An Itô process or a stochastic integral if X t = X + bds + σdw s }{{}}{{} drift diffusion σdw s or dx t = σdw t or dx t = bdt + σdw t 39 4

X d-dimensional. Itô s formula: dx t = b(x t, t)dt + σ(x t, t)dw t, g : R d R + R X = U g(x, t) continuously differentiable w.r.t. t and twice continuously differentiable w.r.t. x Y t = g(x t, t) dy t = + 1 2 d i=1 g (X t, t)dx (i) t + g x i t (X t, t)dt m l=1 i,j=1 d 2 g σ i,l (X t, t)σ j,l (X t, t) (X t, t)dt x i x j Let d = 1 in The Itô formula dx t = b(t, X t )dt + σ(t, X t )dw t Let g(x, t) be twice continuously differentiable on R R +. Then Y t = g(x t, t) is again an Itô process, and { g dy t = t (X t, t) + 1 } 2 σ2 2 g x 2 (X t, t) dt + g x (X t, t)dx t 41 42 Calculate Example: Choose X t = W t and g(x, t) = 1 2 x2. Then W s dw s Y t = g(w t, t) = 1 2 W 2 t Apply Itô s formula: { g dy t = t (X t, t) + 1 2 σ2 2 g { = + 1 } dt + W t dw t 2 } x 2 (X t, t) dt + g x (X t, t)dx t Hence or Finally ( ) 1 dy t = d 2 W t 2 1 2 W 2 t = 1 2 t + = 1 2 dt + W tdw t W s dw s. W s dw s = 1 2 W 2 t 1 2 t. 43 44

Example: Let us return to the population growth model dn t = an t dt + σn t dw t Choose X t = N t and g(x, t) = log x. Apply Itô s formula: { g dy t = d(log N t ) = t (X t, t) + 1 } 2 σ2 (X t, t) 2 g x 2 (X t, t) dt + g x (X t, t)dx t { = + 1 2 σ2 Nt 2 ( 1 } Nt 2 ) dt + 1 dn t N t Hence Finally log N t = log N + (a 12 ) σ2 t + σw t N t = N exp {(a 12 ) } σ2 t + σw t = 1 2 σ2 dt + 1 (an t dt + σn t dw t ) N t = (a 12 ) σ2 dt + σdw t (Corresponding Stratonovich solution is N t = N exp {at + σw t }) 45 46 Exercise: Show that e Ws dw s = e Wt e W 1 2 e Ws ds Hint: apply Itô s formula with X t = W t and g(x, t) = e x 47