CENTRO ESCOLAR UNIVERSITY Biological Sciences Department Manila*Malolos*Makati SYLLABUS PRBS 131 BIOSCI131 CELL BIOLOGY 3 units 3 hours lec Course Number Course Title Descriptive Title Credit Unit(s) Hour(s)/Week I. COURSE DESCRIPTION This course deals with the study of cells in higher organisms, specifically a discussion of the following: molecules that make up cells and their interactions; structures of the cells and their functions; cell growth and oncogenic transformation transport and cell signaling and communications; cytoskeleton and the extracellular matrix; chromatin structure and RNA synthesis; genetic mechanisms of heritability of characteristics; and cell movements. II. COURSE OBJECTIVES A. General Objectives: Determine structures and functions that make the cell as a vital unit of the organism. B. Specific Objectives: 1. Seeks to explain the physiologic changes in living things as affected by their physico-chemical and metabolic processes of cellular parts; 2. Find out how the organelles perform their roles in the maintenance and sustenance of life; 3. Relate how this unit of structure of living things is affected by real life conditions. Page 1 of 6
Licensure Exam for Teachers (LET) Table of Specification (TOS) Competencies 1. Describe the development of Cell Theory 2. Differentiate prokaryotic from eukaryotic cell 3. Compare the structure and function of a plant and an animal cell 4. Explain the process of transporting materials into and out of cell 5. Describe the basic processes of mitosis and the result of its malfunction 6. Describe the basic processes in meiosis SPECIFIC OBJECTIVES CONTENT OUTLINE TEACHING STRATEGIES Prepare a model of prokaryotic and eukaryotic cells using modeling clay as medium. Describe the different model organisms and identify their applications in cell biology studies. Unit I - INTRODUCTION TO CELLS 1. Unity and diversity of the cells 2. Cells under the microscope 3. Prokaryotic cells 4. Eukaryotic cells 5. Model organisms Preparing models of various cell types Discuss the various molecules and macromolecules and their functions in the biological system. Unit II- CHEMICAL COMPONENTS OF THE CELLS 1. Molecules in cells 2. Macromolecules in cells Page 2 of 6
SPECIFIC OBJECTIVES CONTENT OUTLINE TEACHING STRATEGIES PRELIM EXAMINATION Explain the various pathways of metabolism in prokaryotic and eukaryotic cells. Unit III- BIOCHEMICAL ENERGETICS 1. The use of energy by the cells 2. Enzymes as biological catalysts 3. Metabolism Unit IV- STRUCTURE OF THE BIOLOGICAL MEMBRANE Video Presentation Concept Mapping Understand the role of the biological membrane in various physiological activities of the cell. Prepare a concept map to explain the mechanisms by which nerve impulses are generated. 1. The chemical composition of membranes 2. Principles of membrane transport 3. Transporters and their functions 4. Movement of substances across the membrane 5. Ion channels and membrane potentials 6. Membrane potentials and nerve impulses Unit V- ENERGY GENERATION & MITOCHONDRIA Compute for the total energy generated in aerobic respiration in prokaryotes and eukaryotes. 1. Mitochondrial structure and function 2. Oxidative metabolism in the mitochondrion 3. The role of mitochondria in ATP synthesis 4. Proton- motive force and the machinery of ATP formation Page 3of 6
SPECIFIC OBJECTIVES CONTENT OUTLINE TEACHING STRATEGIES Prepare a schematic diagram to illustrate the different stages and enzymes involved in photosynthesis. Unit VI- PHOTOSYNTHESIS & THE CHLOROPLAST 1. Overview of the photosynthetic mechanism 2. Photosynthetic units and reaction centers 3. Photophosphorylation 4. Carbon dioxide fixation and the synthesis of carbohydrates Video Presentation Concept Mapping MIDTERM EXAMINATION Unit VII- CELL COMMUNICATION Discuss the different types of receptors involved in cell signaling. 1. General principles of cell signaling 2. G- protein coupled receptors 3. Enzyme- coupled receptors Construct a table that shows the differences among the different types of filaments that make up the cytoskeleton. Prepare a flowchart to discuss the process of muscle contraction. Unit VIII- CYTOSKELETON & CELL MOTILITY 1. Microtubules 2. Intermediate filaments 3. Microfilaments 4. Muscle contractility Unit IX- THE CELL DIVISION CYCLE Create a visual representation of the cell division cycle in eukaryotic cells. 1. Overview of the cell cycle 2. Cell cycle control system Page 4of 6
SPECIFIC OBJECTIVES CONTENT OUTLINE TEACHING STRATEGIES 3. S Phase 4. M Phase 5. Cytokinesis 6. Control of cell number and cell size Video Presentation Prepare a model to illustrate the process of DNA replication and repair. Unit X- DNA REPLICATION & REPAIR 1. DNA Replication 2. DNA Repair Concept Mapping 3 hours Report journal articles that features genes involved in cancer. Discuss how stem cells can be used in the treatment of cancer. Unit XII.- STEM CELLS AND CANCER 1. Tissue maintenance and renewal 2. Basic properties of cancer cells 3. The causes of cancer 4. The genetics of cancer Unit XIII- THE IMMUNE RESPONSE Special reports Construct a concept map which illustrates the activation of the pathways of complementary system. Demonstrate how MHC plays an important role in activation of T lymphocytes. Prepare a model that shows the different types of antibodies. 1. An overview of the immune response 2. The complementary system 3. Major Histocompatibility Complex 4. Activation and mechanism of action of T lymphocytes 5. Signal transduction pathway in lymphocyte activation 6. The clonal selection theory 7. Structure of Antibodies FINAL EXAMINATION Page 5 of 6
III. READING MATERIALS Books: Alberts, Bruce. et al, 3 rd Edition. Essential Cell Biology. New York: Garland Science, 2010 Tompkins, Susan, 2010. Cell Biology. Oakville, On: Apple Academic Press, 2010. Karp, Gerald C. Molecular Biology Concepts and Experiment 6 th Edition. Wiley & Sons, Inc. c 2010 Prasad, S. N. Cell Biology. New Delhi: Campus Books International, 2008 Journals Advances in Molecular Biology Biochemistry & Cell Biology BMC Cell Biology Cells DNA & Cell Biology International Journal of Cell Biology Journal of Cell & Molecular Biology Nature Cell Biology Nature Reviews Molecular Cell Biology Prepared by: Approved by: Dr. Maricar W. Ching Faculty (Cell Biology) Dr. Zenaida D.R. Los Baños Head, Biological Sciences Department Date Approved: Page 6 of 6