Polio Bulletin 2016 Issue No Week 27 (as of 4 July 2016)

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2016 Issue No. 14 - Week 27 (as of 4 July 2016) HIGHLIGHTS The role of data in helping to fight eradicate polio At the heart of the work of the GPEI lie two essential tasks: finding the virus (surveillance) and protecting children against it (immunization). Data is the lifeblood of both, supporting those on the frontline and behind the scenes to do the best job they can. When the virus is isolated, more data is used to assess the numbers of vulnerable children in the affected area to help calculate the amount of vaccines needed to respond. This information is translated into action for vaccinating door to door, to protect every child and interrupt the transmission. In countries with endemic transmission and circulating vaccinederived, data is playing a vital role in defining actions. The programme and the response activities is shifting focus from the number of children reached with vaccines to the number of children missed and left unprotected. Since the end of 2014, almost half a million children who were previously missed have now been protected against polio, partially contributed by this enhanced attention on the most vulnerable. With the success of the unprecedented switch from trivalent to bivalent oral polio vaccine in 155 countries and areas, the world saw evidence of the crucial role played by data. From each and every healthcare center from cities to the most remote rural locations, data was fed up to districts, then countries, regions and finally to the global level to confirm that every vial of the trivalent vaccine had been destroyed and replaced with the bivalent vaccine. Eradicating polio will be one of the greatest achievements in human history, making a positive impact on human health for generations to come. The role of data will be the final one, confirming no single case of virus for three years with good surveillance system in place, enabling us to declare polio finished, once and for all. A video from the Bill and Melinda Gates Foundation has celebrated the role data and information play in the everyday work done by the partners of the Global Polio Eradication Initiative, countries, donors, vaccinators and surveillance officers in their tireless fight against the. Watch it here: https://youtu.be/lrufoabsvey CONTACT US Expanded Programme on Immunization Regional Office for the Western Pacific World Health Organization P.O. Box 2932, 1000 Manila, Philippines Phone: +63 2 5288001 Fax: +63 2 5211036, 5260279 Email: wproepidata@who.int Web: www.wpro.who.int/immunization/en 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0.0 Chart 1. Non-polio AFP rate (per 