Sources of Errors in Trace Element and Speciation Analysis
|
|
- Clementine Norris
- 6 years ago
- Views:
Transcription
1 Sources of Errors in Trace Element and Speciation Analysis Zoltan Mester, National Research Council of Canada, Institute for National Measurement Standards Outline Definitions Sources of errors in the analytical process Detection methods in trace element analysis Trace element measurement methods and the associated errors Summary TAQC-WFD, Budapest, November 2-4, Expression of an analytical result Value 1 ± Value 2 Expression of an analytical result Value 1 ± Value 2 Free of systematic error (bias) Uncertainty Free of systematic error (bias) Uncertainty Verification of traceability of the results: CRMs Primary methods (or reference methods) Consideration of all sources of error of the analytical process: 1. Random errors: Method precision 2. Correction of systematic errors Verification of traceability of the results: CRMs Primary methods (or reference methods) Consideration of all sources of error of the analytical process: 1. Random errors: Method precision 2. Correction of systematic errors 3 4 1
2 Measurand Particular quantity subject to measurement Measurement Set of operations having the object of determining a value of a quantity Result of a measurement Value attributed to a measurand, obtained by measurement Uncertainty (of measurement) Parameter associated with the result of a measurement, that characterises the dispersion of the values that could reasonably be attributed to the Measurand Conventional true value (assigned value, best estimate of the value, conventional value or reference value) Value attributed to a particular quantity and accepted, sometimes by convention, as having an uncertainty appropriate for a given purpose. Error (of measurement) The result of a measurement minus a true value of the measurand Systematic error Mean that would result from an infinite number of measurements of the same measurand carried out under repeatability conditions minus a true value of the measurand 5 6 Arithmetic mean x Arithmetic mean value of a sample of n results Sources of Errors in Trace Element and Speciation Analyses Sample Standard Deviation s An estimate of the population standard deviation σ from a sample of n results
3 Sources of Errors in Trace Element and Speciation Analyses Sources of Errors in Trace Element and Speciation Analyses Perhaps Perhaps it should be Sources of Errors and Uncertainities in Trace Element and Speciation Analyses 9 10 (i) (ii) (iii) (iv) It is easy to recognize that increasing the complexity of an analytical protocol (i.e.: more steps during the analytical process) increases the chance of errors. In an ideal situation, analytical measurements would be done: in-situ, removing the issues related to sampling and sample integrity. Directly in the matrix even for solids, without extensive sample preparation such as leaching, decomposition, etc. Using highly selective, absolute measurements, with the dynamic range of the measurement method extending from percentage to ppt levels, thus removing potential sources of error due to interferences, calibration etc. without human intervention, i.e., automated, removing the human variable from the system. (i) (ii) (iii) (iv) It is easy to recognize that increasing the complexity of an analytical protocol (i.e.: more steps during the analytical process) increases the chance of errors. In an ideal situation, analytical measurements would be done: in-situ, removing the issues related to sampling and sample integrity. Directly in the matrix even for solids, without extensive sample preparation such as leaching, decomposition, etc. Using highly selective, absolute measurements, with the dynamic range of the measurement method extending from percentage to ppt levels, thus removing potential sources of error due to interferences, calibration etc. without human intervention, i.e., automated, removing the human variable from the system
4 Overview of the analytical process Overview of the analytical process Sampling Sample preparation Instrumental analysis Data evaluation Sampling Sample preparation Instrumental analysis Data evaluation Sampling and sample preparation are by far the largest contributors to measurement errors and uncertainty!!!! Contamination, sample loss -Sample Container Material -Container Transpiration -Stability of Metals at ppb Concentration Levels -Environmental Contamination -Contamination From Reagents -Contamination From the Analyst and Apparatus Overview of the analytical process Sampling Sample preparation Instrumental analysis Data evaluation
5 Detection Technologies Optical Absorption, AA, GF-AA Emission, ICP, Flame Fluorescent, Mass spectrometry ICP GD MIP Atomic Absorption spectrometry (AA) Discovered in the late fifties Shine light specific for an element through an atom reservoir (flame or furnace) Light is absorbed by the ground state atoms of given element The absorption rate is proportional with the number of analyte atoms in the atom source AA FAST, (seconds per determination) Low cost per analysis Low capital investment and low operating cost Single element determination Easy to use Well understood interferences (mature technique) Versatile Requires separate lamp for each element to be determined Hollow Cathode (HCL) or Electrodeless Discharge Lamp (EDL) Interferences Technique Type of Interference Compensation Method Flame AA Ionization Ionization buffer Chemical Releasing agent or nitrous - oxide-acetylene flame Physical Dilution, matrix matching or method of additions
6 Graphite Furnace Atomic Absorption (GF-AAS) Low detection limits for most elements parts per billion (μg/l) Slower then flame analysis Min per determination Single element determination Small sample volume (μl) Interferences Cost per analysis higher than Flame AA More technical experience needed Interferences Technique Type of Interference Compensation Method GFAA Molecular absorption background correction Matrix interferences modifiers Special case of AA or AFS Dedicated system for cold vapor Hg analysis Detects ppt levels of Hg High intensity Hg lamp Long path length cell Solid state detector Extremely sensitive but prone to matrix interferences Inductively Coupled Plasma Optical Emission Spectrometry ICP is an argon gas discharge (~6-9000K) Excites atoms in sample and Light being emitted. The emitted light is separated and measured. Wavelengths are characteristic of element Intensity of light emitted is proportional to amount of element in the sample
