Metz Syn 10 Reaction Station

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1 Metz Syn 10 Reaction Station For parallel chemistry, process development and reaction optimisation Simultaneously carry out 10 reactions, but each with a different temperature, from -30 C to +150 C...

1 Metz Syn 10 Reaction Station Simultaneously carry out 10 reactions at the same time - but each with a different temperature, from -30 C to +150 C Versatile parallel synthesiser for medicinal and

.. Technical Specifications Depth 345mm Width 165mm Height (with Reflux) 220mm Positions 10 Accepts Tubes 24mm or 25mm Stirring Speed 250 to 1200rpm Temp. Range -30 C to +150 C Temp. Stability +/-0.

2 1 Metz Syn 10 Reaction Station Simultaneously carry out 10 reactions at the same time - but each with a different temperature, from -30 C to +150 C Versatile parallel synthesiser for medicinal and process chemists, offering variable heating, cooling and stirring for the broadest range of applications in your laboratory... Technical Specifications Depth 345mm Width 165mm Height (with Reflux) 220mm Positions 10 Accepts Tubes 24mm or 25mm Stirring Speed 250 to 1200rpm Temp. Range -30 C to +150 C Temp. Stability +/-0.5 C Inert Gas Yes Reflux Yes Interface RS232 Safety Thermal Cut Out Designed for use in all types of reaction and process optimisation, parallel synthesis, chemical and catalyst development. The Syn 10 can be used to: Optimise the best combination of catalyst, reagent and solvents for synthesis Optimise reaction times in an automated fashion Evaluate the effects of changing temperature and reagent concentrations on yield and purity Define alternative synthetic routes for compound development and production Define end-points, the presence of intermediates and impurities within your reaction vessel Precise temperature control ensures that all reaction cells can be monitored closely... Individual control of each reaction position via dedicated PC Control Software or optional remote Palm Control Software of heating, cooling and stirring. Individual temperature control of each position from -30 C to +150 C, with temperature stability -/+ 0.5 C. Maximum temperature difference between any two positions is 180 C with zero cross talk between wells. Control heating and cooling ramp rates from 0.1 to 5 C per minute. With the option of crash (non-controlled) heating/cooling at much faster rates. Multiple users can even share the Syn 10 at the same time for unrelated experiments. Magnetic stirring bars stay coupled maximising yields... The Syn 10 uses 10 individual stirring motors to stir each well from 250rpm to 1200rpm. This provides excellent magnetic coupling for stirring viscous samples, even at low speeds. The Syn 10 software detects minute changes in the magnetic resistance of each stirring motor, allowing the automatic recapture of a stirring bar should it decouple. Features soft start to ensure a controlled increase in stirrer bar rpm to prevent sample damage and maintain coupling. Standard and rare earth magnetic stirring bars for all types of application web: techsupport@radleys.co.uk

2 For faster process development and reaction optimisation The Syn 10 allows you to do chemistry at a level more advanced than ever before. Quickly discover the optimal conditions for your chemistry.

PTFE cap features an all PTFE valve, which offers superior solvent resistance, gas tight sealing and easy operation. The cap also has a barbed stainless steel inlet for easier removal of tubing.

3 2 For faster process development and reaction optimisation The Syn 10 allows you to do chemistry at a level more advanced than ever before. Quickly discover the optimal conditions for your chemistry... A central inlet/outlet manifold for vacuum and inert gas, combined with gas-tight PTFE caps, allows reactions under an inert atmosphere. PTFE cap features an all PTFE valve, which offers superior solvent resistance, gas tight sealing and easy operation. The cap also has a barbed stainless steel inlet for easier removal of tubing. Maximum temperature differential between any two positions is 180 C. Optional, removable water cooled reflux head ensures even and efficient refluxing, minimising solvent evaporation during synthesis for even the most volatile solvents - eg. ether. Individual stirring control of each position from rpm, with a magnetic stirrer for each position. Provides excellent magnetic coupling for stirring even viscous samples. Adjustable stirring ramps for individual wells. Also features stirring soft startto ensure stirrer bar coupling. Individual well control, via PC Control Software or optional Palm-top Software, of heating, cooling and stirring. Integral Peltier cells cool individual wells. Individual temperature control of each position with a range of -30 C to +150 C, with temperature stability -/+ 0.5 C. web: sales@radleys.co.uk

3 Fully programmable control software for PC and Palm The Syn 10 is remotely controlled via RS232 by either a dedicated PC or Palm handheld computer.

