VPD Update for Week 36, 2015 Data as of 07 September 2015 Immunization and Vaccine Development (IVD) SEARO

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VPD Update for Week 36, 2015 Data as of 07 September 2015 Immunization and Vaccine Development (IVD) SEARO Protecting People from Vaccine Preventable Diseases

Last wild poliovirus case by type, SEAR WPV Type 2 District: Aligarh State: Uttar Pradesh (India) Date of onset: 24-Oct-1999 WPV Type 3 District: Pakur State: Jharkhand (India) Date of onset: 22-Oct-2010 WPV Type 1 District: Howrah State: West Bengal (India) Date of onset: 13-Jan-2011 Last wild poliovirus case by country Year Bangladesh 2006 Bhutan 1986 DPR Korea 1996 India 2011 Indonesia 2006 Maldives 1994 Myanmar 2007 Nepal 2010 Sri Lanka 1993 Thailand 1997 Timor-Leste 1995 *Dots are randomly placed within blocks (Sub-districts) Data as of 07 September 2015

Aug-14 Monthly Distribution of AFP Cases SEAR, 2014 2015 Sep-14 Oct-14 Nov-14 Dec-14 Jan-15 Feb-15 Mar-15 Apr-15 May-15 Jun-15 Jul-15 Aug-15 Sep-15 AFP cases by month of paralysis onset, last 14 months (data from weekly case-based reports) 2014 total AFP 2015 AFP to date Date of last report Bangladesh 1478 983 168 117 102 104 79 87 100 127 121 171 134 110 132 1 06-Sep-15 Bhutan 11 7 2 2 0 1 1 2 0 1 1 0 1 2 0 0 07-Sep-15 DPR Korea 115 71 11 2 15 17 9 15 5 14 3 6 10 11 7 0 03-Sep-15 India 53933 28880 6036 5749 4714 4568 3790 3901 3577 3446 3325 3532 3863 3915 3321 0 04-Sep-15 Indonesia 1765 699 87 158 165 170 125 152 104 112 92 78 103 26 32 0 03-Sep-15 Maldives 1 4 0 1 0 0 0 2 0 0 1 0 0 1 0 0 07-Sep-15 Myanm ar 389 160 47 42 29 24 26 22 21 17 15 27 19 25 14 0 07-Sep-15 Nepal 486 259 38 40 37 38 34 32 32 46 25 20 38 37 29 0 04-Sep-15 Sri Lanka 85 47 8 2 8 8 5 4 3 10 2 7 10 6 5 0 28-Aug-15 Thailand 238 103 18 11 19 25 26 14 5 12 16 16 16 17 7 0 28-Aug-15 Tim or-leste 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 31-Aug-15 TOTAL 58504 31213 6415 6124 5089 4955 4095 4231 3847 3785 3601 3857 4194 4150 3547 1 Data as of 07 September 2015

% NPEV Vaccine Wild Primary Culture Results from AFP Cases, 2014 Polio Laboratories Number of AFP cases with specimens received in Lab Positive Culture Positive Culture + NPEV AFP cases NPEV Only Negative Pending 1 <14 days >14 days Received by lab AFP specimens % Primary Culture Reports Within 14 days Specimens from other sources 2 Number received by lab Results Bangladesh IPH, Dhaka 1464 18 1 372 1073 0 0 2924 97.2 22.6 170 4 0 Bhutan NIH, Bangkok 11 0 0 1 10 0 0 22 100.0 9 0 0 0 DPRK NPL, Pyongyang 90 0 0 10 80 0 0 184 98.9 10.9 0 0 0 BJMC, Ahmedabad 7498 365 58 1713 5362 0 0 14979 99.4 18.5 0 0 0 NIV, Bengaluru 5157 235 36 1191 3695 0 0 10333 98.7 19.4 20 2 0 IoS, Kolkatta 8126 155 13 1128 6830 0 0 16232 93.8 10.6 5 0 0 India KIPM, Chennai 6515 140 14 1287 5074 0 0 13016 100.0 15.3 0 0 0 NCDC, Delhi 7759 351 19 1233 6156 0 0 15479 94.3 13.1 22 0 0 CRI, Kasauli 1918 56 3 245 1614 0 0 3843 98.2 11.4 5 0 0 SGPGI, Lucknow 10312 368 52 3363 6529 0 0 20624 97.2 25.2 10 0 0 ERC, Mumbai 5451 175 48 1537 3691 0 0 10929 97.0 24.9 201 15 0 India Sub Total 52736 1845 243 11697 38951 0 0 105435 97.1 17.9 263 17 0 Bio Farma, Bandung 540 0 0 39 501 0 0 1075 98.6 6.0 0 0 0 Indonesia NIHRD, Jakarta 599 7 0 55 537 0 0 1189 96.8 8.2 0 0 0 PHL, Surabaya 583 6 0 45 532 0 0 1160 99.8 6.2 0 0 0 Indonesia Sub Total 1722 13 0 139 1570 0 0 3424 98.4 6.8 0 0 0 Maldives MRI, Colombo 1 0 0 0 1 0 0 2 100.0 0 0 0 0 Myanmar NHL, Yangon 386 3 1 56 326 0 0 772 94.3 13.0 0 0 0 Nepal NIH, Bangkok 466 17 2 78 369 0 0 931 100.0 14.8 66 1 0 Sri Lanka MRI, Colombo 65 0 0 5 60 0 0 134 97.8 6.0 310 6 0 Thailand NIH, Bangkok 222 4 0 14 204 0 0 450 99.8 4.9 0 0 0 Timor-Leste NIH, Bangkok 3 0 0 0 3 0 0 4 100.0 0 0 0 0 SEAR 57166 1900 247 12372 42647 0 0 114282 97.1 17.6 809 28 0 1 Calculation based on date specimen received in laboratory subtracted from date result report to the national programme. 2 Stool samples collected from contact and healthy children survey. Data as of 07 September 2015