7 ICP-OES Fast or very fast analysis time Many elements in a few minutes Low detection limits Parts per billion in axial view mode Wider dynamic range Over 3 times better than flame AA (Two viewing options) Cost per analysis Comparable to flame AA Lower than GF AA Some technical experience needed Interferences Technique Type of Interference Compensation Method ICP-OES Spectral Background correction or use of alternate analytical wavelengths Physical Internal standardization Spectrum of a high Ca containing matrix (red line) causing a sloping background for the Cu or Ge lines are used. Background correction is difficult at best in these situations. 27 Spectrum of a high concentration of Fe (red line) showing a direct spectral overlap upon the B line and a wing overlap on a B
8 Wing overlap interference of Fe (red line) upon the Ba nm line Overview of ICP-OES Detection limits not as good as GFAA or ICP-MS Some specific applications require lower detection limits Some elements in line-rich area of spectrum Thousands of wavelengths for Fe Rare earths (Dy, Eu, La, Ce) Interferences for particular elements Transuranics (U, Am, Pu, Tc) Sensitivity for some elements not sufficient Halogens Higher initial investment than AA More gas consumption than AA Requires ~16 L/min of argon gas Advantages of ICP-OES Multielement technique Speed samples can be analyzed in seconds to minutes Excellent linear dynamic range up to mg/l Detection limits moderate to excellent ug/l Interferences spectral interferences controlled through instrument design / software Plasma view: axial or radial axial view has lower DLs radial view has wider linear range and less interferences Lower cost per (similar to AA)
9 Nebulizers ICP-MS Same type of plasma source as in ICP-OES Ions are generated by intense ICP ion source, separated and detected by a mass spectrometer Nebulizers The main function of the sample introduction system is to generate a fine aerosol of the sample. It achieves this purpose with a nebulizer and a spray chamber Nebulizers generate an aerosol from the aqueous sample and spray chambers filter out heavy droplets and dampen noise. In general, nebulizers designed for use with ICP-OES are not recommended for ICP-MS 1-2% total dissolved solids (TDS) for OES and only % for MS Nebulizers Concentric design. In the concentric nebulizer,the solution is introduced through a capillary tube to a low-pressure region created by a gas flowing rapidly past the end of the capillary. Concentric pneumatic nebulizers can provide excellent sensitivity and stability, particularly with clean solutions. However, the small orifices can be plagued by blockage problems, especially if large numbers of heavy matrix samples are aspirated
10 Nebulizers Crossflow design. For samples that contain a heavier matrix or small amounts of undissolved matter, the crossflow design is probably the best option. With this design the argon gas is directed at right angles to the tip of a capillary tube, in contrast to the concentric design, where the gas flow is parallel to the capillary. Spray chambers Crossflow nebulizers are generally not as efficient as concentric nebulizers at creating the very small droplets needed for ICP-MS analyses. 37 Schematic of a cyclonic spray chamber (shown with concentric nebulizer). 38 Spray chambers Ion source Schematic of a Scott double-pass spray chamber (shown with crossflow nebulizer
11 Plasma Plasma Mass analyzer is the region of the ICP mass spectrometer that separates the ions according to their mass to charge ratio (m/z)
12 Mass analyzers Quadrupole Quadrupole TOF (Iinerar, ortogonal) Sector instruments Schematic of a quadrupole mass analyzer Sensitivity comparison of a quadrupole operated at 3.0, 1.0, and 0.3 amu resolution (measured at 10% of its peak height) Quads are low res analyzers 47 Ions entering the quadrupole are slowed down by the filtering process and produce peaks with a pronounced tail or shoulder at the low-mass end. The abundance sensitivity for quadrupoles is always worse on the low mass side than on the high mass side and is typically 1 x 10-6 at M - 1 and 1 x 10-7 at M
13 Sector instruments Schematic of a double-focusing magnetic-sector ICP mass spectrometer Why we need high mass resolution? Resolution required to resolve some common polyatomic interferences from a selected group of isotopes
14 Q Ion transmission with a magneticsector instrument decreases as the resolution increases. HR TOF (on-axis, ortogonal design) Schematic of an orthogonal acceleration TOF analyzer
15 m/z = 2Ut 2 /D 2 Where (U) is the accelerating voltage, mass-to-charge ratios (m/z), time (t), length of the flight path (D) Schematic of an on-axis acceleration TOF analyzer Mass analyzer Resolution Quad TOF Sector 10,000 Reflectron TOF MS design
16 Resolution required to resolve some common polyatomic interferences from a selected group of isotopes. ICP-Mass Spectroscopy Overview Very fast analysis Comparable to simultaneous ICP-OES Superior detection limits Parts per trillion Semi-Quant analysis Isotope analysis Cost per analysis Same as ICP-OES Some technical experience required Technique Type of Interference Compensation Method ICP-MS Mass Overlap Interelement correction, use of alternate mass values or higher mass Resolution Dynamic Reaction Cell Physical Internal Standardization
17 ICP MS Very fast analysis Comparable to simultaneous ICP-OES and standard ICP-MS Superior detection limits Up to parts per quadrillion Removes isobaric and argon interferences Cost per analysis Slightly more than standard ICP-MS Some technical expertise required
18 Flame AA A few elements per sample to analyze 5 ml/min sample consumption Detection levels needed are in the sub-mg/l region GFAA Detection levels of μg/l to sub- μg/l levels ul sample consumption ICP-OES Several elements per sample (5+) 1-5 ml/min sample consumption Detection levels are in the sub-mg/l and μg/l region ICP-MS Detection levels of sub- μg/l to sub-ng/l levels Typical 1-2 ml/min sample consumption Can use low consumption nebulizers 69 Interferences in ICP MS Isobaric Interferences Polyatomic (Molecular) Interferences Doubly Charged Ion Interferences 70 Isobaric Interferences: Isobaric interference is a result of equal mass isotopes of different elements present in the sample solution. Low-resolution instruments (quad, TOF) cannot distinguish between the isotopes. There are many examples in the intermediate mass regions where the second and third row transitions and the rare earths appear. There are no elemental singly charged isotopes that overlap with monoisotopic elements (9Be, 23Na, 27Al, 45Sc, 55Mn, 75As, 89Y, 103Rh, 127I, 133Cs, 141Pr, 159Tb, 165Ho, 169Tm, 197Au, and 232Th). For elements having more than one isotope, the quickest fix may be to use another isotope of that element. Isobaric Interferences: If the interference is from an isotope with roughly the same or lower peak intensity, it is possible to perform a correction by measuring the intensity of another isotope of the interfering element and subtracting the appropriate correction factor from the intensity of the interfered isotope. If you are working with an unknown sample composition, a semi-quantitative analysis is suggested with low-resolution instruments using a quick scan of the sample and the rather sophisticated semi-quantitative programs available on current instrumentation
