Supplementary Information

Transcription

1 Supplementary Information

2 Supplementary Information Glossary 185 Glossary Industrial Product-specific Terms Bags, single-use Plastic disposable bag used in bioreactors and for storing liquids, such as culture media, intermediate products and biopharmaceuticals Bioreactor In English-speaking countries, a bioreactor is a vessel used for cultivating animal or human cells in a culture medium. In non- English-speaking countries, the term bioreactor is also used synonymously with the term fermenter to denote a system used to multiply microorganisms. In either case, the vessel is used to obtain cells, parts of these or one of their metabolites. Disposable Used synonymously with single-use" Downstream processing Collective term for the various steps that follow fermentation or cell cultivation (upstream processing) in the production of biopharmaceuticals; for example, separation, purification and concentration FDA - Food and Drug Administration U.S. regulatory agency responsible for ensuring the safety and efficacy of human and veterinary pharmaceuticals, biological products, medical devices and foods Membrane (filter) Thin film or foil made of polymers; because of the porous structure, this film is suitable for filtration applications. Monoclonal antibodies Synthetic antibodies used, in particular, in the treatment of cancer, HIV and autoimmune diseases PAT - Process Analytical Technology A strategy for the design, analysis and control of manufacturing processes according to which quality characteristics of intermediate or finished products are defined and then analyzed and monitored using the critical process parameters identified Purification An important step in downstream processing Scale-up Transfer of scale or increase in size. Used to denote the progression of a process that increases in a range from lab scale to pilot scale to process scale, while retaining the same technology, materials of construction and geometries throughout Single-use Reusable product Disposable product, i.e., for one-time usage. A reusable product is designed for repeated use. Fermentation Technical process used to produce or transform intra- or extra-cellular substances with the help of microorganisms Fluid management technologies Technologies and systems for the transportation and storage of biological liquids Membrane chromatography Selective separation of mixtures of substances by adsorption to specifically modified membranes (membrane adsorbers) in a flowing system Upstream processing In the manufacture of biopharmaceuticals, designates the various steps that take place for seeding and propagating cells that produce an active pharmaceutical ingredient Validation Documented verification that systems, devices and processes reproducibly deliver the desired result

3 186 Supplementary Information Glossary Glossary Business Economic Terms Amortization Amortization relates exclusively to potential reductions in the value of goodwill and the allocation of the purchase price to intangible assets acquired as carried out according to IFRS 3 Cash flow The amount of cash earned after paying all expenses and taxes; i.e., the cash balance of inflows and outflows of funds Compliance Observance of applicable laws, codes and other relevant rules and regulations Constant currencies; currency-adjusted In the presentation of figures, identical exchange rates are used for each of the comparative periods. DAX, TecDAX German stock indexes of the transaction service provider and marketplace organizer Deutsche Börse AG D&O insurance Directors and Officers liability insurance that covers Supervisory and Executive Board members and managerial employees DVFA SG The Methods Commission of the Society of Investment Professionals in Germany (DFVA e.v.) and the Schmalenbach- Gesellschaft (SG) EBITDA Earnings before interest, taxes, depreciation and amortization; in this context, amortization refers exclusively to the purchase price allocation (PPA) to intangible assets acquired according to IFRS 3. EBITDA margin The ratio of EBITDA (earnings before interest, taxes, depreciation and amortization) to sales Equity ratio The ratio of equity to the balance sheet total ERP Stands for Enterprise Resource Planning ; IT-based system for resource planning Fixed assets The sum of intangible assets, property, plant and equipment and financial assets Goodwill The difference between the price paid for a company or business and its net assets; a form of intangible asset Holding company A parent company that exists for the purpose of owning a controlling interest or shares in several legally independent subsidiaries that are subordinate within the organizational hierarchy; this holding company conducts its business exclusively through these subsidiaries. Market capitalization The total number of shares outstanding of both classes issued by the company, multiplied by the corresponding share price Normalized financial result Financial result excluding fair value adjustments of hedging instruments, as well as excluding non-periodic expenses and income. Normalized income tax Underlying income tax, based on underlying profit before tax and on non-cash amortization. Prime Standard Market segment of the Frankfurt Stock Exchange with high, internationally accepted transparency requirements to meet the needs of companies seeking to attract international investors. Supply chain management Setup and coordination of integrated flows of materials, information and finances (supply chains) over the entire value-added process Treasury Short- and medium-term liquidity management Underlying Adjusted to eliminate extraordinary items (see definition Extraordinary items Exceptional or one-time expenses and income, such as acquisition costs, restructuring costs and other non-operating expenses