100 000 persons < 15 years of age), 2014 2016* * AFP rate annualized as of week 27 100 80 60 40 20 14 15 16 14 15 16 14 15 16 14 15 16 14 15 16 14 15 16 14 15 16 CHN KHM LAO MYS PHL PNG VNM 0 Chart 3. Percentage of AFP by number of polio vaccination doses, 2016 CHN KHM LAO MYS PHL PNG VNM 3 doses 1-2 doses 0 doses Unknown Chart 2. Adequate specimen collection rate, 2014 2016 Chart 4. Percentage of AFP with pending classification > 90 days after onset, 2016 Note: Priority countries were selected for the charts. Official WHO acronyms have been used for abbreviation: CHN (China), KHM (Cambodia), LAO (Lao People s Democratic Republic), MYS (Malaysia), PHL (Philippines), PNG (Papua New Guinea), and VNM (Viet Nam). 100 80 60 40 20 0 CHN KHM LAO MYS PHL PNG VNM 14 15 16 14 15 16 14 15 16 14 15 16 14 15 16 14 15 16 14 15 16 CHN KHM LAO MYS PHL PNG VNM 0.0 3.8 7.4 8.8 10.0 18.2 17.9 0 5 10 15 20

Table 1A. Classification of AFP with onset in 2015 and key surveillance indicators 2015 Classification Indicators 2014 Country/area Annual expected <15 years of age Confirmed wild Vaccinederived () Poliocompatible Discarded (Non-polio) > 90 days 1 # () Non-polio AFP rate with adequate 2 investigated 2 days of notification 3 Latest report date 4 Days since last report 5 1 80 80 30 Australia 60 44 53 0 0 0 53 0 0 (0.0) 1.20 26 100 19-Feb-16 - Brunei Darussalam 4 1 3 0 0 0 3 0 0 (0.0) 3.00 100 100 18-Feb-16 - Cambodia 72 46 84 0 0 0 84 0 0 (0.0) 1.83 99 100 01-Feb-16 - China 5758 2234 5217 0 0 1 5216 0 0 (0.0) 2.34 93 100 18-May-16 - China, Hong Kong SAR 19 8 10 0 0 0 10 0 0 (0.0) 1.25 80 100 04-Feb-16 - China, Macao SAR 1 1 1 0 0 0 1 0 0 (0.0) 1.00 100 100 15-Jan-16 - Japan - 163 - - - - - - - - - - - - Lao People's Democratic Republic 28 24 71 0 8 6 0 63 0 0 (0.0) 2.96 56 99 11-May-16 - Malaysia 161 77 144 0 0 0 144 0 0 (0.0) 1.87 77 79 18-Apr-16 - Mongolia 9 9 9 0 0 0 9 0 0 (0.0) 1.00 100 100 02-Mar-16 - New Zealand 8 9 7 0 0 0 7 0 0 (0.0) 0.78 29 100 15-Apr-16 - Papua New Guinea 12 34 27 0 0 0 27 0 0 (0.0) 0.79 30 78 31-May-16 - Philippines 272 387 413 0 0 0 413 0 0 (0.0) 1.07 69 98 29-Mar-16 - Republic of Korea 88 70 83 0 0 0 83 0 0 (0.0) 1.19 86 87 22-Mar-16 - Singapore 8 6 8 0 0 0 8 0 0 (0.0) 1.33 100 88 03-Feb-16 - Viet Nam 361 231 379 0 0 0 374 5 5 (1.3) 1.64 96 95 13-Jun-16 21 Pacific island countries and areas 15 10 14 0 0 0 10 4 4 (28.6) 1.40 71 100 27-Jun-16 7 6876 3354 6523 0 8 1 6505 9 9 (0.1) 1.94 90 98 1. Number () of pending classification more than 90 days from date of onset of paralysis to date of last report Green Reached or surpassed target 2. Percentage of with two stool collected 24 hours apart and within 14 days of onset of paralysis Yellow Nearly reached target: 0.5 0.99 for non-polio AFP rate; 60 79 for other indicators 3. Percentage of investigated within two days of notification Red Substantially below target 4. Report date is fixed as soon as all for the year have been classified 5. Countries are expected to submit data at least once per month to WPRO 6. Includes three that are 15 years old or older 2