19 Polyatomic (Molecular) Interferences: Molecular interferences are due to the recombination of sample and matrix ions with Ar and other matrix components such as O, N, H, C, Cl, S, F, etc. The light elements (Li, Be, B) are not affected due to their small masses. Starting with 39K, this type of interference becomes a significant issue. For example, 39K is interfered with by 38ArH and 23Na16O. Some polyatomic interferences can be avoided by eliminating certain matrix elements such as the classic 40Ar35Cl interference upon the monoisotopic element 75As, where the use of HCl in the sample preparation is to be avoided. The isotopes 56Fe, 39K, and 44Ca or 40Ca are all interfered with by combinations of the Ar, O, and N isotopes. 73 Polyatomic (Molecular) Interferences: As we go to the heavier elements the major polyatomic interferences come from isotopes that are 16 atomic mass units lower than the analyte isotope through molecular oxide (MO) interference. The lanthanide element isotopes are especially prone to molecular oxide formation. The use of cool plasma techniques, reaction / collision cells, desolvation, and chromatographic separations -- to name a few approaches -- have resulted in reduction and, in some cases, complete elimination of many polyatomic interferences. 74 Polyatomic (Molecular) Interferences: The severity of the MO interference can be reduced through reduction of the sample argon gas flow rate. Mass corrections may be an option in cases where the use of an alternate isotope is not an option. Polyatomic interferences are particularly troublesome in the determination of first row periodic table elements (K thru Se) due to the vast number of combinations of Ar with matrix components. Doubly Charged Ion Interferences: Doubly charged ion interference is due to doubly charged element isotopes with twice the mass of the analyte isotope. For example, interference from 206Pb++ (m/e = 103) upon 103Rh is likely at high Pb concentration levels. Reduction in the sample Ar will minimize this interference. Fortunately, this type of interference is not as prominent in Ar plasmas, but care should be exercised in matrices containing high levels of mid to heavy mass element isotopes. The alkaline and rare earth elements form doubly charged ions to a extent that is greater, relative to the other elements
20 ICP MS background mass spectrum of high-purity water. 77 Common polyatomic spectral interferences in ICP-MS. 78 Space Charge Effects: These effects are thought to occur at the MS interface, the region between the skimmer tip and ion optics and in the ion optics region. The net result is a suppression of the signal in high concentrations of a matrix element. The kinetic energy of the ion element matrix affects the degree of suppression with larger masses (higher kinetic energy) causing more depression than lower masses. Due to differences between instruments in interface and ion optic designs it is difficult to predict the conditions under which the effect is minimal. Under 'cool plasma' conditions, this suppression effect is more pronounced. Keep the matrix element concentration at or below the 100 µg/g! 79 How to eliminate spectral interferences? isobaric interferences from isobaric element ions cannot be eliminated easily solution: use an other isotope if you can Front end solutions (chromatography, hydride generation etc) polyatomic interferences could be eliminated by solution: cool plasma conditions increased mass resolution gas phase chemistry 80 20
21 How to eliminate spectral interferences? Collision/Reaction Cell Technology isobaric interferences from isobaric element ions cannot be eliminated easily solution: use an other isotope if you can Front end solutions (chromatography, hydride generation etc) polyatomic interferences could be eliminated by solution: cool plasma conditions increased mass resolution gas phase chemistry Examples of polyatomic interferences: 40Ar16O on the determination of 56Fe 38ArH on the determination of 39K 40Ar on the determination of 40Ca 40Ar40Ar on the determination of 80Se 40Ar35Cl on the determination of 75As 40Ar12C on the determination of 52Cr 35Cl16O on the determination of 51V. Elimination of the ArO interference with a dynamic reaction cell
22 Calibration Collision/reaction cells have given a new lease on life to quadrupole mass analyzers used in ICP-MS External Calibration: Use this approach for matrices that are known and can be matched. The use of internal standards is helpful in accounting for drift. Must know your sample composition! A semi-quantitative analysis using a scanning approach for the entire mass range allows the analyst to predict interferences and select internal standards and analyte isotopic masses. Perform interference check analysis. Prepare for the variations in the matrix and analyte composition and determine if corrections that have been built into the procedure are capable of providing the required accuracy. External Calibration: Use this approach for matrices that are known and can be matched. The use of internal standards is helpful in accounting for drift. Must know your sample composition! A semi-quantitative analysis using a scanning approach for the entire mass range allows the analyst to predict interferences and select internal standards and analyte isotopic masses. Perform interference check analysis. Prepare for the variations in the matrix and analyte composition and determine if corrections that have been built into the procedure are capable of providing the required accuracy. Simple and cheap BUT prone to interferences
23 Standard Additions: This approach is common with ICP-OES & ICP-MS. Could correct interferences but not for instrument drift Isotope Dilution: Isotope dilution in mass spectrometry is a type of internal standardization. ID is a primary (definitive) analytical method for the determination of metals in a variety of sample types. (other primary analytical methods are gravimetry, titrimetry, coulometry, differential scanning calorimetry) and nuclear magnetic resonance spectroscopy. Only applicable for multi isotope elements. (not for: 9Be, 23Na, 27Al, 45Sc, 55Mn, 75As, 89Y, 103Rh, 127I, 133Cs, 141Pr, 159Tb, 165Ho, 169Tm, 197Au, and 232Th) ID could correct both for systematic and random errors in the analysis. But it is expensive and involves complicated mathematics Expression of an analytical result Value 1 ± Value 2 Free of systematic error (bias) Verification of traceability of the results: CRMs Primary methods (or reference methods) Uncertainty Consideration of all sources of error of the analytical process: 1. Random errors: Method precision 2. Correction of systematic errors Thank you for your attention!
