Organocatalytic Doubly Annulative Approach to 3,4-Dihydrocoumarins Bearing a Fused Pyrrolidine Scaffold Dorota Kowalczyk, and Łukasz Albrecht* Institute of Organic Chemistry, Chemistry Department, Lodz University of Technology Żeromskiego 116, 90-924 Łódź, Poland E-mail: lukasz.albrecht@p.lodz.pl Supporting Information 1. General methods S2 2. Screening results S3 3. X-ray data for diethyl (3R,3aS,9bR)-3-(4-methoxyphenyl)-8-nitro-4-oxo-1,3a,4,9btetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate 3s S5 4. NMR data S7 5. HPLC traces S31
1. General methods NMR spectra were acquired on the instrument, running at 700 MHz for 1 H and 176 MHz for 13 C, respectively. Chemical shifts (δ) are reported in ppm relative to residual solvent signals (CDCl 3: 7.26 ppm for 1 H NMR, 77.16 ppm for 13 C NMR). Mass spectra were recorded on a spectrometer (qtof) using electrospray (ES+) ionization. Optical rotations were measured on a polarimeter and [ ] D values are given in deg cm g -1 dm -1 ; concentration c is listed in g (100 ml) -1. Analytical thin layer chromatography (TLC) was performed using pre-coated aluminum-backed plates and visualized by ultraviolet irradiation or I 2 stain. The enantiomeric ratio (er) of the products was determined by chiral stationary phase HPLC. Unless otherwise noted, analytical grade solvents and commercially available reagents were used without further purification. For flash chromatography (FC) silica gel (Silica gel 60, 230-400 mesh) was used. Diethyl 2-hydroxyarylideneaminomalonates 1 and diethyl β,γ-unsaturated-α-ketophosphonates 2 were prepared according to literature procedures. 1 Cinchona-alkaloid-derived catalysts 4a,b,h 2 and 4c 3 were synthesized following the literature procedures. 1 (a) Tian, L.; Xu, G.-Q.; Li, Y.-H.; Liang, Y.-M.; Xu, P.-F. Chem. Commun. 2014, 50, 2428. (b) Evans, D. A.; Johnson, J. S.; Olhava, E. J. J. Am. Chem. Soc. 2000, 122, 1635. 2 (a) Yang, W.; Du, D.-M. Org. Lett. 2010, 12, 5450. (b) Vakulya, B.; Varga, S.; Csámpai, A.; Soós, T. Org. Lett. 2005, 7, 1967. 3 Liu, X.; Li, H.; Deng, L. Org. Lett. 2005, 7, 167. S2
2. Screening results 2.1. Catalyst screening a a Reactions performed on 0.1 mmol scale using 1a (1 equiv) and 2a (1 equiv) in 0.2 ml of the solvent. Isolated yields are given. Diastereomeric ratios (dr) as determined by 1 H NMR of a crude reaction mixture. Enantiomeric ratios (er) as determined by a chiral stationary phase HPLC. S3
2.2. Reaction conditions screening a Entry Solvent T [ C] Yield [%] b dr c er d 1 CH 2Cl 2 rt 69 >20:1 89:11 2 CHCl 3 rt 65 >20:1 80:20 3 ClCH 2CH 2Cl rt 66 >20:1 85:15 4 Toluene rt 53 >20:1 74:26 5 THF rt 42 >20:1 71:29 6 1,4-Dioxane rt 65 >20:1 76:24 7 (CH 3CH 2) 2O rt 66 >20:1 76:24 8 CH 3CN rt 67 >20:1 87:13 9 benzene rt 60 >20:1 82:18 10 CH 2Cl 2 40 65 >20:1 91:9 11 CH 2Cl 2 10 67 >20:1 85:15 12 CH 2Cl 2 0 65 >20:1 91:9 13 CH 2Cl 2-10 68 >20:1 90:10 14 CH 2Cl 2-20 68 >20:1 93:7 15 CH 2Cl 2-40 67 >20:1 94:6 16 e CH 2Cl 2-40 60 >20:1 91:9 17 f CH 2Cl 2-40 61 >20:1 90:10 18 g CH 2Cl 2-40 70 >20:1 97:3 19 h CH 2Cl 2-40 54 >20:1 90:10 20 i CH 2Cl 2-40 95 >20:1 98:2 a Reactions performed on 0.1 mmol scale using 1a (1 equiv) and 2a (1 equiv) in 0.2 ml of the solvent. b Isolated yields are given. c Determined by 1 H NMR of a crude reaction mixture. d Determined by a chiral stationary phase HPLC. e Reaction was performed in 0.4 ml of CH2Cl2. f Reaction was performed in 0.1 ml of CH2Cl2. g Reaction was performed using 4e (10 mol%). h Reaction was performed using 4e (5 mol%). i Reaction was performed using 4e (10 mol%) with the addition of extra portion of 2a (1 equiv) after 4h. S4
3. X-ray data for diethyl (3R,3aS,9bR)-3-(4-methoxyphenyl)-8-nitro-4-oxo-1,3a,4,9btetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate 3s Formula C 24H 24N 2O 9, orthorhombic, space group P 2 2 1 2 1, Z = 4, cell constants a = 6.78800(10) Å, b = 13.1767(3) Å, c = 25.9973(5) Å, V = 2325.29(8) Å 3. The data was collected on a Bruker Smart Apex2 diffractometer at 100 K using Incoatec IµS Cu-K α (λ =1.54178 Å) as a source of radiation. The integration of the data yielded a total of 29996 reflections to a θ angle of 75.044, of which 4787 were independent (R int = 2.12%,) and 4786 were greater than 2σ(F 2 ). The final anisotropic full-matrix leastsquares refinement on F 2 with 323 variables converged at R 1 = 2.81%, for the observed data and wr 2 = 7.34% for all data. Hydrogen atom connected to nitrogen atom in pyrrole ring was located in the difference Fourier map and allowed to refine freely in isotropic model. The rest of hydrogen atoms were placed in calculated positions and refined isotropically by using a riding model. The goodness-offit was 1.095. The absolute configuration of 3s was determined from anomalous scattering, by calculating the Flack parameter: 0.03(2) from 2016 selected quotients (Parsons' method) and Hooft parameter: 0.017(19). CCDC 1474177 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif. S5
An asymmetric unit of X crystal structure. Atomic displacement ellipsoids draw with 50% probability level. Hydrogens atoms are shown as fixed-size spheres for better clarity. S6
4. NMR data 3a Diethyl (3R,3aS,9bR)-8-nitro-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) 1 H NMR 13 C NMR S7
3b Diethyl (3R,3aS,9bR)-8-bromo-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) 1 H NMR 13 C NMR S8
3c Diethyl (3R,3aS,9bR)-8-chloro-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) 1 H NMR 13 C NMR S9
3d Diethyl (3R,3aS,9bR)-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)- dicarboxylate (Scheme 3) 1 H NMR 13 C NMR S10
3e Diethyl (3R,3aS,9bR)-6-methyl-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) 1 H NMR 13 C NMR S11
3f Diethyl (3R,3aS,9bR)-8-metoxy-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) 1 H NMR 13 C NMR S12
3g Diethyl (3R,3aS,9bR)-6,8-dichloro-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) 1 H NMR 13 C NMR S13
3h Diethyl (3R,3aS,9bR)-8-fluoro-6-methyl-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Scheme 3) 1 H NMR 13 C NMR S14
3i Diethyl (3R,3aS,9bR)-4-oxo-3-phenyl-1,3a,4,9b-tetrahydro-2H-benzo[g]chromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) 1 H NMR 13 C NMR S15
3j Diethyl (3R,3aS,9bR)-3-(4-trifluoromethylphenyl)-8-nitro-4-oxo-1,3a,4,9btetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate (Table 2, entry 2) 1 H NMR 13 C NMR S16
3k Diethyl (3R,3aS,9bR)-3-(4-cyanophenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 3) 1 H NMR 13 C NMR S17
3l Diethyl (3R,3aS,9bR)-3-(4-nitrophenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 4) 1 H NMR 13 C NMR S18
3m Diethyl (3R,3aS,9bR)-3-(4-bromophenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 5) 1 H NMR 13 C NMR S19
3n Diethyl (3R,3aS,9bR)-3-(4-chlorophenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 6) 1 H NMR 13 C NMR S20
3o Diethyl (3R,3aS,9bR)-3-(3-chlorophenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 7) 1 H NMR 13 C NMR S21
3p Diethyl (3R,3aS,9bR)-3-(2-chlorophenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 8) 1 H NMR 13 C NMR S22
3q Diethyl (3R,3aS,9bR)-3-(4-methylphenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 9) 1 H NMR 13 C NMR S23
3r Diethyl (3R,3aS,9bR)-3-(4-methoxyphenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 10) 1 H NMR 13 C NMR S24
3s Diethyl (3R,3aS,9bR)-3-(4-methoxyphenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 11) 1 H NMR 13 C NMR S25
3t Diethyl (3R,3aS,9bR)-3-naphtyl-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Table 2, entry 12) 1 H NMR 13 C NMR S26
3u Diethyl (3R,3aS,9bR)-3-(1,3-benzodioxol-5-yl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 13) 1 H NMR 13 C NMR S27
3v Diethyl (3R,3aS,9bR)-3-(furan-2-yl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Table 2, entry 14) 1 H NMR 13 C NMR S28
3w Diethyl (3R,3aS,9bR)-3-ethyl-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Table 2, entry 15) 1 H NMR 13 C NMR S29
