IDRaman reader and IDRaman mini: Raster Orbital Scanning (ROS)

Transcription

1 IDRaman reader and IDRaman mini: Raster Orbital Scanning (ROS) Tightly focused beam may give noisy signals or miss the Raman active target completely leading to false negatives from unidentified samples Simply increasing the spot size of the laser dilutes the valuable information about the material leading to inconclusive matches or false identification of samples ROS increases the effective size of a tightly focused beam - information is obtained with complete integrity while sampling the large area needed for complex mixtures or irregularly-shaped samples leading to confident identification. ROS

2 Advantages of Raster Orbital Scanning Lower background More Raman signal, less background High resolution and higher sensitivity Better data Better matching Non-homogeneous samples Lower average power Delicate samples Explosives ROS

3 IDRaman micro: OneFocus System optimized for Raman sensitivity and imaging One Focal plane for both Raman and imaging Aberrations in some systems force users to adjust the focus before measurement

4 IDRaman Products: Key Discriminators Raster Orbital scanning Small, rugged, handheld and portable Runs more than 11 hrs off two AA batteries Advanced spectral processing removes background for highly confident identification Raster orbital scanning Sampling in vials, cuvettes or surfaces with downward facing lens Fully integrated system turn-key and easy to use Free-space performance without the burden of expensive optical microscopes OneFocus for easy, aberration free focusing Includes sample vial holder for flexibility is sample type

5 What can you do with Raman? Incident light How can you do anything when you re only measuring 1 out of 10 6 scattered photons?

6 Raman Markets Authentication & Counterfeit Detection Material Identification Nanotechnology Raman-based sensors Materials Science Organic and Inorganic chemistry research Petrochemicals Clinical Diagnostics Electronics/Semiconductors Life Sciences Pharmaceutical R&D and QA/QC Alternative Energy Forensics

7 Raman Applications Pharmaceutical industry: Chemical characterization In situ crystal growth monitoring Kinetics Active ingredients Polymer characterization and ID Quality Control Incoming material ID Homeland Security Explosives detection Forensic Science Counterfeit Drug Detection On-Line Process Monitoring

8 Food Processing Biodiesel Fuel markers Biomedical Applications Art Pigments Material Science Diamond films Semiconductors Nanotubes Gemology Gemstone authentication Geology Raman Applications

9 Pharmaceutical Applications Incoming raw materials inspection in the warehouse Inspection of intermediate At-line sampling Counterfeit drug identification Analysis of release rate in time-release drugs

10 Pharmaceuticals : Study of a time-release drug Mostly coating 1 second Coating + API 1 second Time Release Coating API phenyl nitrile

11 Food Edible Oils Sugar Sugar cane Sugar beets Corn Sweetner Flavors Sanitation-CIP

12 IDRaman Product Positioning Microscope Reader Mini OneFocus for easy optimization of focus High spatial resolution for measuring specific locations or structures on a sample Imaging to find the proper measurement location Best collection efficiency Vial sampling ROS for: Heterogeneous samples Non-uniform samples Delicate samples Downward facing lens measurements from surfaces ROS for: Heterogeneous samples Non-uniform samples Delicate samples Portable handheld measurements Battery powered Point and shoot measurements Real time library matching Sample Types: Solid samples and surfaces Vials or cuvettes Small volumes in cuvettes or vials Sample Types: Vials or cuvettes Small volumes in cuvettes or vials Solid samples and surfaces Sample Types: Vials Small volumes in vials Solid samples and surfaces

13 Integrated System vs Modular Components Fixed configuration Fixed spectrometer configuration Fixed or limited sampling Fixed laser excitation wavelengths Limited laser excitation wavelengths available Advanced Sampling Techniques ROS sampling Integrated Systems Heterogeneous and irregular samples OneFocus sampling Simplifies optimization of Raman focus Highly configurable Modular Systems Customizable spectrometer configurations Flexible sampling accessories Flexible laser choice Starting wavelength configurable for any laser User changeable slits for flexibility in throughput and optical resolution

14 Think About It Like This Long integration times Weak Raman signals Fast measurements Low cost Wide Raman Shift range Measurement of specific locations/structure Raman microscopy Carbon nanomaterials Portable, handheld Field measurements Heterogeneous samples Explosives SERS samples Delicate samples

15 Raman Microscopes Most Raman microscopes are based at the extremes High dollar optical systems emphasizing image quality and Raman signal collection efficiency Low cost, inefficient microscopes based on fiber optics IDRaman micro offers a high value alternative to current offerings Free-space performance you need without the burden of expensive optical microscopes Portable Microscope designed for Raman spectroscopy

16 Who are IDRaman mini Target Customers? Threat Detection/Force Protection Weak signals from an unknown material are a common issue ROS technology enables rapid detection of weak Raman signals in the field Military/Homeland Security: Explosives detection First Responders: Hazardous material identification Law Enforcement: Illegal drugs Materials Identification Weak signals, mixtures and photosensitive materials are a common issue ROS technology enables detection of weak signals in harsh demanding environments with in-line/at-line testing Pharmaceutical: QA/QC, Verification of incoming and outbound materials Industrial: QA/QC, Verification of incoming and outbound materials Authentication: Detection of authentication markers, Detection of counterfeit materials

17 Intensity IDRaman Micro Signal-to-Noise Comparison Caffeine IDR micro = 0.1 second, S/N (sec) 1/2 = 806 Common System = 10 second, S/N (sec) 1/2 = 52 Common System = 1.0 second, S/N (sec) 1/2 = Wavenumber (cm -1 ) Comparison of the IDRaman micro with competitive Raman microscope systems. We see a SNR improvement of 2X to 100X over the competitors. Parameters: 50 mw, 0.1 to 1.0 second integration, 40X long working distance objective.

18 IDRaman reader Signal-to-Noise Comparison Buffer solution IDR reader = 10 second, S/N = 1777 Common System = 10 second, S/N = Comparison of the IDRaman reader with a competitive fiber optic based Raman system. We see a SNR improvement of 2X to 100X over the competitors. Parameters: 50 mw, 10second integration.

19 Lower Background with ROS for SERS mw Laser Power Relative Intensity 19 mw Laser Power 800 Relative Intensity Relative Intensity second Integration mw Laser Power 3 second Integration RASTER OFF RASTER ON 3 second Integration The use of ROS for SERS sampling reduces the background of the samples due to the averaging of the SERS hotspots. It also enables the use of higher laser powers

20 Lower Average Power with ROS for Samples that Degrade The Raman spectrum for improvised explosive device (IED) component Ammonium Nitrate changes with exposure to high laser power leading to possible misidentification as Calcium Nitrate 20

21 Lower Average Power with ROS for Flammable or Explosive Samples Black Powder

22 Modular Spectrometer Positioning Feature Maya2000Pro NIR QE Pro Raman Ventana 785 Configurable Custom Configurations Yes - User Changeable Slits Cooled Detector No -15 C +15 C No Resolution Spectral Range Raman Shift Range 0.8 nm 0.7 nm (Slit dependent) 0.7 nm nm nm nm ~ cm -1 ~ cm -1 ~ cm -1 SNR 450:1 1000:1 450:1 Dynamic Range 15000: : :1 Best For Low cost Long integration times Maximum flexibility Fast measurements