[ FOOD SAFETY SOLUTIONS ] FASTER, EASIER, AND MORE ACCURATE FOOD SAFETY ANALYSES

Size: px
Start display at page:

Download "[ FOOD SAFETY SOLUTIONS ] FASTER, EASIER, AND MORE ACCURATE FOOD SAFETY ANALYSES"

Transcription

1 [ FOOD SAFETY SOLUTIONS ] FASTER, EASIER, AND MORE ACCURATE FOOD SAFETY ANALYSES

2 Growing Worldwide Concern The safety of our food supply can no longer be taken for granted. As the world changes and populations continue to grow, so will the responsibility of laboratories to meet the increasing demand for safe food supplies. Growing Regulatory Requirements To meet these worldwide demands, the requirements of regulatory bodies are also increasing. As continual food safety monitoring is required, legislation for the testing of a variety of contaminants in food and beverages for exported, imported, and domestic consumption continues to become more rigorous. Growing Demands on Your Business It is no longer enough to differentiate and establish your brand based strictly on taste or dietary benefits. Now you must assure your customers that it is safe and has no negative health effects. Growing Laboratory Demands Today, food safety testing laboratories face numerous scientific and operational challenges meeting mandated detection limits, developing sample preparation techniques for complex matrices, increasing sample throughput, and maximizing their return on investment. Addressing these challenges requires innovative analytical solutions that will enhance laboratory effectiveness.

3 [ FOOD SAFETY SOLUTIONS ] THE WATERS SOLUTION Waters helps laboratories meet these challenges with technologies that are unparalleled in the industry. Our solutions deliver the sensitivity, stability, reproducibility, and versatility required to identify diverse chemical compounds, meet compliance requirements, reduce operational costs, and increase productivity. By integrating analytical standards and reagents, column and sample preparation chemistries, chromatography, mass spectrometry, and data management software, we continue to push the limits of key food safety applications. Waters is committed to developing new methods that will help you meet new and emerging legislative requirements. Look to us as a partner who delivers scientific expertise, flexible, superior service, and a commitment to your success. Sample Preparation and Consumables ACQUITY UPLC and UPLC Detectors UPLC/MS/MS UPLC/QTof MS APGC/MS Data Management Waters Global Services

4 SAMPLE PREPARATION AND CONSUMABLES SPE Method For The Cleanest Extracts Oasis Sample Extraction Products Oasis Solid Phase Extraction (SPE) products allow for simple and rapid sample preparation and method development. With the Oasis product line, you can expect robust SPE methods without having to endure irreproducible results and low recoveries, sorbent drying, or ph limitations. Greater capacity. Excellent stability over entire ph range. Cleanest extracts. Elimination of matrix effects. Reduction of ion suppression. Superior recovery, reproducibility, retention, and selectivity for a wide variety of compounds. Dispersive Sample Preparation for Multi-Residue Pesticide Analysis DisQuE Dispersive Sample Preparation Dispersive SPE is a simple sample preparation technique suitable for multi-residue pesticide analysis in a wide variety of food and agricultural products. One specific method which has become popular is the QuEChERS technique which was created to facilitate the rapid screening of large numbers of agricultural samples for pesticides. Easy and straightforward methods that require little training. Decrease in overall sample preparation time. Efficient, cost-effective method that can accommodate a wide variety of commodities. Improve consistency in extraction products. Improve lab efficiency and workflow. Improve quality. Conveniently packaged centrifuge tubes and foil pouches containing pre-weighed sorbents and buffers for use with both the AOAC and CEN QuEChERS methods.

5 [ FOOD SAFETY SOLUTIONS ] UPLC AND UPLC DETECTORS Faster Sample Turnaround and Lower Costs For Liquid Chromatography Separations ACQUITY UPLC H-Class System The Waters ACQUITY UPLC H-Class System offers the flexibility of a quaternary-based HPLC with the performance advantages of UPLC this means greater sample throughput, reduced cost per analysis, and better quality results for food testing laboratories that use traditional HPLC. Runtimes are up to 10 times faster. Seamlessly transition to UPLC separations. Maximize chromatographic resolution. Solvent consumption reduced by up to 95%. Significant reduction in method development times. Single Class and Compound Specific Analyses with High Performance Detectors ACQUITY UPLC Detectors ACQUITY UPLC optical and mass detectors enhance high-efficiency UPLC separations, allowing you to analyze a wide variety of food contaminants. The ACQUITY UPLC TUV, PDA, and Fluorescence detectors provide fast data acquisition capabilities for rapid analyses, and the sensitivity required for trace impurity detection and quantification. And with the ACQUITY QDa Detector, any analytical scientist can consistently generate the highest quality mass spectral data routinely no special training or expertise required. Apply the performance of UPLC to high volume, routine testing. Reduce instrument training time. Easily meet or exceed regulatory detection limits. Improve analytical workflow with Empower Chromatography Data (CDS) Software. Quantify compounds with no UV response at levels not amenable to or accessible by optical detection with the ACQUITY QDa Detector. Application areas include the detection of polyaromatic hydrocarbons (PAHs), pesticides, and aflatoxins. ACQUITY QDa Detector. A. 1 µg/l patulin B. 5 µg/l patulin Peak-to-peak S/N = 4 Peak-to-peak S/N = 19 Analysis using the ACQUITY UPLC H-Class System with the ACQUITY QDa Detector. Single ion recording (SIR) chromatograms of patulin spiked into extracted apple juice equivalent to A. 1 μg/l and B. 5 μg/l. The signal-to-noise ratio (calculated using peak-to-peak) is annotated on each chromatogram.

6 UPLC/MS/MS Multi-Class Compound Testing with Advanced Quantitative UPLC/MS/MS Xevo TQ-S The Xevo TQ-S provides the ultimate in quantitative capabilities for the analysis of food and beverage samples. This system is designed to enable uncomplicated access to superior UPLC/MS/MS performance, delivering the highest levels of sensitivity, selectivity, robustness, speed, and accuracy. RADAR Technology - Monitor matrix interferences by simultaneously monitoring full scan background data during quantitative MS/MS method development. StepWave off-axis ion source technology allows for the detection of target compounds at very low concentrations, dilution of samples to reduce matrix effects, and the use of smaller sample volumes. ScanWave Technology allows scientists to get both the very best 100 Xevo TQ-S. Acetamiprid 4.59 F9:MRM of 2 channels,es+ 223 > Pyraclostrobin 9.79 F27:MRM of 2 channels,es > 163 quantitative data as well as superior spectral MS/MS information. % % Automated instrument optimization with IntelliStart Technology Acetamiprid 4.59 min 0 F9:MRM of 2 channels,es+ 223 > Pyraclostrobin 9.79 min F27:MRM of 2 channels,es > Search, manage, and automatically optimize methods with MassLynx workflow software tools including the Quanpedia Database. Simple dilute-and-shoot approach improves laboratory productivity by eliminating sample prep for certain beverage matrices. Minimize sample runtime and maximize the number of compounds assayed in a single method. % min min Pesticide analysis with the ACQUITY UPLC I-Class System and the Xevo TQ-S. MRM chromatograms of acetamiprid and pyraclostrobin in mixed vegetable juice samples at ultra-trace levels (acetamiprid at 0.51 ppb and pyraclostrobin at 0.17 ppb). % Application areas include the detection of pesticides, veterinary drugs, mycotoxins, and marine biotoxins.