Table 1B. Classification of AFP with onset in 2016 and key surveillance indicators 2016 Classification Indicators 2015 Country/area Annual expected <15 years of age Confirmed wild Vaccinederived () Poliocompatible Discarded (Non-polio) > 90 days 1 # () Non-polio AFP rate 2 with adequate 3 investigated 2 days of notification 4 Latest report date Days since last report 5 1 80 80 30 Australia 53 45 29 0 0 1 18 10 6 (20.7) 1.24 48 86 24-Jun-16 10 Brunei Darussalam 3 1 0 - - - - - - - - - 06-Jun-16 28 Cambodia 84 45 20 0 0 0 15 5 2 (10.0) 0.86 95 95 27-Jun-16 7 China 5217 2234 2421 0 0 0 1393 1028 214 (8.8) 2.09 93 100 29-Jun-16 5 China, Hong Kong SAR 10 8 5 0 0 0 5 0 0 (0.0) 1.20 80 100 06-Jun-16 28 China, Macao SAR 1 1 1 0 0 0 0 1 0 (0.0) 1.93 100 100 30-Jun-16 4 Japan - 163 - - - - - - - - - - - - Lao People's Democratic Republic 71 24 53 0 3 6 0 35 15 2 (3.8) 4.25 72 96 24-Jun-16 10 Malaysia 144 77 66 0 0 0 30 36 12 (18.2) 1.65 82 56 07-Jun-16 27 Mongolia 9 8 5 0 0 0 3 2 0 (0.0) 1.20 60 100 01-Jul-16 3 New Zealand 7 9 7 0 0 0 1 6 0 (0.0) 1.50 43 86 26-May-16 39 Papua New Guinea 27 30 13 0 0 0 9 4 0 (0.0) 0.83 62 77 07-Jun-16 27 Philippines 413 394 148 0 0 0 111 37 11 (7.4) 0.72 61 93 16-Jun-16 18 Republic of Korea 83 69 30 0 0 0 23 7 0 (0.0) 0.84 93 100 16-Jun-16 18 Singapore 8 6 2 0 0 0 2 0 0 (0.0) 0.64 100 100 07-Jun-16 27 Viet Nam 379 231 95 0 0 0 21 74 17 (17.9) 0.79 91 95 17-Jun-16 17 Pacific island countries and areas 14 10 9 0 0 0 6 3 2 (22.2) 1.73 78 100 27-Jun-16 7 6523 3355 2904 0 3 1 1672 1228 266 (9.2) 1.67 89 98 1. Number () of pending classification more than 90 days from date of onset of paralysis to date of last report Green Reached or surpassed target 2. Annualized non-polio AFP rate per 100 000 population under 15 years of age Yellow Nearly reached target: 0.5 0.99 for non-polio AFP rate; 60 79 for other indicators 3. Percentage of with two stool collected 24 hours apart and within 14 days of onset of paralysis Red Substantially below target 4. Percentage of investigated within two days of notification 5. Countries are expected to submit data at least once per month to WPRO 6. Includes two that are 15 years old or older 3

