Pharmacological and genomic profiling identifies NF-κB targeted treatment strategies for mantle cell lymphoma

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1 CORRECTION NOTICE Nat. Med. 0, 87 9 (014) Pharmacoogica and genomic profiing identifies NF-κB targeted treatment strategies for mante ce ymphoma Rami Raha, Mareie Fric, Rodrigo Romero, Joshua M Korn, Robert Kride, Fong Chun Chan, Barbara Meissner, Hyo-eun Bhang, Dave Ruddy, Audrey Kauffmann, Ai Farsidjani, Adnan Derti, Danie Raiec, Tara Nayor, Estee Pfister, Steve Kovats, Sunyu Kim, Kerstin Dietze, Bernd Dören, Christian Steid, Aexandar Tzanov, Michae Humme, John Monahan, Michae P Morrissey, Christine Fritsch, Wiiam R Seers, Vesseina G Cooe, Randy D Gascoyne, Georg Lenz & Fran Stegmeier In the version of this suppementary fie originay posted onine, the name of the NIK pharmacoogica inhibitor used in Suppementary Figure 7 was incorrect. It shoud have been 4-[1-(-aminopyrimidin-4-y)-1H-1,-benzodiazo-6-y--(1,-thiazo--y)but--yn--o. The authors aso added its biochemica IC 50 as 11 nm at 8 μm ATP. The error has been corrected in this fie as of 7 February 014.

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7 S D XW V D & ' ( ) * +, + ' -. / 0 1 J HI FG E B C A J HI FG E K A J HI P I HQ P FO U Q GT J HI P I HQ P FO E J HI P I HQ P FO N KLM J HI FG L R C G / & : ; * +, + ' -. 5 < = & >? * +, + ' -. 5 < =

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14 ò ì ï ö ßÚ Ù ßÚ Ù ô õ ó ðñ è ç è ç î æ í êëì ç è é æ ç ø ù ø ú ø û ø ü ö Ó Ô Õ Ö Ø ö û ö ù ö ä Ù ÝÙå ãþä àá â ã ÝÙÞ Ü Ú Û Ù ä Ù ÝÙå ãþä Ù Þ â ã àá ÝÙÞ Ü Ú Û Ù

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17 œ š F œ š o p q r s { v } ~ t ~ q ~ ƒ t ~ q ~ ƒ t o p q r s { v } ~ Ÿ ž ˆ ˆ Š ˆ ˆ Œ ˆ ˆ Ž ˆ ˆ ˆ t ~ q ~ ƒ Ž Œ Š Ÿ ž ˆ ˆ Š ˆ ˆ Œ ˆ ˆ Ž ˆ ˆ ˆ t ~ q ~ ƒ Ž Œ Š t u v w x y z t u v w x y z h g cceb f c a bcd d a ^ n n m j b i a : 5 6 ; 5 6 < 5 6 = 5 6 G H I B J K 4 M N O K > P Q R G S R K ; 4 7 L K 4 = 8 F R T B Q K 4 I R A H U C V W Q S S O Y A Z [ H A R G B R T B J H G S Q H O E > < : A B C D E

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25 î î î î ß Ü Ú Û Ù Ø Ì Ö Õ Ì Ë Ð Ë Ñ Ê Ó Ô ÒÑ ÎÏÐ Ë Ì Í Ê Ë ß ë ì ß ë í ë á ë ï ë ì ë í ò ó ô ò õ ö ß ò õ ö í ð ñ ð ñ ð ñ ð ñ ð ñ ð ñ ð ñ ð ñ ð ñ Ç È É Ý Þ ß à á â ã ä å æ Þ ß ç ã è é ê

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32 š œ ž Ÿ ª «š œ ž Ÿ ± œ ²

33 ³ µ ¹ º» ¾ À Á Â Ã Ë Å Â Ì Í Ç Ä Å Å Î É Ê Ç Ï Å Å Ð É Ñ Ò Ó Ó Ô Õ Ö ³ µ ¹ º» ¾ À Á  à Á È Î Ø Ï Ê Ñ Ò Ó Ó Ô Õ Ö ³ µ ¹ º» ¼ ½ ¾ À Á Â Ã Ä Å Å Å Æ Ç Ä Å Å È É Ê

34 ø Ú ð ê ã ß à á â ó ä å æ å ç Ù Ú Û Ü Ý Þ ß à á â ã ä å æ å ç è Û é ê ë ì í å ß æ á â å ä å æ å ç Û Ù è î à ß ï á â ï æ ä å æ å ç ð ð ñ ò ì å ó ß ó á â å à ä å æ å ç ù Ú ú å ã ß ó á â å ó ä å æ å ç Ù é ú ê å ö ß à á â å î ä å æ å ç ñ ô Ù ð õ ì å ö ß à á â å î ä å æ å ç û ü û û û û û û ü û û û û û

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