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1 (i) (B) 20 P(Exactly 20 cured) = 0.78 0.22 20 20 0 = 0.0069 For 0.78 20 oe P(At most 18 cured) = 1 (0.0069 + 0.0392) For P(19) + P(20) Allow M2 for 0.9488 for linear interpolation from tables or for 1 0.9918 = 0.0082 and second for correct FT using answer to (i)(a) Zero for use of p = 0.8 here Not necessarily correct, but both attempts at binomial, including coefficient in (i) and no extra terms (such as P(X=18)) Condone use of p = 0.8 Allow 0.95 with working = 0.954 (0.95385) CAO (i) (C) E(X) = np = 20 0.78 = 15.6 CAO Do not allow final answer of 15 or 16 even if correct 15.6 given earlier [1] (ii) Let X ~ B(20, 0.78) Let p = probability of a patient being cured (for population) H 0 : p = 0.78 H 1 : p > 0.78 For definition of p For H 0 For H 1 In context See below for additional notes No further marks if point probabilities

P(X 19) = 0.0392 + 0. 0069 = 0.0461 * For NOTATION P(X 19) or P(X > 18) or 1 P(X 18) or 1 P(X < 19) CAO For 0.0461 allow 0.0462 used Notation P(X = 19) scores B0. If they have the correct P(X 19) then give and ignore any further incorrect notation. 0.0461 > 1% So not significant. Conclude that there is not enough evidence to suggest that the new drug is more effective than the old one. ALTERNATIVE METHOD FOR FINAL 5 MARKS P(X 19) = 0.0461 > 1% * E1 [8] For comparison with 1% If combination of methods used, mark both and give higher mark. For either probability FT answer to (i)b for following three marks provided based on 1 (P(19) + P(20)) Dep on sensible attempt at P(X 19) Allow accept H 0 or reject H 1 Must include insufficient evidence or something similar such as to suggest that ie an element of doubt either in the A or E mark. Must be in context to gain E1 mark. Do NOT allow sufficient evidence to suggest proportion cured is 0.78 or similar 99% method: P(X 18) = 0.9539 * CAO 0.9539 < 99% * then as per scheme No further marks if point probabilities used Do not insist on correct notation as candidates have to work out two probabilities for full marks.

Question Answer Marks Guidance P(X 20) = 0.0069 < 1% For at least one comparison with 1% So critical region is {20} (19 not in CR so) not significant. * Dep on correct CR Conclude that there is not enough evidence to suggest that the new drug E1* Ignore any work on is more effective than the old one. lower critical region 1 (iii) With a 5% significance level rather than a 1% level, the null hypothesis * oe would have been rejected. OR: there would be enough evidence to suggest that the new drug is more effective than the old one. This is because 0.0461 < 5% * oe * [2] CAO on the two correct probabilities Allow comparison in form of statement critical region at 1% level is No marks if CR not justified Condone X 20, X = 20, oe but not P(X 20,) etc Allow accept H 0 or reject H 1 FT their probability from (ii) but NO marks if point probabilities used There must be a sensible attempt to use P(X = 19) + P(X =20) or must have correct CR. Dep on correct answer of 0.0461 compared with 5% or 0.9539 compared with 95% or correct CR.

2 (i) (A) 2 (i) (B) X ~ B(15, 0.85) For 0.85 12 0.15 3 P(exactly 12 germinate) = 15 12 3 15 0.85 0.15 For 12 12 12 p 3 q = 0.2184 OR OR CAO from tables: 0.3958 0.1773 M2 For 0.3958 0.1773 = 0.2185 CAO P(X <12) = P(X 11) = 0.1773 For P(X 11) or P( 11) (With no extras) CAO (as final answer) May see alternative method: 0.3958 0.2185 = 0.1773 0.3958 - their wrong answer to part (i) scores A0 [2]

Question Answer Marks Guidance 2 (ii) Let p = probability of a seed germinating (for the population) For definition of p See below for additional notes H 0 : p = 0.85 For H 0 (iii) H 1 : p < 0.85 H 1 has this form because the test is to investigate whether the proportion of seeds which germinate is lower. Let X ~ B(20, 0.85) P(X 13) = 0.0219 0.0219 > 1% So not enough evidence to reject H 0. Not significant. Conclude that there is not enough evidence to indicate that the proportion of seeds which have germinated has decreased. E1 [4] * * * E1 * For H 1 Dep on < 0.85 used in H 1 Do not allow just Germination rate will be lower or similar. For probability (provided not as part of finding P(X = 13)) Ignore notation For comparison For not significant oe For conclusion in context Must mention decrease, not just change For use of 0.15 as P(not germinating), contact team leader E0 for simply stating H 1 in words No further marks if point probs used - P(X = 13) = 0.0160 DO NOT FT wrong H 1, but see extra notes Allow accept H 0 or reject H 1 Must include sufficient evidence or something similar such as to suggest that ie an element of doubt either in the A or E mark. ALTERNATIVE METHOD follow method above unless some mention of CR seen Critical region method No marks if CR not justified Condone {0,1,2,, 12}, X 12, oe but not P(X 12) etc LOWER TAIL P(X 13) = 0.0219 > 1% P(X 12) = 0.0059 < 1% So critical region is {0,1,2,3,4,5,6,7,8,9,10,11,12} 13 not in CR so not significant There is insufficient evidence to indicate that the proportion of seeds which have germinated has decreased. * E1 * [4] For either probability cao on at least one correct comparison with 1% Could get A0E1 if poor notation for CR Do not allow just 13 not in CR - Must say not significant or accept H 0 or similar

Question Answer Marks Guidance 2 (iv) 33 < 35 For comparison Allow 33 lies in the CR Must include sufficient evidence or something similar such as to suggest that ie an element of doubt either in the A So there is sufficient evidence to reject H 0 * or E mark. Do not FT wrong H 1 : In part (iv) ignore any interchanged H 0 and H 1 seen in part (ii) (v) Conclude that there is enough evidence to indicate that the proportion of seeds which have germinated has decreased. E1* For n = 3, P(X 0) = 0.0034 < 0.01 For n = 2, P(X 0) = 0.0225 > 0.01 So the least value of n for which the critical region is not empty and thus H 0 could be rejected is 3. ALTERNATIVE METHOD using logs 0.15 n < 0.01 n > log 0.01 / log 0.15 n > 2.427 Least n = 3 For conclusion in context Must mention decrease, not just change For P(X 0) = 0.0034 For P(X 0) = 0.0225 CAO If use a calculator to find P(X 33) = 0.000661 and compare with 1% then B2 for P(X 33) = 0.000661 < 0.01 so reject H 0 then final E1 as per scheme. Allow 0.003 Condone just n = 3 for final A mark on both M marks If wrong H 1 allow max M2A0 if correct probabilities seen.

3 (i) 11 Seen 3 = 165 Cao [2] (ii) 5 6 5 6 2 1 3 0 60 10 70 14 = 0.424 11 11 165 165 165 33 3 3 Alternative 5 6 5 6 5 4 1 P(1 or 0) = 1 3 11 10 9 11 10 9 5 4 = 1 = 14 11 33 33 For intention to add correct two fractional terms For numerator of first term For numerator of sec term Do not penalise omission 6 of 0 Or For attempt at correct two terms For prod of 3 correct fractions =4/33 For whole expression ie 5 4 6 4 3 (= 3 0.1212 ) 11 10 9 11 for 1 P(1 or 0), for first product, for 3, for second product, [5] For correct denominator cao For attempt at 5 4 3 2 11 10 9 33 cao Use of binomial can get max first