3x Diethyl (3R,3aS,9bR)-3-hexyl-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Table 2, entry 16) 1 H NMR 13 C NMR S30
5. HPLC traces 3a Diethyl (3R,3aS,9bR)-8-nitro-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) Racemic sample Enantiomerically enriched sample S31
3b Diethyl (3R,3aS,9bR)-8-bromo-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) Racemic sample Enantiomerically enriched sample S32
3c Diethyl (3R,3aS,9bR)-8-chloro-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) Racemic sample Enantiomerically enriched sample S33
3d Diethyl (3R,3aS,9bR)-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)- dicarboxylate (Scheme 3) Racemic sample Enantiomerically enriched sample S34
3e Diethyl (3R,3aS,9bR)-6-methyl-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) Racemic sample Enantiomerically enriched sample S35
3f Diethyl (3R,3aS,9bR)-8-metoxy-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) Racemic sample Enantiomerically enriched sample S36
3g Diethyl (3R,3aS,9bR)-6,8-dichloro-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) Racemic sample Enantiomerically enriched sample S37
3h Diethyl (3R,3aS,9bR)-8-fluoro-6-methyl-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Scheme 3) Racemic sample Enantiomerically enriched sample S38
3i Diethyl (3R,3aS,9bR)-4-oxo-3-phenyl-1,3a,4,9b-tetrahydro-2H-benzo[g]chromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Scheme 3) Racemic sample Enantiomerically enriched sample S39
3j Diethyl (3R,3aS,9bR)-3-(4-trifluoromethylphenyl)-8-nitro-4-oxo-1,3a,4,9btetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate (Table 2, entry 2) Racemic sample Enantiomerically enriched sample S40
3k Diethyl (3R,3aS,9bR)-3-(4-cyanophenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 3) Racemic sample Enantiomerically enriched sample S41
3l Diethyl (3R,3aS,9bR)-3-(4-nitrophenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 4) Racemic sample Enantiomerically enriched sample S42
3m Diethyl (3R,3aS,9bR)-3-(4-bromophenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 5) Racemic sample Enantiomerically enriched sample S43
3n Diethyl (3R,3aS,9bR)-3-(4-chlorophenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 6) Racemic sample Enantiomerically enriched sample S44
3o Diethyl (3R,3aS,9bR)-3-(3-chlorophenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 7) Racemic sample Enantiomerically enriched sample S45
3p Diethyl (3R,3aS,9bR)-3-(2-chlorophenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 8) Racemic sample Enantiomerically enriched sample S46
3q Diethyl (3R,3aS,9bR)-3-(4-methylphenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 9) Racemic sample Enantiomerically enriched sample S47
3r Diethyl (3R,3aS,9bR)-3-(4-methoxyphenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 10) Racemic sample Enantiomerically enriched sample S48
3s Diethyl (3R,3aS,9bR)-3-(4-methoxyphenyl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 11) Racemic sample Enantiomerically enriched sample S49
3t Diethyl (3R,3aS,9bR)-3-naphtyl-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Table 2, entry 12) Racemic sample Enantiomerically enriched sample S50
3u Diethyl (3R,3aS,9bR)-3-(1,3-benzodioxol-5-yl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3- b]pyrrole-2,2(3h)-dicarboxylate (Table 2, entry 13) Racemic sample Enantiomerically enriched sample S51
3v Diethyl (3R,3aS,9bR)-3-(furan-2-yl)-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Table 2, entry 14) Racemic sample Enantiomerically enriched sample S52
3w Diethyl (3R,3aS,9bR)-3-ethyl-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Table 2, entry 15) Racemic sample Enantiomerically enriched sample S53
3x Diethyl (3R,3aS,9bR)-3-hexyl-8-nitro-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole- 2,2(3H)-dicarboxylate (Table 2, entry 16) Racemic sample Enantiomerically enriched sample S54