4 Supplementary Information Glossary 187 Other Terms CRM Abbreviation for Customer Relationship Management ; practices, strategies and technologies that companies use to manage and analyze customer interactions and data to improve customer retention and drive sales growth EHS Abbreviation for "Environment, Health and Safety EMEA The region comprising Europe, the Middle East and Africa; one of the three reporting regions in the geographical allocation of the Sartorius Group besides the Americas and Asia / Pacific ERP Stands for "Enterprise Resource Planning"; IT-based resource planning system ESG Abbreviation for Environment, Social and Governance ; refers to the three major factors of sustainable corporate management. GEC Stands for the "Group Executive Committee"; the central management body of the Sartorius Group. It currently is comprised of six members: the three Executive Board members of Sartorius AG and further executives with global responsibility GHG Abbreviation for Greenhouse Gas Protocol, the international standard for measuring and managing greenhouse gas emissions, including reporting. The WHO stands for the World Heath Organization, the coordination authority of the United Nations for international public health

5 188 Supplementary Information Index Index A Acquisitions ff 20 24ff. 29ff. 36f. 41f f. 55f ff f ff. 186 Addresses 192ff. Annual financial statements 14 51ff. 75f Annual Shareholders Meeting Cover 8 12ff ff Amortization 31ff ff. 122f. 133ff. Appropriation of profits Auditor(s) ff. B Balance sheet Cover ff f ff Bioprocess Solutions 8f f ff ff f f C Capital expenditures f. 50f f ff. Cash flow(s) f f ff. 186 Compliance 12ff f. 73ff. 88f f Consolidated financial statements f Corporate governance 13f. 71ff f Currency f f. D Depreciation 31 f ff. 122 f. 135 f. Distribution 8 24ff. 31 f f. 46 f. 54 f ff. 149 Dividend(s) Cover f ff f E Earnings Cover 14f ff ff f f. 125 f. 129f 132ff. 136ff. 146ff ff. 165f. 167f ff. Earnings per share Cover Earnings reserves EBIT 33ff EBITDA f. 140f. 169 Employees Cover f ff. 91ff f. 157f Employee benefits expense Equity f f. 129ff f. 174 Executive Board 8 12ff ff ff. 84f ff. 175ff. 180ff. F Financial instruments f f ff. Financing Financial result 20 34f f Fixed assets 51f f Forecast report 53 63ff. Foreign exchange, foreign exchange rates f f. G German Act on Equal Participation of Women and Men 74 Group companies 54f f Group Executive Committee 10f Group financial statements f Group structure 22f Group management report f 172ff. I Industrial Technologies 27 Intangible assets f ff. 186 Interest income Inventories f f. Investments f. 50f f ff. Investor relations Cover 18 87f. 180

6 Supplementary Information Index 189 L Lab Products & Services 8f ff. 46ff Liabilities 37 40f f f. 136ff ff. 168f. M Marketing f N Net debt Cover 23 39ff Net profit Cover 14 f ff ff f f. 125f. 129f 132ff. 136ff. 146ff ff. 165f. 167f ff. Note loans O Ordinary shares Cover 8f. 15ff P Pension commitments Pension provisions f. 172 Phantom stock, phantom stock units 76ff. 82f Positions held 180ff. Preference share(s) 8f. 15ff Procurement 56 f. 130 Production 8f. 23f ff f ff. 49f. 56f. 59ff. 62f ff ff Products 8f. 24ff ff. 48ff ff f f. 108ff Profit Cover 14 f ff ff f f. 125f. 129f 132ff. 136ff. 146ff ff. 165f. 167f ff. Property, plant and equipment f f f. Provisions f. 135f R Ratio of Net Debt to Underlying EBITDA 41 Regions 22 28f. 32f ff Remuneration of the Executive Board Research and Development f Reserves f. 135 f Restructuring Results Cover 14f ff ff f f. 125f. 129f 132ff. 136ff. 146ff ff. 165f. 167f ff. Retained profit 14 51ff. 172 Risk management system 53ff. 69 Risk and opportunities report S Sales (and distribution) ff f f f f. Sales revenue Cover ff f f f f. Sartorius Stedim Biotech 22 f f f f. Segment reports 139f. Shareholder structure 19 Share(s) Cover 8 12f. 16ff. 22f. 34f ff ff f. 170ff. 186 Statement of profit or loss ff. 130ff ff. 152ff Stedim transaction 152 Supervisory Board 8 12ff ff ff. 84f ff. 175ff. 180ff. Supply chain management Sustainability 86ff. T Taxes 34f ff. 133f. 139ff f. 156f f. 186 Treasury U Unqualified audit certificate ff. W Working capital 23 40f