Country/area Polio no. of AFP with Table 2A. Laboratory investigation of stool samples from AFP with onset in 2015 and key laboratory indicators positive positive + only Results of virus isolation for AFP Negative > 14 days results positive for Latest report date 80 80 Australia VIDRL 45 0 0 4 41 0 0 95 5 04-Mar-16 VIDRL 0 - - - - - - - - - - - - - Brunei Darussalam VIDRL 3 0 0 1 2 0 0 100 33 04-Mar-16 VIDRL 0 - - - - - - - - - - - - - Cambodia NIID 84 1 0 10 73 0 0 96 11 14-Jan-16 NIID 0 - - - - - - - - - - - - - China (total) 5172 68 1 471 4632 0 0 96 8 18-May-16 177 0 52 1 0 61 7 0 54 0 2 0 0 98 China, Anhui Prov. Lab 305 2 0 21 282 0 0 97 6 Prov. Lab/CCDC 4 0 1 0 0 1 0 0 2 0 0 0 0 100 China, Beijing Prov. Lab 30 3 0 0 27 0 0 100 0 Prov. Lab/CCDC 10 0 3 0 0 4 0 0 3 0 0 0 0 100 China, Fujian Prov. Lab 158 4 0 25 129 0 0 99 15 Prov. Lab/CCDC 11 0 0 0 0 7 0 0 4 0 0 0 0 100 China, Gansu Prov. Lab 80 0 0 10 70 0 0 95 9 Prov. Lab/CCDC 0 - - - - - - - - - - - - - China, Guangdong Prov. Lab 356 9 0 13 334 0 0 96 3 Prov. Lab/CCDC 31 0 4 0 0 14 5 0 8 0 0 0 0 100 China, Guangxi Prov. Lab 279 3 0 42 234 0 0 98 12 Prov. Lab/CCDC 6 0 0 0 0 2 0 0 4 0 0 0 0 100 China, Hebei Prov. Lab 303 6 1 58 238 0 0 99 15 Prov. Lab/CCDC 10 0 7 0 0 3 0 0 0 0 0 0 0 100 China, Heilongjiang Prov. Lab 129 1 0 5 123 0 0 100 4 Prov. Lab/CCDC 1 0 0 0 0 0 0 0 1 0 0 0 0 100 China, Henan Prov. Lab 503 8 0 48 447 0 0 90 7 Prov. Lab/CCDC 16 0 11 0 0 1 0 0 4 0 0 0 0 100 China, Hunan Prov. Lab 295 1 0 33 261 0 0 98 10 Prov. Lab/CCDC 2 0 0 0 0 2 0 0 0 0 0 0 0 100 China, Jiangsu Prov. Lab 234 4 0 4 226 0 0 99 2 Prov. Lab/CCDC 6 0 2 0 0 2 0 0 2 0 0 0 0 100 China, Jiangxi Prov. Lab 177 6 0 4 167 0 0 100 2 Prov. Lab/CCDC 12 0 6 0 0 4 0 0 2 0 0 0 0 100 China, Jilin Prov. Lab 51 0 0 5 46 0 0 98 7 Prov. Lab/CCDC 0 - - - - - - - - - - - - - China, Shaanxi Prov. Lab 98 1 0 5 92 0 0 96 4 Prov. Lab/CCDC 2 0 2 0 0 0 0 0 0 0 0 0 0 100 China, Shandong Prov. Lab 371 1 0 34 336 0 0 98 7 Prov. Lab/CCDC 1 0 0 0 0 1 0 0 0 0 0 0 0 100 China, Shanghai Prov. Lab 39 0 0 1 38 0 0 100 3 Prov. Lab/CCDC 4 0 2 0 0 2 0 0 0 0 0 0 0 100 China, Shanxi Prov. Lab 126 0 0 12 114 0 0 90 8 Prov. Lab/CCDC 0 - - - - - - - - - - - - - China, Sichuan Prov. Lab 359 1 0 25 333 0 0 94 6 Prov. Lab/CCDC 5 0 0 0 0 2 0 0 3 0 0 0 0 100 China, Tianjin Prov. Lab 42 1 0 0 41 0 0 100 0 Prov. Lab/CCDC 2 0 0 0 0 0 0 0 2 0 0 0 0 100 China, Xinjiang Prov. Lab 114 3 0 16 95 0 0 98 13 Prov. Lab/CCDC 6 0 2 0 0 4 0 0 0 0 0 0 0 100 China, Yunnan Prov. Lab 212 7 0 21 184 0 0 93 9 Prov. Lab/CCDC 16 0 6 0 0 4 0 0 6 0 0 0 0 86 China, Zhejiang Prov. Lab 187 3 0 18 166 0 0 95 8 Prov. Lab/CCDC 10 0 2 1 0 4 0 0 1 0 2 0 0 100 China, Chongqing Prov. Lab 75 1 0 8 66 0 0 99 7 CCDC 3 0 0 0 0 0 0 0 3 0 0 0 0 67 China, Guizhou Prov. Lab 210 0 0 27 183 0 0 99 11 CCDC 2 0 2 0 0 0 0 0 0 0 0 0 0 100 China, Hainan Prov. Lab 39 0 0 3 36 0 0 90 6 CCDC 2 0 0 0 0 2 0 0 0 0 0 0 0 100 China, Hubei Prov. Lab 179 1 0 22 156 0 0 96 12 CCDC 4 0 