% NPEV Vaccine Wild Primary Culture Results from AFP Cases, 2015 Polio Laboratories Number of AFP cases with specimens received in Lab Positive Culture Positive Culture + NPEV AFP cases NPEV Only Negative Pending 1 <14 days >14 days Received by lab AFP specimens % Primary Culture Reports Within 14 days Specimens from other sources 2 Number received by lab Results Bangladesh IPH, Dhaka 979 13 1 210 696 58 1 1955 98.4 20.9 142 5 0 Bhutan NIH, Bangkok 6 0 0 0 6 0 0 12 100 0 0 0 0 DPRK NPL, Pyongyang 51 0 0 4 39 2 6 104 100 9.1 4 0 0 BJMC, Ahmedabad 4185 248 46 801 2857 233 0 8337 98.2 16.5 15 3 0 NIV, Bengaluru 2907 176 21 584 1968 158 0 5818 99.5 17.7 0 0 0 IoS, Kolkatta 3747 81 17 641 2960 48 0 7462 95.7 13.9 0 0 0 India KIPM, Chennai 3106 70 6 550 2480 0 0 6150 100.0 14.1 0 0 0 NCDC, Delhi 4392 232 10 623 3504 23 0 8749 89.7 12.1 0 0 0 CRI, Kasauli 1017 16 1 224 747 29 0 2044 98.9 20.2 0 0 0 SGPGI, Lucknow 5155 207 20 1062 3539 327 0 10289 99.1 17.5 0 0 0 ERC, Mumbai 2745 146 28 826 1745 0 0 5508 96.3 26.5 123 4 0 India Sub Total 27254 1176 149 5311 19800 818 0 54357 96.8 16.6 138 7 0 Bio Farma, Bandung 239 1 0 10 224 4 0 471 98 3.7 0 0 0 Indonesia NIHRD, Jakarta 201 2 0 24 167 6 2 400 100 10.9 0 0 0 PHL, Surabaya 245 1 0 19 213 12 0 489 100 6.0 0 0 0 Indonesia Sub Total 685 4 0 53 604 22 2 1360 99.4 6.6 0 0 0 Maldives MRI, Colombo 0 0 0 0 0 0 0 0 0 0 0 0 0 Myanmar NHL, Yangon 151 4 0 15 124 7 1 304 93 9.0 34 6 0 Nepal NIH, Bangkok 252 5 0 46 165 36 0 505 100 18.5 39 0 0 Sri Lanka MRI, Colombo 43 0 0 4 34 4 1 86 96 9.1 189 4 0 Thailand NIH, Bangkok 96 3 0 3 83 7 0 195 100.0 2.2 0 0 0 Timor-Leste NIH, Bangkok 0 0 0 0 0 0 0 0 0.0 0 0 0 0 SEAR 29517 1205 150 5646 21551 954 11 58878 96.7 15.7 546 22 0 1 Calculation based on date specimen received in laboratory subtracted from date result report to the national programme. 2 Stool samples collected from contact and healthy children survey. Data as of 07 September 2015