7 190 Supplementary Information A Local Presence Worldwide A Local Presence Worldwide The Americas Oakville, ON, Canada Bohemia, NY, USA Boston, MA, USA Ann Arbor, MI, USA Arvada, CO, USA New Oxford, PA, USA Albuquerque, NM, USA Mexico City, Mexico Yauco, Puerto Rico São Paulo, Brazil Buenos Aires, Argentina Lima, Peru Sales Production Production and Sales

8 Supplementary Information A Local Presence Worldwide 191 Europe Africa Dublin, Ireland Royston, UK Stonehouse, UK Epsom, UK Glasgow, UK Brussels, Belgium Dourdan, France Aubagne, France Lourdes, France Florence, Italy Milan, Italy Madrid, Spain Barcelona, Spain Kajaani, Finland Helsinki, Finland Malmo, Sweden Umeå, Sweden St. Petersburg, Russia Goettingen, Germany Guxhagen, Germany Laupheim, Germany Poznan, Poland Budapest, Hungary Vienna, Austria Tagelswangen, Switzerland Mohamdia, Tunisia Beit Haemek, Israel Asia Pacific Beijing, China Shanghai, China Hong Kong, China Seoul, South Korea Tokyo, Japan Hanoi, Vietnam Bangkok, Thailand Bangalore, India Kuala Lumpur, Malaysia Singapore, Singapore Melbourne, Australia

9 192 Supplementary Information Addresses Addresses Europe Germany Austria Finland Sartorius AG Otto-Brenner-Strasse Goettingen Phone Fax info@sartorius.com Sartorius Stedim Austria GmbH Modecenter Strasse Vienna Phone Fax separation.austria@sartorius.com Sartorius Biohit Liquid Handling Oy Laippatie Helsinki Phone Fax lhinfo.finland@sartorius.com Sartorius Stedim Biotech GmbH August-Spindler-Strasse Goettingen Phone Fax Sartorius Austria GmbH Modecenter Strasse Vienna Phone Fax info.austria@sartorius.com Sartorius Stedim Nordic Oy Laippatie Helsinki Phone Fax lhinfo.finland@sartorius.com Sartorius Lab Instruments GmbH & Co. KG Otto-Brenner-Strasse Goettingen Phone Fax info@sartorius.com Sartorius Stedim Plastics GmbH Karl-Arnold-Strasse Goettingen Phone Fax Sartorius Stedim Systems GmbH Robert-Bosch-Strasse Guxhagen Phone Fax Belgium Sartorius Stedim Belgium N.V. Rue Colonel Bourg Schaerbeek-Brussels Phone Fax info.belgium@sartorius.com Sartorius Belgium N.V. Rue Colonel Bourg Schaerbeek-Brussels Phone Fax info.belgium@sartorius.com Sartorius Nordic Oy Laippatie Helsinki Phone Fax lhinfo.finland@sartorius.com Sartorius Stedim Cellca GmbH Erwin-Rentschler-Strasse Laupheim Phone Fax Sartorius Corporate Administration GmbH Otto-Brenner-Strasse Goettingen Phone Fax info@sartorius.com

10 Supplementary Information Addresses 193 France Hungary Poland Sartorius Stedim Biotech S.A. Zone Industrielle Les Paluds Avenue de Jouques CS Aubagne Cedex Phone Fax Sartorius Stedim FMT S.A.S. Zone Industrielle Les Paluds Avenue de Jouques CS Aubagne Cedex Phone Fax Sartorius Stedim Hungária Kft. Kagyló u Budapest Phone Fax ssb@sartorius.hu Sartorius Hungária Kft. Kagyló u Budapest Phone Fax mechatronika@sartorius.hu Ireland Sartorius Stedim Poland sp. z o.o. ul. Wrzesinska Kostrzyn Phone Fax biuro.pl@sartorius.com Sartorius Poland sp z o.o. ul. Wrzesinska Kostrzyn Phone Fax info.pl@sartorius.com Russia Sartorius Stedim France S.A.S. Zone Industrielle Les Paluds, Avenue de Jouques CS Aubagne Cedex Phone Fax info-biotech.france@sartorius-stedim.com Sartorius Stedim Ireland Ltd. Unit 41, The Business Centre Stadium Business Park 11 Dublin Phone Fax ne.customersupport@sartorius.com LLC Sartogosm River Volkova Embankment 9, litera A, premises 1-N, 3-N, 4-N St. Petersburg Phone Fax info@sartogosm.ru Sartorius Stedim Aseptics S.A.S. Zone Industrielle de Saux, Rue Ampère Lourdes Phone Fax Sartorius France S.A.S. 2, rue Antoine Laurent de Lavoisier Zone d activité de la Gaudrée Dourdan Phone Fax commercial.france@biohit.com Sartorius Ireland Ltd. Unit 41, The Business Centre Stadium Business Park 11 Dublin Phone Fax ne.customersupport@sartorius.com Italy Sartorius Stedim Italy S.r.l. Via dell' Antella 76/A Antella Bagno a Ripoli (Florence) Phone Fax info.italy@sartorius.com LLC Sartorius Stedim RUS 5th line V.O. 70, litera A, premises , / 11N St. Petersburg Phone Fax russia@sartorius.com LLC Sartorius RUS 5th line V.O. 70, litera A, premises , / 11N St. Petersburg Phone Fax russia@sartorius.com Sartorius Italy S.r.l. Viale Alfonso Casati Muggiò (Monza e Brianza) Phone Fax info.italy@sartorius.com

