Biology 2020 PRINCIPLES OF CELL BIOLOGY Spring 2004 In Principles of Cell Biology, we will explore the structure, function, and evolution of living cells, including prokaryotes (archae and eubacteria) and eukaryotes (plants, animals and fungi). Instructor: Dr. Darryl Kropf 203 S. Biology 581-5432 kropf@bioscience.utah.edu ; please put cell biology in subject line Lectures are held M/W from 11:50 AM 1:10 PM in ASB 220. Note that lectures are 80 min periods. This is a 3 hour class. The University of Utah Policies and Procedures, Chapter VII section 2, defines one credit hour as:...approximately three clock hours of the student's time a week for one semester... and section 3F states: At the University of Utah we assume that there is at least one hour in class and two hours outside of class per week or the equivalent combination connected to every credit hour.. Accordingly, you should expect to spend a total of approximately nine hours per week on this course, including attendance at lectures and discussion sections, assigned reading, and problem sets. Texts: Alberts et al., Essential Cell Biology SECOND EDITION (Garland Publishing). The text is available at the University bookstore. In addition, multiple copies of the text will be placed on general reserve at Marriot library. Teaching assistants: five teaching assistants will be available for consultation: T.A.s: Phone: e-mail: Office hours: Mark Hansen 7-9262 msh10@utah.edu W1:10-2 206 Bldg44 W3-4, 306 SB Joshua Plant 1-7393 jjplant@hotmail.com W10:45-11:35, F10:40-11:30; 208 SB Dan Richardson 5-1823 dan.richardson@hci.utah.edu W10:40-11:40 206 Bldg44 TH10:40-11:40 206 Bldg44 Kevin Rigby 1-6713 kevin.rigby@hsc.utah.edu TH2-3; F2-3 306 SB Mary Lou Spencer mls15@utah.edu TU10:45-11:35, TH10:45-11:35 306 SB *TAs are also available by appointment. SB is the South Biology building. ASB is the Aline Skaggs Biology building. LS is the Life Sciences Building Dr. Kropf will hold office hours M 2-4 pm. 1
Assigned reading: Students will be responsible for all material covered in the reading assigned from the text [Alberts et al., Essential Cell Biology (ECB)2 nd edition] or other supplementary sources. Problem sets: Problems and questions for thought are included with each chapter of ECB. Answers to problems from ECB are provided at the back of the book. Discussion sections: When registering for this course, you signed up for one of eight discussion sections. Due to the large enrollment, there are now 10 discussion sections, two each day. These T.A.-led discussion sections are OPTIONAL, and you may attend any or all of them, at your discretion. Mondays TA 10:45 AM-11:35 AM 212 South Biology (SB) MH 02:00 PM-02:50 PM 212 SB MLS Tuesdays 3:00PM-3:55PM 212 SB JP Wednesdays 9:40AM-10:30AM 212 SB DR 2:00PM-2:50PM 212 SB MH Thursdays 9:40AM-10:30AM 212 SB DR 12:55PM-1:45PM 212 SB KR Fridays 8:35AM-9:25AM 212 SB MLS 12:55PM-1:45PM 212 SB KR Saturdays 12-1 212 SB JP Booklet: The syllabus, contact information, lecture slides and reading assignments are all provided in a booklet for sale by BioSac. All proceeds go to BioSac. Exams: There will be three in-class mid-term exams, the first two are tentatively scheduled for February 11 and March 8 (we will try and provide a weeks notice if the exam schedule changes). Mid-term exams will be 80 minutes in length. 2
A 2 hr final exam is scheduled for Friday, April 30 at 10:30 AM. -12:30 PM. All exams will be closed book. In general, there will be no make-up exams. A missed exam will be given a score of 0. Requests to reschedule an exam will only be granted for medical or legal reasons, and will require a written note from a medical doctor or officer of the law. Grading policy: After dropping the lowest exam score, the top three exam scores will be added and used to determine final grades. A missed exam will automatically count as the dropped score. Grades will be assigned according to a curve. Drop policy: The drop policy of this class is consistent with that of the University: the last day to drop (delete) classes is Wednesday, January 21. Classes dropped before this date will not appear on transcripts. The last day to withdraw from classes is Friday,Feb. 6. A W will appear on transcripts. A.D.A. policy: The University of Utah seeks to provide equal access to its programs, services, and activities for people with disabilities. If you will need accommodations in this class, reasonable prior notice needs to be given to the instructor and to the Center for Disability Services, 162 Olpin Union Building, 581-5020 (V/TDD) to make arrangements for these accommodations. All written information in this course can be made available in alternative format with prior notification. 3
Biol 2020 LECTURE SCHEDULE Spring 2004 The following schedule of lectures and reading may change during the course of the semester. Week 1 Lec. 1 Jan. 12 Lec. 2 Jan. 14 Week 2 Jan. 19 Lec. 3 Jan. 21 Week 3 Lec 4 Jan. 26 Lec 5 Jan 28 Week 4 Lec 6 Feb. 2 Lec 7 Feb. 4 Week 5 Lec. 8 Feb. 9 Lecture topic and assigned reading: Course organization (grading, etc.). What is a cell? Diversity of cell form and function. ECB 1: 1-35. Prokaryotes vs. eukaryotes. An introduction to the structure, function, and evolution of organelles in eukaryotic cells. How do we look at cells: light and electron microscopy. ECB 1: 1-35; 7: 258-262 (origin of life). MLK Jr. Holiday Chemistry: Chemical composition of cells bonds, elements, water. Basic groups of macromolecules; polysaccharides ECB 2: 39-61; panels 2-1 to 2-3 (pp 66-71). Molecules: Membranes: Lipids, lipid diversity, membrane fluidity, permeability, other membrane components. Introduction to proteins. ECB 2: 53-55; 11: 365-374; and 4: 119-144. Molecules: Protein structure and function: catalysis and thermodynamics Membrane proteins and membrane transport. ECB 4: 145-158; 3: 91-105; and 12: 374-385, 389-404. Overview of energy production, catalysis, and biosynthesis. Energy carrying molecules. ATP synthase. 3: 106-112; and 14: 460-466. Photosynthesis, light and dark reactions. Respiration, mitochondrial electron transport. ECB 14: 478-492, 453-477. Glycolysis, Citric Acid Cycle, ß-Oxidation glyoxylate cycle. Global warming ECB 4: 119-124; 110-119. 4
Week 5 Feb 11 First midterm exam on February 11 Week 6 Feb. 16 Lec. 9 Feb. 18 Week 7 Lec. 10 Feb. 23 President s Day Holiday Central Dogma -- DNA > RNA > protein, DNA Structure. DNA Organization: chromosomes to genes. ECB 2: 56-58, 5:169-191, 6:195-20 Replication, Mutation, DNA Repair, Transcription, Prokaryotic Transcription. ECB 6: 195-214; 7:229-235; 8:271-275. Lec. 11 Feb. 25 Eukaryotic Transcription; Gene Organization, RNA Processing; ECB 8: 275-289; and 7: 236-243 and 7: 258-262 Week 8 Lec. 12 Mar. 1 Lec. 13 Mar. 3 Translation. ECB 7: 243-259. Genes, Genomes and Biotechnology ECB 10; 323-360 Week 9 Mar. 8 Second midterm exam on March 8 5