Wild Poliovirus Detected in Sewage Samples, 2014

Wild Poliovirus Detected in Sewage Samples, 2015 Data (NPSP) as of 04 Sep 2015

# Deaths # Tested for serology # Measles +ve # Rubella +ve Investigated # Deaths Neonatal Tetanus Diphtheria Pertussis Encephalitis Number of Cases of AEFI 2 Date of last report # reports expected % Completeness % Timeliness VPD Reporting, 2014 Routine Reporting of clinically suspected measles cases Suspected measles outbreaks Laboratory Confirmed 1 Number of Cases Measles Rubella Mixed Bangladesh 1668 0 1607 97 176 71 71 1368 0 9 178 11 166 2 31 105 13 12 NR 3490 15-Apr-15 12 100 100 Bhutan 69 0 69 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 35 18 18-Mar-15 12 75 75 DPR Korea 11 0 11 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13-Mar-14 12 8 8 India 54193 110 NR NR NR 1693 1013 34818 101 768 26113 110 4993 17 614 NR NR NR NR NR 19-Jun-15 12 8 0 Indonesia 12943 7 5719 1471 713 173 108 2104 21 80 803 7 69 3 13 75 421 NR NR NR 20-Apr-15 12 83 17 Maldives 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 15-Jan-15 12 42 25 Myanmar 242 0 242 8 24 7 7 236 0 3 102 1 5 0 0 32 35 3 0 34 20-Mar-15 12 83 75 Nepal 350 1 292 9 14 2 2 18 0 0 0 0 0 0 0 7 NR NR 1423 19 12-Feb-15 12 100 75 Sri Lanka 3117 0 2123 1560 10 1 1 10 0 0 0 1 10 0 0 0 0 81 191 6957 17-Mar-15 12 100 100 Thailand 1191 0 427 70 19 0 0 0 0 0 0 0 0 0 0 2 17 14 589 NR 22-Jan-15 12 83 25 Timor-Leste 47 1 40 25 1 2 2 33 1 2 20 0 0 0 0 1 2 3 6 3 23-Jan-15 12 8 0 Total 73831 119 10539 3240 961 1949 1204 38587 123 862 27216 130 5243 22 658 222 488 113 2244 10524 1 At least 5 blood samples should be collected and tested from each outbreak. 2 Adverse Events Follow ing Immunization; Sri Lanka AEFI data do not reflect cases but events. 3 Monthly VPD and AEFI reports due to SEARO/IVD on or before 15th of each month. NR=No report Data as of 31 May 2015

# Deaths # Tested for serology # Measles +ve # Rubella +ve Investigated # Deaths Neonatal Tetanus Diphtheria Pertussis Encephalitis Number of Cases of AEFI 2 Date of last report # reports expected % Completeness % Timeliness VPD Reporting, 2015 Routine Reporting of clinically suspected measles cases Suspected measles outbreaks Laboratory Confirmed 1 Number of Cases Measles Rubella Mixed Bangladesh 1372 0 1333 74 70 54 54 701 0 3 49 3 48 2 5 34 0 7 0 1251 12-Aug-15 7 100 100 Bhutan 44 0 44 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 5 10-Aug-15 7 57 57 DPR Korea 91 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 19-Aug-15 7 14 0 India 44219 146 NR NR NR 1641 824 19644 100 528 13305 72 2084 27 698 NR NR NR NR NR 18-Aug-15 7 43 14 Indonesia 2943 0 1659 257 265 25 3 330 0 11 73 3 75 0 0 NR NR NR NR NR 21-Aug-15 7 100 14 Maldives 9 0 9 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 08-Jun-15 7 57 29 Myanmar 150 0 150 2 26 0 0 0 0 0 0 0 0 0 0 14 52 2 0 143 12-Aug-15 7 100 86 Nepal 170 3 138 19 4 8 8 137 1 5 44 0 0 0 0 4 NR NR 374 1 13-Aug-15 7 100 86 Sri Lanka 1538 0 1011 798 1 1 1 53 0 1 53 0 0 0 0 0 0 33 73 5611 12-Aug-15 7 100 100 Thailand 184 0 184 4 17 2 2 35 0 0 0 2 35 0 0 0 4 16 249 NR 13-Jun-15 7 43 29 Timor-Leste 34 0 21 3 3 0 0 0 0 0 0 0 0 0 0 1 1 3 2 0 17-Aug-15 7 14 0 Total 50754 149 4549 1157 388 1731 892 20900 101 548 13524 80 2242 29 703 53 57 62 698 7011 1 At least 5 blood samples should be collected and tested from each outbreak. 2 Adverse Events Follow ing Immunization; Sri Lanka AEFI data do not reflect cases but events. 3 Monthly VPD and AEFI reports due to SEARO/IVD on or before 15th of each month. NR=No report Data as of 31 July 2015