11 194 Supplementary Information Addresses North America Spain UK Canada Sartorius Stedim Spain S.A. Avda. de la Industria, 32, Edificio PAYMA Alcobendas (Madrid) Phone Fax pedidos.sartorius@sartorius.com Sartorius Spain S.A. Avda. de la Industria, 32, Edificio PAYMA Alcobendas (Madrid) Phone Fax pedidos.sartorius@sartorius.com Sartorius Sales Office Carrer del Comte Borell, Barcelona Phone Fax spain.weighing@sartorius.com Sweden Sartorius Stedim Data Analytics AB Tvistevaegen Umeå Phone Fax umetrics@sartorius-stedim.com Sartorius Stedim Data Analytics AB Arenagatan 8b Malmo Phone Fax umetrics@sartorius-stedim.com Switzerland Sartorius Stedim Switzerland AG Ringstrasse 24a 8317 Tagelswangen Phone Fax biotech.switzerland@sartoriusstedim.com Sartorius Stedim UK Ltd. Longmead Business Centre, Blenheim Road KT19 9 QQ Epsom, Surrey Phone Fax ne.customersupport@sartorius.com Sartorius Stedim Lab Ltd. Sperry Way, Stonehouse Park GL10 3UT Stonehouse, Gloucestershire Phone Fax ne.customersupport@sartorius.com Sartorius UK Ltd. Longmead Business Centre, Blenheim Road KT19 9 QQ Epsom, Surrey Phone Fax ne.customersupport@sartorius.com The Automation Partnership (Cambridge) Ltd. Grantham Close, York Way SG8 5WY Royston Hertfordshire Phone Fax Royston-info@sartorius.com Sartorius Stedim BioOutsource Ltd. 1 Technology Terrace, Acre Road, Todd Campus, West of Scotland Science Park G20 0XA Glasgow Phone Fax information@sartorius-stedim.com Israel Sartorius Israel Ltd. Kibbutz Beit Haemek Phone Fax info.israel@sartorius.com Sartorius Canada Inc North Service Road West, Unit D- 4 L6M 2V9 Oakville, ON Phone Fax sales.canada@sartorius.com Puerto Rico Sartorius Stedim Filters Inc. Carretera 128 Int. 376, Barriada Arturo Lluveras Road Yauco, Phone Fax marcos.lopez@sartorius.com USA Sartorius Stedim North America Inc. 5 Orville Dr Suite Bohemia, NY Phone Fax Sartorius North America Inc. 5 Orville Dr Suite Bohemia, NY Phone Fax info@sartorius.com Sartorius Corporation 5 Orville Dr Suite Bohemia, NY Phone Fax info@sartorius.com

12 Supplementary Information Addresses 195 Latin America Africa Argentina Tunisia Essen Instruments Inc. 300 West Morgan Road Ann Arbor, MI Phone Fax Sartorius Argentina S.A. Int. A. Avalos 4251 B1605ECS Munro, Buenos Aires Phone Fax leadsarg@sartorius.com Sartorius Stedim Bioprocess SARL Km 24, Route de Zaghouan, BP Mohamdia Phone Fax IntelliCyt Corporation 5700 Pasadena Ave NE Albuquerque, NM Phone Fax Brazil Sartorius do Brasil Ltda. Avenida Senador Vergueiro, 2962, Bairro Anchieta CEP: São Bernardo do Campo, SP Phone Fax leadsbr@sartorius.com Mexico Sartorius de México S.A. de C.V. Libramiento Norte del Tepotzotlán, int. 5, Tlacatego Tepotzotlán, Estado de México Phone Fax leadsmex@sartorius.com Peru Sartorius Peru S.A.C. Avda. Alberto del Campo 411, Floor 12, The Office Magdalena del Mar San Isidro, Lima Phone Fax leadspe@sartorius.com

