CCHEMISTRY 366. Inorganic Chemistry with Emphasis on Bioinorganic, Medicinal & Materials Chemistry

Transcription

1 CCHEMISTRY 366 Inorganic Chemistry with Emphasis on Bioinorganic, Medicinal & Materials Chemistry Instructor: North Building Office Hours: to be decided by class, probably Tuesday after class or by appointment. Please use to communicate with me outside of class or office hours. Lecture: Text: D. Shriver, P. Atkins, Inorganic Chemistry, 5 th Edition Course Description The course expands learning of the structure, symmetry and bonding of atoms, simple molecules and covalent and ionic solids. The reactivity of inorganic compounds (acid/base chemistry, oxidation and reduction) as covered. Symmetry and point groups, and the application of these to some inorganic spectroscopy is covered. It is expected that students enrolled in this class already have a basic understanding of periodic trends, VSEPR, Lewis dot structures, atomic orbitals, and some familiarity with both valence bond theory and molecular orbital theory. The chemistry and properties of the transition metals and lanthanides and actinides are covered. Electron configurations for the elements and oxidation state trends for each group, the 18 valence electron rule, bonding and isomerism in coordination compounds, crystal field theory, and electronic properties of ligands. Covered also are metal bonding in clusters, the HSAB concept, chelate effect, and complex stability. Reactions of complexes are analyzed, and the role of transition metal compounds in catalysis is described with examples. Learning Objectives To recognize the importance of inorganic molecules in supporting organic biological systems. To learn about how metal ions function as catalytic and structural centers in biological systems. To learn about the metal ion transport and storage within cells and how any malfunction can result in various diseases. To gain insight into cutting edge developments that utilize metal ions for medical purposes. To learn methods, including spectroscopy techniques, used to study metal ions in biological systems. To develop the skill to critically read primary literature, and to interpret experimental observations. To develop an appreciation for the structure and function of metal ions in the biological systems and how chemists aim to mimic them. Grading: tentative; may change as we move on in the course: 3 Hourly Exams (100 pts each) 300 pts (Homework Problem Sets 200 pts) Chem 366 Syllabus page 1

2 Presentation Final Exam (comprehensive) Total Points 200 pts 200 pts 900 pts Course grades will be based on a modified curve, which means that I have no particular quota system for grades. In cases where the student is borderline between two grades, consideration will be given to performance on the final exam, attendance and attitude as shown in the class, and improvement over the course of the semester. If you wish, I can let you know your scores relative to others, so that you may assess your relative standing in the class. No letter grades will be assigned until the end of the semester. Generally I am generous with the grading. If you have any concerns, please see me. Homework: Homework problems involving the material covered in the course are listed in the syllabus. These particular homework problems will neither be collected nor graded. I strongly encourage you to work the homework problems in order to keep up and learn the material. The best way to do these problems is to work with other students in the class. If you can explain to another student how to do the problem, you understand the material. I will assign a few proble m sets that I will grade. These will be handed out in class and will be collected for grading. You may work in groups to solve the problems, but each student will turn in a problem set. Projects: Students will give a presentation on an aspect of inorganic chemistry. We will discuss how this will proceed in class. I can help you decide on a topic and can guide you as far as reference materials. Usually, presentations are given the last 2-3 days of classes. Hour Exams: Three hourly (50 minute) exams will be given during the regularly scheduled lecture period. Since we need to identify a second lecture period, we will choose these dates later. I would like to schedule them for the Date, Date, and Date. Each exam will cover a distinct section of the course material. Calculators are allowed and encouraged during exams, but no tables, books or notes are allowed. Traditionally, there are no make-up exams and students are expected to attend the scheduled exam unless prevented by real necessity. In that case, a written excuse is required to avoid a zero for the missed exam. I should be able to accommodate all of your schedules. Contact me immediately in the case that you have a conflict with an exam. Final Exam: The final exam is comprehensive. The final is scheduled for Date and Time, according to the academic calendar on the web site of the registrar. Chem 366 Syllabus page 2