4 3 Fully programmable control software for PC and Palm The Syn 10 is remotely controlled via RS232 by either a dedicated PC or Palm handheld computer. The Syn 10 control software allows programming of all reaction parameters, including heating, cooling, stirring and reaction duration. The user friendly software interface allows the setting of individual temperature and stirring ramps and dwells for each position. There is no limit to the number of reaction steps or duration of each reaction. The user can determine when reactions start and for how long they run for. Choose from two software options: Palm Control Software The Palm software features a simple mode for setting of temperature & ramp directly from the Palm display 323 PC Control Software Offered as standard with all Syn 10 units. The 323 PC Control Software kit allows you to connect your PC or laptop directly to the Syn 10 so you can program and store any number of individual reaction profiles. Each reaction profile can be run immediately or stored and retrieved (and amended) whenever required. The 323 PC Control Software also data logs all parameters and records any errors that may occur. (PC is not included) 328 Palm Control Software Available as an optional extra. Use the 323 PC Control Software (included with your Syn 10 ) to program and store individual reaction profiles, then download these to your Palm for remote operation of the Syn 10 via the Palm. The Palm software option also offers a simple mode for basic setting of temperature and ramp facilities directly from the Palm display - an ideal feature for more simple experiments. (Palm is not included - please contact your local RDT distributor for latest Palm specifications) RR98059 PTFE cap, RR98060 glass reaction tube with thermocouple pocket and RR66615 wire thermocouple e. b. Individual temperature control of each reaction position... The Syn 10 uses 10 individual Peltier cells to control the heating and cooling of each well completely independent of each other. Combined with high performance insulation, this allows adjacent wells to achieve a temperature differential of 180 C (-30 C to 150 C). This powerful feature is perfect for temperature optimisation, a key factor affecting reaction rates. a. Data logging of solution temperature... Using the Syn 10 Thermcouple Module and any Type T thermocouple probe you can monitor and record the solution temperature within each reaction tube. The RR66609 Thermocouple Module is connected to the Syn 10 via a dedicated data cable. Details of the individual reaction temperatures are then data logged back to the Palm or PC via the Thermocouple Module/Syn 10 interface. The unit features 12 individual Type T thermocouple ports, into which are plugged any number of thermocouples. c. Probes can be inserted into the reaction tubes via either of two methods; through a port in the RR98055 PTFE Probe Cap or via a glass pocket in the modified RR98051 reaction tube. d. COMING SOON Solution temperature control... Development is under way to provide a interface between the Syn 10 Thermcouple Module and the Syn 10 software to provide control of the solution temperature within each reaction tube. (Available late 2002) a. RR66609 Metz Syn 10 Thermocouple Module 1 b. RR66615 Flexible Wire Thermocouple. 6 RR66616 Rigid S/Steel Thermocouple Probe & 1m Lead. 6 c. RR66617 Rigid PFA Thermocouple Probe & 1m Lead. 6 d. RR98055 PTFE Probe Cap with PTFE valve & probe port. 6 RR98056 Replacement PTFE Plug for RR e. RR98051 Glass Reaction Tube with thermocouple pocket 6 web: techsupport@radleys.co.uk

4 Efficient water cooled reflux head provides optimum condensing performance - minimising solvent evaporation during synthesis An optional, removable water cooled reflux head ensures even and

Cooling water is introduced to the reflux head via barbed connectors at the rear of the unit. The reflux head features clearly numbered reaction positions from 1 to 10.

allow the introduction of inert gas to each reaction position, for air or moisture sensitive chemistries. Inert gas is introduced into the reflux head via a single inlet at the rear of the unit.

