NMDA receptor dependent functions of hippocampal networks in spatial navigation and memory formation de Oliveira Cabral, H.

Transcription

1 UvA-DARE (Digital Academic Repository) NMDA receptor dependent functions of hippocampal networks in spatial navigation and memory formation de Oliveira Cabral, H. Link to publication Citation for published version (APA): de Oliveira Cabral, H. (214). NMDA receptor dependent functions of hippocampal networks in spatial navigation and memory formation General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 112 WP Amsterdam, he Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam ( Download date: 18 Jun 218

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8 session # trial # surgery pre-training recording P P P training trial P P P P P P P P P P P probe trial firing rate (Hz) interneuron pyramidal time (ms) mean AC (msec) -3 3 time (ms) prob < 7% prob > 7% prob > 8% prob > 9% ISVD (%) > ± th

9 µ µ

10 a RAINING PLACE SEQUENCE b speed (cm/sec) normalized trial length CR KO average velocity (cm/sec) CR RAINING PLACE SEQUENCE KO

11 ISV D = 1 V v V.26 A PV, v.26 v PV %

12 x P f(x) p(x)f(x)log2 F SpatialInf ormation =, F x x x x Sparsity = (P p(x)f(x)) 2 P (p(x)f(x) 2 ) idx idx idx o o

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14 a long short b PLACE SEQUENCE reward localization score c CR KO pre-training session surgery recording session d trials fraction trials fraction CR 1 KO experiment block PLACE SEQUENCE serial random < x

15 trials fraction ratio correct choices a b ** ** short long CR KO CR KO CR KO raining PLACE SEQUENCE short raining long * CR KO ratio correct choices ratio correct choices c d short short SEQUENCE long PLACE long *** % e probability correct outcome f 6 4 % 2 % choice LONG # * % g * localization score long short * short long pretraining recording 55 pretraining recording 2 < 2 <

16 2 < 2 < < 2 2 < 2 < < 2 < 2 < < < 2 < 2 <

17 2 < 2 < < 2 2 < < < <

18 fraction CR KO area PF.16.8 *** ratio in-field FR increase *** Hz max FR # # of PFs *** bits/spike Spatial Information.8.4 ***.4.2 sparsity *** < < <

19 9y a CR r PLACE b KO SEQ 7.6 PLACE r 5.5 c SEQ * ** d C R KO C 2.5 firing rate (Hz) 2.3 R KO 2.3 Sidx 2.5 Pidx * RAINING PLACE SEQUENCE 2 1 CR e KO 2 CR KO Pidx Sidx 6B;m`2 kxe hq [m MiB7v i?2b2 2z2+ib- r2 + H+mH i2/ irq bbkbh `Biv BM/B+2b, H +2 USidx V M/ b2[m2m+2 BM/2t Uaidx VX h?2 }`bi r b + H+mH i2/ b i?2 S2 `@ bqmƕb +Q``2H ibqm #2ir22M }`BM; ` i2 K b BM i` BMBM; i`b Hb M/ `Q#2 i`b Hb- mbbm; i?2 Qp2`H BM; Q`iBQM Q7 i?2 `Qmi2bX aidx Bb i?2 S2 `bqmƕb +Q``2H ibqm #2ir22M i?2 }`BM; ` i2 K b BM i` BMBM; i`b Hb M/ i?2 }`BM; ` i2 K BM b2[m2m+2@bi` i2;v i`b Hb- `Qi i2/ #v dko iq K F2 i` BMBM; M/ `Q#2 /2 `im`2 `Kb +QBM+B/2X "Qi? +Q``2H ibqmb r2`2 MQ`K HBx2/ #v K2 Mb Q7 b?m 2/ +QM/BiBQM Ub22 J2i?Q/bVX "Qi? *h_ M/ L_R@EP KB+2 b?qr2/ 2H2p i2/ Sidx p Hm2b- b2p2` H@7QH/?B;?2` i? M b?m 2/ +QM@

20 idx idx < idx idx o idx < < < idx idx < < idx idx < < <

21 < idx idx < idx idx < idx 8 * SEQ. short SEQ. long idx < S Idx CR

22 P idx S idx session block CR KO idx idx idx < < idx < < < idx <

23 fraction of place cells.8.4 CR KO Spatial Information (spikes/bin) sessions 1-7 sessions < < < < < 1 idx < fraction CR KO

24 r Distribution of P idx in SEQ trials SEQ CR PC fraction KO -1 1 n.sig sig r P idx Distribution of S idx in PLACE trials PLACE.2 CR.2 P idx KO PC fraction S idx -1 1 S idx th < < idx

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