13 196 Supplementary Information Addresses Asia Pacific China Japan Sartorius Stedim Biotech (Beijing) Co., Ltd. Westside of the 2nd Floor, No. 33 Yu An Road, Airport Economic Zone, Shunyi District Beijing Phone Fax enquiry.cn@sartorius-stedim.com Sartorius Scientific Instruments (Beijing) Co., Ltd. Workshop Building, No. 33 Yu An Road, Zone B, Tianzhu Airport Industry Zone, Shunyi District Beijing Phone Fax info.cn@sartorius.com Sartorius Hong Kong Ltd. Unit 1012, Lu Plaza, 2 Wing Yip Street, Kwun Tong, Kowloon Hong Kong Phone Fax enquiry.hongkong@sartorius.com Sartorius Stedim (Shanghai) Trading Co., Ltd. 3 rd Floor, North Wing, Tower1, No Jinke Road, Zhangjian High-Tech park, Pudong District, Shanghai Phone Fax info.cn@sartorius.com Sartorius (Shanghai) Trading Co., Ltd. 3 rd Floor, North Wing, Tower 1, No Jinke Road, Zhangjian High-Tech park, Pudong District, Shanghai Phone Fax info.cn@sartorius.com India Sartorius Stedim India Pvt. Ltd. #69/2 & 69/3, Jakkasandra Nelamangala, Bangalore Phone Fax biotech.india@sartorius.com Sartorius India Pvt. Ltd. #69/2 & 69/3, Jakkasandra Nelamangala, Bangalore Phone Fax swi.lps@sartorius.com Sartorius Stedim Japan K.K. Daiwa Shinagawa North Bldg. 4F, Kita-Shinagawa , Shinagawa-Ku Tokyo Phone Fax info@sartorius.co.jp Sartorius Japan K.K. Daiwa Shinagawa North Bldg. 4F, Kita-Shinagawa , Shinagawa-Ku Tokyo Phone Fax info@sartorius.co.jp Essen BioScience K.K. 301 Daiya Office, , Taito Tokyo Phone Fax Malaysia Sartorius Stedim Malaysia Sdn. Bhd. Lot L3 -E- 3B, Enterprise 4, Technology Park Malaysia, Bukit Jalil Kuala Lumpur Phone Fax ehtan@sartorius.com.my Sartorius Malaysia Sdn. Bhd. Lot L3 -E- 3B, Enterprise 4, Technology Park Malaysia, Bukit Jalil Kuala Lumpur Phone Fax ehtan@sartorius.com.my

14 Supplementary Information Addresses 197 Singapore Thailand Australia Sartorius Stedim Singapore Pte. Ltd. 10 Science Park Road, The Alpha #02 013/14 Singapore Science Park II Singapore Phone Fax marz.janamin@sartorius-stedim.com Sartorius Singapore Pte. Ltd. 10 Science Park Road, The Alpha #02 013/14 Singapore Science Park II Singapore Phone Fax aishah.amat@sartorius.com Sartorius (Thailand) Co., Ltd. 129 Rama 9 Road, Huaykwang Bangkok Phone Fax enquiry.thailand@sartorius.com Vietnam Sartorius Representative Office Unit C, 17th floor, A Tower, BIG Building 18 Pham Hung Street My Dinh, Tu Liem, Hanoi Phone Fax sartoriusvn@hn.vnn.vn Sartorius Stedim Australia Pty. Ltd. Unit 5, 7-11 Rodeo Drive 3175 Dandenong South, Victoria Phone Fax info.australia@sartorius-stedim.com Sartorius Australia Pty. Ltd. Unit 5, 7-11 Rodeo Drive 3175 Dandenong South, Victoria Phone Fax info.australia@sartorius-stedim.com South Korea Sartorius Korea Biotech Co., Ltd. 8F Solid Space, Pangyoyeok-Ro 220, Bundang-Gu Seongnam-Si, Gyeonggi-Do Phone Fax info@sartorius.co.kr Sartorius Korea Ltd. 8F Solid Space, Pangyoyeok-Ro 220, Bundang-Gu Seongnam-Si, Gyeonggi-Do Phone Fax info@sartorius.co.kr For further addresses, please visit our website on the Internet at: