HIF-1 can act as a tumor suppressor gene in murine Acute Myeloid Leukemia.
|
|
- Beatrice Hancock
- 5 years ago
- Views:
Transcription
1 HIF-1 can act as a tumor suppressor gene in murine Acute Myeloid Leukemia. Velasco, Talia; Hyrenius Wittsten, Axel; Rehn, Matilda; Bryder, David; Cammenga, Jörg Published in: Blood DOI: /blood Link to publication Citation for published version (APA): Velasco, T., Hyrenius Wittsten, A., Rehn, M., Bryder, D., & Cammenga, J. (14). HIF-1α can act as a tumor suppressor gene in murine Acute Myeloid Leukemia. Blood, 124(24), DOI: /blood General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Users may download and print one copy of any publication from the public portal for the purpose of private study or research. You may not further distribute the material or use it for any profit-making activity or commercial gain You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. L UNDUNI VERS I TY PO Box L und Download date: 17. Feb. 19
2 α ƒ ƒ ƒ ƒ Ž ƒ ƒž ƒ Žƒ ƒ œ š Ž ƒ Ž ƒ Š ƒ ƒ Ú ƒ ƒ ƒ ˆ Ž Žƒ ƒ Š ƒ ŽŽ ƒ ˆ Ž ƒ ƒ ˆ ƒ Ž ƒ ƒž Ž Ž ˆ α Š Ž ƒ Ú ƒ ƒ ƒ ˆ Ž Žƒ ƒ Š ƒ ŽŽ ÚŽ ƒ ƒ ƒ Ž Œ ƒ ƒ Ž Ž ƒš ƒ š ˆ ˆ ˆ d
3 ƒ ƒ ƒ ƒ ƒ Ž ƒ α Šƒ α ˆ ƒ Ž ƒ Ž ƒ ƒ Žˆ ƒž ˆŠ ƒ ŽŽ ƒ Ž ƒ ƒ ŽŽ Šƒ ˆŽ Ž š Š š ƒ Š ƒž Žƒ Š ŽŽ Žƒ Ž ƒž œƒ Š ƒ Š ƒ ˆŽ š ˆƒ Š ƒ Ž œƒ ˆŠ š ƒ Ž ˆƒ Š Š α ƒ ƒ ƒ Š ƒ ƒ Š ƒ ˆ Ž ƒž ƒ ƒ Šƒ Š ˆˆ Ž ƒ Š Ž ˆ α ƒ Ž Ž ƒ ƒ ƒ Žˆ ƒž ˆ š Ž ˆƒ Ž ƒ Žƒ ˆ ƒ Ž ˆ Š ƒ ŽŽ Žƒ ˆ α ƒ Ž ˆ ˆ α Ž ˆƒ Ž ˆ Š ƒ ƒ ƒ Šƒ Ž ƒ Š ˆ Š ƒ Ž Ž Š ˆ ƒ ƒ ƒ ƒ ˆ Š Ž ˆ αƒ ƒ ƒ Š ƒ ˆ Ž d
4 ƒ Š Ž Ž ƒ ƒ Ž Ž ƒ Š ŽŽ Š Ž Šƒ ƒ ƒ Š Š Š Ž Ž ˆ Š ˆ Š ƒ Š Ž š Šƒ Ž ˆ ˆˆ ƒ ˆ Š Š ƒžž ƒ ƒ Š Š ƒ ƒ ˆ ƒ ƒ ˆƒ ˆ ˆˆ Žƒ ˆ Š Š ƒ ƒ Ž Š Š ˆ ˆ ƒ Ž ƒ ƒ ŠƒŽŽ ˆ Š Ž ˆ Ž Žƒ ƒ Š ƒ ƒž ƒ Šƒ ƒ Ž ƒ ƒ Ž Š ƒ Šƒ Ž ƒ Š ƒ Ž ˆˆ ƒ ˆ ƒ ˆƒ ˆ ŽŽƒŽ š Ž ˆˆ Ž ƒ ƒ Š ˆ ˆ Š Šƒ Ž ŠƒŽ ƒ Š ƒ Ž Š ˆ Ž ƒ ˆ Ž ƒ Š Ž ˆ Ž ˆƒ Ž ƒ Š ˆ ƒ ˆ ƒ Š ƒ Šƒ Š ƒ ŽŽ Ž ƒ Šƒ ƒ ˆ Š ƒ ƒ ˆ Š Šƒ ˆƒ Šƒ Ž ƒˆˆ ƒžž ˆ Ž Š š ƒž Šƒ Š ŽŽ ˆ Š Šƒ Šƒ Š ƒ ŽŽ ƒ ŽŽƒ Ž ƒ ƒ ŽŽ ƒš š ƒ Š Š Š š Š Š ƒ Žˆ ƒžƒ Š ƒ ˆŽ ƒ ƒž Š Š ƒ ƒ Š ƒœ Ž Žƒ Š š ƒ Š ƒ Ž œƒ ˆ š ƒ Ž ƒ ƒˆƒ Ž ˆ ƒ ˆƒ Šƒ ƒ ƒ Š ƒ Ž Š ƒ ƒ Š š ƒ Žƒ d
5 Š ƒ ƒ ƒ Ž ƒ Ž ˆ ƒ ƒ ˆ ˆˆ ƒ š Žƒ Ž α ƒ ƒ Ž š β Š ƒ Š ˆˆ α ˆ Š Š αƒ α ƒ Ž ˆˆ Š š ƒ Š ƒ ƒ ˆ Š ƒ ƒ Ž Žƒ Š ˆ ˆ Š Ž Ž š Ž ˆ Š ˆƒ Ž α Š Š ˆ Š ˆƒ Ž Šƒ ƒ ƒ ƒ Žƒ ˆ Š Ž š Ž ˆ ˆ α Ž ƒ ƒž ˆ Žˆ ƒž Š ƒ ŠƒŽŽ ƒž ƒ Žƒ ƒ Š Ž Š ˆˆ ˆ ˆ α ƒ ƒ Š ƒ Š ˆ Š ˆ α ƒž Š š Žƒ ˆ ƒž ƒ ˆ Š ˆƒ Ž Ž Ž α ƒ ƒž ˆ Š ˆ α Ž ƒžƒ ˆ ˆ Šƒ Š ˆ α Ž ƒ ƒ ƒ ƒ ƒ ˆ ˆ αˆ Š Ž ˆ ˆ αˆ ƒ Šƒ Š ƒž ƒ ƒ ƒ ƒ ˆ Š š ƒ Š ƒž Š ƒ ˆ ƒ Šˆƒ Šƒ ƒ ƒž Š ƒ ˆƒ Š Ž Ž ˆ ƒ ƒ Ž Š Š ƒ Ž α ƒ Ž œƒ Š ƒ ˆ Š š ƒ š Ž ƒ ƒ ƒ ˆ Š α ƒ Š ƒ Š Ž Š Ž ˆ Ž Ž Ž Žƒ ƒ š ƒ Ž ˆ Š Ž Ž ƒ ƒžžˆ ƒ ˆ Š ƒ ƒ ƒ Š š ˆ š Ž ƒ Ž ƒ ˆ ˆ Š Š d
6 ƒ ƒ Š Šƒ ˆ ƒ ƒ Š ƒ ƒ ˆ ƒ Ž ƒ Š Ž ˆ α Ž ƒ Ž Šƒ ˆˆ ƒ Š ƒ Ž Š Š Šƒ αšƒ ƒ ƒ Ž Ž ˆ ƒ ƒ Žˆ ƒž ˆŽ ŽŽ α ˆ Žˆ ƒž ƒ Ž ˆ Š Ž Ž ƒ Žƒ ƒ Šƒ ƒ ˆ Š ˆ α Š ƒ Š Š Š Žƒ ˆ Š Ž š Š Š α ˆ ƒžž ˆ ƒ Ž ƒ ƒ Ž Žƒ ƒ Š ƒˆˆ ƒž ƒ ŽŽ Ž Š Š ˆ α Š ƒ ƒ ƒ ƒ ˆ Š ˆˆ š ƒžž ŽŽ ˆ Ž Ž Šƒ ƒ ƒž Ž ƒ α ƒ ƒ Š Žƒ α ƒ ƒ ƒ ƒ Š Š ƒžž š ˆ ˆ α ƒž ˆ ŽŽ Ž ƒˆ ƒˆ Ž ˆˆ Žƒ ƒ ƒ Š Š α ƒ ƒžž ƒ Šƒ Žˆ ƒž ˆ ƒˆ ˆ α Ž ŽŽ Ž Š ƒ ƒ Ž ƒ ƒ ƒ α ƒ ƒ ƒž ƒ Š ƒ ƒ ƒ ƒž Š ƒ ƒ ˆ d
7 ƒ ƒž ƒ Š ƒ ˆ αˆž ˆŽ Š Š ˆ Ž š ƒ ƒž ˆ αˆž ˆŽ š ƒ Ž ˆ Ž ƒ ŽŽ Ž Š ƒž ƒž ƒ ˆŽ ƒ Š ƒ ˆ ƒ ƒ ŽŽ Œ Žƒ ƒ ƒ Ž Ž ƒ ƒ Ž Š ˆ ƒ Š ƒ ƒž ŽŽ ƒ Š ƒ Ž ƒ ƒ ƒ Ž ˆ Š ƒ ƒ š Ž ƒ Ž Ž ŽŽ ƒ ˆ ƒ ˆ ŽŽ ƒ ƒž ƒ ƒ ƒ ƒ ƒ Š Š ƒž Žƒ ƒž ƒ Š ˆ ŽŽ ƒž ˆ ƒ ƒ ƒ š š ƒ Š Ž ƒžš š ƒ ƒ ˆ Š ƒ Ž ƒž Š ƒž ƒ ƒ ƒ ƒ ƒ ˆ ˆ ƒ Š Š š ŽŽ Žƒ Žƒ ƒ ƒ ˆ ƒ ƒ ƒ Šƒ ƒˆ Š ƒž ƒ ƒ ƒ Ž e
8 ƒž ƒ ŽŽ ˆ ˆ ƒ ƒ Š ˆ Ž Šƒ ˆ ƒž ƒ ƒ Žƒ ƒ š ŽŽ Žƒ ƒ ƒ ƒ ƒ ƒ ƒ ƒ ƒ Ž ŽŽ Ž ƒ ŽŽ Š Ž Ž Š Š Šƒ ˆ Š ˆ ƒ ˆ Š ˆ ŽŽ ƒ Š ƒ Š ŽŽ ƒ Žƒ Š ˆ Š ƒ ƒˆ Šƒ ƒ Žƒ ƒ ƒ ˆ Ž Ž ŠƒŽŽ ƒ ƒ Š Š ƒ Žƒ ƒ š ŽŽ ƒ Ž Œ Š ƒ Ž ˆ ƒ ƒ š ˆ ŠŽ Žƒ ƒž ŽŽ ˆ š Š ƒ Ž ƒ Ž ƒ ƒž œ Š ƒž Ž ƒ ƒž Ž ˆ ˆ α ƒ ƒ ƒž Œ ˆ μ ˆ ƒ ƒž ƒ ƒ ƒˆ ƒ Žƒ ƒ ˆ α Ž ƒ ˆ ƒ ƒž ˆ Ž Žƒ ƒž Š Ž ŽŽ ƒ ŽŽ š ƒ ƒ Žƒ ƒ ƒž š Ž ƒ ŽŽ Œ Ž ŠƒŽŽ ƒ ƒ ƒ Š š ŽŽ e
9 ƒ ƒž ƒˆ ƒ š ƒ ˆ ƒ ŽŽ ˆŽ ƒ ƒž ˆ ƒ Ž ŽŽ ƒ Ž Ž Š ƒ ŠŽ ŽŽ Š Ž ƒ ƒ ƒ š Ž ƒ ŽŽ Š ƒ Ž ƒ ƒ ƒž Š ˆ ŽŽ ƒ ƒ ƒ Ž ˆ ƒ ƒ Ž ˆ ƒ ƒ Žƒ ŽŽ Žƒ Š Ž ŽŽ Ž Ž Š Š Ž ŽŽ Š Ž Ž ƒ Ž ƒ ƒˆ ƒ ˆ Ž Ž Ž ˆ μ ˆ š Ž ƒ ƒ ƒžƒ ƒž ŽŽ ƒ ƒƒ š ƒ Š ƒ ˆˆ ƒ ƒ ˆˆ ƒ ˆˆ ƒ ƒ ˆ ŽŽ ƒ ˆ Ž Ž ƒ ƒ ƒž ƒ ƒž ˆ ƒž ƒ ˆ ƒ Ž šž ƒ ŽŽƒ ƒž ˆ Š ˆ ƒ ƒ Šƒ ˆ ƒ e
10 Ž α ƒžˆ ƒ ˆ ƒ Ž ƒ Ž ˆ ƒ ƒ ƒ Ž Ž ƒ Š Š ƒ ƒ ˆ Š Šƒ Š ƒ ƒ ƒ Žƒ ƒ Ž Š Š ƒ ƒ α ƒž Š ƒ ƒ ŽŽ ŽŽ ˆ ˆ αˆž ˆŽ š ˆ αˆž ˆŽ ƒ Š ƒ ƒž š ƒ ƒ ƒ Žƒ ˆ Š ƒ ˆ α Δ/Δ ƒ Ž Ž Š Ž ˆ ˆ α ˆ ƒˆ ƒ Žƒ ƒ ƒ ˆ Ž ˆˆ Ž Ž ˆ ŽŽ Ž ƒž Šƒ Š š Ž Ž ƒ ˆ ƒ ƒ Ž ˆ Š ˆŽ š Š ƒ ˆ α1 Š Š ƒž ƒ ƒ Žƒ ƒ Ž Šƒ Š ƒ Ž ˆ ƒ ƒ Š š ƒ ƒ Š Š Š ˆƒ Š Š Šƒ Š Ž ƒ ƒ ƒ Šƒ ƒ Š ƒ Šƒ Š ŽŽ Š ˆˆ ˆ α ˆ Š Œ ƒ Ž ƒ ƒž ƒ ˆ ƒžž Š ƒ ˆ Š ƒ ŽŽ ƒ Žƒ Ž Š ƒ ˆ ƒˆ ƒ Žƒ ƒ ƒˆ Š Š Š ƒ ˆ ˆ ƒ ƒž ƒ ˆ Š ƒ ƒ Žƒ ˆ α Δ/Δ ƒ Ž ƒ ƒž Š ƒ ˆ ŽŽ ƒ Š Š ˆ α Δ/Δ ƒ Žƒ ƒ ƒ Ž e
11 Š Š ƒ ƒ ƒ ƒ Ž Š ƒ Ž ŽŽ ƒ ƒ Š Š ˆƒ Šƒ ƒ Ž ƒ Ž ƒ ƒ ƒ Ž ƒ Ž ŽŽ ˆ ƒ ƒ ƒž ƒ ƒž œ ˆŽ ˆ Ž ƒ ƒ ƒ š ˆƒ Ž ƒ ƒžž ˆ ƒ ˆˆ Š ƒž Š Š Š ƒ ƒ ƒ Ž ˆ ƒ ŽŽ ƒ ƒ Š Š ˆ ƒ ˆ ŽŽ ƒ ƒ ƒž ˆ Š ˆ α Δ/Δ ƒ ƒ ƒ Š Š ƒ ƒ Š Ž ˆ ŽŽ ˆˆ Š Š Š Š ˆ ƒ ƒˆˆ Š ƒ ˆ ˆ α, ˆ ƒ ƒ ˆˆ Š ƒ š ƒ Š ƒ Ž ˆ ŽŽ ƒ Š ŽŽ Š š ˆ α Ž ƒ ƒ ƒ Š Š ƒ Š Š ŽŽ Š ˆˆ ˆ α ƒ š ƒ ƒ ƒ Š ƒƒ ƒ Žƒ ƒ Šƒ ˆ ˆ α Ž Žƒ ƒ ƒ Ž ƒ ƒ ƒ ˆ ƒ Š Ž ƒ Ž ƒ ƒ ˆ Š ŽŽ ˆ ƒ ˆ Ž Ž ƒ ˆ Š ˆ ˆ α Ž Š Š ˆ α Δ/Δ ƒ ˆ α +/+ ) ˆ Š ƒ ƒ Šƒ ˆ Š Šƒ ƒ ƒ ƒ ƒ Š ƒ Š ƒ ƒ ˆ Šƒ ˆ α ƒ ˆŽ ƒ ƒ ƒ Š Š ƒ ƒ Ž Šƒ Š ƒ ˆ dd
12 ˆ α ƒ Ž ƒ ƒˆˆ Š ƒ ˆ Š ƒ Š Ž ˆ ˆ α ƒˆˆ Žˆ ƒž ˆ ƒ š ƒ ƒ Ž ˆ ƒ Š ˆ ˆ ˆ Š Žˆ ƒž ˆ Ž ƒ Ž Šƒ ƒ Ž Š ƒ ƒ Žƒ ƒ Š ˆ Š Š ˆ α Šƒ ƒ Ž Žˆ ƒž ƒ ƒ ˆ ˆ ƒ ƒ Žƒ ƒ Š ŽŽ ˆ ƒ Ž ƒ ƒ Žƒ ƒž ˆ ŽŽ ˆ Š ƒˆ ƒ Žƒ ƒ ˆ α Δ/Δ ƒ Žƒ ƒ ƒž Žƒ ˆ ƒ Š Ž Ž ƒ ƒž ƒ ƒ Š ƒž Š ƒž ƒ ƒ ƒ ˆ ƒ Š Žƒ ˆ ˆ α Δ/Δ ƒ Ž ƒ ƒž ˆ ƒ ƒ ƒ ƒ ƒ Š Š ƒ ˆ ŽŽ ƒ Š ˆ Š ƒž ƒ Žƒ Š ƒ ƒž ƒ ƒ ˆ ƒˆ ƒ Žƒ ƒ Š ƒ ˆ ƒ ƒ ƒž œ ƒ ƒ ƒžž ˆ ƒ ƒ Ž ƒ Ž œ ˆ α Δ/Δ ƒ ƒ ƒ ƒ ƒ ˆ Š ƒ Š ƒ ƒ ƒ ƒ Š Š ƒ ˆ ƒ ŽŽ Ž ƒ ŽŽ ƒ Š Š ƒ ƒ Šƒ Ž ˆ α ƒ ƒ Ž ƒ Š ˆ Š ƒ ƒ Š Šƒ ƒ Ž ƒ Š Žˆ ƒž Š ƒ Ž ƒ Ž dd
13 α ƒ ˆŽ Š ƒ ˆ Ž ƒ š ƒ Ž ŠƒŽˆ ˆ ƒžž ƒ Š ƒ ƒ ƒ ˆ š ƒ ƒ ˆƒ ƒ ƒž Ž ˆ α 14 Š ˆ ƒ ƒ Š Š Šƒ ƒ ˆ ƒ ˆŽ Š ƒ ˆ ˆ α Žƒ Š ƒ Ž ƒ ŽŽ ˆ ˆ αˆž ˆŽ š ˆ αˆž ˆŽ Š š š š ˆ š ƒ ˆˆ ƒ ˆ ƒ Žƒ ƒ ˆ Ž ŽŽ ƒ Žƒ Ž ƒžž ˆˆ ƒž ƒ Š š ƒž ƒ ƒ Š Š ƒˆ ƒ Žƒ ƒ ˆ α Δ/Δ ƒ Š Žƒ Ž Ž ƒ ƒ ˆ Ž ŽŽ ƒ š ƒ ƒž ƒ ˆ ƒ ˆ ƒˆ ƒ Žƒ ƒ ƒ ƒ Ž ŽŽ ƒ ƒž œ ˆ α Ž ƒˆˆ Š Ž ˆ Š ƒ Š Ž ƒ ƒ ƒž ˆ ƒžƒ Ž ŽŽ ƒ Ž ˆ ˆ Š Š ˆˆ Ž Ž œ ƒ ƒ ƒ Š ƒ ˆˆ Š ˆ ˆ Š Š Š ˆ α Š Ž Žˆ ƒžƒ ˆ Š ƒ ˆ ƒ ƒ Žƒ ƒ Š š ˆƒ Ž ƒž dd
14 ˆˆ ƒžž ƒž ˆ α Δ/Δ ƒ Ž Š Š ˆ Š ƒ Š ˆˆ α ƒ ƒ Žƒ Š ƒ Ž ŽŽ Š Š ƒž Ž ƒ Ž Š Ž ƒ ˆ ˆˆ ƒž ƒ Ž ŽŽ Š ƒ Š Š Ž ƒ Šƒ Š ƒ ˆ α ƒ ƒžž ƒ š Ž ƒ Ž Š Š Š Šƒ ƒž Ž Š α ƒ Š ƒ ˆ ƒ ƒ Ž œ α ƒ ˆŽ Š ƒ Ž ƒ Ž Š Ž ƒ Š ˆ Šƒ ˆ ŽŠ ƒ ƒ ˆ Ž ƒ ƒ ƒ Ž ƒž š ˆ Š ˆ ƒ ƒ ˆŽ ƒ Š ˆƒ Šƒ Ž ƒž ˆ αž ƒ Š Š œ Šƒ ˆ α Š Ž ƒ Ž œ ˆ ƒ Š Š ˆ ƒ ƒ ˆ α, ŽŽ ˆ Š š Ž Ž š ˆ ƒž ƒž ƒ ƒ ƒ Š ŠƒŽ ƒžš š ƒ ƒ Ž œƒ ˆ Š α Ž Š ƒ ƒ ƒ ˆ ƒ Š ˆ š Ž Ž ƒ ƒ ƒ ƒ ˆŽ š š ƒ Š š š Ž ƒž ƒ ƒ ˆˆ ˆ Š ˆ α ƒ Ž œƒ dd
15 Š Š α ƒ Ž œƒ ƒ ˆ ˆ ƒ Žƒ ƒ š Š Žƒ Ž ƒ ƒ š Š Žƒ ˆ Ž ƒ Š ƒ ƒž ƒ ˆ ƒ Ž ˆˆ Š ˆ α Δ/Δ ƒ Ž ƒž ˆ ƒ Ž ŽŽ ƒ ƒ Žƒ Ž ˆ Š Ž ƒ Š Ž ˆ Š ˆ α ƒž ˆ Š ƒ ƒ ƒ Žƒ ƒ Š Š Š ˆ ƒ ƒž ˆ ƒ ˆˆ Ž ƒ ƒ ƒ Š ˆ α ƒ Š Ž ˆ α Žˆ ƒž ˆ ƒ Žƒ ƒž ˆ ŽŽ ƒ ƒž Š ƒ Ž Š ƒ Ž ƒ ˆ ƒ ƒž ƒ Žƒ Š ˆ α Δ/Δ ŽŽ ƒž ƒ Š ƒž Š ƒ Ž ƒž ˆ Š ƒ Žƒ ƒ Š ƒ Žƒ Š ˆ Š ƒ Ž Ž ƒ Š Ž ƒ ƒ ƒž ƒž ƒ Š ƒ ƒ Š Ž ˆ α Δ/Δ Š Ž ƒ ˆˆ Š ˆ ˆ α Δ/Δ ŽŽ Ž ƒ Š Ž Š Šƒ Šƒ ƒ ˆ Ž Šƒ ƒž Ž ƒ α š ƒ α ƒ ƒ ƒ ƒž Žƒ ˆ Žˆ ƒž Š Š Š ƒ Ž œ αƒ ˆ Š Ž ˆ αž ƒ ƒ ƒ š ˆ α ƒ ƒž œ Š Ž Ž ˆ Š ŽŽ ˆ ƒ ˆ Š Š ˆˆ Ž ƒ Ž Ž ƒž dd
16 ƒ ˆ ƒ ƒ š ˆ αƒˆ Ž ˆ α Ž Š ƒ Ž Š Ž ƒ Ž Ž ˆ α Ž ƒ ƒ ƒ Žƒ ˆ α ƒ Ž ƒ ƒž Š ˆ ˆ α Δ/Δ ƒ ŽŽ ŽŽ αšƒ Žƒ ƒ ƒ Š ˆ Š Š ˆ ƒ Šƒ ƒ ƒ š ƒ ƒ ƒ α Š ˆ ƒ š Ž Ž Š ˆ š ƒ ƒ Ž Ž ƒ Ž Š š ŽŽ ƒ Š Š Š ƒ ˆ α Š Š Ž ƒ Ž ƒˆˆ Š ƒ Ž ˆ ƒ ˆ Š ŽŽ Ž ˆ Ž ƒ ƒ Ž ƒ Š ˆ ŽŽ Š Š ˆˆ Šƒ ˆ Š ŽŽ Ž ƒ ƒž Š ˆ α Δ/Δ ƒ Ž Š ˆƒ ˆ Š ƒ Š ˆ α Δ/Δ Š Ž ˆ ƒ ˆ ƒ ˆ Ž ŽŽ Šƒ ƒ Ž ˆ ˆ α Δ/Δ Š Š ƒ Šƒ α Ž ƒ ƒ ƒ ƒ ŽŽ Ž Žƒ ƒ Ž ƒ ƒ ˆ Š ƒ ˆ Ž ƒ ƒž ƒ ŽŽ ƒ Žƒ ŽŽ Ž ˆ Ž Š ƒ ƒ Žƒ ˆ Š ƒ Ž ˆ Š α ƒ ˆ Š ŽŽ ƒžž Šƒ Š Ž Šƒ Š ˆˆ Ž Š ƒ Ž ŽŽ Š Ž Ž ƒž dd
17 š ƒ š Ž Š Š Š ˆˆ ˆ ˆ α Δ/Δ ƒ ˆŽ Š ƒ Ž ƒ ƒ Ž Ž ˆƒ ƒ Š ƒž ƒ Š ƒ ƒž œ ŽŽ ˆ ƒƒ ƒ ƒ Š Ž Žƒ ƒ ˆ Š Ž ƒ š ŽŽ ƒ Š Š ˆ ŽŽ ƒ Š ˆ α Δ/Δ ŽŽ ƒ Ž ƒž Š Ž ƒ ƒš Š ˆ Š ŽŽ ƒš Š ƒ Žƒ ˆ ƒ ƒ ˆƒ Ž ƒ ƒž ˆ Š ƒž ƒ ƒ Š ƒž ƒž Š ˆ α Δ/Δ ŽŽ ˆ Š Š ˆˆ Ž ƒ Ž ƒž Ž ˆ Š ƒ Ž Š ˆ ƒ ˆˆ Š ƒ Š ƒ Ž ƒ Šƒ ƒƒ ƒ ƒ Š Š ƒžƒ ˆ Š ŽŽ ƒ ˆ α Ž ƒž ƒ Ž Š ƒ Ž ƒ ƒž ˆ Š ƒ Ž ƒž ƒ Žƒ Š Ž ˆ Š α ƒ de
18 Ž Žƒ Šƒ ˆ Žˆ ƒž ƒž ƒ ƒž ƒ ƒ Žƒ Ž Ž š ƒƒ Š š ƒ ƒž Š Š Š ƒ ˆƒ α,šƒ Ž Ž ƒ Š ƒž ƒ ŽŽ Š Šƒ ƒž ƒ Ž ˆ α ƒ ƒ ƒž Š Š ˆ Š ƒ Š ƒ ƒ Š ƒ ˆ Š ƒ Žƒ ƒ ƒž ƒ Š ƒ Šƒ Ž Šƒ Š ƒ ŽŽ Š α ƒ α Š Šƒ ƒ Š ƒ Š Ž α ˆ ˆ ŽŽ ƒ Žƒ ƒ ŽŽ ƒž ƒ ˆ Š ƒ Ž ƒ ƒ Ž ƒ Š Š Š ˆ ƒž Ž α Š ƒž ƒ ˆ ƒ Š ƒ Žƒ ƒ Ž ƒžž Š ƒ Š ƒ ƒ α ƒ ˆ Š ˆˆ ƒ ˆˆ Šƒ Š Ž ƒ ˆ š Š ƒ ˆ Šƒ ƒ Šƒ Š ˆ ƒ Ž œ α Ž Š ƒ ŽŽ α ˆ Ž ˆ ƒ. ˆˆ Ž ƒ Žƒ ƒ ƒ Žƒ ƒ ƒ ƒ Ž ˆ α Š Žˆ ƒž ˆ Š ƒ ƒ ƒ Ž ˆ α Š Š ƒ Ž ƒž ƒž ƒ de
19 Š ƒ ˆ Ž Šƒ Šƒ ˆ α ƒ ƒ ƒ ƒ Ž ƒ ƒž ŽŽ ƒ ƒ Š Ž ˆ ˆ Ž ƒ ƒ ƒ Žƒ ˆ α α Ž ƒ Ž Š Žƒ ƒ ˆ Š Š ƒš š ƒ ƒž Šƒ ƒ ƒ ˆ ƒ ƒž ˆˆ ƒ ˆ Š ƒ Ž œƒ ˆ ƒ Š ƒ Š š Ž ƒ Š ƒ ƒ ˆ ƒž Š ˆ ƒ ƒ ƒ ƒ Š Š Ž Ž ˆ Ž ƒ ƒ Š š Š Š Ž ƒ š Ž Ž Žƒ Š ƒ Š Ž Šƒ Ž ƒž ƒ ƒ Ž ƒ ƒ ƒ ˆ ƒ ŽŽ ƒ Š š ƒž š ƒ Š Ž ƒžž Š š ƒ ƒ Š Š Š Š ƒšƒžž ƒ ˆŽ ƒ Š Š ˆ ˆ Š α ˆ ƒ ƒ Ž ˆ ˆ αƒ ƒ ƒž Š ƒ Ž ƒž ƒ Š Š Š Š ƒ ˆˆ Š ˆ α Š ˆ Š, š ˆˆ Ž Šƒ Š Ž ƒ α ƒ ƒ Šƒ Š š ƒž ƒ ˆ ŽŽ ƒ ˆ ƒ Žƒ ƒ Š ˆ Š Ž Š ƒ ƒ Ž ƒž ƒ Ž Šƒ Ž ˆ Š Š Ž ƒ α Š ƒ Ž ƒ ƒ ƒ Žˆ ƒž de
20 ƒ Š ˆ Šƒ Ž ˆ α Ž ƒ Ž ˆ ƒ ˆ Š Ž Š Ž Ž ƒ ƒ Ž Š ˆƒ Ž ˆ ƒ Š Š α Š ƒž ƒ Šƒ α ƒ ƒ Š Š Š Š ƒ ˆˆ ˆ α Ž ƒ ƒ ˆˆ ˆ š αšƒ ƒ Ž Ž ˆ Š ƒ š ˆ α Š ƒ Ž Š Š Ž Šƒ ƒž Š ƒ ƒ ˆ Š ƒ ˆ Ž ƒ Ž Š ƒ Žƒ ˆ Š α α ƒ ˆˆ ƒ Ž ƒˆˆ ƒˆ ˆŠ ƒ ŽŽ ƒ ƒ ŠƒŽŽ Š Ž ˆ α ƒ ƒ ƒ ƒ Žˆ ƒž ƒ Ž Š ƒ ƒ ƒž ˆ Ž ˆ Žˆ ƒž Š ˆ α Δ/Δ ŽŽ Š Š Žƒ Š Š ƒˆ ƒ ƒ Žƒ ƒ ƒ ˆˆ Ž ƒ ˆ α +/+ ŽŽ ƒ ƒ ˆƒ Ž ƒ Ž Š ƒ Ž Ž ƒž ˆƒ Ž ƒ Ž ˆ Šƒ Š Š š ˆ Š Ž ƒ Š Ž ˆ α ƒ Žƒ Š ƒ Žˆ ƒž Š ƒ ƒœ ˆˆ Š ƒ ƒ ƒ ƒˆ ƒ ƒžž ˆˆ Ž ˆ α Ž ƒ Šƒ Šƒ ƒ Š Ž ˆ α Ž ƒ ƒ ƒ ƒ Žƒ Š Ž Š Š Š Š ƒ ƒ Ž ƒ Šƒ α ƒ ƒž ƒ ƒ ƒ Ž Ž ˆ ƒ Š Š Š ƒ Žƒ ƒž ƒ Šƒ ƒ Š ƒž ƒ Ž Š ˆ Šƒ Ž ƒ ˆ Š ƒ ƒ ƒ α ƒ de
21 ƒ ƒž Š Š ˆ Š ƒ Š Š α ƒ ƒ ƒ Š ƒ ƒ ˆˆ Ž Žƒ Ž ˆ ˆ Ž Šƒ ƒ ƒ ƒ ± ±ƒž ƒ ƒ ƒ ˆ Ž Š šƒ ƒ ƒ Š ˆ Š Š ƒ Œ ƒ ˆ ƒ ˆ ƒ ƒ ˆ ƒ Š Š ƒ ƒ ± ƒ ƒ ƒ ƒ ˆ ƒ ƒ ˆ Š Š Š ƒ Š ˆ š ƒ ƒž œ ƒ ƒ ƒ ˆ ƒ Š ƒ ƒ ˆ š ƒ Ž ƒ ƒ ƒž œ ƒ ƒƒ ƒ ƒ ƒ Š Œ Š ƒ Šƒ Š ƒ ŽŽƒ Š ƒ ƒ ƒ Š ˆ ƒž ƒ ˆŽ ˆ Ž Š ƒ Š Žƒ ˆ ƒ ƒž Ú ƒ ƒ ƒ ˆ Ž Žƒ ƒ Š ƒ ŽŽ ÚŽ ƒ ƒ ƒ Ž Œ ƒ ƒ Ž dd
22 ˆ d ' E :D dddd dee dd ddde dded d E ^< :,D : ^ dddd ee e dded ddee d / & z ^ ^ z D> E ddde dd dd dddd dddd d ^ '>, dddd dde d dee dde d ^ '> t '> D deed dd dd ddde dddd e < : Z^ ^ D,/&d,/&d E Z dddd dd d e dd e D z < t t: d, W > / W^ /W^ d : dddd dee de ddddd dddde e d < ' E z t Z,/& d ^ dddd e d ded ddd e ' s ^, d dddd ddd dd dedd dedd dd E W ' t Y E dddd dd d ddd ddd dd < < & E < E < < d s'&,/& d dddd ddd dd ddde dded dd W D > d ^ :, D > W ^ Z > ^,/& d Z ddde dee d ee ddd dd, d ^ ^ Z Z, D d DK: dddd dd d ddd dde dd ^ d < & : d ^ dddd e d ded ded dd K ^ : : D D/^d,Kye > Z dddd dd dd ede edd de <,, Z< ^,:,,Ky,Ky D>> > deee dd d eee eee de >,: Z ^ &,Kye D/^d > deee dd dd deed deee dd
23 de < s ^ D>> E Z ddde e dd edd edd de, >, y,^ > ^,/&d dddd dde dd dded dede dd t z > z D ^E W z > d,/&d ^ dddd e d dee ddd dd Z W < > K > & <,/& d ^ dddd dd d dde ded dd t W / D ^ d ^ t D> D d D>> ' ddde dd dd deed deed dd z D < W >& e dd E D ddde dd e edd ede dd Z, W D D E t, d Z dddd ed dd dddd dddd dd < Z ^ & D Z < / ^ deed dee ddde ddde ddde de, < W < t : Z ' ddde dd d dd de de D : z > z Dt Z,/& d dddd d d dde ddd de E > h ' W / ^ deee ded ddde ded dee de < Z /,,, > t : E Z dddd dd dd ed dd D > K E & d /d > dddd de e dede dedd dd > : ^ ' d E dddd ddd eede ddd ded dd < < : d h ^ D ^ ', e D d W d DK: deee de dd dedd dedd dd E,,/&d E Z ddde e e edd edd dd D D s W ^ tz ' : ^ Z > d d dddd ddd dd deee deed dd d : : ',/& d dddd e d ddd ddd dd
24 de D :, DD W <,/& d < W E ^ h^ dddd dde dd ddded dddee de < < < tz > D < t' : /,/&d s,> W> ^ dddd d d ed de D :< s :Z Z : :^ > td < Z d s,>,/&d s,> dddd d d dde ddd dd
25 Ž α ˆ Š ƒ ˆ ƒ Ž ƒ ƒ Žƒ ƒž ˆ ƒ Žƒ Š ƒ š ŽŽ Ž ˆ α Δ/Δ ƒ ˆ αˆž ˆŽ ƒ ˆ α Δ/Δ ˆ αˆž ˆŽ ƒ ƒ Ž š ƒ ƒ ƒ ƒž ˆ ƒ ƒ ˆ ƒ ŽŽ ƒ ƒˆ ƒ Žƒ ƒ ˆ α Δ/Δ ˆ αˆž ˆŽ ƒ ˆ Ž ŽŽ ƒ ƒ ƒ ƒˆ ƒ Žƒ ƒ ˆ α Δ/Δ ˆ αˆž ˆŽ ƒ Ž ˆ ŽŽ ˆ ƒ Š Šƒ Š ŽŽ ƒ ƒžž Ž Š ƒž ƒ Žƒ Š ˆˆ ƒ Žƒ ƒ ƒ Š Š ˆ ŽŽ ƒ ˆ ŽŽ ˆ ŽŽ ƒ ƒ ˆ Ž ŽŽ ƒž ˆ ˆˆ ƒ ƒ ˆ ƒ ˆ ƒ ƒ ƒ ƒ ƒ ˆ Š ƒ Ž ŽŽ ŽŽ ƒ ˆ α Δ/Δ ˆ αˆž ˆŽ ŽŽ ˆ Ž Š Žƒ Š Ž ˆ Š ƒ Žƒ Š ƒž ƒ μ ƒ ƒ ˆ ŽŽ ˆ Š ˆ α Δ/Δ ˆ αˆž ˆŽ ƒ ˆ Ž ˆ ŽŽ ˆ ƒ Š ƒ ƒ Žƒ ƒ Ž ƒ Ž ƒ ƒ š ƒ ƒš ƒž Ž Š ƒ ƒ Ž ƒ ƒ ƒ ƒž ˆ ƒ dd
26 ˆ α Ž ƒ Ž ƒ Š ƒ ƒž ƒ Š ƒ ƒ Žƒ ƒž ˆ ƒ ˆ š ƒ Žƒ Š ŽŽ ˆ Ž ˆ Š ˆ α Δ/Δ ˆ αˆž ˆŽ ƒ ƒ Ž š ƒ ƒ ƒ ƒž ˆ ƒ Š Ž ˆ Š ƒ ƒ ƒ Š ƒ ˆ ƒ ŽŽ Ž ŽŽ ƒ ƒ ƒ ŽŽ ƒ ƒˆ ƒ Žƒ ƒ ˆ α Δ/Δ ˆ αˆž ˆŽ Ž ƒˆ ƒ Žƒ ƒ ƒ ˆ ƒ ƒ ƒ ƒž œ ƒ ƒž ƒ ƒ ƒž Ž ƒ Ž Š ƒ ƒ ŽŽ ƒ Ž ˆ α Δ/Δ ˆ αˆž ˆŽ ƒ ƒ ƒ ƒ ƒž ˆ ƒ ƒž Š ˆˆ ƒ Ž ˆ Ž ŽŽ ˆ ƒ Š Šƒ Š ŽŽ ƒ ƒžž Ž Š ƒž ƒ Žƒ Š ˆˆ ƒ Žƒ ƒ ƒ Š Š ˆ ŽŽ ƒ ˆ ŽŽ ˆ ŽŽ ƒ ƒ ˆ Ž ŽŽ Ž ƒ Ž Š ƒ ƒ Ž ƒ ƒ ƒ ƒž ˆ ƒ ˆ α Ž ƒ Ž ƒ ƒ Ž Ž ˆ ƒ Žƒ ƒž ˆ ƒ Žƒ Š š š ŽŽ ƒ ƒ Ž š ƒ ƒ ƒ ƒž ˆ ƒ ƒ ˆ Ž ŽŽ ˆ ƒ Žƒ ƒ ƒž ƒ ˆˆ ƒˆ dd
27 ƒ Žƒ ƒ ˆ α Δ/Δ ˆ αˆž ˆŽ ˆ α Δ/Δ ˆ αˆž ˆŽ ƒ ƒ ƒ ƒž ˆ ƒ ƒ Ž ˆ ŽŽ ƒ ƒˆ ƒ Žƒ ƒ Š ƒ Š Ž Žƒ ˆ ˆ α Δ/Δ ƒ Ž Š ˆˆ ƒ Žƒ ƒ ƒ Š Š ˆ ŽŽ ƒ ˆ ŽŽ ˆ ŽŽ ƒ ƒ ˆ Ž ŽŽ ƒ ƒ ˆ ƒ ƒ ƒ ƒ ƒ ˆ ƒ ƒ ƒž ƒ ƒ ƒ ƒž œ ƒ ˆ Ž ŽŽ ƒ Ž ƒ Ž ƒ Ž Š ˆ α Δ/Δ ˆ αˆž ˆŽ ƒ ƒ ˆ ŽŽ ˆ Š Ž ƒ Ž ƒ Ž Š ƒ ƒ Ž ƒ ƒ ƒ ƒž ˆ ƒ Š ˆˆ Žˆ ƒž Š α. ƒ Žƒ ƒž ˆ ƒ Žƒ Š š š ŽŽ ˆ ƒ ŽŽ ˆ ˆˆ ƒ Žƒ š ŽŽ ƒ ƒ ƒ Ž š ƒ ƒ ƒ ƒž ˆ ƒ ƒ ƒž ˆ š ƒ ˆ ƒ ƒˆ ƒ Žƒ ƒ ƒ ƒ ˆ Ž ŽŽ ƒ Ž ƒ Ž ƒ Ž Š ƒ ƒž œ ˆ ƒž ƒ Š ƒ ˆ Š ƒ Ž ƒ ƒ Ž ƒ ƒ ƒ ƒž ˆ ƒ de
28 Ž ƒ ƒ ˆ α ƒ ƒž Š Š ƒž Ž ƒ. š ˆ ƒ Ž ˆ š Ž Ž ŽŽ ƒ Š ƒ Š š ŽŽ ˆ Š Ž Š Ž ŽŽ Ž ˆ š š Š š š ƒ š Ž š ƒ š ƒ ƒž œ ˆŽ ƒ Žƒ ƒž ˆ ƒ Žƒ Š š ŽŽ ˆ α Δ/Δ ˆ αˆž ˆŽ ƒ ƒ Ž š ƒ ƒ ƒ ƒž ˆ ƒ Š Ž ˆ Š ƒ ƒ ƒ Š ƒ ˆ ƒ ŽŽ ƒ Ž ŽŽ ƒ ƒ ƒ ƒˆ ƒ Žƒ ƒ ƒˆ ƒ Žƒ ƒ ƒ ˆ ƒ ƒ ˆ ƒ Š Š ˆ Š ƒ ƒ ƒž œ ƒ ƒž ƒ ƒ ŽŽ ƒ Ž ŽŽ ƒ ƒ ƒ Ž ƒ Ž ƒ Ž Š Ž ƒ Ž ƒ ƒ Ž ƒ ƒ ƒ ƒž ˆ ƒ α ƒ ƒˆˆ Š Žˆ ƒž ˆ ƒž Š š ƒ ŽŽƒ Ž ƒ ˆ ˆ Ž ƒ Ž ŽŽ ƒ Žƒ ƒž ˆ ƒ ƒ Žƒ Š ŽŽ ˆ Ž ˆ Š ƒ ƒ Ž š ƒ ƒ ƒ ƒž ˆ ƒ ƒž Š ˆ šƒ ƒ ƒ Š ƒˆ ƒ Žƒ ƒ Š Ž ˆ Š ƒ ƒ ƒ ƒˆ ƒ Žƒ ƒ ƒ ƒž ˆ š de
29 ˆ ƒ ˆ ƒ ŽŽ ƒ Ž ŽŽ ƒ ƒ ˆ ƒ ƒ ˆ ƒ ƒ ˆ Š ƒ ƒ ƒž œ Ž ƒ Ž Š ƒ šƒ ƒ ˆ Š Ž ŽŽ ƒ Ž ŽŽ ƒ ƒ ƒ Ž Ž ƒ ƒ š ƒ ƒš ƒž ƒ Ž ƒ ƒ ƒ ƒž ˆ ƒ α ƒ ƒžž ˆŽ ŽŽ Ž ƒ Ž ˆ Ž ŽŽ Ž ƒ ƒ ŽŽ Ž ƒ ƒž ˆ Š Ž ŽŽ Ž Š Ž ˆ Š ˆˆ ƒ ƒ ˆ ƒ ˆ š ƒ š ƒ ƒž ˆ Š Ž ŽŽ Ž Š Ž ˆ Š ˆˆ ƒ ƒ ˆ ƒ š ƒž ˆ Š ƒžƒ Š ƒžƒ ƒž ƒ ˆŽ ˆ ƒ ƒ ƒ ŽŽ ƒ Ž ŽŽ ŽŽ ƒƒ Ž ƒ Ž ŽŽ Ž ˆ ƒ ƒ ƒ Ž ƒ ƒž œ Š ƒ Ž ƒž Ž ƒ ƒ Ž ƒ ƒ ƒ ƒž ˆ ƒ de
30 B2 CD3 B2 CD3 A B C Survival (%) 1 + AE9a Hif-1 + AE9a + MIGR1 Hif-1 + MIGR1 P=.3941 Time (weeks) GFP+ cells in PB (%) weeks weeks * Gr1 + /Mac1 + cells in PB (%) *** * D Hif-1a Hif-1a E F fl/fl D/D GFP (T) 2.74 (B) Gr1 Mac1 B (M) 5K 1K 15K K 25K FSC Gr1 Mac1 B (T) 3.35 (B) (M) K 1K 15K K 25K k.779 Gr1 + /Mac1 + cells in PB (%) G Lin - cells in BM (%) I Colonies / 1, cells P=.2398 P=.9371 P= w 7w Lin - cells in PB (%) H J GFP + colonies (%) 1 1w *** w P=.964 Hif-1 COlonies from mix cells HIF-1 fl/fl P=.5579 fl/fl D/D HIF-1 / Figure 1
31 B2 CD3 B2 CD3 A B C D F Lin - cells in PB (%) Spleen Weight (% of body weight) G Survival (%) GFP + cells (%) *** *** 3 weeks 7 weeks 1 weeks BM Time (weeks) *** ** Spleen ***P= E GFP+ cells in PB (%) WBC (x 1 9 /L) Liver Weight (% of body weight) Lin - cells (%) *** *** 3 weeks 7 weeks 1 weeks 15 *** 1 5 BM *** * ** Spleen H GFP Gr1 + /Mac1 + cells in PB (%) (T) 13. (B) Gr1 Mac1 B FSC Gr1 Mac1 B2 3 weeks 7 weeks 1 weeks Hif-1a fl/fl (M) K 1K 15K K 25K Hif-1a D/D 1.28 (T) (B).851(M) K 1K 15K K 25K Figure 2
32 B2 CD3 A B Survival (%) C 1 Hif Time (weeks) 5 1.1(T) 59.5 (B) Hif-1a fl/fl Gr1 Mac1 B (M) Hif-1a D/D (T) 34.6 (B) (M) D Gr1 + /Mac1 + cells in PB (%) Gr1 + /Mac1 + cells at death (%) 1 1 * 3 weeks 8 weeks 12 weeks PB BM Spleen Hif-1 E 3 P=.251 F 2. P=.5268 WBC (x 1 9 /L) 1 Spleen Weight (% of body weight) G Colonies / 1, cells 15 P= Liver Weight (% of body weight) Hif-1 P=.533 Hif-1 Figure 3
33 A Survival (%) C 1 P= Gr1 + /Mac1 + cells in PB (%) Time (days) Hif-1 B D WBC (x 1 9 /L) Gr1 + /Mac1 + cells (%) WBC-ok ** *** 1 BM Spleen E 2.5 *** 9 P=.772 Spleen Weight (% of body weight) Liver Weight (% of body weight) Figure 4
34 A % of Max 1 C GFP+ cells in PB (%) 1 E WBC (x 1 9 /L) H 15 1 Spleen Weight (% of body weight) GFP weeks 7 weeks 1 weeks F GFP + cells (%) 1 Hypoxia -Dox Normoxia -Dox Hypoxia +Dox Normoxia +Dox Untransduced + Hypoxia Liver Weight (% of body weight) BM B D Survival (%) Gr1 + /Mac1 + cells in PB (%) Spleen 1 P= Time (weeks) 3 weeks 7 weeks 1 weeks G Gr1 + /Mac1 + cells (%) 1 BM Spleen Figure 5
35 A Survival (%) WBC (x 1 9 /L) 1 P= P= Time (days) C D E GFP+ cells in PB (%) B 15 P=.4542 Total weight (g) *** Gr1 + /Mac1 + cells in PB (%) 1 * 9 7 F Spleen Weight (% of body weight) P=.5826 Liver Weight (% of body weight) P=.3376 H Hif-1a fl/fl Hif-1a D/D 1. G GFP + cells (%) 1 BM Spleen Gr1 + /Mac1 + cells (%) 1 * BM Spleen Hif-1 Figure 6
36 A AE9a B BM GFP + cells (%) BM myeloid cells (%) BM GFP + cells (%) Spleen GFP + cells (%) 1 1 HOXA9-MEIS1 *** * Spleen myeloid cells (%) MLL-AF9 Spleen GFP + cells (%) 1 1 * G2/S/M G1 G Annexin V + cells (%) Annexin V + cells (%) HOXA9-MEIS1 BM *** BM MLL-AF9 *** Spleen * Spleen Hif-1 Hif-1 C BM Spleen MitoTracker Normalized MFI (%) 25 *** 15 1 *** Normalized MFI (%) * 1 MitoSOX Normalized MFI (%) 15 1 * Normalized MFI (%) CellROX Normalized MFI (%) Normalized MFI (%) Normalized MFI (%) 15 ** Figure 7 AE9a HoxA9-Meis1 MLL-AF9 AE9a HoxA9-Meis1 MLL-AF9
ƒ ƒ ƒ ƒ Š ƒ Š Ž Ž ƒ ƒ ƒ ˆ ƒ ƒž ƒ ƒ ƒž ƒ Š ƒ Š ƒ ƒ ƒ ƒ ŽŽ ƒ ƒ ƒ ƒ ƒ ƒ ƒ ˆ Š Š ƒ ƒ ƒ Žƒ Ž ƒ Š ƒ ƒž Ž ƒ Ž ƒ ƒ Š ƒ ˆ Š Š Š ƒ š Ž ƒ ƒ Š Š ƒ Ž ƒ Ž š ƒž š Š
Š ƒžˆ Š Ž ƒ ƒ Ž Š ˆ Š ƒ d KEdydd d &hed/ke>^z/wd/kek&d,^zs/dk/dw>ded d d d &hed/ke>>k/dzKEdZK>E^^hZE dd d d Z,/s/E' dd d d WZKhd/^^D/Ed/KEdd d d h^zde'ded dd d e /EdZ&^ de d e ^Zs/sK>hd/KE
More informationF ST. ] = p anc Var(p s s. p anc. (1 p anc ) = F ST + F ST. ] p anc
ƒ ƒ Š ƒ ˆƒ ƒ ƒ ƒ ƒ Šƒ ƒ ƒ ƒ ƒƒ ƒ ƒ ƒ Ž ƒ ƒ ƒ ƒ Š ˆ Š Ž ˆ ƒž Š ƒ Š Ž ƒ ƒ ˆƒ ƒ ƒ ƒ ƒ ˆ Ž ƒ ƒ Š Ž ˆ Ž ƒž Š ƒ ˆ ƒ ƒ ƒ Š Ž ˆ Ž ƒž Š ƒ ˆ ƒ ƒ ƒž Š Ž Š ƒ Š ƒžž Š Š Ž ƒ Šƒ ƒ ƒ ƒ Š Š Šƒ ƒ Ž ƒ ƒ Žƒ Žƒ ˆˆ ƒ ƒ ƒž Ž
More informationPublished Ahead of Print on May 24, 2018, as doi: /haematol Copyright 2018 Ferrata Storti Foundation.