Atomic Spectroscopy AA/ICP/ICPMS:
Atomic Spectroscopy AA/ICP/ICPMS: A Comparison of Techniques VA AWWA/VWEA Lab Practices Conference July 25, 2016 Dan Davis Shimadzu Scientific Instruments AA/ICP/ICPMS: A Comparison of Techniques Topics
More informationLecture 7: Atomic Spectroscopy
Lecture 7: Atomic Spectroscopy 1 Atomic spectroscopy The wavelengths of absorbance and emission from atoms in the gas phase are characteristic of atomic orbitals. 2 In the lowest energy transition, the
More informationSample Analysis Design PART II
Sample Analysis Design PART II Sample Analysis Design Generating high quality, validated results is the primary goal of elemental abundance determinations It is absolutely critical to plan an ICP-MS analysis
More informationDetermination of Impurities in Silica Wafers with the NexION 300S/350S ICP-MS
APPLICATION NOTE ICP - Mass Spectrometry Author Kenneth Ong PerkinElmer, Inc. Singapore Determination of Impurities in Silica Wafers with the NexION 300S/350S ICP-MS Introduction The control of impurity
More informationatomic absorption spectroscopy general can be portable and used in-situ preserves sample simpler and less expensive
Chapter 9: End-of-Chapter Solutions 1. The following comparison provides general trends, but both atomic absorption spectroscopy (AAS) and atomic absorption spectroscopy (AES) will have analyte-specific
More informationhigh temp ( K) Chapter 20: Atomic Spectroscopy
high temp (2000-6000K) Chapter 20: Atomic Spectroscopy 20-1. An Overview Most compounds Atoms in gas phase high temp (2000-6000K) (AES) (AAS) (AFS) sample Mass-to-charge (ICP-MS) Atomic Absorption experiment
More informationAtomic Absorption & Atomic Fluorescence Spectrometry
Atomic Absorption & Atomic Fluorescence Spectrometry Sample Atomization Atomic Absorption (AA) Atomic Fluorescence (AF) - Both AA and AF require a light source - Like Molecular Absorption & Fluorescence,
More informationOES - Optical Emission Spectrometer 2000
OES - Optical Emission Spectrometer 2000 OES-2000 is used to detect the presence of trace metals in an analyte. The analyte sample is introduced into the OES-2000 as an aerosol that is carried into the
More informationDetermination of trace elements in ultrapure semiconductor grade sulfuric acid using the Agilent 8900 ICP-QQQ in MS/MS mode
Determination of trace elements in ultrapure semiconductor grade sulfuric acid using the Agilent 8900 ICP-QQQ in MS/MS mode Application note Semiconductor Authors Michiko Yamanaka, Kazuo Yamanaka and Naoki
More informationAr Ar + e - INDUCTIVELY+COUPLED+ PLASMA+SPECTROMETRY+ What+is+Plasma?+ FuncDon+of+Plasma+
INDUCTIVELY+COUPLED+ PLASMA+SPECTROMETRY+ Applied'Analy+cal'and'Inorganic'Chemistry'Program' Department'of'Chemistry,'Faculty'of'Science' Mahidol'University' What+is+Plasma?+ Ar Ar + e - Plasma is an ionized
More informationSample Analysis Design PART III
Sample Analysis Design PART III Sample Analysis Design Generating high quality, validated results is the primary goal of elemental abundance determinations It is absolutely critical to plan an ICP-MS analysis
More informationPartial Energy Level Diagrams
Partial Energy Level Diagrams 460 nm 323 nm 610 nm 330 nm 819 nm 404 nm 694 nm 671 nm 589 / 590 nm 767 / 769 nm Lithium Sodium Potassium Gas Mixtures Maximum Temperatures, C Air-Coal Gas 1825 Air-Propane
More informationChapter 9. Atomic emission and Atomic Fluorescence Spectrometry Emission spectrophotometric Techniques
Chapter 9 Atomic emission and Atomic Fluorescence Spectrometry Emission spectrophotometric Techniques Emission Spectroscopy Flame and Plasma Emission Spectroscopy are based upon those particles that are
More informationINDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY
INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY Edited by AKBAR MONTASER George Washington University Washington, D.C. 20052, USA WILEY-VCH New York Chichester Weinheim Brisbane Singapore Toronto CONTENTS
More information2101 Atomic Spectroscopy
2101 Atomic Spectroscopy Atomic identification Atomic spectroscopy refers to the absorption and emission of ultraviolet to visible light by atoms and monoatomic ions. It is best used to analyze metals.
More information3 - Atomic Absorption Spectroscopy
3 - Atomic Absorption Spectroscopy Introduction Atomic-absorption (AA) spectroscopy uses the absorption of light to measure the concentration of gas-phase atoms. Since samples are usually liquids or solids,
More informationAnalysis of Trace Metal Impurities in High Purity Hydrochloric Acid Using ICP-QQQ
Application Note Semiconductor Analysis of Trace Metal Impurities in High Purity Hydrochloric Acid Using ICP-QQQ Authors Kazuo Yamanaka and Kazuhiro Sakai Agilent Technologies, Japan Introduction Hydrochloric
More informationCharacterization of Catalysts and Surfaces. Elemental Analysis (ICP, AAS etc.) Fall Semester 2016 Bodo Hattendorf HCI G105
Outline Characterization of Catalysts and Surfaces Elemental Analysis (ICP, AAS etc.) Fall Semester 2016 Bodo Hattendorf HCI G105 bodo@inorg.chem.ethz.ch Instrumental Methods for Determination of the Elements
More informationCH. 21 Atomic Spectroscopy
CH. 21 Atomic Spectroscopy 21.1 Anthropology Puzzle? What did ancient people eat for a living? Laser Ablation-plasma ionization-mass spectrometry CH. 21 Atomic Spectroscopy 21.2 plasma In Atomic Spectroscopy
More informationTrace Analyses in Metal Matrices Using the ELAN DRC II
www.perkinelmer.com Trace Analyses in Metal Matrices Using the ELAN DRC II Introduction Analyses of matrices containing high levels of metals present a challenge for ICP-MS. First, the concentrations of
More informationAtomization. In Flame Emission
FLAME SPECTROSCOPY The concentration of an element in a solution is determined by measuring the absorption, emission or fluorescence of electromagnetic by its monatomic particles in gaseous state in the
More informationAnalysis of high matrix samples using argon gas dilution with the Thermo Scientific icap RQ ICP-MS
TECHNICAL NOTE 4322 Analysis of high matrix samples using argon gas dilution with the Thermo Scientific icap RQ ICP-MS Keywords Argon gas dilution, AGD, High matrix samples, Seawater Goal To critically
More informationThermo Scientific icap RQ ICP-MS: Typical limits of detection
TECHNICAL NOTE 43427 Thermo Scientific icap RQ ICP-MS: Typical limits of detection Author Tomoko Vincent Keywords BEC, interference removal, KED, LOD Introduction Inductively Coupled Plasma Mass Spectrometry
More informationAgilent ICP-MS. Fundamentals of ICP-MS Analysis and Its Applications for Low Level Elemental Determination in Cannabis
