Study of Chemical Reactions
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1 Study of Chemical Reactions
2 Introduction to Mechanisms There are four different types of organic reactions: Additions Eliminations Substitutions Rearrangements 149
3 Addition Reactions Occur when 2 reactants add together to form a single product with no atoms left over A + B C 150
4 Elimination Reactions Are the opposite of addition, i.e. single reactant splits into 2 (or more) products A B + C 151
5 Substitution Reactions Occur when 2 reactants exchange parts to give 2 new products A B + C D A C + B D 152
6 Rearrangement Reactions Occur when a single reactant undergoes a reorganization of bonds and atoms, leading to an isomeric product A A' 153
7 Reaction Mechanism An overall description of how a reaction occurs. It is a representation of the electron flow that would accompany the breaking of bonds and the formation of new bonds. In this process, reactive intermediates are normally formed. 154
8 Pushing electrons is a good graphic way to describe each step. We use arrows to describe the electronic movement in a mechanism. Arrow Representations reactants going to products equilibrium resonance represents the movement of electrons 155
9 Bonds can break in 2 different ways: Homolytic cleavage: each partner takes one electron (Half-headed arrow = 1 electron moves) Heterolytic cleavage: one partner takes 2 electrons, the other partner takes none. (normal-headed arrow = 2 electrons move) 156
10 Radical reactions: process involving the symmetrical bond breaking and bond making. Polar Reactions: process involving the unsymmetrical bond breaking and bond making. 157
11 Radical Reactions normally require three kinds of steps: Initiation (formation of a radical) Propagation (radical cascade process) Termination (2 radicals join to end the reaction) We have already seen one example in the Chapter dealing with Alkanes: Monochlorination of Methane 158
12 Mechanism of monochlorination of methane homolytic cleavage Cl Cl h 2Cl initiation step Cl H CH 3 HCl + CH 3 first propagation step CH 3 Cl Cl CH 3 Cl + Cl second propagation step Cl Cl Cl 2 CH 3 CH 3 CH 3 CH 3 termination steps Cl CH 3 CH 3 Cl 159
13 Polar Reactions: in polar reactions, the electron rich site of one reactant react with the electron poor site of the other reactant. IMPORTANT: understand dipole moment 160
14 Electron Rich Site: the reactant with the electron rich site is often referred to as: Nucleophile Cl - OH - CH 3 NH 2 H 2 O nucleophiles since they have apairofelectronstoshare Electron Poor Site: the reactant with the electron poor site is often referred to as: Electrophile H + CH 3 CH 2 + BH 3 electrophiles since they can accept a pair of electrons 161
15 Example of polar reaction: Curved arrows are used to describe the reaction that took place? 162
16 Rule 1 Electrons move from a nucleophilic source (Nu:) to an electrophilic site. (Nu: must have an electron pair available, either as lone pair or a multiple bond) O E N E C - E E 163
17 The electrophilic site must be able to accept the electrons. Normally, this site has a positively charged atom or a positively polarized atom. Nu: Nu: Nu: Nu: C + C Halogen H O O 164
18 Rule 2 The nucleophile can either be neutral or charged Rule 3 The electrophile can either be neutral or charged Rule 4 The octet rule must be followed 165
19 In each step of our example, which species is the nucleophile and which is the electrophile? step1 H Br + H step2 Br - Br H 166
20 Let s look at the mechanism of this reaction with arrow representation. 167
21 Reactive Intermediates Are short-lived species that are never present in high concentrations because they react almost as quickly as they are formed. Types: species with trivalent carbon. They are classified according to their charge. C+ C C - C carbocation radical carbanion carbene 168
22 Carbocations and radicals: are stabilized by inductive effect. Inductive effect: is the sharing of electrons density through the σ bonds of molecules 169
23 Rule more highly substituted (with alkyl groups) carbocations (or radicals) are more stable. R R C + R more stable R R C + H R C + H H H C + H H 3 o 2 o 1 o methyl carbocation least stable 170
24 Same analysis is valid for radicals 171
25 Carbanions: are sp 3 hybridized. They are electron rich and nucleophilic Stability of carbanions is opposite to that of carbocations due to the inductive effect. 172
26 Like all other reactions, organic reactions require collision between species in order to take place Therefore, a certain amount of energy is required for these reactions to proceed 173
27 Activation Energy (E a ) The minimum kinetic energy the molecules must possess to overcome the repulsions between their electron clouds when they collide When enough energy is provided, the species involved in the reaction reach the transition state Figure
28 Transition state Highest energy state in a molecular collision that leads to reaction A B + C A B C A + B C reactants transition state products 175
29 Figure 4-4 When reactive intermediates are formed, there are usually more than one transition states. One example would be the first propagation step in the chlorination of methane. 176
30 Energy diagrams are also useful in understanding the stability of reactive intermediate. For example, the chlorination of propane should result in the formation of 2-chloropropane rather than 1-chloropropane due to the difference in stability of the radicals formed. Figure
31 Figure 4-12 Hammond Postulate Related species that are similar in energy are also similar in structure.the structure of a transition state resembles the structure of the closest stable species 178
32 Mechanisms Mechanism are very important to understand organic reactions. When you are drawing mechanisms, always remember: Are the structures respecting Lewis rules? Is there 2 electrons moving and is it from the Nu to E? Are there charges to the new species formed? Here are some general rules: 179
33 How to decide on charges? Neutral molecules as Nu When a lone pair/bonding pair is used as Nu to form a new bond, the resulting species is normally positively charged. In the original alkene, both carbon provided one electron each to form the double bond. But in the product, the red carbon lost one electron and is positively charged 180
34 Charged Nu When a charged nucleophile attacks a neutral molecule, the resulting species is normally negatively charged: O _ O NC _ CN 181
35 Neutral Nu and Neutral E When a neutral nucleophile and a neutral electrophile react, the resulting species normally has both negative and positive charges O Cl H2O + _ O O H Cl H 182
36 Questions: Complete the mechanism by adding the proper arrows and charges O NC O- H3C C CH3 -CN H CN NC OH + CN - 183
37 Ph3P CH3 Br + Ph 3P CH2 H B- + - Ph3P CH2 Ph3P=CH2 184
38 + - Ph3P CH2 Ph3P=CH2 O C + O- PPh3 O PPh3 Ph3P=O + 185
39 O - + CH2S(CH3)2 O C O + CH2 S(CH3)2 C + (CH3)2S 186
40 HO O- N O H O- + HO N + + H O + H2O + NO2 187
41 4-36 Study Problems Draw a reaction-energy diagram for a one-step exothermic reaction. Label the parts that represent the reactants, products, transition state, activation energy and heat of reaction. 188
42 4-43 Write a mechanism for the light-initiated monochlorination of cyclohexane with chlorine producing chlorocyclohexane. Identify each of the steps. 189
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