Published Ahead of Print on May 24, 2018, as doi:10.3324/haematol.2018.193151. Copyright 2018 Ferrata Storti Foundation. Reducing mortality in newly diagnosed standard-risk acute promyelocytic leukemia
More informationHistorical review of glasses used for parenteral packaging
Downloaded from on November 13, 2018 Historical review of glasses used for parenteral packaging Robert A Schaut and W. Porter Weeks PDA Journal of Pharmaceutical Science and Technology 2017, Access the
More informationMolecular Pharmacology Fast Forward. Published on June 29, 2016 as DOI: /mol This article has not been copyedited and formatted.
, W D E / & h E D D D Z W, W D / & h dddd h D D d dddddedddede dddddeddddee & dddddedddede d d d & d dee d eddd Z dde DW d d d W/ d d e e d d d d d, d /^ d db d db E< E l
More informationh D t del d ddl ddl el del d < d
> Z Z d : d h D d, Z d d / d W < ^ d d d ' e W E e > ^ d d / & d e ^ < e Z d e & D d e h s d : ^ d e d ' D ' h ' ' ' d / / ' h ^ ^ ' d / / ' & ' h D ' ' ' d W ' h ' ' ' d ' D ' ' > ' h ' ' ' e D /' /EZh
More informationOverview of the Accountancy Profession in China
2016I1-024 Overview of the Accountancy Profession in China (Released by CICPA, Updated on January 21, 2016) /K D d // / W d ///^ d d d /s^ / ^ e s^ W D & e s/^ E ^ e s///d^ W e s///y W dd /y/ dd y/ dd
More informationd ^dzd K DZ/ '^ ^ '^ K '^ / '^ / DZ/ W / ^ d Eled ^ d Eldd dd d e t d d e de ^ '^ de ddl '^
DZ/, ^ : ' t ' D ^ E > E / D, ^ : ' W > E/D, E/, dd Z d dde Dddeed ddee ddd ddd dede E /, D d ^dzd K DZ/ '^ ^ '^ K '^ / '^ / DZ/ W / ^ d Eled ^ d Eldd dd d e t d d e de ^ '^ de ddl '^ d d '^ t '^ d /EdZKhd/KE
More informationPublished Ahead of Print on August 16, 2018, as doi: /haematol Copyright 2018 Ferrata Storti Foundation.
Published Ahead of Print on August 16, 2018, as doi:10.3324/haematol.2018.196121. Copyright 2018 Ferrata Storti Foundation. Computed tomography pulmonary angiography versus ventilation-perfusion lung scan
More informationUniversity of Bristol - Explore Bristol Research. Peer reviewed version. Link to published version (if available): /jeb.
How, M. J., Porter, M., Radford, A. N., Feller, K., Temple, S. E., R.L., C.,... Roberts, N. W. (2014). Out of the blue: the evolution of horizontally polarized signals in Haptosquilla (Crustacea, Stomatopoda,
More informationW W D D ddd ^ D,, Z > tdddee d lddddddededdedd ' d W d
dd WZde de& WZddd ' d d d E < d K d ' ^ d Z d Z E ' d d >, d K D d K d Z E d > E d D e E ^ e W D D d d ^ D / > > h < d W D / W W E < > > h < d / / ^ > h < d Y ^ D ^ / E h > > h < d / > > h < e D ^ E h
More informationMolecular Pharmacology Fast Forward. Published on January 6, 2017 as DOI: /mol This article has not been copyedited and formatted.
d/d>w' d zddd & Z d ' W d : z t Z ' :, & D W, > > d/w/ D^ Z / Dh^ d W zt Z' d D^ Z / Dh^ ' d: :, &D >> d/w/ D ^ ' W, d ZhEE/E'd/d>W' Z W D^ Z / ddd d Dddedd ld eee ded dddd d de E d E e E de ddd / edd
More informationCan we reduce health inequalities? An analysis of the English strategy ( )
Can we reduce health inequalities? An analysis of the English strategy (1997-2010) Johan P Mackenbach To cite this version: Johan P Mackenbach. Can we reduce health inequalities? An analysis of the English
More informationModelling Salmonella transfer during grinding of meat
Downloaded from orbit.dtu.dk on: Nov 24, 2018 Modelling Salmonella transfer during grinding of meat Hansen, Tina Beck Publication date: 2017 Document Version Publisher's PDF, also known as Version of record
More informationResistivity survey at Stora Uppåkra, Sweden
Resistivity survey at Stora Uppåkra, Sweden Dahlin, Torleif Published in: Uppåkra - Centrum i analys och rapport 2001 Link to publication Citation for published version (APA): Dahlin, T. (2001). Resistivity
More informationMediastinal Grey Zone Lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the LYSA
Published Ahead of Print on October 6, 2016, as doi:10.3324/haematol.2016.152256. Copyright 2016 Ferrata Storti Foundation. Mediastinal Grey Zone Lymphoma: clinico-pathological characteristics and outcomes
More informationCopyright 2010 by the American Society for Pharmacology and Experimental Therapeutics.
DMD This Fast article Forward. has not been Published copyedited and on formatted. July 15, The 2010 final as version doi:10.1124/dmd.110.033936 may differ from this version. / & W W, / > W > Z z d >,
More informationA beam theory fracture mechanics approach for strength analysis of beams with a hole
A beam theory fracture mechanics approach for strength analysis of beams with a hole Danielsson, Henrik; Gustafsson, Per-Johan Published in: International Network on Timber Engineering Research - Proceedings
More informationCOMPARISON OF THERMAL HAND MODELS AND MEASUREMENT SYSTEMS
COMPARISON OF THERMAL HAND MODELS AND MEASUREMENT SYSTEMS Kuklane, Kalev Published in: [Host publication title missing] Published: 2014-01-01 Link to publication Citation for published version (APA): Kuklane,
More informationSound absorption properties of a perforated plate and membrane ceiling element Nilsson, Anders C.; Rasmussen, Birgit
Aalborg Universitet Sound absorption properties of a perforated plate and membrane ceiling element Nilsson, Anders C.; Rasmussen, Birgit Published in: Proceedings of Inter-Noise 1983 Publication date:
More informationPublished Ahead of Print on July 9, 2015, as doi: /haematol Copyright 2015 Ferrata Storti Foundation.
Published Ahead of Print on July 9, 2015, as doi:10.3324/haematol.2015.125864. Copyright 2015 Ferrata Storti Foundation. Impact of prior treatment and depth of response on survival in MM-003, a randomized
More informationRadioactivity in the Risø District January-June 2014
Downloaded from orbit.dtu.dk on: Dec 20, 2017 Radioactivity in the Risø District January-June 2014 Nielsen, Sven Poul; Andersson, Kasper Grann; Miller, Arne Publication date: 2014 Document Version Publisher's
More informationAnalytical Studies of the Influence of Regional Groundwater Flow by on the Performance of Borehole Heat Exchangers
Analytical Studies of the Influence of Regional Groundwater Flow by on the Performance of Borehole Heat Exchangers Claesson, Johan; Hellström, Göran Published in: [Host publication title missing] Published:
More informationLidar calibration What s the problem?
Downloaded from orbit.dtu.dk on: Feb 05, 2018 Lidar calibration What s the problem? Courtney, Michael Publication date: 2015 Document Version Peer reviewed version Link back to DTU Orbit Citation (APA):
More informationTransmuted distributions and extrema of random number of variables
Transmuted distributions and extrema of random number of variables Kozubowski, Tomasz J.; Podgórski, Krzysztof Published: 2016-01-01 Link to publication Citation for published version (APA): Kozubowski,
More informationMatrix representation of a Neural Network
Downloaded from orbit.dtu.dk on: May 01, 2018 Matrix representation of a Neural Network Christensen, Bjørn Klint Publication date: 2003 Document Version Publisher's PDF, also known as Version of record
More informationAalborg Universitet. Lecture 14 - Introduction to experimental work Kramer, Morten Mejlhede. Publication date: 2015
Aalborg Universitet Lecture 14 - Introduction to experimental work Kramer, Morten Mejlhede Publication date: 2015 Document Version Publisher's PDF, also known as Version of record Link to publication from
More informationRadioactivity in the Risø District July-December 2013
Downloaded from orbit.dtu.dk on: Jan 02, 2019 Radioactivity in the Risø District July-December 2013 Nielsen, Sven Poul; Andersson, Kasper Grann; Miller, Arne Publication date: 2014 Document Version Publisher's
More informationA Note on Powers in Finite Fields
Downloaded from orbit.dtu.dk on: Jul 11, 2018 A Note on Powers in Finite Fields Aabrandt, Andreas; Hansen, Vagn Lundsgaard Published in: International Journal of Mathematical Education in Science and Technology
More informationGraphs with given diameter maximizing the spectral radius van Dam, Edwin
Tilburg University Graphs with given diameter maximizing the spectral radius van Dam, Edwin Published in: Linear Algebra and its Applications Publication date: 2007 Link to publication Citation for published
More informationResistivity imaging for mapping of quick clays
Resistivity imaging for mapping of quick clays Dahlin, Torleif; Leroux, Virginie; Larsson, Rolf; Rankka, Karin 5 Link to publication Citation for published version (APA): Dahlin, T., Leroux, V., Larsson,
More informationThe dipole moment of a wall-charged void in a bulk dielectric
Downloaded from orbit.dtu.dk on: Dec 17, 2017 The dipole moment of a wall-charged void in a bulk dielectric McAllister, Iain Wilson Published in: Proceedings of the Conference on Electrical Insulation
More informationTHE EURES WORLD. Handbook
THE EURES WORLD Handbook 01. EURES: general information hz^ deed / W ^ W^ D ^ h E / > ^ hz^ dd hz^ History and objectives, W hz^ deed W ^ W^ D ^ h E / > ^ hz^ d / W^ d h K h d hz^ hz^ d d hz^ d hz^ d >
More informationAn Equivalent Source Method for Modelling the Lithospheric Magnetic Field Using Satellite and Airborne Magnetic Data
Downloaded from orbit.dtu.dk on: Oct 03, 2018 An Equivalent Source Method for Modelling the Lithospheric Magnetic Field Using Satellite and Airborne Magnetic Data Kother, Livia Kathleen; D. Hammer, Magnus;
More informationA note on non-periodic tilings of the plane
A note on non-periodic tilings of the plane de Bruijn, N.G. Published: 01/01/1985 Document Version Publisher s PDF, also known as Version of Record (includes final page, issue and volume numbers) Please
More informationSorption isotherms for textile fabrics and foam used in the indoor environment
Sorption isotherms for textile fabrics and foam used in the indoor environment Svennberg, Kaisa 2005 Link to publication Citation for published version (APA): Svennberg, K. (2005). Sorption isotherms for
More informationBlood First Edition Paper, prepublished online March 7, 2018; DOI /blood
Blood First Edition Paper, prepublished online March 7, 2018; DOI 10.1182/blood-2017-12-822817 ^ E& /s>> > >zdw,k/ekw>^/, Dzee ee D Z ^ d W D : d Z t d D, s d D : d ^ & ^ d :,, s d Z d t < d D : < d D
More informationReducing Uncertainty of Near-shore wind resource Estimates (RUNE) using wind lidars and mesoscale models
Downloaded from orbit.dtu.dk on: Dec 16, 2018 Reducing Uncertainty of Near-shore wind resource Estimates (RUNE) using wind lidars and mesoscale models Floors, Rogier Ralph; Vasiljevic, Nikola; Lea, Guillaume;
More informationR-CHOP 14 with or without radiotherapy in non-bulky limited-stage diffuse large B-cell lymphoma (DLBCL)
R-CHOP 14 with or without radiotherapy in non-bulky limited-stage diffuse large B-cell lymphoma (DLBCL) Thierry Lamy, Gandhi Damaj, Pierre Soubeyran, Emmanuel Gyan, Guillaume Cartron, Krimo Bouabdallah,
More informationA numerical study of vortex-induced vibrations (viv) in an elastic cantilever
A numerical study of vortex-induced vibrations (viv) in an elastic cantilever Lorentzon, Johan; Austrell, Per Erik; Szász, Robert-Zoltán; Revstedt, Johan 2009 Link to publication Citation for published