2 0 0 0 0 0 2 0 0 0 0 100 China, Liaoning Prov. Lab 91 0 0 5 86 0 0 97 4 CCDC 2 0 0 0 0 0 2 0 0 0 0 0 0 100 China, Neimongol Prov. Lab 89 2 0 3 84 0 0 99 2 CCDC 5 0 0 0 0 2 0 0 3 0 0 0 0 100 China, Ningxia Prov. Lab 20 0 0 1 19 0 0 98 3 CCDC 4 0 0 0 0 0 0 0 4 0 0 0 0 100 China, Qinghai Prov. Lab 19 0 0 2 17 0 0 100 11 CCDC 0 - - - - - - - - - - - - - China, Tibet Prov. Lab 2 0 0 0 2 0 0 100 0 CCDC 0 - - - - - - - - - - - - - China, Hong Kong SAR PHLC 10 0 0 0 10 0 0 84 0 19-Jan-16 PHLC 0 - - - - - - - - - - - - - China, Macao SAR PHLC 0 - - - - - - - - 19-Jan-16 PHLC 0 - - - - - - - - - - - - - Japan NIID - - - - - - - - - - NIID - - - - - - - - - - - - - - Lao People's Democratic Republic NIID 76 11 2 7 56 0 0 99 10 07-Mar-16 NIID 18 0 5 6 0 2 0 0 5 0 0 0 0 100 Malaysia IMR 147 0 0 11 136 0 0 98 5 11-Feb-16 IMR 0 - - - - - - - - - - - - - Mongolia PHI 9 0 0 2 7 0 0 94 22 11-Jan-16 NIID 0 - - - - - - - - - - - - - New Zealand IESR 4 0 0 0 4 0 0 100 0 20-Jan-16 IESR 0 - - - - - - - - - - - - - Papua New Guinea VIDRL 25 1 0 6 18 0 0 95 21 01-Feb-16 VIDRL 1 0 1 0 0 0 0 0 0 0 0 0 0 100 Philippines RITM 483 4 0 61 418 0 0 89 10 16-Mar-16 RITM 9 0 1 0 0 2 0 0 6 0 0 0 0 100 Republic of Korea NIH 83 0 0 8 75 0 0 87 8 22-Mar-16 NIH 0 - - - - - - - - - - - - - Singapore SGH 8 0 0 1 7 0 0 100 6 15-Jan-16 SGH 0 - - - - - - - - - - - - - Viet Nam (North) NIHE 211 3 0 20 188 0 0 99 9 12-Jan-16 NIHE 7 0 4 0 0 2 0 0 0 0 1 0 0 100 Viet Nam (South) PI 175 0 0 17 158 0 0 98 10 16-Feb-16 PI 0 - - - - - - - - - - - - - Pacific island countries and areas VIDRL 15 1 0 3 11 0 0 93 18 01-Feb-16 VIDRL 2 0 0 0 0 0 0 0 2 0 0 0 0 100 6550 89 3 622 5836 0 0 95 8 214 0 63 7 0 67 7 0 67 0 3 0 0 98 1. CCDC (Chinese Center for Disease Control and Prevention, China); IESR (Institute of Environmental Science and Research, New Zealand); IMR (Institute of Medical Research, Malaysia); NIH (National Institute of Health, Republic of Korea); NIHE (National Institute of Hygiene and Epidemiology, Ha Noi, Viet Nam); NIID (National Institute of Infectious Diseases, Japan); PHI (Public Health Institute, Mongolia); PHLC (Public Health Laboratory Center, China, Hong Kong SAR); PI (Pasteur Institute, Ho Chi Minh, Viet Nam); RITM (Research Institute for Tropical Medicine, Philippines); SGH (Singapore General Hospital); VIDRL (Victorian Infectious Diseases Reference Laboratory, Australia) 2. growing in cells Intratypic differentiation/ Sequencing No. of received W ild Results of intratypic differentiation ()/sequencing for virus Type 2 Type 3 Wild W ild 2 Discordant pending sequencing results 7 days of receipt 4