7 [ FOOD SAFETY SOLUTIONS ] Routine Quantitative Analyses that are Rapid, Robust, and Reliable Xevo TQD Created to reduce complexity in mass spectrometry, the Xevo TQD ensures maximum productivity with minimum effort. The advanced technology of the ACQUITY UPLC H-Class System and the robust universal ion source architecture available with the Xevo TQD ensure dependability, while providing a flexible platform to accommodate ever-changing food and beverage sample types. A cost-effective solution that everyone in the lab can use. The only system in its class that enables simultaneous acquisition of high quality quantitative and qualitative data from the widest range of experiments. ACQUITY UPLC H-Class System with Xevo TQD. IntelliStart Technology simplifies MS setup and routine operation with automated quantification workflow tools that minimize variability between different operators, departments, and laboratories. Observe MRM (multiple reaction monitoring) data and full scan background data simultaneously for faster, more robust method development. RADAR Technology provides the sensitivity and selectivity to monitor for matrix interferences, metabolites, impurities, and degradants in samples while accurately quantifying target compounds.

8 UPLC/Tof MS A Comprehensive, Fit-For-Purpose Screening Solution Waters Screening Platform Solution with UNIFI Integrates unsurpassed chromatography and mass spectrometry instrumentation with next-generation Informatics. Target, identify, quantify, and review using a streamlined analytical workflow that enables more accurate results across a wide range of food safety applications including pesticides, veterinary drugs, natural toxins, and food packaging contaminants. The ACQUITY UPLC I-Class System: Rapid, high-resolution separations help resolve components of interest from complex matrix interference peaks faster than ever before. Maximizes peak signal-to-noise to enhance mass spectral sensitivity. Provides the lowest carryover. The Xevo G2-S QTof: Xevo G2-S Q-Tof. The UNIFI Scientific Information System: Data acquisition, processing, and reporting functionality within a single easy-to-use Informatics platform. Facilitates data standardization so that information can be exchanged among departments and third-party partners. The scientific library allows you to make use of your prior work, as well as the data of colleagues. Analyze the broadest range of compounds in the most complex samples. StepWave ion optics allow for unsurpassed levels of robust sensitivity. MS E Technology simplifies and deconvolutes spectra, associating fragment ions with their specific precursor. Meet rigorous regulatory requirements by reducing false positives and false negatives. Analysis of antibiotics using the Waters Screening Platform Solution with UNIFI. A mix of 12 sulfonamides was spiked into a sample of bovine milk at 100 μg/l prior to extraction. The 12 sulfonamides were identified in the extracted sample using the accurate mass of molecular ions and retention time contained in the UNIFI Scientific Library. The identified components are displayed in the component plot. Information rich MS E data allows for confirmation of the individual sulfonamides using accurate mass high energy fragments obtained in the same injection. Annotated spectra and extracted ion chromatograms are displayed for all low and high energy masses identified for each component.

9 [ FOOD SAFETY SOLUTIONS ] Resolution in Three Dimensions SYNAPT G2-Si SYNAPT High Definition Mass Spectrometry is the combination of high-efficiency T-Wave ion mobility (IM) measurements and separations with high-performance tandem MS, enabling the differentiation of samples by size, shape and charge, as well as mass. StepWave, QuanTof, and MS E data independent acquisition combine to provide the most comprehensive and confident untargeted identification and quantification of compounds with UPLC/MS/MS, at the lowest concentration levels in complex matrices. Provides a large increase in analytical peak capacity, and delivers more information than is available with the highest chromatographic or mass resolution alone. SYNAPT G2-Si. The orthogonal dimension of gas-phase ion mobility separation allows you to take advantage of a molecule s Collision Cross-Section (CCS) to significantly enhance separation, specificity, sensitivity, and structural insight in your analysis. Singly charged up to 5x total MS peak capacity. Multiply charged up to 10x total MS peak capacity. retention UPLC x mobility T-Wave IMS x m/z QuanTof = peak capacity LC/HDMS

10 APGC/MS No Compromise GC/MS Atmospheric Pressure GC Atmospheric Pressure GC (APGC) adds GC capability to today s advanced MS technologies. This provides users with access to ultra-trace quantification, comprehensive qualitative MS and MS/MS, and high resolution, ion-mobility separations. Soft ionization means less fragmentation for many compounds compared with techniques such as electrospray ionization (EI). This can yield higher sensitivity and specificity, simplifying pre-cursor ion selection. Maximize uptime and asset utilization - Changeover from UPLC to GC is quick and simple, and since APGC is not a vacuum technique, equilibration times between modes of operation are kept to a minimum. APGC tandem quadrupole MS, using the Xevo TQ-S, enables detection limits at ultra-trace levels. This allows compliance with regulatory limits and the ability to inject less sample matrix. APGC with Xevo G2-S QTof enables the most complete screening of samples using both ACQUITY UPLC and GC separations. High-resolution, ion mobility separations with APGC and the SYNAPT G2-Si allow you to use the Collision Cross Section (CCS) of a molecule to provide significant enhancements in sensitivity, separation, specificity, and structural insight. Application areas include the detection of multi-residue pesticides, dioxins, and PCBs. Chlorpyrifos Molecular formula C9H 11 Cl 3 NO 3 PS Molar mass NIST Library 197 Cl 100 APGC Cl O O P S O N 50 Cl 314 % m/z Pesticide analysis with APGC. Spectral comparison for chlorpyrifos: EI (left) and APGC (right). The EI spectrum (taken from NIST) is highly fragmented whereas the APGC spectrum shows less fragmentation and provides the [M+H] + as the base peak.

11 [ FOOD SAFETY SOLUTIONS ] WATERS LABORATORY INFORMATICS SOFTWARE Effective Data Management for Food Safety Analyses Empower 3 Chromatography Data Software (CDS) makes it easier than ever to run samples and produce meaningful results. Empower 3 s interface is designed to maximize your productivity, improving how you collect, process, and print chromatography data. Grows seamlessly from a single workstation to an enterprise-wide system with Empower 3 s scalable, modular architecture, which fits into the most modern, secure, HA (high availability) corporate architecture. NuGenesis 8 Platform is a comprehensive data management and workflow solution that supports the entire product lifecycle from discovery through manufacturing. This user-centric platform encompasses NuGenesis SDMS, a compliant-ready data repository, and NuGenesis ELN, a flexible analytical electronic laboratory notebook. Capabilities such as sample management, laboratory inventories, data retention and legal hold, and electronic laboratory execution methods, allow NuGenesis 8 to connect the scientific data from your laboratories to the business systems of your organization more effectively than ever before. MassLynx Software acquires, analyzes, and distributes Waters mass spectrometry information for comprehensive instrument control and data processing. To assist with both data acquisition and the transformation of data into usable results, MassLynx Software offers easy-to-use Application Managers that allow you to focus the power of MS on your laboratory's specific tasks. Paradigm Scientific Search is the next-generation of search technology for science-driven organizations. Offers a solution for accessing scientifically relevant information (chemical structures, methods, chemical reactions, chromatograms, spectra etc.), across an organization, spanning information silos, performing searches based on science objects, and adding structure to unstructured data. Waters Global Services Be Assured. Choose Waters Global Services. Waters Global Services focuses on optimizing Waters products with superior service, support, upgrades, training, and Waters Quality Parts. Proven Satisfaction For thirteen consecutive years, an independent quality auditing firm ranked Waters Global Services Best-in-Class in providing expert technical knowledge, quick resolution of system issues, and process support. 1 1 Achievement in Customer Excellence Award, CustomerSat, Inc., ; NorthFace ScoreBoard Award, sm Omega Management Group Corporation,

12 SALES OFFICES: Austria Australia Belgium and Luxembourg Brazil Canada China Czech Republic Denmark Finland France Germany Hong Kong Hungary India Ireland Israel Italy Japan Korea Mexico The Netherlands Norway Poland Portugal Puerto Rico Russia/CIS / Singapore Spain Sweden Switzerland Taiwan UK US Waters Corporation 34 Maple Street Milford, MA U.S.A. T: F: Waters, Oasis, ACQUITY UPLC, UPLC, ACQUITY, Xevo, UNIFI, Empower, High Definition Mass Spectrometry, MassLynx, NuGenesis, SYNAPT, Waters Quality Parts, and The Science of What s Possible are registered trademarks of Waters Corporation. ACQUITY QDa, DisQuE, StepWave, ScanWave, IntelliStart, Quanpedia, RADAR, Paradigm, and T-Wave are trademarks of Waters Corporation. All other trademarks are the property of their respective owners Waters Corporation. Printed in the U.S.A. March EN VW-SIG

FORENSIC TOXICOLOGY SCREENING APPLICATION SOLUTION

FORENSIC TOXICOLOGY SCREENING APPLICATION SOLUTION FORENSIC TOXICOLOGY SCREENING APPLICATION SOLUTION A purpose-built collection of the best-inclass components for forensic toxicology Whether you re challenged to present reliable and secure forensic sample

More information

IN QUALITATIVE ANALYSIS,

IN QUALITATIVE ANALYSIS, IN QUALITATIVE ANALYSIS, YOU VE ALWAYS HAD TO CHOOSE BETWEEN ACCURACY AND THROUGHPUT. NOW THERE S NO REASON TO ever have to. WATERS QUALITATIVE ANALYSIS solutions Waters ACQUITY UPLC System with the Waters

More information

[ xevo G2 tof ] Your Quantitative and Qualitative Questions Answered. Exactly.

[ xevo G2 tof ] Your Quantitative and Qualitative Questions Answered. Exactly. [ xevo G2 tof ] Your Quantitative and Qualitative Questions Answered. Exactly. Xevo G2 Tof Quantitative and qualitative answers from a single analysis. For scientists who need to confidently identify and

More information

[ XEVO G2-XS QTOF ] EXTRAORDINARY POSSIBILITIES FOR YOUR EVERYDAY ANALYSIS

[ XEVO G2-XS QTOF ] EXTRAORDINARY POSSIBILITIES FOR YOUR EVERYDAY ANALYSIS [ XEV G2-XS QTF ] EXTRARDIARY PSSIBILITIES FR YUR EVERYDAY AALYSIS EXTREME SESITIVITY, EXTRARDIARY SELECTIVITY, Whether you re a scientist who wants to truly understand your samples, or a lab manager with

More information

[ OSTRO PASS-THROUGH SAMPLE PREPARATION PRODUCT ] The Simpler Way to Cleaner Samples

[ OSTRO PASS-THROUGH SAMPLE PREPARATION PRODUCT ] The Simpler Way to Cleaner Samples [ OSTRO PASS-THROUGH SAMPLE PREPARATION PRODUCT ] The Simpler Way to Cleaner Samples SIMPLE EASY EFFICIENT DEPENDABLE 2 waters.com/ostro 3 SIMPLE The Ostro Pass-Through Sample Preparation Product provides

More information

Thermo Scientific Pesticide Explorer Collection. Start-to-finish. workflows for pesticide analysis

Thermo Scientific Pesticide Explorer Collection. Start-to-finish. workflows for pesticide analysis Thermo Scientific Pesticide Explorer Collection Start-to-finish workflows for pesticide analysis Comprehensive Pesticide Analysis Solutions Pesticide Explorer Collection Selection table Lab Profile Routine

More information

[ Care and Use Manual ]

[ Care and Use Manual ] Oasis HLB DISKS I. Introduction Oasis HLB is a Hydrophilic-Lipophilic-Balanced, water-wettable, reversed-phase sorbent for all your SPE needs. It is made from a specific ratio of two monomers, the hydrophilic

More information

SEAMLESS INTEGRATION OF MASS DETECTION INTO THE UV CHROMATOGRAPHIC WORKFLOW

SEAMLESS INTEGRATION OF MASS DETECTION INTO THE UV CHROMATOGRAPHIC WORKFLOW SEAMLESS INTEGRATION OF MASS DETECTION INTO THE UV CHROMATOGRAPHIC WORKFLOW Paula Hong, John Van Antwerp, and Patricia McConville Waters Corporation, Milford, MA, USA Historically UV detection has been

More information

Sensitive and Repeatable Analysis of Pesticides in QuEChERS Extracts with APGC-MS/MS

Sensitive and Repeatable Analysis of Pesticides in QuEChERS Extracts with APGC-MS/MS Sensitive and Repeatable Analysis of Pesticides in QuEChERS Extracts with APGC-MS/MS Dominic Roberts, 1 Sara Stead, 1 and Jennifer A. Burgess 2 1 Waters Corporation, Manchester, UK 2 Waters Corporation,

More information

Quantitation of High Resolution MS Data Using UNIFI: Acquiring and Processing Full Scan or Tof-MRM (Targeted HRMS) Datasets for Quantitative Assays

Quantitation of High Resolution MS Data Using UNIFI: Acquiring and Processing Full Scan or Tof-MRM (Targeted HRMS) Datasets for Quantitative Assays : Acquiring and Processing Full Scan or Tof-MRM (Targeted HRMS) Datasets for Quantitative Assays Mark Wrona, Jayne Kirk, and Yun Alelyunas Waters Corporation, Milford, MA, USA APPLICATION BENEFITS Ability

More information

Multi-residue analysis of pesticides by GC-HRMS

Multi-residue analysis of pesticides by GC-HRMS An Executive Summary Multi-residue analysis of pesticides by GC-HRMS Dr. Hans Mol is senior scientist at RIKILT- Wageningen UR Introduction Regulatory authorities throughout the world set and enforce strict

More information

Yun W. Alelyunas, Mark D. Wrona, Russell J. Mortishire-Smith, Nick Tomczyk, and Paul D. Rainville Waters Corporation, Milford, MA, USA INTRODUCTION

Yun W. Alelyunas, Mark D. Wrona, Russell J. Mortishire-Smith, Nick Tomczyk, and Paul D. Rainville Waters Corporation, Milford, MA, USA INTRODUCTION Quantitation by High Resolution Mass Spectrometry: Using Target Enhancement and Tof-MRM to Achieve Femtogram-level On-column Sensitivity for Quantitation of Drugs in Human Plasma Yun W. Alelyunas, Mark

More information

A Rapid Approach to the Confirmation of Drug Metabolites in Preclinical and Clinical Bioanalysis Studies

A Rapid Approach to the Confirmation of Drug Metabolites in Preclinical and Clinical Bioanalysis Studies A Rapid Approach to the Confirmation of Drug Metabolites in Preclinical and Clinical Bioanalysis Studies APPLICATION BENEFITS Regulatory guidelines and recommendations place a greater emphasis on the detection

More information

ImprovIng ADmE ScrEEnIng productivity In Drug DIScovEry

ImprovIng ADmE ScrEEnIng productivity In Drug DIScovEry Improving ADME Screening Productivity in Drug Discovery INTRODUCTION Improving the quality of the decisions made at the drug discovery stage can profoundly impact the efficiency of the drug discovery and

More information

2010 Waters Corporation. Xevo TQ-S for Bioanalysis

2010 Waters Corporation. Xevo TQ-S for Bioanalysis Xevo TQ-S for Bioanalysis Key innovations High Performance Stepwave RADAR Scan Wave Versatility Ion Sources Simplicity of Operation Engineered Simplicity The Xevo TQ family Built on the same foundations

More information

Exploring the Benefits of Automated Unattended Sample Derivatization Prior to Gas Chromatography Analysis

Exploring the Benefits of Automated Unattended Sample Derivatization Prior to Gas Chromatography Analysis Exploring the Benefits of Automated Unattended Sample Derivatization Prior to Gas Chromatography Analysis A. Caruso, M. Santoro, P. Magni, S. Pelagatti, and R. Facchetti Thermo Fisher Scientific, Milan,

More information

A Workflow Approach for the Identification and Structural Elucidation of Impurities of Quetiapine Hemifumarate Drug Substance

A Workflow Approach for the Identification and Structural Elucidation of Impurities of Quetiapine Hemifumarate Drug Substance A Workflow Approach for the Identification and Structural Elucidation of Impurities of Quetiapine Hemifumarate Drug Substance Michael D. Jones, Marian Twohig, Karen Haas, and Robert S. Plumb Waters Corporation,

More information

The Use of the ACQUITY QDa Detector for a Selective, Sensitive, and Robust Quantitative Method for a Potential Genotoxic Impurity

The Use of the ACQUITY QDa Detector for a Selective, Sensitive, and Robust Quantitative Method for a Potential Genotoxic Impurity The Use of the ACQUITY QDa Detector for a Selective, Sensitive, and Robust Quantitative Method for a Potential Genotoxic Impurity Janet Hammond Waters Corporation, Wilmslow, UK APPLICATION BENEFITS High

More information

Simplified Approaches to Impurity Identification using Accurate Mass UPLC/MS

Simplified Approaches to Impurity Identification using Accurate Mass UPLC/MS Simplified Approaches to Impurity Identification using Accurate Mass UPLC/MS Marian Twohig, Michael D. Jones, Dominic Moore, Peter Lee, and Robert Plumb Waters Corporation, Milford, MA, USA APPLICATION

More information

Increasing Speed of UHPLC-MS Analysis Using Single-stage Orbitrap Mass Spectrometer

Increasing Speed of UHPLC-MS Analysis Using Single-stage Orbitrap Mass Spectrometer Increasing Speed of UHPLC-MS Analysis Using Single-stage Orbitrap Mass Spectrometer Olaf Scheibner and Maciej Bromirski Thermo Fisher Scientific, Bremen, Germany Overview Purpose: Improve the performance

More information

UNIFI - Targeted and Untargeted Screening MS Software

UNIFI - Targeted and Untargeted Screening MS Software UNIFI - Targeted and Untargeted Screening MS Software Dr David Hardy Senior Product Manager Mass Spectrometry Software 2011 Waters Corporation 1 Waters System Solutions - Available with UNIFI Biopharmaceutical

More information

This document is a preview generated by EVS

This document is a preview generated by EVS TECHNICAL REPORT RAPPORT TECHNIQUE TECHNISCHER BERICHT CEN/TR 15641 August 2007 ICS 67.050 English Version Food analysis - Determination of pesticide residues by LC- MS/MS - Tandem mass spectrometric parameters

More information

MetWorks Metabolite Identification Software

MetWorks Metabolite Identification Software m a s s s p e c t r o m e t r y MetWorks Metabolite Identification Software Enabling Confident Analysis of Metabolism Data Part of Thermo Fisher Scientific MetWorks Software for the Confident Analysis

More information

ApplicationNOTE A STUDY OF THE ANALYSIS OF POLYBROMINATED DIPHENYL ETHER FLAME RETARDANTS BY GC/MS/MS. Introduction. Materials and Methods

ApplicationNOTE A STUDY OF THE ANALYSIS OF POLYBROMINATED DIPHENYL ETHER FLAME RETARDANTS BY GC/MS/MS. Introduction. Materials and Methods Abstract The development of a GC/MS/MS method for the analysis of brominated flame retardants will be presented. Standard methods require the use of high resolution magnetic sector instrumentation, which

More information

viridis Columns Bringing a New Dimension to SFC Combining state-of-the-art media manufacturing with industry leading column technology, Viridis

viridis Columns Bringing a New Dimension to SFC Combining state-of-the-art media manufacturing with industry leading column technology, Viridis [ viridis columns ] viridis Columns Bringing a New Dimension to SFC Combining state-of-the-art media manufacturing with industry leading column technology, Viridis Supercritical Fluid Chromatography (SFC)

More information

ApplicationNOTE Abstract

ApplicationNOTE Abstract Abstract It has long been known that a range of non-native, stable, saturated hydrocarbon biomarkers present in crude oil extracts could be used to identify the original facie from which the oil was formed.

More information

Routine MS Detection for USP Chromatographic Methods

Routine MS Detection for USP Chromatographic Methods Daniel S. Root, Thomas E. Wheat, and Patricia McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS This approach enables mass spectral analysis of peaks directly from unmodified USP HPLC

More information

EXPRESSION MORE PEPTIDES. MORE PROTEINS. MORE REPRODUCIBILITY. MORE QUANTIFICATION.

EXPRESSION MORE PEPTIDES. MORE PROTEINS. MORE REPRODUCIBILITY. MORE QUANTIFICATION. A New Era in Protein Quantification [ systems BIOLOGY Solutions ] [ systems BIOLOGY Solutions ] EXPRESSION MORE PEPTIDES. MORE PROTEINS. MORE REPRODUCIBILITY. MORE QUANTIFICATION. The Waters Expression

More information

ultimate efficiency unleashed [ Cortecs 1.6 µm columns ]

ultimate efficiency unleashed [ Cortecs 1.6 µm columns ] ultimate efficiency unleashed [ Cortecs columns ] [ CORTECS UPLC COLUMNS ] A SUB--µm SOLID-CORE PARTICLE COLUMN THAT LIVES UP TO ITS POTENTIAL. C 8 + C 8 HILIC SOLID-CORE PARTICLE COLUMNS THAT DELIVER

More information

Evaluation of a New HPLC, a New Tandem MS and a New Data Processing Software for General Clinical Use

Evaluation of a New HPLC, a New Tandem MS and a New Data Processing Software for General Clinical Use Evaluation of a New HPLC, a New Tandem MS and a New Data Processing Software for General Clinical Use Shih-Tse Jason Lai, Jia Wang, Brad Hart, Kristine Van Natta, Marta Kozak, Jorge Valdivia, Haibo Wang,

More information

The Emergence of Benchtop Tandem Quadrupole Mass Spectrometers as a Routine Tool in Quantitative GC/MS/MS Applications

The Emergence of Benchtop Tandem Quadrupole Mass Spectrometers as a Routine Tool in Quantitative GC/MS/MS Applications The Emergence of Benchtop Tandem Quadrupole Mass Spectrometers as a Routine Tool in Quantitative GC/MS/MS Applications Doug Stevens Waters Corp. Introduction The range of GC/MS instrument types has expanded

More information

Analysis of Serum 17-Hydroxyprogesterone, Androstenedione, and Cortisol by UPLC-MS/MS for Clinical Research

Analysis of Serum 17-Hydroxyprogesterone, Androstenedione, and Cortisol by UPLC-MS/MS for Clinical Research Analysis of Serum 17-Hydroxyprogesterone, Androstenedione, and Cortisol by UPLC-MS/MS for Clinical Research Heather A Brown, 1 Claudia Rossi, 2 and Lisa J Calton 1 1 Waters Corporation, Wilmslow, UK 2

More information

Introduction to Fourier Transform Infrared Spectroscopy

Introduction to Fourier Transform Infrared Spectroscopy Introduction to Fourier Transform Infrared Spectroscopy Introduction What is FTIR? FTIR stands for Fourier transform infrared, the preferred method of infrared spectroscopy. In infrared spectroscopy, IR

More information

Overview. Introduction. André Schreiber AB SCIEX Concord, Ontario (Canada)

Overview. Introduction. André Schreiber AB SCIEX Concord, Ontario (Canada) Quantitation and Identification of Pharmaceuticals and Personal Care Products (PPCP) in Environmental Samples using Advanced TripleTOF MS/MS Technology André Schreiber AB SCIEX Concord, Ontario (Canada)

More information

ApplicationNOTE ULTRA TRACE ANALYSIS OF DIOXINS AND FURANS IN HUMAN ADIPOSE TISSUE USING SFE-LC EXTRACTION/CLEANUP AND THE WATERS AUTOSPEC ULTIMA NT

ApplicationNOTE ULTRA TRACE ANALYSIS OF DIOXINS AND FURANS IN HUMAN ADIPOSE TISSUE USING SFE-LC EXTRACTION/CLEANUP AND THE WATERS AUTOSPEC ULTIMA NT Introduction Legislative limits for dioxins and furans are ever decreasing 1, providing a greater challenge for the dioxin analyst. The extraction and clean-up processes used by the analyst can be imperative

More information

PesticideScreener. Innovation with Integrity. Comprehensive Pesticide Screening and Quantitation UHR-TOF MS

PesticideScreener. Innovation with Integrity. Comprehensive Pesticide Screening and Quantitation UHR-TOF MS PesticideScreener Comprehensive Pesticide Screening and Quantitation Innovation with Integrity UHR-TOF MS The Challenge of Comprehensive Pesticide Residue Analysis The use of pesticides to reduce crop

More information

for XPS surface analysis

for XPS surface analysis Thermo Scientific Avantage XPS Software Powerful instrument operation and data processing for XPS surface analysis Avantage Software Atomic Concentration (%) 100 The premier software for surface analysis

More information

Online Reaction Monitoring of In-Process Manufacturing Samples by UPLC

Online Reaction Monitoring of In-Process Manufacturing Samples by UPLC Online Reaction Monitoring of In- Manufacturing Samples by UPLC Tanya Tollifson Waters Corporation, Milford, MA, USA APPLICATION BENEFITS Better throughput, yield, and process understanding are possible

More information

Live Webinar : How to be more Successful with your ACQUITY QDa Detector?

Live Webinar : How to be more Successful with your ACQUITY QDa Detector? Live Webinar : How to be more Successful with your ACQUITY QDa Detector? Q&A Transcript ---------------- Q - How do you generate multiple charges reproductively? A - If you use the same settings on the

More information

Lirui Qiao, 1 Rob Lewis, 2 Alex Hooper, 2 James Morphet, 2 Xiaojie Tan, 1 Kate Yu 3

Lirui Qiao, 1 Rob Lewis, 2 Alex Hooper, 2 James Morphet, 2 Xiaojie Tan, 1 Kate Yu 3 Using Natural Products Application Solution with UNIFI for the Comparison of the Chemical Ingredients of Shuanghuanglian Oral Drink from Two Different Manufacturers Lirui Qiao, 1 Rob Lewis, 2 Alex Hooper,

More information

Improved Throughput and Reproducibility for Targeted Protein Quantification Using a New High-Performance Triple Quadrupole Mass Spectrometer

Improved Throughput and Reproducibility for Targeted Protein Quantification Using a New High-Performance Triple Quadrupole Mass Spectrometer Improved Throughput and Reproducibility for Targeted Protein Quantification Using a New High-Performance Triple Quadrupole Mass Spectrometer Reiko Kiyonami, Mary Blackburn, Andreas FR Hühme: Thermo Fisher

More information

Accelerated Solvent Extraction GC-MS Analysis and Detection of Polycyclic Aromatic Hydrocarbons in Soil

Accelerated Solvent Extraction GC-MS Analysis and Detection of Polycyclic Aromatic Hydrocarbons in Soil Accelerated Solvent Extraction GC-MS Analysis and Detection of Polycyclic Aromatic Hydrocarbons in Soil Che Jinshui, 1 Deng Guifeng, 1 Liang Lina, 1 and Aaron Kettle, 2 1 Thermo Fisher Scientific (China)

More information

Automated and accurate component detection using reference mass spectra

Automated and accurate component detection using reference mass spectra TECHNICAL NOTE 72703 Automated and accurate component detection using reference mass spectra Authors Barbara van Cann 1 and Amit Gujar 2 1 Thermo Fisher Scientific, Breda, NL 2 Thermo Fisher Scientific,

More information

A Strategy for an Unknown Screening Approach on Environmental Samples using HRAM Mass Spectrometry

A Strategy for an Unknown Screening Approach on Environmental Samples using HRAM Mass Spectrometry A Strategy for an Unknown Screening Approach on Environmental Samples using HRAM Mass Spectrometry O. Scheibner, 1 P. van Baar, 2 F. Wode, 2 U. Dünnbier, 2 K. Akervik, 3 J. Humphries, 3 M. Bromirski 1

More information

Guide to Peptide Quantitation. Agilent clinical research

Guide to Peptide Quantitation. Agilent clinical research Guide to Peptide Quantitation Agilent clinical research Peptide Quantitation for the Clinical Research Laboratory Peptide quantitation is rapidly growing in clinical research as scientists are translating

More information

Identification and Characterization of an Isolated Impurity Fraction: Analysis of an Unknown Degradant Found in Quetiapine Fumarate

Identification and Characterization of an Isolated Impurity Fraction: Analysis of an Unknown Degradant Found in Quetiapine Fumarate Identification and Characterization of an Isolated Impurity Fraction: Analysis of an Unknown Degradant Found in Quetiapine Fumarate Michael D. Jones, Xiang Jin Song, Robert S. Plumb, Peter J. Lee, and

More information

ANALYSIS OF BASIC COMPOUNDS

ANALYSIS OF BASIC COMPOUNDS COMPARISON OF Fully AND Superficially POROUS PARTICLE COLUMNS FOR THE ANALYSIS OF BASIC COMPOUNDS Kenneth J. Fountain, Jane Xu, Zhe Yin, Pamela C. Iraneta, Diane M. Diehl Waters Corporation GOAL Compare

More information

Food & Environmental. Overview. Introduction. Method Details. André Schreiber and Yun Yun Zou SCIEX, Concord, Ontario, Canada

Food & Environmental. Overview. Introduction. Method Details. André Schreiber and Yun Yun Zou SCIEX, Concord, Ontario, Canada Food & Environmental Comprehensive Quantitation and Identification of Pesticides in Food Samples using LC-MS/MS with Scheduled MRM, Fast Polarity Switching, and MS/MS Library Searching André Schreiber

More information

Rapid, Reliable Metabolite Ratio Evaluation for MIST Assessments in Drug Discovery and Preclinical Studies

Rapid, Reliable Metabolite Ratio Evaluation for MIST Assessments in Drug Discovery and Preclinical Studies Rapid, Reliable Metabolite Ratio Evaluation for MIST Assessments in Drug Discovery and Preclinical Studies Jonathan Danaceau, Erin Chambers, and Kenneth J. Fountain Waters Corporation, Milford, MA, USA

