24.1 Sex-Linked Inheritance. Chapter 24 Chromosomal Basis of Inheritance Sex-Linked Inheritance Sex-Linked Inheritance
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1 ptr 24 romosoml sis o Inritn 24. Sx-Link Inritn Normlly, ot mls n mls v 23 pirs o romosoms 22 pirs r ll utosoms On pir is t sx romosoms Mls r XY mls r XX opyrit T Mrw-Hill ompnis, In. Prmission rquir or rproution or isply. 24. Sx-Link Inritn Sx-link trits r ontroll y ns on t sx romosoms X-link r oun on t X romosom Most sx-link trits No mtin n on t Y Y- link r oun on t Y romosom 24. Sx-Link Inritn Most X-link trits r rssiv ml must riv two llls On rom prnt Ml inrits X rom is motr Y rom is tr os not rry n lll or t trit
2 24. Sx-Link Inritn R-rn olorlinnss Wll known X-link rssiv isorr rrir ml pl o pssin rssiv lll olor-lin mls r mor ommon tn olor-lin mls X Y " " # opyrit T Mrw-Hill ompnis, In. Prmission rquir or rproution or isply. Prnts X! ooyts X X X # Ky X = Norml vision X = olor lin Norml vision olor lin notyps X X X X X X X Y Pnotyps ml wo s norml olor vision rrir ml wo s norml olor vision ml wo is olor lin Ml wo s norml vision sprm X X X X X Y X Y X Y Pnotypi Rtio mls Mls ll X Y Ml wo is olor lin Osprin 24. Sx-Link Inritn Ky Unt ml opyrit T Mrw-Hill ompnis, In. Prmission rquir or rproution or isply. X-link Rssiv isorrs o Intrst unn musulr ystropy rtriz y wstin wy o t musls sn o protin ystropin ril X synrom Most ommon us o inrit mntl impirmnt Most ommon known us o utism Hmopili sn or miniml prsn o lottin tor Missin lottin tor now vill s iotnoloy prout Vitori Hmopili Unt ml rrir rrik III (rmny) Qun Vitori li Hnry Irn rrik (i t 3) Wlmr (i t 56) Hnry (i t 4) lxnr Louis IV (Hss) 4 ilrn o 9 r sown 2 ilrn o 26 r sown lxi (murr) Niols II (Russi) Prin lrt Prinss Hln o Wlk 6 ilrn o 34 r sown li Lopol (i t 3) lxnr (rl o tlon) Ruprt (i t 2) lonso XII (Spin) lonso (i t 3) tri Vitori onzlo (i t 20) Prin Hnry o ttnr Lopol (i t 32) (qun): Stplton olltion/oris; (prin): Huton riv/tty Ims;
3 24.2 n Link opyrit T Mrw-Hill ompnis, In. Prmission rquir or rproution or isply. romosom ontins mny llls in init ix orr Link roup ll t llls on on romosom tt r inrit totr llls tt r link o not sow inpnnt ssortmnt no rossin- ovr urin miosis no rossin- ovr urin miosis rossin-ovr urin miosis 50% 50% 2 typs o mts in qul proportions. omplt link 97% 3% rominnt mts 4 typs o mts in unqul proportions. Inomplt link 24.2 n Link I rossin-ovr ours, iyri prous our typs o mts inst o two Ourrn o rossin-ovr n lp tll t squn o ns on romosom rossin-ovr ours mor otn twn istnt ns tn twn losr ns Z S R z s r pir o omoloous romosoms 24.3 ns in romosom Numr Nonisjuntion Ours urin miosis I, wn ot mmrs o omoloous romosom pir o into t sm utr ll Or urin miosis II, wn t sistr romtis il to sprt n ot utr romosoms o into t sm mt Rsults in trisomy or monosomy wn rtiliz
4 . 2n norml 2n norml opyrit T Mrw-Hill ompnis, In. Prmission rquir or rproution or isply. pir o omoloous romosoms nonisjuntion 2n + 2n - Miosis I Miosis II rtiliztion Zyot. nonisjuntion pir o omoloous romosoms 2n + 2n + 2n - 2n ns in romosom Numr Norml vlopmnt pns on xtly two o kin o romosom own Synrom trisomy 2 Most ommon utosoml trisomy sn mon umns sily roniz pysil turs Mil to svr mntl impirmnt ns o womn vin own synrom il inrs rpily wit, strtin t out 40 Kryotypin n us wit mniontsis or orioni villus smplin to inos tus opyrit T Mrw-Hill ompnis, In. Prmission rquir or rproution or isply ns in romosom Numr ns o survivl r rtr wn trisomy or monosomy involvs t sx romosoms Norml XX mls v on X intiv Zyot wit on X romosom (Turnr synrom) n surviv ll xtr X romosoms om tivt Poly-X mls n XXY mls r sn irly rquntly xtr Y romosoms r lso tolrt XYY (Jos synrom) Jos rrilo/potoit
5 24.3 ns in romosom Numr ns in sx romosom numr Prsn o Y romosom, not t numr o X, trmins mlnss SRY n (on Y romosom) prous tstistrminin tor 24.3 ns in romosom Strutur romosoml muttions our wn romosoms rk nvironmntl nts or viruss n us rk Orinrily, rk runits wit sm squn o ns ilur to runit orrtly n rsult in: ltion, uplition, trnslotion, or invrsion opyrit T Mrw-Hill ompnis, In. Prmission rquir or rproution or isply. ltion ltion + lost uplition invrsion uplition l m n trnslotion o p q r Trnslotion q r l m n o p omoloous romosoms invrt smnt rion o rossin-ovr Invrsion uplition n ltion in ot
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