Country/area Polio no. of AFP with Table 2B. Laboratory investigation of stool samples from AFP with onset in 2016 and key laboratory indicators positive positive + only Results of virus isolation for AFP Negative > 14 days results positive for Latest report date 80 80 Australia VIDRL 21 0 0 2 19 0 0 92 5 16-Jun-16 VIDRL 0 - - - - - - - - - - - - - Brunei Darussalam VIDRL 0 - - - - - - - - 16-Jun-16 VIDRL 0 - - - - - - - - - - - - - Cambodia NIID 17 1 0 3 13 0 0 94 15 25-May-16 NIID 2 0 0 0 0 2 0 0 0 0 0 0 0 100 China (total) 2385 24 0 134 2179 0 48 96 5 29-Jun-16 65 0 7 0 0 16 0 0 33 0 4 5 0 98 China, Anhui Prov. Lab 119 0 0 4 113 0 2 100 3 Prov. Lab/CCDC 0 - - - - - - - - - - - - - China, Beijing Prov. Lab 17 0 0 0 16 0 1 100 0 Prov. Lab/CCDC 0 - - - - - - - - - - - - - China, Fujian Prov. Lab 77 2 0 1 74 0 0 100 1 Prov. Lab/CCDC 7 0 0 0 0 0 0 0 2 0 0 5 0 100 China, Gansu Prov. Lab 50 2 0 0 48 0 0 96 0 Prov. Lab/CCDC 6 0 0 0 0 3 0 0 3 0 0 0 0 80 China, Guangdong Prov. Lab 179 2 0 5 172 0 0 81 2 Prov. Lab/CCDC 2 0 0 0 0 1 0 0 1 0 0 0 0 100 China, Guangxi Prov. Lab 145 0 0 13 130 0 2 100 7 Prov. Lab/CCDC 0 - - - - - - - - - - - - - China, Hebei Prov. Lab 123 1 0 8 112 0 2 98 5 Prov. Lab/CCDC 2 0 0 0 0 0 0 0 2 0 0 0 0 100 China, Heilongjiang Prov. Lab 44 0 0 2 42 0 0 98 5 Prov. Lab/CCDC 0 - - - - - - - - - - - - - China, Henan Prov. Lab 171 1 0 20 150 0 0 82 9 Prov. Lab/CCDC 6 0 0 0 0 0 0 0 2 0 4 0 0 100 China, Hunan Prov. Lab 115 1 0 10 101 0 3 100 8 Prov. Lab/CCDC 2 0 0 0 0 0 0 0 2 0 0 0 0 100 China, Jiangsu Prov. Lab 81 0 0 2 76 0 3 100 3 Prov. Lab/CCDC 0 - - - - - - - - - - - - - China, Jiangxi Prov. Lab 109 1 0 5 103 0 0 100 4 Prov. Lab/CCDC 2 0 1 0 0 0 0 0 1 0 0 0 0 100 China, Jilin Prov. Lab 23 0 0 0 22 0 1 100 0 Prov. Lab/CCDC 0 - - - - - - - - - - - - - China, Shaanxi Prov. Lab 48 0 0 2 38 0 8 95 3 Prov. Lab/CCDC 0 - - - - - - - - - - - - - China, Shandong Prov. Lab 147 2 0 6 138 0 1 99 3 Prov. Lab/CCDC 5 0 0 0 0 2 0 0 3 0 0 0 0 100 China, Shanghai Prov. Lab 21 1 0 0 20 0 0 100 0 Prov. Lab/CCDC 4 0 0 0 0 2 0 0 2 0 0 0 0 100 China, Shanxi Prov. Lab 88 4 0 2 81 0 1 98 2 Prov. Lab/CCDC 9 0 4 0 0 0 0 0 5 0 0 0 0 100 China, Sichuan Prov. Lab 197 3 0 25 169 0 0 97 10 Prov. Lab/CCDC 5 0 0 0 0 2 0 0 3 0 0 0 0 100 China, Tianjin Prov. Lab 17 0 0 0 17 0 0 100 0 Prov. Lab/CCDC 0 - - - - - - - - - - - - - China, Xinjiang Prov. Lab 44 1 0 0 40 0 3 98 0 Prov. Lab/CCDC 4 0 0 0 0 2 0 0 2 0 0 0 0 100 China, Yunnan Prov. Lab 141 0 0 4 122 0 15 93 3 Prov. Lab/CCDC 0 - - - - - - - - - - - - - China, Zhejiang Prov. Lab 78 1 0 2 75 0 0 99 1 Prov. Lab/CCDC 3 0 0 0 0 2 0 0 1 0 0 0 0 100 China, Chongqing Prov. Lab 31 0 0 1 30 0 0 100 2 CCDC 0 - - - - - - - - - - - - - China, Guizhou Prov. Lab 93 1 0 6 83 0 3 97 7 CCDC 6 0 2 0 0 2 0 0 2 0 0 0 0 100 China, Hainan Prov. Lab 20 0 0 2 18 0 0 95 8 CCDC 0 - - - - - - - - - - - - - China, Hubei