More information

A Quality by Design (QbD) Based Method Development for the Determination of Impurities in a Peroxide Degraded Sample of Ziprasidone

A Quality by Design (QbD) Based Method Development for the Determination of Impurities in a Peroxide Degraded Sample of Ziprasidone A Quality by Design (QbD) Based Method Development for the Determination of Impurities in a Peroxide Degraded Sample of Ziprasidone Mia Summers and Kenneth J. Fountain Waters Corporation, 34 Maple St.,

More information

USP Method Transfer and Routine Use Analysis of Irbesartan Tablets from HPLC to UPLC

USP Method Transfer and Routine Use Analysis of Irbesartan Tablets from HPLC to UPLC USP Method Transfer and Routine Use Analysis of Tablets from HPLC to UPLC Aparna Chavali, Tanya Jenkins and Patricia McConville Waters Corporation, 34 Maple Street, Milford, MA USA APPLICATION BENEFITS

More information

C HA R AC T E RIZ AT IO N O F INK J E T P RINT E R C A RT RIDG E INK S USING A CHEMOMETRIC APPROACH

C HA R AC T E RIZ AT IO N O F INK J E T P RINT E R C A RT RIDG E INK S USING A CHEMOMETRIC APPROACH C HA R AC T E RIZ AT I N F INK J E T P RINT E R C A RT RIDG E INK S USING A CHEMMETRIC APPRACH Diana Uría and Paul Silcock Waters Corporation, Manchester, UK AIM To evaluate the potential of UPLC -ToF-MS

More information

Analytical Instrumentation

Analytical Instrumentation Gas Chromatography and Mass Spectrophotometry Environmental, food safety, toxicology, and forensic gas chromatography applications are more demanding than ever. Our portfolio of GC, GC- MS, GC-MS/MS and

More information

Q-TOF PREMIER DYNAMIC RANGE ENHANCEMENT AND ACCURATE MASS MEASUREMENT PERFORMANCE

Q-TOF PREMIER DYNAMIC RANGE ENHANCEMENT AND ACCURATE MASS MEASUREMENT PERFORMANCE Q-TOF PREMIER DYAMIC RAGE EHACEMET AD ACCURATE MASS MEASUREMET PERFORMACE Michael McCullagh, Jose Castro-Perez, and Lisa Calton Waters Corporation, Manchester, UK ITRODUCTIO The use of time-of-flight (TOF)

More information

Utility of H-SRM to Reduce Matrix Interference in Food Residue Analysis of Pesticides by LC-MS/MS Using the TSQ Quantum Discovery

Utility of H-SRM to Reduce Matrix Interference in Food Residue Analysis of Pesticides by LC-MS/MS Using the TSQ Quantum Discovery Application Note: 3 Utility of H-SRM to Reduce Matrix Interference in Food Residue Analysis of Pesticides by LC-MS/MS Using the TSQ Quantum Discovery Yoko Yamagishi, Thermo Fisher Scientific, C-2F 3-9

More information

Key Words Q Exactive, Accela, MetQuest, Mass Frontier, Drug Discovery

Key Words Q Exactive, Accela, MetQuest, Mass Frontier, Drug Discovery Metabolite Stability Screening and Hotspot Metabolite Identification by Combining High-Resolution, Accurate-Mass Nonselective and Selective Fragmentation Tim Stratton, Caroline Ding, Yingying Huang, Dan

More information

A Study of Stability, Robustness and Time Efficiency of a New HPLC and a New Tandem MS

A Study of Stability, Robustness and Time Efficiency of a New HPLC and a New Tandem MS A Study of Stability, Robustness and Time Efficiency of a New HPLC and a New Tandem MS Jason Lai, Jia Wang, Brad Hart, Pavel Aronov, Kristine Van Natta, Marta Kozak, Jorge Valdivia, Andy Jacobs, Haibo

More information

Thermo Scientific ICP-MS solutions for the semiconductor industry. Maximize wafer yields with ultralow elemental detection in chemicals and materials

Thermo Scientific ICP-MS solutions for the semiconductor industry. Maximize wafer yields with ultralow elemental detection in chemicals and materials Thermo Scientific ICP-MS solutions for the semiconductor industry Maximize wafer yields with ultralow elemental detection in chemicals and materials Trace impurity analysis in chemicals an used in the

More information

Natural Products. Innovation with Integrity. High Performance NMR Solutions for Analysis NMR

Natural Products. Innovation with Integrity. High Performance NMR Solutions for Analysis NMR Natural Products High Performance NMR Solutions for Analysis Innovation with Integrity NMR NMR Spectroscopy Continuous advancement in Bruker s NMR technology allows researchers to push the boundaries for

More information

Multiple Fragmentation Methods for Small Molecule Characterization on a Dual Pressure Linear Ion Trap Orbitrap Hybrid Mass Spectrometer

Multiple Fragmentation Methods for Small Molecule Characterization on a Dual Pressure Linear Ion Trap Orbitrap Hybrid Mass Spectrometer Application ote: 54 Multiple Fragmentation Methods for Small Molecule Characterization on a Dual Pressure Linear Ion Trap rbitrap Hybrid Mass Spectrometer Kate Comstock, Yingying Huang; Thermo Fisher Scientific,

More information

of mass spectrometry

of mass spectrometry Thermo Scientific 253 Ultra High resolution isotope ratio MS Discover a new world of mass spectrometry Paleoclimatology Atmospheric science Biogeochemistry Petrology Discover the isotopic anatomy of molecules

More information

All Ions MS/MS: Targeted Screening and Quantitation Using Agilent TOF and Q-TOF LC/MS Systems

All Ions MS/MS: Targeted Screening and Quantitation Using Agilent TOF and Q-TOF LC/MS Systems All Ions MS/MS: Targeted Screening and Quantitation Using Agilent TOF and Q-TOF LC/MS Systems Technical Overview Introduction All Ions MS/MS is a technique that is available for Agilent high resolution

More information

Thermo Scientific ELEMENT GD PLUS Glow Discharge Mass Spectrometer. Defining quality standards for the analysis of solid samples

Thermo Scientific ELEMENT GD PLUS Glow Discharge Mass Spectrometer. Defining quality standards for the analysis of solid samples Thermo Scientific ELEMENT GD PLUS Glow Discharge Mass Spectrometer Defining quality standards for the analysis of solid samples Redefine your quality standards for the elemental analysis of solid samples

More information

Hints and Tips for APGC Coupled with Xevo TQ-S for Food and Environmental Analysis

Hints and Tips for APGC Coupled with Xevo TQ-S for Food and Environmental Analysis Hints and Tips for APGC Coupled with Xevo TQ-S for Food and Environmental Analysis Adam Ladak, Lauren Mullin, and Rhys Jones Waters Corporation, Milford, MA, USA TECHNOLOGY BENEFITS The Xevo TQ-S APGC,

More information

Improved Screening for 250 Pesticides in Matrix using a LC-Triple Quadrupole Mass Spectrometer

Improved Screening for 250 Pesticides in Matrix using a LC-Triple Quadrupole Mass Spectrometer Improved Screening for 2 Pesticides in Matrix using a LC-Triple Quadrupole Mass Spectrometer Mary lackburn, Jia Wang, Jonathan eck, Charles Yang, Dipankar Ghosh, Thermo Fisher Scientific, San Jose, C,

More information

MassHunter TOF/QTOF Users Meeting

MassHunter TOF/QTOF Users Meeting MassHunter TOF/QTOF Users Meeting 1 Qualitative Analysis Workflows Workflows in Qualitative Analysis allow the user to only see and work with the areas and dialog boxes they need for their specific tasks

More information

LC-HRMS: Challenges for Routine Implementation

LC-HRMS: Challenges for Routine Implementation Joint EURL pesticides meeting October 23 rd -25th, 2013 Almeria Spain LC-HRMS: Challenges for Routine Implementation Richard J. Fussell Food and Environment Research Agency (York, UK) www.fera.defra.gov.uk

More information

Making Sense of Differences in LCMS Data: Integrated Tools

Making Sense of Differences in LCMS Data: Integrated Tools Making Sense of Differences in LCMS Data: Integrated Tools David A. Weil Agilent Technologies MassHunter Overview Page 1 March 2008 How Clean is our Water?... Page 2 Chemical Residue Analysis.... From

More information

Exploring Mixed-Mode Chromatography Column Chemistry, Properties, and Applications

Exploring Mixed-Mode Chromatography Column Chemistry, Properties, and Applications Exploring Mixed-Mode Chromatography Column Chemistry, Properties, and Applications Xiaodong Liu and Christopher Pohl; Thermo Fisher Scientific, Sunnyvale, CA Overview Review mixed-mode column technology

More information

ABI 3200 Q TRAP LC/MS/MS System

ABI 3200 Q TRAP LC/MS/MS System www.ietltd.com Proudly serving laboratories worldwide since 1979 CALL 001.847.913.0777 ABI 3200 Q TRAP LC/MS/MS System The advantages of an ion trap and the performance of a triple quad. All in one system.

More information

WALKUP LC/MS FOR PHARMACEUTICAL R&D

WALKUP LC/MS FOR PHARMACEUTICAL R&D Pharmaceutical Workflow Solutions WALKUP LC/MS FOR PHARMACEUTICAL R&D Chemists, Peptide/Protein Chemists, Biologists, and Beyond MASSHUNTER WALKUP A Single User Interface for Robust and Reliable LC/MS

More information

Rapid Screening and Confirmation of Melamine Residues in Milk and Its Products by Liquid Chromatography Tandem Mass Spectrometry

Rapid Screening and Confirmation of Melamine Residues in Milk and Its Products by Liquid Chromatography Tandem Mass Spectrometry Rapid Screening and Confirmation of Melamine Residues in Milk and Its Products by Liquid Chromatography Tandem Mass Spectrometry Application Note Food Authors Jianqiu Mi, Zhengxiang Zhang, Zhixu Zhang,

More information

Performing Peptide Bioanalysis Using High Resolution Mass Spectrometry with Target Enhancement MRM Acquisition

Performing Peptide Bioanalysis Using High Resolution Mass Spectrometry with Target Enhancement MRM Acquisition Performing Peptide Bioanalysis Using High Resolution Mass Spectrometry with Target Enhancement MRM Acquisition Yun Wang Alelyunas, Mark D. Wrona, and Nick Tomczyk Waters Corporation, Milford, MA, USA GOAL

More information

Quadrupole Time-of-Flight Liquid Chromatograph Mass Spectrometer LCMS-9030 C146-E365

Quadrupole Time-of-Flight Liquid Chromatograph Mass Spectrometer LCMS-9030 C146-E365 Quadrupole Time-of-Flight Liquid Chromatograph Mass Spectrometer LCMS-9030 C146-E365 Effortless Performance The LCMS-9030 quadrupole time-of-flight (Q-TOF) mass spectrometer integrates the world s fastest

More information

High-Field Orbitrap Creating new possibilities

High-Field Orbitrap Creating new possibilities Thermo Scientific Orbitrap Elite Hybrid Mass Spectrometer High-Field Orbitrap Creating new possibilities Ultrahigh resolution Faster scanning Higher sensitivity Complementary fragmentation The highest

More information

Introduction to Fourier Transform Infrared Spectroscopy

Introduction to Fourier Transform Infrared Spectroscopy molecular spectroscopy Introduction to Fourier Transform Infrared Spectroscopy Part of Thermo Fisher Scientific Introduction What is FT-IR? FT-IR stands for Fourier Transform InfraRed, the preferred method

More information

Traditional Herbal Medicine Structural Elucidation using SYNAPT HDMS

Traditional Herbal Medicine Structural Elucidation using SYNAPT HDMS Traditional Herbal Medicine Structural Elucidation using SYNAPT HDMS with Time-Aligned Parallel (TAP) Fragmentation Kate Yu, Jose Castro-Perez, and John Shockcor Waters Corporation, Milford, MA, U.S. INTRODUCTION

More information

DI 3500 Discrete Aoalvzer

DI 3500 Discrete Aoalvzer DI 3500 Discrete Aoalvzer Automated Chemistry and Ion Analysis ':t O+Analytical:!, A World ofsolutions. - Discrete Analysis Efficient Microscale Chemistry Increasingly laboratories are being challenged

More information

Implementation of Methods Translation between Liquid Chromatography Instrumentation

Implementation of Methods Translation between Liquid Chromatography Instrumentation Implementation of Methods Translation between Liquid Chromatography Instrumentation Michael D. Jones, Peter Alden, Kenneth J. Fountain, and Andrew Aubin Waters Corporation, Milford, MA, U.S. APPLICATION

More information

A Strategy for an Unknown Screening Approach on Environmental Samples Using HRAM Mass Spectrometry

A Strategy for an Unknown Screening Approach on Environmental Samples Using HRAM Mass Spectrometry A Strategy for an Unknown Screening Approach on Environmental Samples Using HRAM Mass Spectrometry Olaf Scheibner, 1 Patrizia van Baar, 2 Florian Wode, 2 Uwe Dünnbier, 2 Kristi Akervik, 3 Jamie Humphrie,

More information

APPLICATION BENEFITS INTRODUCTION WATERS SOLUTIONS KEY WORDS. Simultaneous high-throughput screening of melamine (MEL) and cyanuric acid (CYA).

APPLICATION BENEFITS INTRODUCTION WATERS SOLUTIONS KEY WORDS. Simultaneous high-throughput screening of melamine (MEL) and cyanuric acid (CYA). A Rapid and Sensitive Method for the Simultaneous Determination of and Cyanuric Acid in Infant Formulas, Adult utritional Products, and Protein Powders APPLICATIO BEEFITS Simultaneous high-throughput screening

More information

Stephen McDonald and Mark D. Wrona Waters Corporation, Milford, MA, USA INT RO DU C T ION. Batch-from-Structure Analysis WAT E R S SO LU T IONS

Stephen McDonald and Mark D. Wrona Waters Corporation, Milford, MA, USA INT RO DU C T ION. Batch-from-Structure Analysis WAT E R S SO LU T IONS Chemical Intelligence in UNIFI: Enhancing in-silico Decision Making to Provide Confident and Accurate Results for Metabolite Identification Experiments Stephen McDonald and Mark D. Wrona Waters Corporation,

More information

New Dynamic MRM Mode Improves Data Quality and Triple Quad Quantification in Complex Analyses

New Dynamic MRM Mode Improves Data Quality and Triple Quad Quantification in Complex Analyses New Dynamic MRM Mode Improves Data Quality and Triple Quad Quantification in Complex Analyses Technical Overview Authors Abstract Peter Stone, Thomas Glauner, Frank Kuhlmann, Tim Schlabach and Ken Miller