Measles and Rubella Serology (IgM), 2014 # % # % Bangladesh Dhaka 2051 1992 143 7.2 221 12.0 99.6 Bhutan Thimphu 69 61 0 0.0 4 6.6 77.0 DPR Korea Pyongyang 55 55 2 3.6 0 0.0 100.0 India India Total Indonesia Indonesia Total Ahmedabad 468 468 306 65.4 25 15.4 99.6 Bengaluru 528 381 258 67.7 27 22.0 93.7 Bhopal 212 212 134 63.2 21 26.9 63.7 Chennai 796 263 150 57.0 20 17.7 86.7 Guw ahati 74 74 28 37.8 32 69.6 95.9 Hyderabad 138 138 103 74.6 3 8.6 95.7 Jaipur 289 289 205 70.9 17 20.2 95.2 Kolkata 1386 1386 752 54.3 281 44.3 0.0 Lucknow 683 623 496 79.6 15 11.8 62.8 Patna 171 171 117 68.4 11 20.4 66.7 Pune 889 869 570 65.6 38 12.7 91.6 5634 4874 3119 64.0 490 27.9 60.8 Bandung 902 902 369 40.9 231 43.3 96.1 Jakarta 4083 4027 1558 38.7 531 21.5 65.7 Surabaya 2860 2857 1718 60.1 189 16.6 44.5 Yogyakarta 2643 2643 661 25.0 394 19.9 58.3 10488 10429 4306 41.3 1345 22.0 60.6 Maldives Male 695 695 0 0.0 3 0.4 100.0 Myanmar Yangon 282 282 24 8.5 29 11.2 83.3 Nepal Kathmandu 328 328 8 2.4 15 4.7 97.3 Sri Lanka Colombo 2080 2054 1496 72.8 10 1.8 86.8 Thailand Bangkok 147 147 12 8.2 8 5.9 100.0 Timor-Leste Dilli NR NR NR NR NR NR NR TOTAL Laboratories Source: Reported by SEAR Measles Laboratory Netw ork 1 To be reported w ithin 4 days in 2014 - in transition state Number of Serum Samples Received Number Tested 21829 20917 9110 43.6 2125 18.0 69.6 NR=No Report Measles +ve Results Rubella +ve % Results Reported w ithin 7 Days 1 Data as of 31 January 2015

Measles and Rubella Serology (IgM), 2015 # % # % Bangladesh Dhaka 1654 1654 96 5.8 90 5.8 95.4 Bhutan Thimphu 44 44 0 0.0 0 0.0 100.0 DPR Korea Pyongyang NR NR NR NR NR NR NR India Indonesia Indonesia Total Ahmedabad 355 355 230 64.8 48 38.4 99.7 Bengaluru 402 336 142 42.3 102 52.6 100.0 Bhopal 174 174 130 74.7 11 25.0 96.0 Chandigarh 106 105 78 74.3 12 44.4 97.1 Chennai 583 162 104 64.2 21 36.2 92.6 Delhi 350 347 233 67.1 23 20.2 73.5 Guw ahati 215 157 121 77.1 9 25.0 96.8 Hyderabad 46 46 23 50.0 12 52.2 100.0 Jaipur 364 364 255 70.1 25 22.9 98.1 Kolkata 938 938 534 56.9 187 46.3 50.6 Lucknow 1976 1771 1254 70.8 85 16.4 63.9 Patna 451 446 287 64.3 30 18.9 83.4 Pune 485 407 259 63.6 36 24.3 87.5 6445 5608 3650 65.1 601 30.7 75.9 Bandung 866 807 228 28.3 351 60.6 88.0 Jakarta 2517 2132 562 26.4 466 29.7 75.6 Surabaya 1385 1275 487 38.2 183 23.2 63.8 Yogyakarta 1444 1362 137 10.1 386 31.5 83.7 6212 5576 1414 25.4 1386 33.3 76.6 Maldives Male 9 9 0 0.0 2 22.2 100.0 Myanmar Yangon 138 138 2 1.4 26 19.1 97.8 Nepal Kathmandu 236 236 57 24.2 10 5.6 97.9 Sri Lanka Colombo 1407 1043 817 78.3 1 0.4 89.6 Thailand Bangkok 122 122 2 1.6 13 10.8 100.0 Timor-Leste Dilli NR NR NR NR NR NR NR TOTAL India Total Laboratories Source: Reported by SEAR Measles Laboratory Netw ork 1 To be reported w ithin 4 days from 2014 - in transition state Number of Serum Samples Received Number Tested 16267 14430 6038 41.8 2129 25.4 80.3 NR=No Report Measles +ve Results Rubella +ve % Measles Results Reported w ithin 4 Days 1 Data as of 31 July 2015