Prov. Lab 99 0 0 10 88 0 1 97 9 CCDC 0 - - - - - - - - - - - - - China, Liaoning Prov. Lab 39 0 0 1 36 0 2 99 1 CCDC 0 - - - - - - - - - - - - - China, Neimongol Prov. Lab 33 0 0 1 32 0 0 91 3 CCDC 0 - - - - - - - - - - - - - China, Ningxia Prov. Lab 15 0 0 0 15 0 0 93 0 CCDC 0 - - - - - - - - - - - - - China, Qinghai Prov. Lab 19 0 0 2 17 0 0 92 8 CCDC 0 - - - - - - - - - - - - - China, Tibet Prov. Lab 2 1 0 0 1 0 0 100 0 CCDC 2 0 0 0 0 0 0 0 2 0 0 0 0 100 China, Hong Kong SAR PHLC 5 0 0 0 5 0 0 82 0 31-May-16 PHLC 0 - - - - - - - - - - - - - China, Macao SAR PHLC 0 - - - - - - - - 31-May-16 PHLC 0 - - - - - - - - - - - - - Japan NIID - - - - - - - - - - NIID - - - - - - - - - - - - - - Lao People's Democratic Republic NIID 97 14 0 8 75 0 0 99 7 30-Jun-16 NIID 25 0 10 4 0 3 0 0 8 0 0 0 0 100 Malaysia IMR 55 0 0 1 54 0 0 99 2 09-May-16 IMR 0 - - - - - - - - - - - - - Mongolia PHI 4 0 0 0 4 0 0 88 0 21-Jun-16 NIID 0 - - - - - - - - - - - - - New Zealand IESR 7 0 0 0 6 1 0 100 0 29-Jun-16 IESR 0 - - - - - - - - - - - - - Papua New Guinea VIDRL 10 0 0 2 8 0 0 100 22 16-Jun-16 VIDRL 0 - - - - - - - - - - - - - Philippines RITM 189 3 0 18 162 6 0 95 8 30-Jun-16 RITM 8 0 2 0 0 3 0 0 3 0 0 0 0 100 Republic of Korea NIH 29 0 0 2 27 0 0 95 7 22-Jun-16 NIH 0 - - - - - - - - - - - - - Singapore SGH 4 0 0 0 3 1 0 100 0 01-Jul-16 SGH 0 - - - - - - - - - - - - - Viet Nam (North) NIHE 93 3 0 13 60 17 0 97 15 01-Jul-16 NIHE 4 0 1 0 0 0 0 0 3 0 0 0 0 100 Viet Nam (South) PI 43 2 0 6 28 7 0 96 15 14-Jun-16 PI 6 0 0 0 0 2 0 0 4 0 0 0 0 100 Pacific island countries and areas VIDRL 8 0 0 3 5 0 0 94 22 16-Jun-16 VIDRL 0 - - - - - - - - - - - - - 2967 47 0 192 2648 32 48 96 5 110 0 20 4 0 26 0 0 51 0 4 5 0 99 1. CCDC (Chinese Center for Disease Control and Prevention, China); IESR (Institute of Environmental Science and Research, New Zealand); IMR (Institute of Medical Research, Malaysia); NIH (National Institute of Health, Republic of Korea); NIHE (National Institute of Hygiene and Epidemiology, Ha Noi, Viet Nam); NIID (National Institute of Infectious Diseases, Japan); PHI (Public Health Institute, Mongolia); PHLC (Public Health Laboratory Center, China, Hong Kong SAR); PI (Pasteur Institute, Ho Chi Minh, Viet Nam); RITM (Research Institute for Tropical Medicine, Philippines); SGH (Singapore General Hospital); VIDRL (Victorian Infectious Diseases Reference Laboratory, Australia) 2. growing in cells Intratypic differentiation/ Sequencing No. of received W ild Results of intratypic differentiation ()/sequencing for virus Type 2 Type 3 Wild W ild 2 Discordant pending sequencing results 7 days of receipt 5