More information

Insights Into the Nanoworld Analysis of Nanoparticles with ICP-MS

Insights Into the Nanoworld Analysis of Nanoparticles with ICP-MS Insights Into the Nanoworld Analysis of Nanoparticles with ICP-MS Daniel Kutscher, 1 Jörg Bettmer, 2 Torsten Lindemann, 1 Shona McSheehy-Ducos, 1 Lothar Rottmann 1 1 Thermo Fisher Scientific, Germany 2

More information

Screening Method for 30 Pesticides in Green Tea Extract Using Automated Online Sample Preparation with LC-MS/MS

Screening Method for 30 Pesticides in Green Tea Extract Using Automated Online Sample Preparation with LC-MS/MS Application Note: 514 Screening Method for 3 Pesticides in Green Tea Extract Using Automated Online Sample Preparation with LC-MS/MS Yang Shi, Catherine Lafontaine, Thermo Fisher Scientific, Franklin,

More information

Highly Sensitive and Rugged GC/MS/MS Tool

Highly Sensitive and Rugged GC/MS/MS Tool Highly Sensitive and Rugged GC/MS/MS Tool For Pesticide Multiresidue Analysis in Food Samples Agilent 7 Series Triple Quadrupole GC/MS. The world s first MS/MS designed specifically for GC Analysis Introduction

More information

Overview. Introduction. André Schreiber 1 and Yun Yun Zou 1 1 AB SCIEX, Concord, Ontario, Canada

Overview. Introduction. André Schreiber 1 and Yun Yun Zou 1 1 AB SCIEX, Concord, Ontario, Canada LC-MS/MS Based Strategy for the Non-Targeted Screening of an Unlimited Number of Contaminants in Food Using the AB SCIEX TripleTOF 5600 System and Advanced Software Tools André Schreiber 1 and Yun Yun

More information

Everyday NMR. Innovation with Integrity. Why infer when you can be sure? NMR

Everyday NMR. Innovation with Integrity. Why infer when you can be sure? NMR Everyday NMR Why infer when you can be sure? Innovation with Integrity NMR Only NMR gives you definitive answers, on your terms. Over the past half-century, scientists have used nuclear magnetic resonance

More information

AB SCIEX SelexION Technology Used to Improve Mass Spectral Library Searching Scores by Removal of Isobaric Interferences

AB SCIEX SelexION Technology Used to Improve Mass Spectral Library Searching Scores by Removal of Isobaric Interferences AB SCIEX SelexION Technology Used to Improve Mass Spectral Library Searching s by Removal of Isobaric Interferences Differential Mobility Used as a Tool to Address Selectivity Challenges Adrian M. Taylor

More information

Impurity Profiling of Pharmaceutical Starting Materials Using Gas Chromatography Coupled with High- Resolution Accurate Mass Spectrometry

Impurity Profiling of Pharmaceutical Starting Materials Using Gas Chromatography Coupled with High- Resolution Accurate Mass Spectrometry Impurity Profiling of Pharmaceutical Starting Materials Using Gas Chromatography Coupled with High- Resolution Accurate Mass Spectrometry Cristian Cojocariu and Paul Silcock Thermo Fisher Scientific, Runcorn,

More information

Thermo Scientific HyperSep Dispersive SPE Products. Efficient sample preparation and clean-up using the QuEChERS Method

Thermo Scientific HyperSep Dispersive SPE Products. Efficient sample preparation and clean-up using the QuEChERS Method Thermo Scientific HyperSep Dispersive SPE Products Efficient sample preparation and clean-up using the QuEChERS Method The QuEChERS method overcomes the problems associated with time consuming, expensive

More information

A Case of Pesticide Poisoning: The Use of a Broad-Scope Tof Screening Approach in Wildlife Protection

A Case of Pesticide Poisoning: The Use of a Broad-Scope Tof Screening Approach in Wildlife Protection A Case of Pesticide Poisoning: The Use of a Broad-Scope Tof Screening Approach in Wildlife Protection George Keenan 1, Anna Giela 1, Michael Taylor 1, Jennifer Watson 1, Eleanor Riches 2, James Morphet

More information

Macrolides in Honey Using Agilent Bond Elut Plexa SPE, Poroshell 120, and LC/MS/MS

Macrolides in Honey Using Agilent Bond Elut Plexa SPE, Poroshell 120, and LC/MS/MS Macrolides in Honey Using Agilent Bond Elut Plexa SPE, Poroshell 120, and LC/MS/MS Application Note Food Testing and Agriculture Author Chen-Hao (Andy) Zhai and Rong-jie Fu Agilent Technologies (Shanghai)

More information

Basic Principles for Purification Using Supercritical Fluid Chromatography

Basic Principles for Purification Using Supercritical Fluid Chromatography Basic Principles for Purification Using Supercritical Fluid Chromatography Jo-Ann M. Jablonski, Christopher J. Hudalla, Kenneth J. Fountain, Steven M. Collier, and Damian Morrison Waters Corporation, Milford,

More information

Confirmation of In Vitro Nefazodone Metabolites using the Superior Fragmentation of the QTRAP 5500 LC/MS/MS System

Confirmation of In Vitro Nefazodone Metabolites using the Superior Fragmentation of the QTRAP 5500 LC/MS/MS System Confirmation of In Vitro Nefazodone Metabolites using the Superior Fragmentation of the QTRAP 5500 LC/MS/MS System Claire Bramwell-German, Elliott Jones and Daniel Lebre AB SCIEX, Foster City, California

More information

Metabolic Phenotyping Using Atmospheric Pressure Gas Chromatography-MS

Metabolic Phenotyping Using Atmospheric Pressure Gas Chromatography-MS Metabolic Phenotyping Using tmospheric Pressure Gas hromatography-ms Vladimir Shulaev, 2 Ghaste Manoj, 2,3 Steven Lai, 1 arolina Salazar, 2 Nobuhiro Suzuki, 2 Janna rossley, 2 Feroza Kaneez oudhury, 2

More information

EGASUS. 4D GCxGC TOFMS. Delivering the Right Results

EGASUS. 4D GCxGC TOFMS. Delivering the Right Results P EGAU 4D GCxGC TFM Delivering the Right Results LEC s P EGAU 4D GCxGC-TFM The Ultimate Analytical Instrument Pioneering GCxGC technology, combined with the Pegasus TFM and ChromaTF software provides today

More information

WADA Technical Document TD2003IDCR

WADA Technical Document TD2003IDCR IDENTIFICATION CRITERIA FOR QUALITATIVE ASSAYS INCORPORATING CHROMATOGRAPHY AND MASS SPECTROMETRY The appropriate analytical characteristics must be documented for a particular assay. The Laboratory must

More information

Thermo Scientific ConFlo IV Universal Interface. Continuous Flow Interface. Isotope Ratio MS

Thermo Scientific ConFlo IV Universal Interface. Continuous Flow Interface. Isotope Ratio MS Thermo Scientific ConFlo IV Universal Interface Continuous Flow Interface Isotope Ratio MS 3 ConFlo IV Universal Interface for Continuous Flow Isotope Ratio MS The development of Continuous Flow carrier

More information

Achieve confident synthesis control with the Thermo Scientific ISQ EC single quadrupole mass spectrometer

Achieve confident synthesis control with the Thermo Scientific ISQ EC single quadrupole mass spectrometer APPLICATION NOTE 72385 Achieve confident synthesis control with the Thermo Scientific ISQ EC single quadrupole mass spectrometer Authors Stephan Meding, Katherine Lovejoy, Martin Ruehl Thermo Fisher Scientific,

More information