SciFinder Premier CAS solutions to explore all chemistry MethodsNow, PatentPak, ChemZent, SciFinder n

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ACS International Ltd vhyttinen@cas.org SciFinder Premier CAS solutions to explore all chemistry MethodsNow, PatentPak, ChemZent, SciFinder n Veli-Pekka Hyttinen May 23, 2018 CAS Hyttinen

CAS supports the mission of the ACS ACS Mission To improve people s lives through the transforming power of chemistry. CAS Mission To provide the world s best digital research environment to search, retrieve, analyze and link chemical information.

CAS scientists analyze, summarize and make scientific information accessible to colleagues worldwide Source Selection Document Indexing Reaction Indexing Markush Indexing Authority Processing Proprietary, standardized indexing in CAS databases ensures consistent, comprehensive search results. 3

CAS scientists find the chemistry, and save you time! CAS RN 203796-03-6 4

Percentage of Total Increasingly, new compounds in the literature are first disclosed in patents 100% Percentage of New Compounds from Patents 80% 60% 77% 40% 20% 00% 14% 1976 2015 Year 5

6 CAplus coverage of patents from Asia is unmatched Japanese Patent Office (JP) China (CN) Republic of Korea (KR) India (IN) Taiwan (TW) Hong Kong (HK) Philippines (PH) Singapore (SG) Malaysia (MY)

CAS analyzes the world s disclosed research to keep SciFinder the most valuable tool supporting your organization s research enterprise 47 million+ Literature References Plus integrated access to 25 million records in the MEDLINE database from the U.S. National Library of Medicine gives you access to the world s most authoritative disclosed chemistry and related sciences content. 67 million+ protein and nucleic acid sequences 63 Patent Authorities 25% more than any other scientific information provider 143 million+ uniquely identified organic and inorganic substances Ranging from the largest proteins to the smallest molecules Data as of March 2016 7

SciFinder saves you time by delivering valuable information to advance your research PatentPak TM Efficient access to 14 million indexed patents including location 6.8 million+ experimental reaction procedures with 0.9 million added in the last year alone! 1.4 million experimental spectra >100,000 protons and carbon-13 NMR additions 106+ million Single and multistep reactions and synthetic preparations > 4.5 million experimental properties r ChemZent TM Collection of 3 million German abstracts published from 1830-1969 MethodsNow TM Immediate access to 5 million detailed experimental methods Data as of March 2016 8

SciFinder EXPLORE REFERENCES curated and indexed 47+mill CAplus references from 10,000+ journals and 63 patent offices; and 25+mill MEDLINE references from 5,000 journals c c c 9

10 Get References Quick View

SciFinder EXPLORE SUBSTANCES 143+ million organic and inorganic small molecules, 67+ million bio sequences and 1,1+ million MARKUSH structures from patents structures; names, molecular formulae 11

SciFinder EXPLORE REACTIONS 106+ million reactions/synthetic preparations by substructures, CAS Nr, InChi, Smiles c 12

Categorize and analyze options make it easy to find relevant information 13

14

Step-by-step experimental protocols 15

Chemisches Zentralblatt predates the introduction of Chemical Abstracts by almost 80 years Published German language abstracts from 1830-1969 Chronicles the birth of chemistry as a science Before 1800, chemistry was more alchemy (i.e. how to turn lead into gold) than actual science Searchable substance structures in 3 million machine translated abstracts First Issue: Note, the name changed several times before 1856 16

SciFinder-n Get to actionable results more quickly with a streamlined new interface Streamlined search navigation saves you clicks Immediately run past searches More conveniently search structures and text Copyright 2017 American Chemical Society. All rights reserved. 17

SciFinder-n Information presented to facilitate rapid understanding Powerful filtering capabilities allow rapid focus Intuitive information layouts fosters quick comprehension Copyright 2017 American Chemical Society. All rights reserved. 18

One idea can lead you to another - SciFinder n has you covered! Simultaneous searches can be performed in new browser/windows Copyright 2017 American Chemical Society. All rights reserved. 19

SciFinder-n Citation Mapping helps you understand where to go next in your literature review Interactive map allows speedy identification of important research (maybe even that one paper you wouldn t otherwise find!) Copyright 2017 American Chemical Society. All rights reserved. 20