5 4 Efficient water cooled reflux head provides optimum condensing performance - minimising solvent evaporation during synthesis An optional, removable water cooled reflux head ensures even and efficient refluxing, minimising solvent evaporation during synthesis for even the most volatile solvents, such as ether. Cooling water is introduced to the reflux head via barbed connectors at the rear of the unit. The reflux head features clearly numbered reaction positions from 1 to 10. Syn 10 Reflux Head Syn 10 Synthesiser Simple central inert gas distribution system A gas distribution system is built into the centre of the reflux head, which when combined with gas-tight PTFE caps, allow the introduction of inert gas to each reaction position, for air or moisture sensitive chemistries. Inert gas is introduced into the reflux head via a single inlet at the rear of the unit. Heat Removal The Syn 10 utilises Peltier technology for cooling of the reaction tubes. The heat that these Peltier cells generate must be dissipated and the Syn 10 requires a supply of cooling water for this purpose. Tests prove that tap water at 15 C can be utilised for operation of the Syn 10 at -20 C. However to achieve the maximum performance (-30 C) for the Syn 10 in all wells, you will require a source of chilled water at 5 C or below. Therefore you may require an independent chiller system for this purpose. Such a unit should be capable of achieving at least 5 C and if ALL 10 reaction positions are to achieve -30 C simultaneously it must to be able to remove a minimum of 1KW of heat. Lesser-powered chillers can be used, but it is likely that you will not be able to achieve -30 C in all of the reaction positions simultaneously. The recommended Chiller System for use with Metz Syn 10 is the Huber Unichiller. Reflux Cooling Water Reflux Inert Gas Power Supply Peltier Cooling RR66614 Huber Unichiller 10 C to +40 C 1 Cooling capacity at 15 C = 1.5 kw Cooling capacity at 0 C = 1.0 kw Cooling capacity at -10 C = 0.4 kw Pump max 25L/min at 3.0 bar. Dimensions: 410 x 480 x 540mm RR66613 One metre insulated hose to connect Unichiller to Syn 10 1 (Two hoses will be required) Comms Ports Metz Syn 10 accepts 24 and 25mm tubes The Syn 10 is supplied as standard to accept RDT s 24mm threaded reaction tubes. Units can however be supplied to accept 25mm tubes (1 nominal) on request. The Syn 10 Reflux Head includes inserts for use with both 24mm and 25mm tubes. Inserts included with the Syn 10 Reflux Head web: sales@radleys.co.uk

5 a All caps now feature a barbed side arm for easy removal of tubing c d e RR98059 PTFE Reaction Caps - with PTFE Valve This new cap features an all PTFE valve, which offers greater solvent

Other features of the RR98059 include:- PTFE valve allows individual reaction tubes to be isolated or removed during synthesis, whilst the others are still under inert conditions.

6 5 a All caps now feature a barbed side arm for easy removal of tubing c d e RR98059 PTFE Reaction Caps - with PTFE Valve This new cap features an all PTFE valve, which offers greater solvent resistance, improved sealing and easy operation. The cap also has a barbed stainless steel inlet for easier removal of tubing. Other features of the RR98059 include:- PTFE valve allows individual reaction tubes to be isolated or removed during synthesis, whilst the others are still under inert conditions. This is particularly useful when optimising reactions. The simple open/close valve permits on/off control of the gas flow to individual tubes, allowing you to use as many tubes as you wish; simply leave the valve shut on the unused tubes. The valves can be closed at the end of a reaction to allow the tubes removal whilst maintaining the inert atmosphere. Alternatively choose from any of five compatible cap styles. a. RR Cap with suba-seal, barbed sidearm and PTFE valve. b. RR As RR98059 with a probe port and removal PTFE plug. c. RR Cap with suba-seal, barbed sidearm and stainless steel valve. d. RR Cap with suba-seal and barbed sidearm. e. RR Storage cap with suba-seal, but without sidearm. Suba-Seal Septum - located in the top of the PTFE cap permits the addition of liquid reagents during synthesis or monitoring of the reaction through the withdrawal of aliquots during synthesis. Glass Reaction Tubes - high quality, heavy duty borosilicate glass reaction tubes with threaded tops. Threaded reaction tubes, when used with PTFE caps, give an excellent gas tight seal up to 1psi. b RR98055 Threaded PTFE Cap + Barbed S/S Sidearm + PTFE Valve & Probe Port 6 RR98056 Replacement PTFE Plug for RR RR98059 Threaded PTFE Cap + Barbed S/S Sidearm + PTFE Valve 6 RR98067 Threaded PTFE Cap + Barbed S/S Sidearm + Stainless Steel Valve 6 RR98068 Threaded PTFE Cap + Barbed S/S Sidearm 6 RR98078 Threaded PTFE Storage Cap 6 RR98076 Replacement Suba-Seals for Caps 100 RR98051 Threaded Glass Reaction Tube with Thermocouple Pocket, 24 x 150mm 6 RR98061 Threaded Glass Reaction Tube, 24mm x 150mm 6 RR98062 Threaded Glass Reaction Tube, 24mm x 150mm 12 RR98904 Silicone Blanking Plugs (For Reflux Head Gas outlets) 100 Magnetic Stirring Bars & Other Accessories 5 Choose from three convenient zinc plated wire racks for tube storage, for 36, 40 & 80 tubes The RR98091 Rare Earth Medium Cross Shaped Stirring Bar is the preferred stirring bar for use with the Syn 10. It creates a deep vortex and is ideal for stirring resins and viscous samples. The RR98113 Rare Earth Cylindrical Stirring Bar is also ideal for use with the Syn 10. RR98075 Small Cross Shaped Stirring Bar creates a vortex even at slow speeds. General purpose Octagonal Stirring Bars are available in small (RR98071) and large (RR98070) sizes. PTFE Stirring Bar Evaluation Kit - Includes selection of all stirring bar styles. 1 RR98070 Large Octagonal Stirring Bar (13 x 10mm diameter) 20 RR98071 Small Octagonal Stirring Bar (12 x 7mm diameter ) 40 RR98075 Small Cross Shaped Stirring Bar (10 x 10mm) 40 2 RR98091 Rare Earth Medium Cross Shaped Stirring Bar (17.5 x 17.5mm) 20 3 RR98096 Rare Earth Small Elliptical Stirring Bar (10 x 7mm diameter) 40 RR98113 Rare Earth Medium Cylindrical Stirring Bar (12 x 4.5mm diameter) 20 4 RR98094 Stirring Bar Retriever, 350mm 1 RR98095 PTFE Stirring Bar Evaluation Kit, 3 of each type 21 5 RR98901 Zinc Plated Wire Rack for 36 x 24mm Reaction Tube 1 RR98902 Zinc Plated Wire Rack for 40 x 24mm Reaction Tube 1 RR98903 Zinc Plated Wire Rack for 80 x 24mm Reaction Tube 1 web: techsupport@radleys.co.uk

