Copyright 2012 by the American Society for Pharmacology and Experimental Therapeutics.

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1 DMD Fast This Forwar. article has not Publishe been copyeite on an February formatte. 16, The final 2012 version as oi: /m may iffer from this version. D, D:, z > z < ^ < ^ < :, ' < ^& W t Z W D ^ < h<, D : ^ < < ^ & W t Z W D ' h^, z > z < < W Z ^ W W ^ h D D h< ^ :, ' Copyright 2012 by the American Society for Pharmacology an Experimental Therapeutics.

2 Z W, D: W t Z W D D h ^ leeeeeee E E E E e E E / ee E e

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7 W< KW ^,, & ^,, / D WW< W< e

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11 = </> <WD l > s s l n> l <WD l > s s l n> <Dl> s <Dl> s </> l> s l l l l l > n> D D l s s s s D μ> Z W = + E s s < W e W e e = = < s s

12 = = < s e s t > >,>D μ> μ> D,>D > > > > < EKEDD s/ ED ZE /// / ^ D h^ e y e, > h^,zz/ EKEDD &K Z / WW< WW< : e : e : s = Y Y e

13 Y l > l > s l > l l l l < W < l Wl s = Y Y > e > l > > > ^ D ^ < Z Z e > e < W / WW< ^> ^> ^> ^>

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15 D e e h h^ eee e D > > > l> / / h / e ^> ^> ^> WW< & ^> ^> ^> & ^> ^> D & W< WW< W< t E D s s > > > y e, > h^

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35 W > e < W,>D> μ W e e e ee e e e & e e e ee Z e e s ee e e Z e e e e l l l > eee l ee ' DMD Fast Forwar. Publishe on February 16, 2012 as DOI: /m Downloae from m.aspetjournals.org at ASPET Journals on June 19, 2018

36 / m > μ D > μ D > μ D W W e e e e e e e ee e e e & e e e e Z e e e e ee e s e e e ee Z e ee e > W e l,hee l e l,hee l,hee l & e l,hee l Z e le,hee l s e l,hee l Z,hee l ZD l DMD Fast Forwar. Publishe on February 16, 2012 as DOI: /m e Downloae from m.aspetjournals.org at ASPET Journals on June 19, 2018

37 / ^> > ^> > ^> > / / ^ / / ^ / / ^ W e e e ee e e e e - ee eee ee e e & e ee e e e e e ee Z ee e e e e ee s e e e e Z e e ee ee e ' e e ^> ^> > DMD Fast Forwar. Publishe on February 16, 2012 as DOI: /m e Downloae from m.aspetjournals.org at ASPET Journals on June 19, 2018

38 W > s > > s > < / / l^ / / l^ W e e e e e e ee e & e e e e e e Z e e e s e Z e e e e e e e > s ^ D ^ > s DMD Fast Forwar. Publishe on February 16, 2012 as DOI: /m e Downloae from m.aspetjournals.org at ASPET Journals on June 19, 2018

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Copyright 2010 by the American Society for Pharmacology and Experimental Therapeutics.

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