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mm ) 2 25 2 15 1 5 ) PGE (ng/ g 2 8 6 4 2 75 6 45 15 GBF AT ULC ER M ARGIN (% c ontrol) Initial ( day) Veh Diabetes Veh Diabetes ROFECOXIB (5 mg/kg-d i.g.).ec! -BBA?J BJDAJHA=J A JMEJDLADE? AI= E A= @H BA? NE># C C @E C JDA=HA= B C=IJHE?K?AHE @K?A@>O=?AJE?=?E@=J@=OKF K?AHE @K?JE = @JDA=?? F= OE C?D= CAI E JDAC=IJHE? K? I= > @B M/.= @JDACA AH=JE B2/- E JDAC=IJHE? K? I=E H=JI MEJD@E=>AJAIE @K?A@>OIE C AE A?JE BIJHAFJ?E 56 % C CE F A= 5- BH $ &H=JIFAHCH KF )IJAHEI A= I=IEC EBE?= J?D= CABH JDA? HHAIF @E CL= KAE LADE? A JHA=JA@ @E=>AJE?H=JI H II@A JAI=IJ=JEIJE?= OIEC EBE?= J@EBBAHA?ABH JDA? HHAIF @E C L= KAIE @E=>AJE?H=JIMEJD KJH BA? NE>=@ E EIJH=JE
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