Agilent ICP-MS Fundamentals of ICP-MS Analysis and Its Applications for Low Level Elemental Determination in Cannabis High Sample Matrix Tolerance Superior & Simple Interference Removal Ultra Wide Linear
More informationEnhancing the productivity of food sample analysis with the Agilent 7700x ICP-MS
Enhancing the productivity of food sample analysis with the Agilent 77x ICP-MS Application note Foods testing Authors Sebastien Sannac, Jean Pierre Lener and Jerome Darrouzes Agilent Technologies Paris,
More informationApplications of ICP-MS for Trace Elemental Analysis in the Hydrocarbon Processing Industry
Applications of ICP-MS for Trace Elemental Analysis in the Hydrocarbon Processing Industry Fundamentals and Applications to the Petrochemical Industry Outline Some background and fundamentals of ICPMS
More informationa. An emission line as close as possible to the analyte resonance line
Practice Problem Set 5 Atomic Emission Spectroscopy 10-1 What is an internal standard and why is it used? An internal standard is a substance added to samples, blank, and standards. The ratio of the signal
More informationFundamentals of the ICP-MS Technique and How to Resolve Issues for Pharmaceutical Materials (In 20 Minutes) Tim Shelbourn, Eli Lilly and Company
Fundamentals of the ICP-MS Technique and How to Resolve Issues for Pharmaceutical Materials (In 20 Minutes) Tim Shelbourn, Eli Lilly and Company Why ICP Mass Spectrometry? Ultra-trace multi-element analytical
More informationInductively Coupled Plasma Mass Spectrometry (ICP-MS) Debjani Banerjee Department of Chemical Engineering IIT Kanpur
Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Debjani Banerjee Department of Chemical Engineering IIT Kanpur Introduction What is ICP-MS? Inductively Coupled Plasma Mass Spectrometry Mass spectrometry
More informationAN INTRODUCTION TO ATOMIC SPECTROSCOPY
AN INTRODUCTION TO ATOMIC SPECTROSCOPY Atomic spectroscopy deals with the absorption, emission, or fluorescence by atom or elementary ions. Two regions of the spectrum yield atomic information- the UV-visible
More informationINTRODUCTION Atomic fluorescence spectroscopy ( AFS ) depends on the measurement of the emission ( fluorescence ) emitted from gasphase analyte atoms
INTRODUCTION Atomic fluorescence spectroscopy ( AFS ) depends on the measurement of the emission ( fluorescence ) emitted from gasphase analyte atoms that have been excited to higher energy levels by absorption
More informationOptical Atomic Spectroscopy
Optical Atomic Spectroscopy Methods to measure conentrations of primarily metallic elements at < ppm levels with high selectivity! Two main optical methodologies- -Atomic Absorption--need ground state
More informationSample Analysis Design Polyatomic Interferences
Sample Analysis Design Polyatomic Interferences More serious than isobaric interferences Result from possible, short-lived combination of atomic species in the plasma or during ion transfer Common recombinants
More informationThe New Agilent 7700 Series ICP-MS
The New Agilent 7700 Series ICP-MS the best ICP-MS just got better! Presenter: Uwe Noetzel and Jerome Darrouzes ICP-MS Product Specialist Life Sciences and Chemical Analysis Global Footprint Liquid Separation
More informationTrace elemental analysis of distilled alcoholic beverages using the Agilent 7700x ICP-MS with octopole collision/ reaction cell
Trace elemental analysis of distilled alcoholic beverages using the Agilent 77x ICP-MS with octopole collision/ reaction cell Application note Food testing Author Glenn Woods Agilent Technologies Cheadle
More informationPRINCIPLE OF ICP- AES
INTRODUCTION Non- flame atomic emission techniques, which use electrothermal means to atomize and excite the analyte, include inductively coupled plasma and arc spark. It has been 30 years since Inductively
More informationTrace elemental analysis solutions for your application. June 6, 2018
Trace elemental analysis solutions for your application June 6, 2018 Understanding how each technique works Components of instrument Selection Criteria Application Fields OUTLINE All these techniques can
More informationThe ultratrace determination of iodine 129 in aqueous samples using the 7700x ICP-MS with oxygen reaction mode
The ultratrace determination of iodine in aqueous samples using the 7700x ICP-MS with oxygen reaction mode Application note Nuclear Authors Kazumi Nakano, Yasuyuki Shikamori, Naoki Sugiyama and Shinichiro
More informationCh. 9 Atomic Absorption & Atomic Fluorescence Spectrometry
Ch. 9 Atomic Absorption & Atomic Fluorescence Spectrometry 9.1 9A. Atomization Most fundamental for both techniques. Typical types 1. flame - burner type 2. Electrothermal graphite furnace 3. Specialized
More informationTechniques for the Analysis of Organic Chemicals by Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
Techniques for the Analysis of Organic Chemicals by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Petrochemical Authors Ed McCurdy & Don Potter Agilent Technologies Ltd. Lakeside Cheadle Royal
More informationChemistry Instrumental Analysis Lecture 18. Chem 4631
Chemistry 4631 Instrumental Analysis Lecture 18 Instrumentation Radiation sources Hollow cathode lamp Most common source Consist of W anode and a cathode sealed in a glass tube filled with Ne or Ar. Hollow
More informationDetermination of challenging elements in ultrapure semiconductor grade sulfuric acid by Triple Quadrupole ICP-MS
Determination of challenging elements in ultrapure semiconductor grade sulfuric acid by Triple Quadrupole ICP-MS Application note Semiconductor Authors Junichi Takahashi Agilent Technologies, Japan Introduction
More informationApplication note. Trace level analysis of sulfur, phosphorus, silicon and chlorine in NMP using the Agilent 8800 Triple Quadrupole ICP-MS
Trace level analysis of sulfur, phosphorus, silicon and chlorine in NMP using the Agilent 8800 Triple Quadrupole ICP-MS Application note Semiconductor Author Naoki Sugiyama Agilent Technologies, Tokyo,
More informationFergus Keenan Shona McSheehy Julian Wills
Novel QCell Technology for Inference Removal in ICP-MS - Combining Low Mass Filtration with Kinetic Energy Discrimination Fergus Keenan Shona McSheehy Julian Wills 1 The world leader in serving science
More information9/13/10. Each spectral line is characteristic of an individual energy transition
Sensitive and selective determination of (primarily) metals at low concentrations Each spectral line is characteristic of an individual energy transition 1 Atomic Line Widths Why do atomic spectra have
More information5. Is Chlorine important (far UV option for some ICP-OES spectrometers)?
