Dr. Mohamed El-Newehy
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1 By Dr. Mohamed El-Newehy Chemistry Department, College of Science, King Saud University Amines 1
2 Classification and Structure of Amines -The relation between ammonia and amines is illustrated by the following structures: - Amines are classified as primary, secondary, or tertiary, depending on whether one, two, or three organic groups are attached to the nitrogen. -NOTE: t-butyl alcohol is a tertiary alcohol(because three carbons are attached to the carbinol carbon). t-butyl amine is a primary amine (because only one carbon is attached directly to the nitrogen atom). Classification and Structure of Amines - Aliphatic amines contain only alkyl groups bonded directly to the nitrogen atom. -Aromaticaminesarethoseinwhichoneormorearylgroupsarebondeddirectlytonitrogen. 2
3 Common Names Nomenclature of Amines - Amines are named by specifying the alkyl groups attached to the nitrogen and adding the suffix amine (Alkylamine). IUPAC System Nomenclature of Amines -Theaminogroup,-NH 2,isnamedasasubstituent. - Amines can be named as alkanamines. -Whenotherfunctionalgroupsarepresent,theaminogroup,-NH 2,isnamedasasubstituent. 3
4 Nomenclature of Amines IUPAC System - Aromatic amines are named as derivatives of aniline. - In the CA system, aniline is called benzenamine. Physical Properties of Amines Boiling Point - Methylamine and ethylamine are gases, but primary amines with three or more carbons are liquids. - Primary amines boil well above alkanes with comparable molecular weights, but below comparable alcohols. Intermolecular N-H N hydrogen bonds are important and raise the boiling points of primary and secondary amines but are not as strong as the O-H O bonds of alcohols. The reason for this is that nitrogen is not as electronegative as oxygen. - Tertiary amines are also polar compounds, but because hydrogen is not bonded to nitrogen, these amines are incapable of intermolecular hydrogen bonding. Their boiling points are Lower than primary and secondary amines of identical molecular weights and Higher than those of alkanes of similar molecular weight. 4
5 Solubility in Water Physical Properties of Amines -Allthreeclassesofaminescanformhydrogenbondswiththe-OHgroupofwater(thatis,O- H N). -Primaryandsecondaryaminescanalsoformhydrogenbondswiththeoxygenatominwater: N-H O. - Amines with up to six carbons show appreciable solubility in water. The Basicity of Amines - The unshared pair of electrons on the nitrogen atom dominates the chemistry of amines. - Because of this electron pair, amines are both basic and nucleophilic. - Aqueous solutions of amines are basic because of the following equilibrium: - Electron-donating groups increase the basicity of amines. Electron-withdrawing groups decrease their basicity. 5
6 The Basicity of Amines - Aromatic amines are much weaker than aliphatic amines or ammonia. - Example: aniline is less basic than cyclohexylamine. The reason is the resonance delocalization of the unshared electron pair that is possible in aniline, but not in cyclohexylamine: 1) Alkylation of Ammonia Preparation of Amines - Ammonia reacts with alkyl halides to give amines via a two-step process. The first step is a nucleophilic substitution reaction. The free amine can then be obtained from its salt by treatment with a strong base - Primary, secondary, and tertiary amines can be similarly alkylated. 6
7 Preparation of Amines 2) Reduction of Nitro Groups -The best route to aromatic primary amines is by reduction of the corresponding nitro compounds. The nitro group is easily reduced,either catalytically with hydrogen or by chemical reducing agents. 3) Reduction of Nitriles - Reduction of nitriles(cyanides) gives primary amines. 4) Reduction of Amides - Amides can be reduced to amines with lithium aluminum hydride. Reactions of Amines 1) Reactions with Acids: Salt Formation - Amines react with strong acids to form alkylammonium salts 2) Acylation of Amines: Amides Formation - Primary and secondary amines react with acyl halides to form amides. 3) Imines Formation -Primaryamines,R-NH 2 orarnh 2,undergonucleophilicadditionwithaldehydesorketones in an acidic buffer to give substituted imines. 7
8 Reactions of Amines 4) Aromatic Diazonium Salts - Primary aromatic amices react with nitrous acid at 0ºC to yield aryldiazonium ions. The process is called diazotization. -Theyareusefulinsynthesisbecausethediazoniogroum(-N 2+ )canbereplacedbynucleophiles; the other product is nitrogen gas. 8
Dr. Mohamed El-Newehy
By Dr. Mohamed El-Newehy Chemistry Department, College of Science, King Saud University http://fac.ksu.edu.sa/melnewehy Aldehydes and Ketones 1 Structure of Aldehydes and Ketones - Aldehydes and ketones
Dr. Mohamed El-Newehy
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Page 1 of 6 AMINES Amines are derivatives of ammonia (NH3), obtained by replacement of 1, 2 or all the 3 hydrogen atoms by alkyl and/or aryl groups. In nature amines are present in - proteins, vitamins,
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