6 Simultaneously perform 10 reactions at the same time - but each with a different temperature, from -30 C to +150 C The Syn 10 uses the same glass reaction tubes and PTFE caps as the popular

PTFE cap features an all PTFE valve, which offers superior solvent resistance, gas tight sealing and easy operation.

7 6 Simultaneously perform 10 reactions at the same time - but each with a different temperature, from -30 C to +150 C The Syn 10 uses the same glass reaction tubes and PTFE caps as the popular Carousel Reaction Station Optional Huber Chiller unit for dissipation of heat from Peltier cells when cooling to -30 C. PTFE cap features an all PTFE valve, which offers superior solvent resistance, gas tight sealing and easy operation. Optional, removable water cooled reflux head ensures even and efficient refluxing, minimising solvent evaporation during synthesis. Universal voltage power supply. Individual temperature control of each position with a range of -30 C to 150 C. Integral Peltier cells cool each individual well. Individual well control, via PC Control Software or optional Palm-top Software, of heating, cooling and stirring. PC & Palm are not included. Please contact your local RDT distributor for full specifications. web: sales@radleys.co.uk

7 Save time and money by buying the popular Syn 10 System 7, which includes all the components and accessories required for efficient operation.

Metz Syn 10-328 Control Software Kit for Palm (Palm not included) RR98061 6 x Threaded Glass Reaction Tube, 24mm x 150mm RR98062 12 x Threaded Glass Reaction Tube, 24mm x 150mm RR98059 6 x Threaded

Stirring Bar RR98091 20 x Rare Earth - Medium Cross Shape PTFE Magnetic Stirring Bar RR98094 1 x PTFE Magnetic Stirring Bar Retriever 350mm RR98095 21 x PTFE Magnetic Stirring Bar Evaluation Kit, 3

synthesis, combinatorial chemistry, chemical and catalyst development.