CRITERIA for method selection ATOMIC SPECTROSCOPY 1 Introduction Inductively coupled plasma-optical emission spectrometry (ICP-OES) is an attractive technique that has led many analysts to ask whether
More informationCHAPTER 4: ANALYTICAL INSTRUMENTATION
CHAPTER 4: ANALYTICAL INSTRUMENTATION 4.1 INTRODUCTION In this section, a review of the analytical instrumentation used during sample preparation and analysis is presented which includes an overview of
More informationHandling Interferences in the Modern Laboratory with Advanced Triple Quadrupole ICP-MS Technology
Handling Interferences in the Modern Laboratory with Advanced Triple Quadrupole ICP-MS Technology Shona McSheehy Ducos The world leader in serving science Elemental Analysis What are you trying to accomplish?
More informationKey Analytical Issues: Sample Preparation, Interferences and Variability. Tim Shelbourn, Eli Lilly and Company
Key Analytical Issues: Sample Preparation, Interferences and Variability Tim Shelbourn, Eli Lilly and Company Presentation Outline Sample preparation objectives and challenges Some common interferences
More informationImplementing EPA Method 6020 with the Agilent ICP-MS Portfolio
Implementing EPA Method 6020 with the Agilent ICP-MS Portfolio NEMC August 2018 Craig Jones Applications Specialist ICP-MS, ICP-MS/MS The Agilent Atomic Spectroscopy Lineup An Instrument for Any Application!
More informationToday s Agilent Solutions for Determining Heavy Metals in Food using Atomic Spectroscopy
Today s Agilent Solutions for Determining Heavy Metals in Food using Atomic Spectroscopy Evrim Kilicgedik Product Specialist, Atomic Spectroscopy Agilent Technologies 04.11.2011 2011 The Atomic Spectroscopy
More informationAccurate analysis of neptunium 237 in a uranium matrix, using ICP-QQQ with MS/MS
Accurate analysis of neptunium in a uranium matrix, using ICP-QQQ with MS/MS Application note Nuclear, environmental Authors Garry Duckworth, Springfields Fuels Ltd, K, Glenn Woods, Agilent Technologies,
More informationUltra trace measurement of potassium and other elements in ultrapure water using the Agilent 8800 ICP-QQQ in cool plasma reaction cell mode
Ultra trace measurement of potassium and other elements in ultrapure water using the Agilent 8800 ICP-QQQ in cool plasma reaction cell mode Application note Semiconductor Author Katsuo Mizobuchi Masakazu
More informationDetermination of Chromium in Gelatin Capsules using an Agilent 7700x ICP-MS
Determination of Chromium in Gelatin Capsules using an Agilent 7700x ICP-MS Application note Pharmaceutical Authors Miao Jing, Yingping Ni, Yanping Wang and Zhixu Zhang Agilent Technologies, China Introduction
More informationSpectrometric Methods of Analysis. OCN 633 Fall 2013
Spectrometric Methods of Analysis OCN 633 Fall 2013 Plasma Emission and Plasma Mass Spectroscopy Two fields of elemental analysis undergoing the most study Myriad analytical applications Three categories
More informationChemistry 311: Instrumentation Analysis Topic 2: Atomic Spectroscopy. Chemistry 311: Instrumentation Analysis Topic 2: Atomic Spectroscopy
Atomic line widths: Narrow line widths reduce the possibility of spectral overlap and thus interferences. The band width at half height is used to indicate width. This is also sometimes called the effective
More informationChapter 8: An Introduction to Optical Atomic Spectrometry
Chapter 8: An Introduction to Optical Atomic Spectrometry Sample is atomized (gaseous atoms/ions) absorption or emission measured Optical Atomic Spectra Atomization Methods Sample Introduction Methods
More informationMulti-Element Analysis of Petroleum Crude Oils using an Agilent 7900 ICP-MS
Multi-Element Analysis of Petroleum Crude Oils using an Agilent 7900 ICP-MS Application note Energy and fuels Authors Jenny Nelson, Agilent Technologies, USA Ed McCurdy, Agilent Technologies, UK Introduction
More informationAnalysis of Arsenic, Selenium and Antimony in Seawater by Continuous-Flow Hydride ICP-MS with ISIS
ICP-MS Environmental Analysis of Arsenic, Selenium and Antimony in Seawater by Continuous-Flow Hydride ICP-MS with ISIS Application Note Steve Wilbur Analysis of arsenic and selenium in seawater at trace
More informationATOMIC SPECROSCOPY (AS)
ATOMIC ABSORPTION ANALYTICAL CHEMISTRY ATOMIC SPECROSCOPY (AS) Atomic Absorption Spectroscopy 1- Flame Atomic Absorption Spectreoscopy (FAAS) 2- Electrothermal ( Flame-less ) Atomic Absorption Spectroscopy
More informationDirect Analysis of Trace Metal Impurities in High Purity Nitric Acid Using ICP-QQQ
Application Note Semiconductor Direct Analysis of Trace Metal Impurities in High Purity Nitric Acid Using ICP-QQQ Authors Kazuo Yamanaka and Kazuhiro Sakai Agilent Technologies, Tokyo, Japan Introduction
More informationElemental analysis of river sediment using the Agilent 4200 MP-AES
Elemental analysis of river sediment using the Agilent 4200 MP-AES Application note Environmental: Soils, sludges & sediments Authors Neli Drvodelic Agilent Technologies, Melbourne, Australia Introduction
More informationEmission spectrum of H
