The Art of Building Small from molecular switches to motors
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1 The Art of Building Small from molecular switches to motors Stockholm december 8 th, 2016 Ben Feringa
2 Bioinspired Motion the early days fascinated by but no copy or mimic! 17 th of December 1903 at Kitty Hawk heading for..?
3 The Art of Building Small Chemical Synthesis
4 Nano Macro Natural Robot Artifical Robot soft ± 24 nm = m effect of length scales Low Reynolds number Brownian motion ± 2 m hard
5 Biomolecular Machines Ribosome protein synthesis Bio-Nanomotors transport muscle function Rotary Motor transport-catalysis Bacterial Flagellar Motor propulsion ptical Switching Information
6 Molecular Nanoscience molecular light switch 0 1
7 ptical Molecular Switch Binary System at the Molecular Level S S I Me 2 N N nm 435 nm Me 2 N N 2 S (M)-cis S (P)-trans Information Storage Non-destructive read-out Left (0) Right (1)
8 Potential of Molecular Nanotechnology Storage capacity of one CD: MB = > 240 years of music Molecular Electronics
9 Challenges from Molecules to Dynamic Molecular Systems out of Equilibrium Responsive Materials Self-assembly? Trigger & Response? Motion? Smart Drugs Cell Soft Robotics
10 MEMBRANE Self-Assembly amphiphile H S S H Polar Headgroup Aromatic Core Apolar Tail S R R Molecular switch photo- and electro-chemical switching S
11 Nanotube by self-assembly 100 nm
12 Controlling the disassembly of a Nanotube with light
13 Nano-channel: trigger & response open & close with light?? Mechanosensitive Channel from E. coli bacterium 3-4 Nm channel in open state
14 Molecular Device MscL channel protein Liposome 2 N N N 2 UV (366 nm) Vis (>460 nm) N R Switch R Controlled drug delivery Self-healing materials
15 Smart Pharmaceuticals 0 1 (off) (on) inactive Target Switching a medicine on with a light signal High precision in therapeutic action
16 Bacterial Resistance one of humanity s ticking time-bombs Cancer Treatment chemotherapy
17 Photocontrolled Antibiotic H H N N N N 0 1 N N (off) (on) No resistance build-up Control biofilm formation
18 Photocontrolled Chemotherapeutic Agent Bortezomib N N N H H N H B H n the market (US; 2003) for the treatment of mantle cell cancer and multiple myeloma Avoiding severe side-effects in chemotherapy Simon Jarratt/Corbis
19 Photopharmacology 0 1 (off) (on) Triggering activation with non-invasive light signal Target Response Spatio-temporal precision in action Challenges: near-infrared light imaging > drug activation Smart Pharmaceuticals
20 From Switches to Motors Molecular Motor
21 Me ax > 280 nm Me eq Me ax Me eq stable (P,P)-trans unstable (M,M)-cis 1977 (PhD thesis, p 61) First synthesis of vercrowded alkene Me eq Me eq Me ax Me ax 1999 Unidirectional molecular motor unstable (M,M)-trans > 280 nm stable (P,P)-cis 2006 Unidirectional molecular motor controlled liquid crystals First electric car `to Stockholm Chiroptical vercrowded alkene switch 2005 Unidirectional Motor on a surface 2011 Molecular nanocar Powered translational motor on surface
22 Man s Motor vs. Nature s Motor Motor ATP - ase
23
24 Molecular Motor How to control rotary motion? How to control left or right? in the nanoworld
25 My Teachers and Hero s Jacobus van t Hoff Hans Wijnberg Stereochemistry mirror image symmetry a signature of life
26 Mirror Image Breaking Symmetry
27 Unidirectional Rotary Molecular Motor Powered by Light DEFINITIN: A rotary motor is a device that is able to convert energy input into controlled, directional, rotary motion in a continuous fashion REQUIREMENTS: Controlled Motion Consumption of Energy Directional Movement Repetitive (Continuous) Process a power-stroke motor Size: 1 nanometer
28 Molecular Motor powered by light slow fast slow fast
29 multitasking organo-catalyst sequence control Responsive Catalysts dynamic control of chiral space using a molecular motor product R,S R S chirality
30 Second Generation Molecular Motor Molecular Design enhancing the speed from 1 rotation/hour to more than 10 million rotations/sec
31 Molecular Control of Motion dynamics & length scales Mesoscopic surfaces & catalysts micro-objects & droplets Macromolecular polymer helicity Nano single molecule movement
32 Rotation of a micro object Molecular motor 1nm Glass rod, 5 x 28 µm
33 Design of Molecular Motors on Surfaces S Me S (CH 2 ) 8 (CH 2 ) 8 SH SH Target Motor Molecule Responsive Surfaces CD (mdeg) hν >280 nm hν 365 nm hν 365 nm hν 365 nm
34
35 Molecular Car 2 meter meter Four-wheel drive
36 Four Wheel Drive Molecular Car Nano Car How to convert rotary motion into translational motion??? Single molecule motion!!!
37 Molecular Car
38 Single Molecule Nano Car on Surface
39 Autonomous Propulsion System Chemical Catalysis Glucose as fuel?
40 Fantastic Voyage Nano-Swimmer Fuel: sugar 100 nm Applications: roving sensors delivery systems micro-nano-robots
41 Nanorobots, science or science fiction The best way to predict the future is to invent it. Alan Kay
42 N The Art of Building Small programming molecules responsive & adaptive functions motion dynamic systems Perspective 0 1 Information systems Responsive materials Smart surfaces Self-healing materials Delivery systems Precision therapeutics Adaptive catalysts Roving sensors NanoEnergy converters Soft-robotics...
43 Acknowledgment enerations students & co-workers, colleagues & staff, collaborators, mol machine comm, family AC Cope Foundation
44 Leonardo da Vinci Where Nature finishes producing its own species man begins,with the help of Nature, to create an infinity of species Imagine the unimaginable
45
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