3 Lecture Schedule The following is tentative. We need to cover pieces of Chapters 1-7 in Shriver to understand the concepts that are important in inorganic chemistry. But I will try to minimize the material that will not be pertinent to the bioinorganic and medicinal chemistry that we will cover. Thus I am trying to cover pertinent parts of Chapters 1-7 before exam 3 and then focus the last month on Bioinorganic, Medicinal Chemistry and other Inorganic Chemistry of interest. Lecture Schedule Week Topic Chapter and Exercises Student-Centered Learning Goals 1 Course Introduction/Expectations, Atomic Structure Chapter 1: Exercises: 1.9, 1.12, 1.,13, 1.14, 1.15, 1.17, 1.18,1.19, , 1.26, 1.27, 1.29 Review and expansion of Atomic Structure and bonding theories and use of the periodic table as a predictive and experimental tool. 2 Atomic Structure, Chapter 1 and Chpt 9 Periodic Trends 3 Molecular Structure and Chapter 2: Exercises: 2.1, 2.2, Bonding theory using Bonding: Lewis Structures, VSEPR, hybridization, resonance, 18 e- rule MO Theory--- simple diatomic molecules 4 Ionic Solids Unit Cells, energetic of 2.3, 2.5, 2.8, 2.9, , 2.23 different models Chapter 3: Exercises: , , 3.15, 3.16, 3.18, 3.19, Understanding the fundamentals of solidstate chemistry ionic solids EXAM 1 Chapters 1,2,3 5 Molecular Symmetry Chapter 6: Exercises: , Understanding symmetry of molecules and how to classify molecules into symmetry groups 6 Molecular Symmetry 7 Molecular Symmetry: constructing MOs using symmetry Chapter 6: 6.15 use SALCs from appendix Use of molecular symmetry to construct molecular orbital bonding models 8 Coordination Complexes: Chapter 7: Exercises: Understanding molecular structure, nomenclature used in isomers, nomenclature Inorganic chemistry and the types of structures found in inorganic Chem 366 Syllabus page 3

4 9 Coordination Complexes: Ligand and Crystal Field Theory Parts of Chapter 20 and handout notes EXAM 2 Chapters 6,7,20 10 Coordination Complexes: Spectrochemical Series, Electronic and Magnetic Properties, Reactivity Parts of Chapter 20 and handout notes Parts of Chapter Acids and Bases Chapter 4: Exercises: 4.1, 4.2, 4.3, 4.4, 4.6, 4.9, 4.10, 4.13, 4.15, 4.16, 4.17, 4.19, 4.20, 4.21, 4.25, 4.26, , Oxidation and Reduction Chapter 5: Exercises: 5.1, 5.2, 5.3, 5.4, 5.5,5.6, 5.7, 5.9, 5.10, 5.11, 5.12, 5.13, 5.14 Identifying the theoretical frameworks associated with the inorganic molecule structures Understanding spectroscopy and magnetic properties and reactivity of inorganic molecular Understanding the definitions of acid and base as related to inorganic chemistry. Use of acid and base chemistry in the synthesis of inorganic molecules and clusters. Use of acid and base chemistry for prediction of compound formation Understanding how to write and balance oxidation and reduction Chem 366 Syllabus page 4

5 EXAM 3 13 Bioinorganic Chemistry and/or Materials Chemistry 14 Bioinorganic or Materials 15 Tentative Student Presentations on any area of inorganic chemistry. If student is doing research involving inorganic chemistry, a presentation on research is welcome. Chapters 20 (parts), 21 (parts) 4,5 Different Notes and Text to be handed out 16 FINAL EXAM Comprehensive understanding variable metal oxidation states and metal electrochemistry. Applications of oxidation and reduction in the Discussion on current applications in bioinorganic, medicinal and/or materials Develop communication skills: The student should understand how to choose a seminar topic, research the topic, organize a seminar (or poster presentation) and deliver/ defend the presenation Chem 366 Syllabus page 5