Atomic Spectroscopy Atomic spectroscopy measures the spectra of elements in their atomic/ionized states. Atomic spectrometry, exploits quantized electronic transitions characteristic of each individual
More informationThermo Scientific icap TQ ICP-MS: Typical limits of detection
TECHNICAL NOTE 43287 Thermo Scientific icap TQ ICP-MS: Typical limits of detection Authors Tomoko Vincent Keywords BEC, LOD, SQ-KED, TQ mass shift, TQ on mass, typical performance Introduction Inductively
More informationDetermination of Trace Metals in Human Urine Using the NexION 300 ICP-MS
application Note ICP Mass Spectrometry Authors: David Bass Daniel Jones PerkinElmer, Inc. Shelton, CT USA Determination of Trace Metals in Human Urine Using the NexION 300 ICP-MS Abstract This application
More informationThe Agilent 7700x ICP-MS Advantage for Drinking Water Analysis
The Agilent 77x ICP-MS Advantage for Drinking Water Analysis Application Note Environmental Authors Steve Wilbur Agilent Technologies, Inc. 338 146th Place SE, Suite 3, Bellevue Washington, 987 USA Introduction
More informationDetermination of ultratrace elements in photoresist solvents using the Thermo Scientific icap TQs ICP-MS
APPLICATION NOTE 43374 Determination of ultratrace elements in photoresist solvents using the Thermo Scientific icap TQs ICP-MS Authors Tomoko Vincent, Product Specialist, Thermo Fisher Scientific Keywords
More informationIonization Techniques Part IV
Ionization Techniques Part IV CU- Boulder CHEM 5181 Mass Spectrometry & Chromatography Presented by Prof. Jose L. Jimenez High Vacuum MS Interpretation Lectures Sample Inlet Ion Source Mass Analyzer Detector
More informationFebruary 20, Joe Cerniglia The International Group for Historic Aircraft Recovery (TIGHAR) Job Number: S0CHG688. Dear Joe:
February 20, 2012 Joe Cerniglia The International Group for Historic Aircraft Recovery (TIGHAR) Subject: ICP-MS Report Job Number: S0CHG688 Dear Joe: Please find enclosed the procedure report for the analysis
More informationRapid Analysis of High-Matrix Environmental Samples Using the Agilent 7500cx ICP-MS. Application. Author. Abstract. Introduction.
Rapid Analysis of High-Matrix Environmental Samples Using the Agilent 7500cx ICP-MS Application Environmental Author Steven Wilbur Agilent Technologies, Inc. 3380 146th Place, SE, Suite 300 Bellevue, WA
More informationDirect Measurement of Metallic Impurities in 20% Ammonium Hydroxide by 7700s/7900 ICP-MS
Direct Measurement of Metallic Impurities in 20% Ammonium Hydroxide by 7700s/7900 ICP-MS Application Note Semiconductor Authors Junichi Takahashi Agilent Technologies Tokyo, Japan Abstract Ammonium hydroxide
More informationOpening the analytical black box: Insights into interferences, corrections, and data quality
Opening the analytical black box: Insights into interferences, corrections, and data quality Dr. Anthony J. Bednar Research Chemist USACE ERDC-EL 29 March 2012 D.M. Sirkis, W.E. Harris, T.J. Kelly USACE-NAP
More informationHands on mass spectrometry: ICP-MS analysis of enriched 82 Se samples for the LUCIFER experiment
: ICP-MS analysis of enriched 82 Se samples for the LUCIFER experiment Max Planck Institute for Nuclear Physics, Heidelberg, Germany E-mail: mykola.stepaniuk@mpi-hd.mpg.de Stefano Nisi E-mail: stefano.nisi@lngs.infn.it
More informationDirect Analysis of Photoresist Using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Application
Direct Analysis of Photoresist Using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Application Semiconductor Author Junichi Takahashi Koichi Yono Agilent Technologies, Inc. 9-1, Takakura-Cho, Hachioji-Shi,
More informationAtomic Emission Spectroscopy
Atomic Emission Spectroscopy Ahmad Aqel Ifseisi Assistant Professor of Analytical Chemistry College of Science, Department of Chemistry King Saud University P.O. Box 2455 Riyadh 11451 Saudi Arabia Building:
More informationELEMENTAL ANALYSIS OF GLASS EXAMINATIONS (PART 1) Module 4
ELEMENTAL ANALYSIS OF GLASS EXAMINATIONS (PART 1) Module 4 Tatiana Trejos, M.Sc Florida International University Department of Chemistry and Biochemistry International Forensic Research Institute Outline
More informationComparing Collision/Reaction Cell Modes for the Measurement of Interfered Analytes in Complex Matrices using the Agilent 7700 Series ICP-MS
Comparing Collision/Reaction Cell Modes for the Measurement of Interfered Analytes in Complex Matrices using the Agilent 7700 Series ICP-MS Technical Overview Abstract Inductively coupled plasma mass spectrometry
More informationBasic and Application Inductively coupled plasma mass spectrometry (ICPMS)
Basic and Application Inductively coupled plasma mass spectrometry (ICPMS) 2 What is ICP MS Inductively coupled plasma mass spectrometry (ICP-MS) is a type of mass spectrometry which is capable of detecting
More informationAccurate Analysis of Trace Mercury in Cosmetics using the Agilent 8900 ICP-QQQ
Application Note Consumer products Accurate Analysis of Trace Mercury in Cosmetics using the Agilent 8900 ICP-QQQ Effective removal of tungsten-based interferences on five Hg isotopes using MS/MS Authors
More informationUNIVERSITI SAINS MALAYSIA. Second Semester Examination Academic Session 2004/2005. March KAA 502 Atomic Spectroscopy.