More informationThe M/G/1 FIFO queue with several customer classes
The M/G/1 FIFO queue with several customer classes Boxma, O.J.; Takine, T. Published: 01/01/2003 Document Version Publisher s PDF, also known as Version of Record (includes final page, issue and volume
More informationNumerical modeling of the conduction and radiation heating in precision glass moulding
Downloaded from orbit.dtu.dk on: May 02, 2018 Numerical modeling of the conduction and radiation heating in precision glass moulding Sarhadi, Ali; Hattel, Jesper Henri; Hansen, Hans Nørgaard; Tutum, Cem
More informationGeoelectrical and IP Imaging Used for Pre-investigation at a Tunnel Project. Danielsen, Berit Ensted; Arver, Henrik; Karlsson, T; Dahlin, Torleif
Geoelectrical and IP Imaging Used for Pre-investigation at a Tunnel Project Danielsen, Berit Ensted; Arver, Henrik; Karlsson, T; Dahlin, Torleif 2008 Link to publication Citation for published version
More informationEmbankment dam seepage assessment by resistivity monitoring
Embankment dam seepage assessment by resistivity monitoring Dahlin, Torleif; Sjödahl, Pontus; Johansson, Sam 2008 Link to publication Citation for published version (APA): Dahlin, T., Sjödahl, P., & Johansson,
More informationhzkwekdd/^^/ke /ZdKZd 'EZ> >/Ddd/KE / D ' e h d^ dddd, & & dd dddd d
hzkwekdd/^^/ke /ZdKZd'EZ> >/D/KE /D 'e hd^,& & d d d / d dd ^' d dd /D' d dd h' d dd d dd ^ d de W d d, e dd,d^ e dd,d^d^ dd,d^d^ d, dd K dd,d^ de dd,d^ dd D dd D de d ^d: dd dd d ^ dd, dd, d d / dd ^'
More informationThe structure of a nucleolytic ribozyme that employs a catalytic metal ion Liu, Yijin; Wilson, Timothy; Lilley, David
University of Dundee The structure of a nucleolytic ribozyme that employs a catalytic metal ion Liu, Yijin; Wilson, Timothy; Lilley, David Published in: Nature Chemical Biology DOI: 10.1038/nchembio.2333
More informationRealtime 3D stress measurement in curing epoxy packaging
Downloaded from orbit.dtu.dk on: Dec 17, 2017 Realtime 3D stress measurement in curing epoxy packaging Richter, Jacob; Hyldgård, A.; Birkelund, Karen; Hansen, Ole; Thomsen, Erik Vilain Published in: International
More informationMulti (building)physics modeling
Multi (building)physics modeling van Schijndel, A.W.M. Published: 01/01/2010 Document Version Publisher s PDF, also known as Version of Record (includes final page, issue and volume numbers) Please check
More informationGeometry explains the large difference in the elastic properties of fcc and hcp crystals of hard spheres Sushko, N.; van der Schoot, P.P.A.M.
Geometry explains the large difference in the elastic properties of fcc and hcp crystals of hard spheres Sushko, N.; van der Schoot, P.P.A.M. Published in: Physical Review E DOI: 10.1103/PhysRevE.72.067104
More informationGeographic variation in thermal physiological performance of the intertidal
First posted online on 13 November 2014 as 10.1242/jeb.108217 J Exp Biol Advance Access Online the most Articles. recent version First at posted http://jeb.biologists.org/lookup/doi/10.1242/jeb.108217
More informationKommerciel arbejde med WAsP
Downloaded from orbit.dtu.dk on: Dec 19, 2017 Kommerciel arbejde med WAsP Mortensen, Niels Gylling Publication date: 2002 Document Version Peer reviewed version Link back to DTU Orbit Citation (APA): Mortensen,
More informationPrediction of airfoil performance at high Reynolds numbers.
Downloaded from orbit.dtu.dk on: Nov 04, 2018 Prediction of airfoil performance at high Reynolds numbers. Sørensen, Niels N.; Zahle, Frederik; Michelsen, Jess Publication date: 2014 Document Version Publisher's
More informationOptimizing Reliability using BECAS - an Open-Source Cross Section Analysis Tool
Downloaded from orbit.dtu.dk on: Dec 20, 2017 Optimizing Reliability using BECAS - an Open-Source Cross Section Analysis Tool Bitsche, Robert; Blasques, José Pedro Albergaria Amaral Publication date: 2012
More informationDocument Version Publisher s PDF, also known as Version of Record (includes final page, issue and volume numbers)
Effect of molar mass ratio of monomers on the mass distribution of chain lengths and compositions in copolymers: extension of the Stockmayer theory Tacx, J.C.J.F.; Linssen, H.N.; German, A.L. Published
More informationTectonic Thinking Beim, Anne; Bech-Danielsen, Claus; Bundgaard, Charlotte; Madsen, Ulrik Stylsvig
Aalborg Universitet Tectonic Thinking Beim, Anne; Bech-Danielsen, Claus; Bundgaard, Charlotte; Madsen, Ulrik Stylsvig Publication date: 2011 Document Version Early version, also known as pre-print Link
More informationDetermination of packaging induced 3D stress utilizing a piezocoefficient mapping device
Downloaded from orbit.dtu.dk on: Dec 15, 2018 Determination of packaging induced 3D stress utilizing a piezocoefficient mapping device Richter, Jacob; Hyldgård, A.; Birkelund, Karen; Arnoldus, Morten Berg;
More informationTilburg University. Strongly Regular Graphs with Maximal Energy Haemers, W. H. Publication date: Link to publication
Tilburg University Strongly Regular Graphs with Maximal Energy Haemers, W. H. Publication date: 2007 Link to publication Citation for published version (APA): Haemers, W. H. (2007). Strongly Regular Graphs
More informationOn a set of diophantine equations
On a set of diophantine equations Citation for published version (APA): van Lint, J. H. (1968). On a set of diophantine equations. (EUT report. WSK, Dept. of Mathematics and Computing Science; Vol. 68-WSK-03).
More informationCitation for published version (APA): Burcharth, H. F. (1988). Stress Analysis. Aalborg: Department of Civil Engineering, Aalborg University.
Aalborg Universitet Stress Analysis Burcharth, Hans Falk Publication date: 1988 Document Version Accepted author manuscript, peer reviewed version Link to publication from Aalborg University Citation for
More informationAalborg Universitet. Land-use modelling by cellular automata Hansen, Henning Sten. Published in: NORDGI : Nordic Geographic Information
Aalborg Universitet Land-use modelling by cellular automata Hansen, Henning Sten Published in: NORDGI : Nordic Geographic Information Publication date: 2006 Document Version Publisher's PDF, also known
More informationLattice Boltzmann Modeling From the Macro- to the Microscale - An Approximation to the Porous Media in Fuel Cells -
Lattice Boltzmann Modeling From the Macro- to the Microscale - An Approximation to the Porous Media in Fuel Cells Espinoza Andaluz, Mayken; Sundén, Bengt; Andersson, Martin Unpublished: 2014-01-01 Link
More informationAccelerating interior point methods with GPUs for smart grid systems
Downloaded from orbit.dtu.dk on: Dec 18, 2017 Accelerating interior point methods with GPUs for smart grid systems Gade-Nielsen, Nicolai Fog Publication date: 2011 Document Version Publisher's PDF, also
More informationThe Wien Bridge Oscillator Family
Downloaded from orbit.dtu.dk on: Dec 29, 207 The Wien Bridge Oscillator Family Lindberg, Erik Published in: Proceedings of the ICSES-06 Publication date: 2006 Link back to DTU Orbit Citation APA): Lindberg,
More informationReflection of sound from finite-size plane and curved surfaces
Downloaded from orbit.dtu.dk on: Sep, 08 Reflection of sound from finite-size plane and curved surfaces Rindel, Jens Holger Published in: Journal of the Acoustical Society of America Publication date:
More informationSteady State Comparisons HAWC2 v12.2 vs HAWCStab2 v2.12
Downloaded from orbit.dtu.dk on: Jan 29, 219 Steady State Comparisons v12.2 vs v2.12 Verelst, David Robert; Hansen, Morten Hartvig; Pirrung, Georg Publication date: 216 Document Version Publisher's PDF,
More informationGlobal Wind Atlas validation and uncertainty
Downloaded from orbit.dtu.dk on: Nov 26, 20 Global Wind Atlas validation and uncertainty Mortensen, Niels Gylling; Davis, Neil; Badger, Jake; Hahmann, Andrea N. Publication date: 20 Document Version Publisher's
More informationDesign of Robust AMB Controllers for Rotors Subjected to Varying and Uncertain Seal Forces
Downloaded from orbit.dtu.dk on: Nov 9, 218 Design of Robust AMB Controllers for Rotors Subjected to Varying and Uncertain Seal Forces Lauridsen, Jonas Skjødt; Santos, Ilmar Published in: Mechanical Engineering
More informationDe Prisco, Renato; Comunian, Michele; Grespan, Franscesco; Piscent, Andrea; Karlsson, Anders
ESS DTL RF MODELIZATION: FIELD TUNING AND STABILIZATION De Prisco, Renato; Comunian, Michele; Grespan, Franscesco; Piscent, Andrea; Karlsson, Anders 2013 Link to publication Citation for published version
More informationGIS Readiness Survey 2014 Schrøder, Anne Lise; Hvingel, Line Træholt; Hansen, Henning Sten; Skovdal, Jesper Høi
Aalborg Universitet GIS Readiness Survey 2014 Schrøder, Anne Lise; Hvingel, Line Træholt; Hansen, Henning Sten; Skovdal, Jesper Høi Published in: Geoforum Perspektiv DOI (link to publication from Publisher):
More informationValidation of Boundary Layer Winds from WRF Mesoscale Forecasts over Denmark
Downloaded from orbit.dtu.dk on: Dec 14, 2018 Validation of Boundary Layer Winds from WRF Mesoscale Forecasts over Denmark Hahmann, Andrea N.; Pena Diaz, Alfredo Published in: EWEC 2010 Proceedings online
More informationBenchmark of Femlab, Fluent and Ansys
Benchmark of Femlab, Fluent and Ansys Verdier, Olivier 2004 Link to publication Citation for published version (APA): Verdier, O. (2004). Benchmark of Femlab, Fluent and Ansys. (Preprints in Mathematical
More informationBattling Bluetongue and Schmallenberg virus Local scale behavior of transmitting vectors
Downloaded from orbit.dtu.dk on: Sep 10, 2018 Local scale behavior of transmitting vectors Stockmarr, Anders; Kirkeby, Carsten Thure; Bødker, Rene Publication date: 2015 Link back to DTU Orbit Citation
More informationBerøringsløs optisk måling af gassammensætning ved UV og IR spektroskopi
Downloaded from orbit.dtu.dk on: Dec 21 2017 Berøringsløs optisk måling af gassammensætning ved UV og IR spektroskopi Clausen Sønnik Publication date: 2008 Document Version Publisher's PDF also known as
More informationDocument Version Publisher s PDF, also known as Version of Record (includes final page, issue and volume numbers)
Magnetic susceptibility of PbSnMnTe in the transition region between ferromagnetic and spin glass phase Story, T.; Galazka, R.R.; Eggenkamp, Paul; Swagten, H.J.M.; de Jonge, W.J.M. Published in: Acta Physica
More informationDesign possibilities for impact noise insulation in lightweight floors A parameter study
Downloaded from orbit.dtu.dk on: Dec 23, 218 Design possibilities for impact noise insulation in lightweight floors A parameter study Brunskog, Jonas; Hammer, Per Published in: Euronoise Publication date:
More informationRoom Allocation Optimisation at the Technical University of Denmark
Downloaded from orbit.dtu.dk on: Mar 13, 2018 Room Allocation Optimisation at the Technical University of Denmark Bagger, Niels-Christian Fink; Larsen, Jesper; Stidsen, Thomas Jacob Riis Published in:
More informationOnline algorithms for parallel job scheduling and strip packing Hurink, J.L.; Paulus, J.J.