Table 3. Laboratory confirmation of polio from environmental samples in 2014 2015 1 2014 2015 Polio Polio Intratypic number number Country/area number Discordant number differentiation lab 2 of samples of samples Type 2 Type 3 of samples pending of samples Type 2 Type 3 with polio with polio processed sequencing processed Wild Wild Wild Wild Wild Wild Discordant pending sequencing Australia VIDRL 3 0 - - - - - - - - - 3 0 0 29 2 0 0 0 0 1 0 0 1 0 26 0 0 China (total) 3 167 167 0 79 0 0 129 2 0 115 0 0 0 0 1486 630 0 193 0 0 243 1 0 274 0 851 5 35 China, Fujian Prov. Lab/CCDC 14 14 0 1 0 0 4 0 0 0 0 0 0 0 77 13 0 0 0 0 12 0 0 1 0 64 0 0 China, Gansu Prov. Lab/CCDC 0 0 - - - - - - - - - - - - 88 46 0 11 0 0 9 0 0 28 0 37 5 0 China, Guangdong Prov. Lab/CCDC 48 48 0 21 0 0 22 0 0 15 0 0 0 0 171 43 0 11 0 0 24 1 0 7 0 128 0 0 China, Guangxi Prov. Lab/CCDC 0 0 - - - - - - - - - - - - 261 71 0 10 0 0 12 0 0 52 0 190 0 0 China, Heilongjiang Prov. Lab/CCDC 18 18 0 11 0 0 37 1 0 47 0 0 0 0 47 20 0 2 0 0 16 0 0 2 0 27 0 0 China, Shandong Prov. Lab/CCDC 48 48 0 13 0 0 16 0 0 23 0 0 0 0 305 108 0 43 0 0 25 0 0 40 0 197 0 0 China, Shanghai Prov. Lab/CCDC 12 12 0 6 0 0 12 0 0 10 0 0 0 0 129 21 0 2 0 0 12 0 0 7 0 108 0 0 China, Xinjiang Prov. Lab/CCDC 27 27 0 27 0 0 38 1 0 20 0 0 0 0 396 308 0 114 0 0 133 0 0 137 0 88 0 35 China, Yunnan Prov. Lab/CCDC 0 0 - - - - - - - - - - - - 12 0 0 0 0 0 0 0 0 0 0 12 0 0 Malaysia IMR 21 7 0 1 0 0 1 0 0 5 0 7 0 0 0 - - - - - - - - - - - - - 191 174 0 80 0 0 130 2 0 120 0 10 0 0 1515 632 0 193 0 0 244 1 0 275 0 877 5 35 1. Based on year of collection of sample, if available. Otherwise, based on year of receipt at reference laboratory. 2. CCDC (Chinese Center for Disease Control and Prevention, China); IMR (Institute of Medical Research, Malaysia); VIDRL (Victorian Infectious Diseases Reference Laboratory, Australia) Cambodia China Table 4. Vaccine-derived identified from laboratory testing 2, 2000-2016 Country/area 2000 2009 3 2010 2011 2012 2013 2014 2015 2016 2006-1 - 2 2009-1 - 27 China, Hong Kong SAR 2005-3 a2 (3 AFP + 1 contact + 1 non-afp) a3 (1 AFP + 1 non-afp) a1 (1 AFP) a2 (2 AFP + 1 contact) c2 (2 AFP) i2 (1 AFP + 1 non-afp) i3 (1 AFP) a1 (1 AFP) a2 (2 AFP) c2 (2 AFP + 1 contact) i2 + i3 (1 AFP) a2 (1 non-afp) i2 + i3 (1 AFP) a1 (1 non-afp) a2 (2 AFP) i3 (1 AFP) a1 (1 AFP) a2 (1 AFP) i2 (1 AFP) Japan 2005-1 - 2 Lao People's Democratic Republic 2004-3 c1 (8 AFP + 21 contacts) c1 (3 AFP + 4 contacts) Mongolia 2003-1 Philippines 2001-3 a2 (1 AFP) Viet Nam a2 (2 AFP) 1. Prefix letter refers to the category: "c" = circulating, "i" = immunodeficiency-associated, "a" = ambiguous, "?" = pending. Suffix number refers to the serotype (types 1, 2 or 3). 2. Source of could be AFP, contacts, or non-afp 3. Refers to year of last case, and aggregate total of for 2000-2009 6