UNIVERSITI SAINS MALAYSIA Second Semester Examination Academic Session 2004/2005 March 2005 KAA 502 Atomic Spectroscopy Time: 3 hours Please make sure this paper consists of FIVE typed pages before answering
More informationThe 30-Minute Guide to ICP-MS
TECHNICAL NOTE The 30-Minute Guide to ICP-MS ICP - Mass Spectrometry A Worthy Member of the Atomic Spectroscopy Team For nearly 30 years, inductively coupled plasma mass spectrometry (ICP-MS) has been
More informationSpeciation of Bromine Compounds in Ozonated Drinking Water using Ion Chromatography and Inductively Coupled Plasma Mass Spectrometry
APPLICATION NOTE Speciation of Bromine Compounds in Ozonated Drinking Water using Ion Chromatography and Inductively Coupled Plasma Mass Spectrometry AN43227 Antonella Guzzonato 1, Shona McSheehy Ducos
More informationExtrel Application Note
Extrel Application Note Real-Time Plasma Monitoring and Detection of Trace H 2 O and HF Species in an Argon Based Plasma Jian Wei, 575 Epsilon Drive, Pittsburgh, PA 15238. (Presented at the 191st Electrochemical
More informationATOMIC ABSORPTION SPECTROSCOPY (AAS) is an analytical technique that measures the concentrations of elements. It makes use of the absorption of light
ATOMIC ABSORPTION SPECTROSCOPY (AAS) is an analytical technique that measures the concentrations of elements. It makes use of the absorption of light by these elements in order to measure their concentration.
More informationAtomic Absorption Spectroscopy (AAS)
Atomic Absorption Spectroscopy (AAS) Alex Miller ABC s of Electrochemistry 3/8/2012 Contents What is Atomic Absorption Spectroscopy? Basic Anatomy of an AAS system Theory of Operation Practical Operation
More informationInterface (backside) & Extraction Lens
Plasma Interface Interface (backside) & Extraction Lens Extraction Lens (-2000 volts) ION OPTICS Tip of the sampler cone is positioned to be in the region of maximum ionization Ions no longer under control
More informationSample Analysis Design Internal Standard
Internal Standard Advantages: Fluctuations are monitored in each sample/ calibration / blank Disadvantages: Assume that behavior of IS is the same as the analyte Instrumental Drift Correct for instrument
More informationFast Analysis of Water Samples Comparing Axially-and Radially- Viewed CCD Simultaneous ICP-OES
Fast Analysis of Water Samples Comparing Axially-and Radially- Viewed CCD Simultaneous ICP-OES Application Note Inductively Coupled Plasma-Optical Emission Spectrometers Author Tran T. Nham Introduction
More informationApplication Note PlasmaQuant PQ 9000 Elite, PlasmaQuant MS Elite
Application Note PlasmaQuant PQ 9000 Elite, PlasmaQuant MS Elite Analysis of Rare Earth Elements by ICP-OES and ICP-MS Potentials and Limitations Challenge Interference-free determination of rare earth
More informationICP-MS. Inductively Coupled Plasma Mass Spectrometry. A Primer
ICP-MS Inductively Coupled Plasma Mass Spectrometry A Primer Table of Contents ICP-MS Primer Section 1 Introduction to ICP-MS 1 History and Development of ICP-MS 2 Agilent Technologies - History in ICP-MS
More informationU.S. EPA SW-846 Method 6010C using the Prodigy High Dispersion ICP
Prodigy ICP Application Note: 1035 U.S. EPA SW-846 Method 6010C using the Prodigy High Dispersion ICP Introduction This Application Note describes the capability of the Teledyne Leeman Labs Prodigy High
More informationMulti-Element Analysis of Cannabis using the Agilent 7800 ICP-MS
Authors Multi-Element Analysis of Cannabis using the Agilent 7800 ICP-MS Application Note Food safety Craig Jones and Jenny Nelson Agilent Technologies, USA Introduction In the U.S., marijuana remains
More information1.0 ACCREDITATION / REGISTRATION 2.0 PRODUCT DESCRIPTION 3.0 CERTIFIED VALUES AND UNCERTAINTIES. Assay Information:
1.0 ACCREDITATION / REGISTRATION INORGANIC VENTURES is accredited to ISO Guide 34, "General Requirements for the Competence of Reference Material Producers" and ISO/IEC 17025, "General Requirements for
More informationUltra-fast determination of base metals in geochemical samples using the 5100 SVDV ICP-OES
Ultra-fast determination of base metals in geochemical samples using the 5100 SVDV ICP-OES Application note Geochemistry, metals, mining Authors John Cauduro Agilent Technologies, Mulgrave, Australia Introduction
More informationSimple, reliable analysis of high matrix samples according to US EPA Method 6020A using the Agilent 7700x/7800 ICP-MS
Simple, reliable analysis of high matrix samples according to US EPA Method 6020A using the Agilent 7700x/7800 ICP-MS Application note Environmental Authors Steve Wilbur, Craig Jones Agilent Technologies,
More informationThe Determination of Toxic, Trace, and Essential Elements in Food Matrices using THGA Coupled with Longitudinal Zeeman Background Correction
application Note Atomic Absorption Authors David Bass Senior Product Specialist Cynthia P. Bosnak Senior Product Specialist PerkinElmer, Inc. Shelton, CT 06484 USA The Determination of Toxic, Trace, and
More informationApplication note. Determination of exchangeable cations in soil extracts using the Agilent 4100 Microwave Plasma-Atomic Emission Spectrometer
Determination of exchangeable cations in soil extracts using the Agilent 4100 Microwave Plasma-Atomic Emission Spectrometer Application note Agriculture Authors Annie Guerin INRA, Laboratoire d Analyses
More informationAccurate measurement of elemental impurities in metals and metal alloys using the Thermo Scientific icap TQ ICP-MS
APPLICATION NOTE 434 Accurate measurement of elemental impurities in metals and metal alloys using the Thermo Scientific icap TQ ICP-MS Authors Introduction Marcus Manecki, Daniel Kutscher, Shona McSheehy
More informationOvercoming Interferences with the Thermo Scientific icap 7000 Plus Series ICP-OES
Overcoming Interferences with the Thermo Scientific icap 7000 Plus Series ICP-OES Technical Note 43332 Key Words Overcoming Interferences, Element Finder plug-in Introduction Interferences are common in
More informationLead isotope analysis: Removal of 204 Hg isobaric interference from 204 Pb using ICP-QQQ in MS/MS mode
Lead isotope analysis: Removal of Hg isobaric interference from using ICP-QQQ in MS/MS mode Application note Authors Geochemistry and isotope analysis Glenn Woods Agilent Technologies, LDA UK Ltd., Stockport,
More information