Online algorithms for parallel job scheduling and strip packing Hurink, J.L.; Paulus, J.J. Published: 01/01/007 Document Version Publisher s PDF, also known as Version of Record (includes final page, issue
More informationCitation for published version (APA): Teixeira, C. (Accepted/In press). Barley malt products for improved intestinal health
Barley malt products for improved intestinal health Teixeira, Cristina Accepted/In press: 2016-01-01 Document Version: Publisher's PDF, also known as Version of record Link to publication Citation for
More informationPublished in: Proceedings of IECON 2016: 42nd Annual Conference of the IEEE Industrial Electronics Society
Aalborg Universitet Design of Energy Storage Control Strategy to Improve the PV System Power Quality Lei, Mingyu; Yang, Zilong; Wang, Yibo; Xu, Honghua; Meng, Lexuan; Quintero, Juan Carlos Vasquez; Guerrero,
More informationImpact of the interfaces for wind and wave modeling - interpretation using COAWST, SAR and point measurements
Downloaded from orbit.dtu.dk on: Oct 21, 2018 Impact of the interfaces for wind and wave modeling - interpretation using COAWST, SAR and point measurements Larsén, Xiaoli Guo; Du, Jianting; Bolanos, Rodolfo;
More informationDevelopment of a Dainish infrastructure for spatial information (DAISI) Brande-Lavridsen, Hanne; Jensen, Bent Hulegaard
Aalborg Universitet Development of a Dainish infrastructure for spatial information (DAISI) Brande-Lavridsen, Hanne; Jensen, Bent Hulegaard Published in: NORDGI : Nordic Geographic Information Publication
More informationComparisons of winds from satellite SAR, WRF and SCADA to characterize coastal gradients and wind farm wake effects at Anholt wind farm
Downloaded from orbit.dtu.dk on: Dec 10, 2018 Comparisons of winds from satellite SAR, WRF and SCADA to characterize coastal gradients and wind farm wake effects at Anholt wind farm Hasager, Charlotte
More informationCatalytically inactive Gla-domainless factor Xa binds to TFPI and restores ex vivo coagulation in hemophilia plasma
Published Ahead of Print on October 5, 2017, as doi:10.3324/haematol.2017.174037. Copyright 2017 Ferrata Storti Foundation. Catalytically inactive Gla-domainless factor Xa binds to TFPI and restores ex
More informationBenchmarking of optimization methods for topology optimization problems
Downloaded from orbit.dtu.dk on: Feb, 18 Benchmarking of optimization methods for topology optimization problems Rojas Labanda, Susana; Stolpe, Mathias Publication date: 14 Document Version Peer reviewed
More informationAalborg Universitet. CLIMA proceedings of the 12th REHVA World Congress Heiselberg, Per Kvols. Publication date: 2016
Aalborg Universitet CLIMA 2016 - proceedings of the 12th REHVA World Congress Heiselberg, Per Kvols Publication date: 2016 Document Version Final published version Link to publication from Aalborg University
More informationDiffusion of sulfuric acid in protective organic coatings
Downloaded from orbit.dtu.dk on: Nov 03, 2018 Diffusion of sulfuric acid in protective organic coatings Wang, Ting; Møller, Victor Buhl; Dam-Johansen, Kim; Frankær, Sarah M.; Kiil, Søren Publication date:
More informationUpper and Lower Bounds of Frequency Interval Gramians for a Class of Perturbed Linear Systems Shaker, Hamid Reza
Aalborg Universitet Upper and Lower Bounds of Frequency Interval Gramians for a Class of Perturbed Linear Systems Shaker, Hamid Reza Published in: 7th IFAC Symposium on Robust Control Design DOI (link
More informationCharacterization of microporous silica-based membranes by calorimetric analysis Boffa, Vittorio; Yue, Yuanzheng
Aalborg Universitet Characterization of microporous silica-based membranes by calorimetric analysis Boffa, Vittorio; Yue, Yuanzheng Published in: 6th Black Sea Conference on Analytical Chemistry - Book
More informationSimulating wind energy resources with mesoscale models: Intercomparison of stateof-the-art
Downloaded from orbit.dtu.dk on: Nov 01, 2018 Simulating wind energy resources with mesoscale models: Intercomparison of stateof-the-art models Olsen, Bjarke Tobias; Hahmann, Andrea N.; Sempreviva, Anna
More informationUniversity of Dundee. Published in: Molecular Biology and Evolution. DOI: /molbev/msw235. Publication date: 2016
University of Dundee Progressive and biased divergent evolution underpins the origin and diversification of peridinin dinoflagellate plastids Dorrell, Richard G.; Klinger, Christen M.; Newby, Robert J.;
More informationStrongly 2-connected orientations of graphs
Downloaded from orbit.dtu.dk on: Jul 04, 2018 Strongly 2-connected orientations of graphs Thomassen, Carsten Published in: Journal of Combinatorial Theory. Series B Link to article, DOI: 10.1016/j.jctb.2014.07.004
More informationOn numerical evaluation of two-dimensional phase integrals
Downloaded from orbit.dtu.dk on: Nov 28, 2018 On numerical evaluation of two-dimensional phase integrals Lessow, H.; Rusch, W.; Schjær-Jacobsen, Hans Published in: E E E Transactions on Antennas and Propagation
More informationExposure Buildup Factors for Heavy Metal Oxide Glass: A Radiation Shield
Downloaded from orbit.dtu.dk on: Jan 16, 2019 Exposure Buildup Factors for Heavy Metal Oxide Glass: A Radiation Shield Manonara, S. R.; Hanagodimath, S. M.; Gerward, Leif; Mittal, K. C. Published in: Journal
More informationPolydiagnostic study on a surfatron plasma at atmospheric pressure
Polydiagnostic study on a surfatron plasma at atmospheric pressure Citation for published version (APA): Palomares, J. M., Iordanova, E. I., Gamero, A., Sola, A., & Mullen, van der, J. J. A. M. (2009).
More informationEstimation of Peak Wave Stresses in Slender Complex Concrete Armor Units
Downloaded from vbn.aau.dk on: januar 19, 2019 Aalborg Universitet Estimation of Peak Wave Stresses in Slender Complex Concrete Armor Units Howell, G.L.; Burcharth, Hans Falk; Rhee, Joon R Published in:
More informationAalborg Universitet. Bounds on information combining for parity-check equations Land, Ingmar Rüdiger; Hoeher, A.; Huber, Johannes
Aalborg Universitet Bounds on information combining for parity-check equations Land, Ingmar Rüdiger; Hoeher, A.; Huber, Johannes Published in: 2004 International Seminar on Communications DOI link to publication
More informationPublished in: Proceedings of the 21st Symposium on Mathematical Theory of Networks and Systems
Aalborg Universitet Affine variety codes are better than their reputation Geil, Hans Olav; Martin, Stefano Published in: Proceedings of the 21st Symposium on Mathematical Theory of Networks and Systems
More informationOrgan doses determined using a RANDO phantom for different radionuclide depositions and photon energies
Organ doses determined using a RANDO phantom for different radionuclide depositions and photon energies Hörnlund, Mikael; Bernhardsson, Christian Published in: Medical Physics in the Baltic States Published:
More informationA Procedure for Classification of Cup-Anemometers
Downloaded from orbit.dtu.dk on: Dec, 17 A Procedure for Classification of Cup-Anemometers Friis Pedersen, Troels; Paulsen, Uwe Schmidt Published in: Proceedings of EWEC 97 Publication date: 1997 Link
More informationDynamic Asset Allocation - Identifying Regime Shifts in Financial Time Series to Build Robust Portfolios
Downloaded from orbit.dtu.dk on: Jan 22, 2019 Dynamic Asset Allocation - Identifying Regime Shifts in Financial Time Series to Build Robust Portfolios Nystrup, Peter Publication date: 2018 Document Version
More information