University of Groningen Action and Function of coagulation FXa on cellular signaling Borensztajn, Keren Sarah IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2009 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Borensztajn, K. S. (2009). Action and Function of coagulation FXa on cellular signaling. s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 20-04-2019
Action and Function of Coagulation Factor Xa on Cellular Signaling 1
The study described in this thesis was performed at the: Center for Experimental and Molecular Medicine, Academic medical center, Amsterdam, The Netherlands Department of cell biology and immunology, University Medical Center Groningen, Rijksuniversiteit Groningen, Groningen, the Netherlands Hopital Trousseau, Paris, France The printing of this thesis was financially supported by the University of Groningen and the University Medical Center Groningen, the Netherlands Printed by Proefschriftmaken.nl 2
RIJKSUNIVERSITEIT GRONINGEN Action and Function of Coagulation Factor Xa on Cellular Signaling Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op woensdag 1 april 2009 om 16.15 uur door Keren Sarah Borensztajn geboren op 1 oktober 1974 te Parijs, Frankrijk 3
Promotores : Copromotor : Prof. dr. M.P. Peppelenbosch Prof. dr. S. Amselem Dr. C. A. Spek Beoordelingscommissie : Prof. dr. R H. Henning Prof. dr. G. Molema Prof. dr. L.F.M.H. de Leij ISBN: 978-90-367-3737-1 4
To François To Henri 5
Contents 1 Preface : aim of this thesis 9 2 Borensztajn K, Spek CA 13 Inherited coagulation factor VII and X deficiencies associated with severe bleeding diathesis: Molecular Genetics and Pathophysiology. Curr. Genom. (2005) 6 : 383-400 3 Borensztajn K, Sobrier ML, Duquesnoy P, et al. 33 Oriented scanning is the leading mechanism underlying 5 ' splice site selection in mammals. PLoS Genetics (2006) 2 : 1297-1306 4 Borensztajn KS, Versteeg HH,, Kerver ME et al. 45 TF:VIIa-specific activation of CREB upregulates proapoptotic proteins via PAR2. J Thromb Haemost (2008) 9 :1550-7 5 Borensztajn K, Peppelenbosch MP. Spek CA. 55 Factor Xa: at the crossroads between coagulation and signaling in physiology and disease. Trends in Molecular Medicine (2008) 10 :429-40. 6 Borensztajn KS, Bijlsma MF, Groot AP, et al. 69 Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation. Exp Cell Res. (2007) 313: 2622-33. 7 Borensztajn K, Bijlsma MF, Stiekema J et al. 83 Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation. In preparation 8 Borensztajn K, Parikh K, Ruela de Souza RR, et al. 109 Kinome profiling of factor VIIa, Xa, and IIa-dependent signalling defines common and coagulation factor-unique signalling. In preparation 6
9 Borensztajn K, Stiekema J, Nijmeijer S et al. 129 Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via Protease Activated Receptor-2 activation. Am. J. Pathol. (2008) 172:309-20. 10 Borensztajn K, Aberson H, Peppelenbosch MP et al. 143 Factor Xa-induced pro-angiogenic phenotype in fibroblasts: effect on fibrosis correlates with aberrant neoangiogenesis. BBA Mol Cell Res. In press 11 Summarizing discussion 153 12 Nederlandse Samenvatting and Acknowledgements 161 13 Publications 167 7
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