8 7 Save time and money by buying the popular Syn 10 System 7, which includes all the components and accessories required for efficient operation. Cat No Description RR66607 System 7 - Metz Syn 10 Comprising of the following:- RR x Metz Syn 10 Reaction Station (with 323 Software kit for PC) RR x Metz Syn 10 Reflux Unit RR x Metz Syn Control Software Kit for Palm (Palm not included) RR x Threaded Glass Reaction Tube, 24mm x 150mm RR x Threaded Glass Reaction Tube, 24mm x 150mm RR x Threaded PTFE Cap + S/S Sidearm + PTFE Valve RR x Threaded PTFE Cap + S/S Sidearm + PTFE Valve RR x Rare Earth Cylindrical PTFE Magnetic Stirring Bar RR x Large Octagonal PTFE Magnetic Stirring Bar RR x Rare Earth - Medium Cross Shape PTFE Magnetic Stirring Bar RR x PTFE Magnetic Stirring Bar Retriever 350mm RR x PTFE Magnetic Stirring Bar Evaluation Kit, 3 of each type RR x Replacement Suba-Seals for Caps RR x Zinc Plated Wire Rack for 36 x 24mm Reaction Tubes Designed for use in all types of reaction and process optimisation, parallel synthesis, combinatorial chemistry, chemical and catalyst development. RR66600 Metz Syn 10 Reaction Station (with 323 Software kit for PC) 1 RR66610 Metz Syn Control Software Kit for PC (PC not included) 1 RR66612 Metz Syn Control Software Kit for Palm (Palm not included) 1 RR66601 Metz Syn 10 Reflux Unit 1 Thermocouples RR66609 Metz Syn 10 Thermocouple Module 1 RR66615 Flexible Wire Thermocouple. 6 RR66616 Rigid S/Steel Thermocouple Probe & 1m Lead. 6 RR66617 Rigid PFA Thermocouple Probe & 1m Lead. 6 Caps, Tubes, Stirring Bars & Other Accessories RR98055 Threaded PTFE Cap + Barbed S/S Sidearm + PTFE Valve & Probe Port 6 RR98056 Replacement PTFE Plug for RR RR98059 Threaded PTFE Cap + Barbed S/S Sidearm + PTFE Valve 6 RR98067 Threaded PTFE Cap + Barbed S/S Sidearm + Stainless Steel Valve 6 RR98068 Threaded PTFE Cap + Barbed S/S Sidearm 6 RR98078 Threaded PTFE Storage Cap 6 RR98076 Replacement Suba-Seals for Caps 100 RR98051 Threaded Glass Reaction Tube with Thermocouple Pocket, 24 x 150mm 6 RR98061 Threaded Glass Reaction Tube, 24mm x 150mm 6 RR98062 Threaded Glass Reaction Tube, 24mm x 150mm 12 RR98904 Silicone Blanking Plugs (For Reflux Head Gas outlets) 100 RR98070 Large Octagonal Stirring Bar (13 x 10mm diameter) 20 RR98071 Small Octagonal Stirring Bar (12 x 7mm diameter ) 40 RR98075 Small Cross Shaped Stirring Bar (10 x 10mm) 40 RR98091 Rare Earth Medium Cross Shaped Stirring Bar (17.5 x 17.5mm) 20 RR98096 Rare Earth Small Elliptical Stirring Bar (10 x 7mm diameter) 40 RR98113 Rare Earth Medium Cylindrical Stirring Bar (12 x 4.5mm diameter) 20 RR98094 Stirring Bar Retriever, 350mm 1 RR98095 PTFE Stirring Bar Evaluation Kit, 3 of each type 21 RR98901 Zinc Plated Wire Rack for 36 x 24mm Reaction Tube 1 RR98902 Zinc Plated Wire Rack for 40 x 24mm Reaction Tube 1 RR98903 Zinc Plated Wire Rack for 80 x 24mm Reaction Tube 1 Metz Parallel Reaction Stations GreenHouse Parallel Synthesiser Multiple position stirred, heated and cooled reaction stations for combi-chem, process development and parallel chemistries Multiple position stirred, heated and cooled reaction stations for process development and parallel chemistry 24 position personal synthesiser for parallel solution phase and solid supported reagent based chemistry A 24 position personal parallel synthesiser designed by medicinal chemists at GlaxoSmithKline Radleys Discovery Technologies are specialists in combi-chem and parallel chemistry... As a dynamic organisation Radleys Discovery Technologies are best able to react to the needs of this constantly developing market sector. Radleys Discovery Technologies specific areas of expertise is focused on parallel synthesis and parallel purification consumables and apparatus. The essential products that are the cornerstone of your parallel chemistry program. Radleys Discovery Technologies 2002 Radleys Discovery Technologies, Shire Hill, Saffron Walden, Essex, CB11 3AZ. United Kingdom. Tel: +44-(0) Fax: +44-(0) sales@radleys.co.uk Web:

For purification/separation of organic and aqueous phases from a two phase mixture within a 96 or 24 array tube system

Lollipop Phase Separator For purification/separation of organic and aqueous phases from a two phase mixture within a 96 or 24 array tube system Lollipop Phase Separator GreenHouse Parallel Synthesiser